Gene info: ID 3158

Gene: HMGCS2

GENE ID: 3158

Synonyms: -

Description: 3-hydroxy-3-methylglutaryl-CoA synthase 2

Gene type: protein-coding

Location: 1p12

dbXrefs: Ensembl:ENSG00000134240 MIM:600234 Vega:OTTHUMG00000012101 UniprotKB:P54868

RefSeq: NG_013348.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.571e-1 (AD) 9.289e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ACPP	0.498
KRT20	0.47
TGM4	0.469
ADH1A	0.464
LTF	0.459
APOC3	0.454
PIGR	0.45
ELF3	0.448
CRISP3	0.445
KLK3	0.443

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SP7	-0.233
PRLHR	-0.204
GJA9	-0.201
ZAR1	-0.197
TRIML2	-0.197
DLX6	-0.184
TACR1	-0.183
DYDC2	-0.181
FTH1P18	-0.18
RIIAD1	-0.178

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of HMGCS2 mRNA"	22698814
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of HMGCS2 mRNA]"	22698814
C495626	14-deoxy-11,12-didehydroandrographolide	"14-deoxy-11,12-didehydroandrographolide results in decreased expression of HMGCS2 mRNA"	22101062
C490166	1-(4-methoxyphenyl)piperazine	1-(4-methoxyphenyl)piperazine results in decreased expression of HMGCS2 mRNA	26821219
C078092	1-piperonylpiperazine	1-piperonylpiperazine results in decreased expression of HMGCS2 mRNA	26821219
C532162	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of HMGCS2 mRNA"	20453058
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of HMGCS2 mRNA	19933214
C525485	2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole	"2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole affects the expression of HMGCS2 mRNA"	27665778
C014211	2,3,7,8-tetrachlorodibenzofuran	"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of HMGCS2 mRNA"	21724226
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of HMGCS2 mRNA"	15059925
C006551	2-amino-2-methyl-1-propanol	2-amino-2-methyl-1-propanol results in decreased expression of HMGCS2 mRNA	25088246
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HMGCS2 mRNA"	23196670\|2639615
C549543	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid analog results in decreased expression of HMGCS2 mRNA	25716159
C473484	4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine	4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine affects the expression of HMGCS2 mRNA	14610520
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HMGCS2 mRNA"	27188386
C029370	4-toluidine	4-toluidine results in decreased expression of HMGCS2 mRNA	27638505
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HMGCS2 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of HMGCS2 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of HMGCS2 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in decreased expression of HMGCS2 mRNA	24126418
D000082	Acetaminophen	Acetaminophen results in increased expression of HMGCS2 protein	21329376
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of HMGCS2 mRNA	17585979
D000082	Acetaminophen	[CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of HMGCS2 protein	25499718
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of HMGCS2 mRNA]	17585979
D000082	Acetaminophen	Acetaminophen results in decreased expression of HMGCS2 mRNA	15120968
D020106	Acrylamide	Acrylamide results in increased expression of HMGCS2 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of HMGCS2 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of HMGCS2 mRNA	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of HMGCS2 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of HMGCS2 mRNA	19770486
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin analog results in decreased expression of HMGCS2 protein	26597043
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of HMGCS2 protein	26597043
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of HMGCS2 mRNA	28522335
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of HMGCS2 mRNA	16483693
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in decreased expression of HMGCS2 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of HMGCS2 mRNA	16269432
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of HMGCS2 mRNA	19770486\|2373587
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of HMGCS2 mRNA	20127859
C038328	BEP protocol	BEP protocol results in increased expression of HMGCS2 mRNA	18987330
D004958	Estradiol	Estradiol results in decreased expression of HMGCS2 mRNA	20106945
D001629	Bezafibrate	Bezafibrate results in increased expression of HMGCS2 mRNA	18787029\|2233809
D001629	Bezafibrate	Butyrates promotes the reaction [Bezafibrate results in increased expression of HMGCS2 mRNA]	22338096
C006780	bisphenol A	bisphenol A results in decreased expression of HMGCS2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of HMGCS2 mRNA	15901920
C032036	bromobenzene	bromobenzene results in decreased expression of HMGCS2 mRNA	12628495
D002087	Butyrates	Butyrates promotes the reaction [Bezafibrate results in increased expression of HMGCS2 mRNA]	22338096
D002087	Butyrates	Butyrates results in increased expression of HMGCS2 mRNA	22338096
D002087	Butyrates	FGF21 protein affects the reaction [Butyrates results in increased expression of HMGCS2 mRNA]	22338096
D002104	Cadmium	Cadmium results in increased oxidation of HMGCS2 protein	24496640
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of HMGCS2 mRNA	18974090
C055494	caffeic acid phenethyl ester	caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of HMGCS2 mRNA]	20360939
D002118	Calcium	Calcium affects the expression of HMGCS2 mRNA	15913539
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of HMGCS2 mRNA	27339419
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of HMGCS2 mRNA	15963342
C010063	carbonyl sulfide	carbonyl sulfide results in increased expression of HMGCS2 mRNA	19395590
D002392	Catechin	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of HMGCS2 mRNA	24763279
D002509	Cephaloridine	Cephaloridine results in decreased expression of HMGCS2 mRNA	18500788
C062876	cetrorelix	[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of HMGCS2 mRNA	18160741
C062876	cetrorelix	[cetrorelix co-treated with testosterone enanthate] results in decreased expression of HMGCS2 mRNA	18160741
D002635	Chenodeoxycholic Acid	Chenodeoxycholic Acid results in decreased expression of HMGCS2 mRNA	27174168
D002713	Chlorine	Chlorine results in decreased expression of HMGCS2 mRNA	18636392
D002713	Chlorine	[Ozone co-treated with Chlorine] affects the expression of HMGCS2 mRNA	18636392
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of HMGCS2 mRNA	25270620
C418118	CI 1044	CI 1044 results in increased expression of HMGCS2 mRNA	17569694
C039671	ciglitazone	[ciglitazone binds to PPARG protein alternative form] which results in increased expression of HMGCS2 mRNA	16197558
C039671	ciglitazone	[ciglitazone binds to PPARG protein] which results in increased expression of HMGCS2 mRNA	16197558
D002922	Ciguatoxins	Ciguatoxins affects the expression of HMGCS2 mRNA	18353800
C019304	ciprofibrate	ciprofibrate results in increased expression of HMGCS2 mRNA	12381268
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of HMGCS2 mRNA	17585979
D002994	Clofibrate	Clofibrate results in increased expression of HMGCS2 mRNA	11171094
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of HMGCS2 mRNA]	17585979
D002994	Clofibrate	PPARA affects the reaction [Clofibrate results in increased expression of HMGCS2 mRNA]	11171094
D002994	Clofibrate	Clofibrate affects the expression of HMGCS2 mRNA	27665778
D002994	Clofibrate	Clofibrate results in increased expression of HMGCS2 mRNA	12851107
D002994	Clofibrate	Clofibrate results in increased expression of HMGCS2 protein	16470657
D002994	Clofibrate	Clofibrate results in increased expression of HMGCS2 mRNA	17363680
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of HMGCS2 mRNA	24386269
D003300	Copper	Copper deficiency results in decreased expression of HMGCS2 mRNA	21784888
D003300	Copper	[Fructose co-treated with Copper deficiency] results in decreased expression of HMGCS2 mRNA	25813056
D003300	Copper	gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of HMGCS2 mRNA]	25813056
D003345	Corticosterone	Corticosterone results in increased expression of HMGCS2 mRNA	15755911
D003471	Cuprizone	Cuprizone results in decreased expression of HMGCS2 mRNA	27523638
D003471	Cuprizone	Cuprizone results in increased expression of HMGCS2 mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in decreased expression of HMGCS2 mRNA	20106945\|2383089
D016572	Cyclosporine	Cyclosporine results in decreased expression of HMGCS2 mRNA	19770486\|2383089
D003561	Cytarabine	Cytarabine results in decreased expression of HMGCS2 mRNA	21198554
D003671	DEET	[fipronil co-treated with DEET] results in decreased expression of HMGCS2 mRNA	27091632
D017135	Desogestrel	[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of HMGCS2 mRNA	18160741
D003907	Dexamethasone	Dexamethasone results in increased expression of HMGCS2 mRNA	14618091\|1696222
D064730	Dexrazoxane	Dexrazoxane results in decreased expression of HMGCS2 mRNA	26873546
D064730	Dexrazoxane	[Doxorubicin co-treated with Dexrazoxane] results in increased expression of HMGCS2 mRNA	26873546
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of HMGCS2 mRNA	28962523
D004008	Diclofenac	Diclofenac results in decreased expression of HMGCS2 mRNA	26934552
D019259	Lamivudine	[Zidovudine co-treated with Lamivudine] results in decreased expression of HMGCS2 mRNA	18313992
D004041	Dietary Fats	Dietary Fats results in increased expression of HMGCS2 mRNA	15238619\|1635704
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of HMGCS2 mRNA	19245819
D004052	Diethylnitrosamine	caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of HMGCS2 mRNA]	20360939
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of HMGCS2 mRNA	28943392
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of HMGCS2 mRNA	20360939
D004237	Diuron	Diuron results in decreased expression of HMGCS2 mRNA	21551480
D004298	Dopamine	Dopamine results in decreased expression of HMGCS2 mRNA	21983523
D004317	Doxorubicin	[Doxorubicin co-treated with Dexrazoxane] results in increased expression of HMGCS2 mRNA	26873546
D004317	Doxorubicin	Doxorubicin results in decreased expression of HMGCS2 mRNA	26873546
D004726	Endosulfan	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HMGCS2 mRNA	26159488
D004726	Endosulfan	Endosulfan results in decreased expression of HMGCS2 mRNA	26159488
C118739	entinostat	entinostat results in increased expression of HMGCS2 mRNA	27188386
D000431	Ethanol	Ethanol results in increased expression of HMGCS2 mRNA	15353170
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of HMGCS2 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of HMGCS2 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of HMGCS2 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of HMGCS2 mRNA	17351261
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of HMGCS2 mRNA	12655037
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of HMGCS2 mRNA	15901920\|1710823
D005228	Fatty Acids, Essential	"Fatty Acids, Essential deficiency results in decreased expression of HMGCS2 mRNA"	23333450
D011345	Fenofibrate	Fenofibrate results in increased expression of HMGCS2 mRNA	25572481
D011345	Fenofibrate	Fenofibrate results in increased expression of HMGCS2 mRNA	27665778
C006012	fenofibric acid	[fenofibric acid binds to PPARA protein] which results in increased expression of HMGCS2 mRNA	16197558
D018818	Fenoldopam	Fenoldopam results in decreased expression of HMGCS2 mRNA	21983523
C082360	fipronil	[fipronil co-treated with DEET] results in decreased expression of HMGCS2 mRNA	27091632
C082360	fipronil	fipronil results in decreased expression of HMGCS2 mRNA	23962444
D005485	Flutamide	Flutamide results in decreased expression of HMGCS2 mRNA	24136188\|2479361
D005485	Flutamide	Flutamide results in increased expression of HMGCS2 mRNA	21525395
D005632	Fructose	[Fructose co-treated with Copper deficiency] results in decreased expression of HMGCS2 mRNA	25813056
D005632	Fructose	gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of HMGCS2 mRNA]	25813056
C056933	fumonisin B1	fumonisin B1 results in decreased expression of HMGCS2 mRNA	16221962
C039281	furan	furan results in decreased expression of HMGCS2 mRNA	15120968
C038958	gadolinium chloride	gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of HMGCS2 mRNA]	25813056
D015248	Gemfibrozil	Gemfibrozil affects the expression of HMGCS2 mRNA	27665778
D019833	Genistein	Genistein results in increased expression of HMGCS2 mRNA	15901920
D005897	Glafenine	Glafenine results in decreased expression of HMGCS2 mRNA	24136188
C511402	Grape Seed Proanthocyanidins	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of HMGCS2 mRNA	24763279
C425931	GW 501516	[GW 501516 binds to PPARD protein] which results in increased expression of HMGCS2 mRNA	16197558
C453899	GW 7647	GW 7647 results in increased expression of HMGCS2 mRNA	23315828
D006534	Heptachlor Epoxide	Heptachlor Epoxide results in decreased expression of HMGCS2 mRNA	25270620
C029424	hydrazine	hydrazine results in increased expression of HMGCS2 mRNA	15282401
D020155	3-Hydroxybutyric Acid	HMGCS2 protein results in increased secretion of 3-Hydroxybutyric Acid	27816970
D007213	Indomethacin	Indomethacin affects the expression of HMGCS2 mRNA	17546600
D007501	Iron	Iron deficiency results in decreased expression of HMGCS2 mRNA	16629162
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of HMGCS2 mRNA	26752646
D007649	Ketamine	Ketamine results in increased expression of HMGCS2 mRNA	20080153
C008261	lead acetate	lead acetate results in decreased expression of HMGCS2 mRNA	25270620
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of HMGCS2 mRNA"	11578593
C482199	lipopolysaccharide, E coli O55-B5	"pyrrolidine dithiocarbamic acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMGCS2 mRNA]"	11578593
D008095	Lithocholic Acid	Lithocholic Acid results in decreased expression of HMGCS2 mRNA	20359477
D008095	Lithocholic Acid	Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of HMGCS2 mRNA]	20359477
D008345	Manganese	Manganese results in decreased expression of HMGCS2 mRNA	26745496
C025340	manganese chloride	manganese chloride results in decreased expression of HMGCS2 mRNA	26745496
D008701	Methapyrilene	Methapyrilene results in decreased expression of HMGCS2 mRNA	16393664
D008713	Methimazole	Methimazole results in increased expression of HMGCS2 mRNA	22504374
D008727	Methotrexate	Methotrexate results in decreased expression of HMGCS2 mRNA	15120968
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of HMGCS2 mRNA"	26251327
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of HMGCS2 promoter"	26251327
D009020	Morphine	Morphine results in increased expression of HMGCS2 mRNA	20144693
C500085	muraglitazar	muraglitazar results in increased expression of HMGCS2 mRNA	21515302
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of HMGCS2 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of HMGCS2 mRNA"	25554681
C461488	N-benzylpiperazine	N-benzylpiperazine results in decreased expression of HMGCS2 mRNA	26821219
D019829	Nevirapine	Nevirapine metabolite results in increased expression of HMGCS2 mRNA	23947594
D019829	Nevirapine	Nevirapine results in increased expression of HMGCS2 mRNA	23947594
D009532	Nickel	Nickel results in decreased expression of HMGCS2 mRNA	24768652\|2558310
C022838	nickel chloride	nickel chloride affects the expression of HMGCS2 mRNA	22110744
C002741	N-nitrosomorpholine	N-nitrosomorpholine affects the expression of HMGCS2 protein	19716841
D015525	Fatty Acids, Omega-3	"Fatty Acids, Omega-3 results in decreased expression of HMGCS2 mRNA"	23333450
D010126	Ozone	[Ozone co-treated with Chlorine] affects the expression of HMGCS2 mRNA	18636392
D017239	Paclitaxel	Paclitaxel results in increased expression of HMGCS2 mRNA	15585946
C036567	perfluorodecanoic acid	perfluorodecanoic acid results in decreased expression of HMGCS2 mRNA	23567314
C522391	perfluorododecanoic acid	perfluorododecanoic acid results in decreased expression of HMGCS2 mRNA	23567314
C471071	perfluorohexanesulfonic acid	perfluorohexanesulfonic acid results in increased expression of HMGCS2 mRNA	23567314
C101815	perfluoro-n-heptanoic acid	perfluoro-n-heptanoic acid results in increased expression of HMGCS2 mRNA	23567314
C101816	perfluoro-n-nonanoic acid	perfluoro-n-nonanoic acid results in increased expression of HMGCS2 mRNA	23567314
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in decreased expression of HMGCS2 mRNA	23602845
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of HMGCS2 mRNA	27153767
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of HMGCS2 mRNA	19429403\|2093613
C076994	perfluorooctane sulfonic acid	PPARA protein promotes the reaction [perfluorooctane sulfonic acid results in increased expression of HMGCS2 mRNA]	20936131
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of HMGCS2 mRNA	18692542\|2172336
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of HMGCS2 mRNA	19162173
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of HMGCS2 mRNA	21723365\|2356731
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of HMGCS2 mRNA	17681415\|1942940
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of HMGCS2 mRNA	19162173\|2172336
D010634	Phenobarbital	Phenobarbital affects the expression of HMGCS2 mRNA	23091169
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of HMGCS2 mRNA	19710929
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of HMGCS2 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in decreased expression of HMGCS2 mRNA	16985257
C006253	pirinixic acid	pirinixic acid results in increased expression of HMGCS2 mRNA	12381268\|1577728
C006253	pirinixic acid	PPARA protein affects the reaction [pirinixic acid results in increased expression of HMGCS2 mRNA]	15777286
C006253	pirinixic acid	pirinixic acid results in increased expression of HMGCS2 mRNA	17164430\|1916217
D011084	Polycyclic Aromatic Hydrocarbons	Polycyclic Aromatic Hydrocarbons affects the expression of HMGCS2 mRNA	23147375
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of HMGCS2 mRNA]	20359477
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of HMGCS2 mRNA	28903501
D011374	Progesterone	Progesterone results in increased expression of HMGCS2 mRNA	20726854
C045950	propiconazole	propiconazole results in decreased expression of HMGCS2 mRNA	21278054
D011441	Propylthiouracil	Propylthiouracil results in increased expression of HMGCS2 mRNA	22504374\|2478091
D015237	Dinoprost	Dinoprost results in decreased expression of HMGCS2 mRNA	11517196
C020972	pyrrolidine dithiocarbamic acid	"pyrrolidine dithiocarbamic acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMGCS2 mRNA]"	11578593
D011794	Quercetin	Quercetin results in decreased expression of HMGCS2 mRNA	25862958
D011794	Quercetin	Quercetin results in increased expression of HMGCS2 mRNA	17103110
C059514	resveratrol	resveratrol results in increased expression of HMGCS2 mRNA	22610192
C488333	Ro 65-7199	Ro 65-7199 results in decreased expression of HMGCS2 mRNA	14610520
C089730	rosiglitazone	rosiglitazone results in increased expression of HMGCS2 mRNA	21515302
C016104	sodium bichromate	sodium bichromate affects the expression of HMGCS2 mRNA	22110744
D013311	Streptozocin	Streptozocin results in increased expression of HMGCS2 mRNA	16684804
D013311	Streptozocin	vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of HMGCS2 mRNA]	16684804
C041711	St. Thomas' Hospital cardioplegic solution	St. Thomas' Hospital cardioplegic solution results in decreased expression of HMGCS2 mRNA	16214533
D014284	Triiodothyronine	Triiodothyronine results in increased expression of HMGCS2 mRNA	23397585
D016559	Tacrolimus	Tacrolimus results in decreased expression of HMGCS2 mRNA	25270620
D013629	Tamoxifen	Tamoxifen affects the expression of HMGCS2 mRNA	17555576
D013629	Tamoxifen	Tamoxifen results in decreased expression of HMGCS2 mRNA	20937368
C501413	tesaglitazar	tesaglitazar results in increased expression of HMGCS2 mRNA	21515302
C004648	testosterone enanthate	[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of HMGCS2 mRNA	18160741
C004648	testosterone enanthate	[cetrorelix co-treated with testosterone enanthate] results in decreased expression of HMGCS2 mRNA	18160741
D013749	Tetrachlorodibenzodioxin	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HMGCS2 mRNA	26159488
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of HMGCS2 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HMGCS2 mRNA	20106945\|2615948
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of HMGCS2 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HMGCS2 gene]	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HMGCS2 mRNA	19770486\|1993321
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of HMGCS2 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HMGCS2 mRNA	16054898\|2121527
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of HMGCS2 mRNA	28973375
D013752	Tetracycline	Tetracycline results in decreased expression of HMGCS2 mRNA	24489787
C020809	tetrathiomolybdate	tetrathiomolybdate results in decreased expression of HMGCS2 mRNA	21784888
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of HMGCS2 mRNA	28943392
C009495	titanium dioxide	titanium dioxide results in decreased expression of HMGCS2 mRNA	23409001
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of HMGCS2 mRNA	20133372
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of HMGCS2 protein	22609517
D014241	Trichloroethylene	Trichloroethylene results in increased expression of HMGCS2 mRNA	28973375
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of HMGCS2 mRNA	19042947
C057693	troglitazone	troglitazone results in decreased expression of HMGCS2 mRNA	28973697
C057693	troglitazone	troglitazone results in increased expression of HMGCS2 protein	18495193
C057693	troglitazone	troglitazone results in increased expression of HMGCS2 mRNA	21515302
D014520	Urethane	Urethane results in decreased expression of HMGCS2 mRNA	28818685
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in decreased expression of HMGCS2 mRNA	15885361
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HMGCS2 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of HMGCS2 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of HMGCS2 mRNA	23179753\|2627250
D014635	Valproic Acid	Valproic Acid affects the expression of HMGCS2 mRNA	17963808
D014635	Valproic Acid	Valproic Acid results in increased expression of HMGCS2 mRNA	24489787
C034028	vanadyl sulfate	vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of HMGCS2 mRNA]	16684804
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of HMGCS2 gene	25560391
D024483	Vitamin K 3	Vitamin K 3 affects the expression of HMGCS2 mRNA	20044591
D015215	Zidovudine	[Zidovudine co-treated with Lamivudine] results in decreased expression of HMGCS2 mRNA	18313992
D015032	Zinc	Zinc deficiency results in decreased expression of HMGCS2 protein	15671213
D019287	Zinc Sulfate	Zinc Sulfate results in increased expression of HMGCS2 mRNA	16330358

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004421	hydroxymethylglutaryl-CoA synthase activity	-	IBA	21873635
GO:0004421	hydroxymethylglutaryl-CoA synthase activity	-	ISS	-
GO:0004421	hydroxymethylglutaryl-CoA synthase activity	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006084	acetyl-CoA metabolic process	-	IBA	21873635
GO:0006695	cholesterol biosynthetic process	-	IEA	-
GO:0008299	isoprenoid biosynthetic process	-	IEA	-
GO:0010142	farnesyl diphosphate biosynthetic process, mevalonate pathway	-	IBA	21873635
GO:0019216	regulation of lipid metabolic process	-	TAS	-
GO:0046951	ketone body biosynthetic process	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005739	mitochondrion	-	IBA	21873635
GO:0005739	mitochondrion	-	IDA	-
GO:0005759	mitochondrial matrix	-	TAS	-

KEGG ID	KEGG Term
hsa00072	Synthesis and degradation of ketone bodies
hsa00280	Valine, leucine and isoleucine degradation
hsa00650	Butanoate metabolism
hsa00900	Terpenoid backbone biosynthesis
hsa01100	Metabolic pathways
hsa03320	PPAR signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-1989781	PPARA activates gene expression	TAS
R-HSA-400206	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-74182	Ketone body metabolism	TAS
R-HSA-77111	Synthesis of Ketone Bodies	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28987936	HMG-CoA synthase 2 drives brain metabolic reprogramming in cocaine exposure. (2017 Oct 4)	Shao X	Neuropharmacology