Gene: AOX1

316
AO|AOH1
aldehyde oxidase 1
protein-coding
2q33.1
Ensembl:ENSG00000138356 MIM:602841 Vega:OTTHUMG00000154536 UniprotKB:Q06278
NC_000002.12
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.495e-1 (AD)  2.725e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2241080chr2:200662516 (GRCh38.p7)G>A / G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs3815502chr2:200661197 (GRCh38.p7)C>A / C>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COL8A10.804
TRABD2B0.767
INMT0.763
GPX80.752
BMX0.748
OGN0.747
PAWR0.741
GATA60.739
ESM10.739
CCL190.737

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YBX2-0.467
CA7-0.449
RTN4R-0.444
ANKRD24-0.444
RECQL4-0.42
EMX1-0.417
BAIAP2L2-0.416
RS1-0.413
SOHLH1-0.411
NAGPA-0.409

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB03516EniluracilSmall Molecule59989-18-3InvestigationalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalEnzyme
DB00170MenadioneSmall Molecule58-27-5Approved|NutraceuticalEnzyme
DB00339PyrazinamideSmall Molecule98-96-4Approved|InvestigationalEnzyme
DB00426FamciclovirSmall Molecule104227-87-4Approved|InvestigationalEnzyme
DB00437AllopurinolSmall Molecule315-30-0ApprovedEnzyme
DB00481RaloxifeneSmall Molecule84449-90-1Approved|InvestigationalEnzyme
DB00484BrimonidineSmall Molecule59803-98-4ApprovedEnzyme
DB00513Aminocaproic AcidSmall Molecule60-32-2Approved|InvestigationalEnzyme
DB00563MethotrexateSmall Molecule59-05-2ApprovedEnzyme
DB00909ZonisamideSmall Molecule68291-97-4Approved|InvestigationalEnzyme
DB00962ZaleplonSmall Molecule151319-34-5Approved|Illicit|InvestigationalEnzyme
DB01033MercaptopurineSmall Molecule50-44-2ApprovedEnzyme
DB04827Ethyl carbamateSmall Molecule51-79-6WithdrawnEnzyme
DB09054IdelalisibSmall Molecule870281-82-6ApprovedEnzyme
DB09078LenvatinibSmall Molecule417716-92-8Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of AOX1 mRNA"28903501
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of AOX1 mRNA"25614096
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of AOX1 mRNA"25305463
C5586632-(4-(3-quinolin-6-ylmethyl-3H-(1,2,3)triazolo(4,5-b)pyrazin-5-yl)pyrazol-1-yl)ethanol"AOX1 protein affects the metabolism of 2-(4-(3-quinolin-6-ylmethyl-3H-(1,2,3)triazolo(4,5-b)pyrazin-5-yl)pyrazol-1-yl)ethanol"20444863
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of AOX1 mRNA]"21851831
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of AOX1 mRNA"20005886|2185183
C0140242,4,5,2',4',5'-hexachlorobiphenyl"Tetrachlorodibenzodioxin promotes the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of AOX1 mRNA]"21851831
C4257842-(4-amino-3-methylphenyl)-5-fluorobenzothiazole2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in decreased expression of AOX1 mRNA25781201
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of AOX1 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of AOX1 mRNA"23196670
C0144643,4-dichloroaniline"3,4-dichloroaniline results in decreased expression of AOX1 mRNA"24172598
C5495433-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid results in decreased expression of AOX1 mRNA25716159
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AOX1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AOX1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AOX1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AOX1 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of AOX1 mRNA19191707
C0293704-toluidine4-toluidine results in increased expression of AOX1 mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AOX1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AOX1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AOX1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AOX1 mRNA"27188386
C1080166-deoxypenciclovirAOX1 protein affects the metabolism of 6-deoxypenciclovir20444863
D000082AcetaminophenAcetaminophen results in decreased expression of AOX1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of AOX1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of AOX1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of AOX1 mRNA19770486
D000447AldehydesAldehydes results in increased expression of AOX1 mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AOX1 mRNA16483693
D001379AzathioprineAzathioprine results in increased expression of AOX1 mRNA19192274
C487081belinostatbelinostat results in decreased expression of AOX1 mRNA27188386
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of AOX1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AOX1 mRNA20045488
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AOX1 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of AOX1 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AOX1 mRNA19770486|2071347
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of AOX1 mRNA19619570
D004958EstradiolEstradiol results in increased expression of AOX1 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of AOX1 mRNA24894866
D004958Estradiolresveratrol inhibits the reaction [Estradiol results in decreased expression of AOX1]24894866
D004958Estradiolresveratrol inhibits the reaction [Estradiol results in decreased expression of AOX1 mRNA]24894866
C006780bisphenol Abisphenol A results in increased expression of AOX1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of AOX1 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of AOX1 mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of AOX1 mRNA26079696
C034939cadmium sulfidecadmium sulfide results in increased expression of AOX1 mRNA27866839
C031720carbazeranAOX1 protein affects the metabolism of carbazeran20444863
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of AOX1 mRNA17484886
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of AOX1 mRNA19395590
C026690cerous chloride[cerous chloride co-treated with lanthanum chloride] results in increased expression of AOX1 mRNA28954213
D048271Chitosan[Chitosan co-treated with Fish Oils] inhibits the reaction [Dietary Fats results in decreased expression of AOX1 mRNA]28987369
D048271ChitosanChitosan inhibits the reaction [Dietary Fats results in decreased expression of AOX1 mRNA]28987369
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AOX1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of AOX1 mRNA26272509
D002737ChloropreneChloroprene results in increased expression of AOX1 mRNA23125180
C018021cobaltous chloridecobaltous chloride results in increased expression of AOX1 mRNA24386269
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of AOX1 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of AOX1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of AOX1 mRNA20106945|2383089
D016572CyclosporineCyclosporine results in increased expression of AOX1 mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of AOX1 mRNA19770486|2383089
D000069439DasatinibDasatinib results in decreased expression of AOX1 mRNA20579391
D003907DexamethasoneDexamethasone results in increased expression of AOX1 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of AOX1 mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of AOX1 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in increased expression of AOX1 mRNA]20032058
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of AOX1 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of AOX1 mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of AOX1 mRNA26924002
D004041Dietary FatsDietary Fats affects the expression of AOX1 mRNA19680557
D004041Dietary Fats[Chitosan co-treated with Fish Oils] inhibits the reaction [Dietary Fats results in decreased expression of AOX1 mRNA]28987369
D004041Dietary FatsChitosan inhibits the reaction [Dietary Fats results in decreased expression of AOX1 mRNA]28987369
D004041Dietary FatsDietary Fats results in decreased expression of AOX1 mRNA28987369
D004041Dietary FatsFish Oils inhibits the reaction [Dietary Fats results in decreased expression of AOX1 mRNA]28987369
D004052Diethylnitrosamine[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of AOX1 mRNA16158176
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of AOX1 mRNA14656948
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of AOX1 mRNA27638505
D004237DiuronDiuron metabolite results in decreased expression of AOX1 mRNA24172598
D004317DoxorubicinAOX1 protein affects the susceptibility to Doxorubicin16217747
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of AOX1 mRNA26379055
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of AOX1 mRNA17557909
D005395Fish Oils[Chitosan co-treated with Fish Oils] inhibits the reaction [Dietary Fats results in decreased expression of AOX1 mRNA]28987369
D005395Fish OilsFish Oils inhibits the reaction [Dietary Fats results in decreased expression of AOX1 mRNA]28987369
D0150732-Acetylaminofluorene[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of AOX1 mRNA16158176
D0150732-Acetylaminofluorene[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of AOX1 mRNA14656948
D0150732-Acetylaminofluorene2-Acetylaminofluorene analog inhibits the reaction [AOX1 protein affects the oxidation of N(1)-methylnicotinamide]3741414
D0150732-Acetylaminofluorene2-Acetylaminofluorene analog results in decreased activity of AOX1 protein3741414
D005485FlutamideFlutamide results in decreased expression of AOX1 mRNA24793618
D005485FlutamideFlutamide results in increased expression of AOX1 mRNA24136188
D005690GalactoseGalactose results in increased expression of AOX1 mRNA23274001
D005690Galactosesodium bisulfide inhibits the reaction [Galactose results in increased expression of AOX1 mRNA]23274001
C004312glycidolglycidol results in increased expression of AOX1 mRNA24915197
D006052Gold Sodium ThiomalateGold Sodium Thiomalate results in increased expression of AOX1 mRNA19192274
D006877Hydroxamic AcidsHydroxamic Acids analog results in decreased activity of AOX1 protein3741414
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of AOX1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of AOX1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of AOX1 mRNA28628672
D007529IsoflavonesIsoflavones affects the expression of AOX1 mRNA16365062
D007545IsoproterenolIsoproterenol results in increased expression of AOX1 mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of AOX1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of AOX1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of AOX1 mRNA24796395
C028521lanthanum chloride[cerous chloride co-treated with lanthanum chloride] results in increased expression of AOX1 mRNA28954213
C045463leflunomideleflunomide results in increased expression of AOX1 mRNA24136188
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of AOX1 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of AOX1 mRNA25613284
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of AOX1 mRNA26378955
C042720mercuric bromidemercuric bromide results in decreased expression of AOX1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AOX1 mRNA"27188386
D008727MethotrexateAOX1 protein affects the metabolism of Methotrexate20444863
D008727MethotrexateMethotrexate results in decreased expression of AOX1 mRNA24449571
D008727MethotrexateMethotrexate results in increased expression of AOX1 mRNA19192274
C002950methylformamidemethylformamide analog results in increased expression of AOX1 mRNA17040096
C002950methylformamidemethylformamide results in increased expression of AOX1 mRNA17040096
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of AOX1 mRNA28001369
D008775MethylprednisoloneMethylprednisolone results in increased expression of AOX1 mRNA19192274
D016685MitomycinAOX1 protein affects the susceptibility to Mitomycin16217747
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of AOX1 mRNA23360888
C517284monomethyl phthalatemonomethyl phthalate affects the expression of AOX1 mRNA26924002
C024058N(1)-methylnicotinamide2-Acetylaminofluorene analog inhibits the reaction [AOX1 protein affects the oxidation of N(1)-methylnicotinamide]3741414
C024058N(1)-methylnicotinamideAOX1 protein affects the oxidation of N(1)-methylnicotinamide3741414
C058332N-(2'-(dimethylamino)ethyl)acridine-4-carboxamideAOX1 protein affects the metabolism of N-(2'-(dimethylamino)ethyl)acridine-4-carboxamide20444863
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of AOX1 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of AOX1 mRNA"25554681|2562005
C051752nefazodonenefazodone results in increased expression of AOX1 mRNA24136188
C001365N-hydroxy-4-acetylaminobiphenylN-hydroxy-4-acetylaminobiphenyl results in decreased activity of AOX1 protein3741414
C008068N-hydroxyphenacetinN-hydroxyphenacetin results in decreased activity of AOX1 protein3741414
C029938nickel sulfatenickel sulfate results in decreased expression of AOX1 mRNA22714537
D009585Nitrogen DioxideNitrogen Dioxide results in increased expression of AOX1 mRNA27206323
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of AOX1 mRNA17616710
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of AOX1 mRNA20971185
C558013NSC 689534NSC 689534 results in increased expression of AOX1 mRNA20971185
C064976O(6)-benzylguanineAOX1 protein affects the metabolism of O(6)-benzylguanine20444863
D010126OzoneOzone results in decreased expression of AOX1 mRNA12763052
D017239PaclitaxelAOX1 protein affects the susceptibility to Paclitaxel16217747
D000073878Palm OilPalm Oil affects the expression of AOX1 mRNA19680557
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AOX1 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of AOX1 mRNA26272509
D010416PentachlorophenolPentachlorophenol results in increased expression of AOX1 mRNA23892564
C046012pentanalpentanal results in increased expression of AOX1 mRNA26079696
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of AOX1 mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of AOX1 mRNA18692542
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of AOX1 mRNA18281256
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of AOX1 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of AOX1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of AOX1 mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AOX1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of AOX1 mRNA26272509
D010695PhlorhizinPhlorhizin results in decreased expression of AOX1 mRNA22538082
D010795Phthalic AcidsPhthalic Acids results in decreased expression of AOX1 mRNA15728792
C006253pirinixic acidpirinixic acid results in decreased expression of AOX1 mRNA18445702
C006253pirinixic acidpirinixic acid results in increased expression of AOX1 mRNA23811191
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of AOX1 mRNA22714537
D011239PrednisolonePrednisolone results in increased expression of AOX1 mRNA19192274
D011374ProgesteroneProgesterone results in increased expression of AOX1 mRNA21540246|2179573
D011374ProgesteroneProgesterone results in increased expression of AOX1 mRNA19690047
D011374ProgesteroneProgesterone results in increased expression of AOX1 mRNA20726854
C005556propionaldehydepropionaldehyde results in increased expression of AOX1 mRNA26079696
D054328Proton Pump InhibitorsProton Pump Inhibitors results in increased expression of AOX1 mRNA25626140
D011794QuercetinQuercetin results in decreased expression of AOX1 mRNA21632981
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride inhibits the reaction [AOX1 protein results in increased metabolism of zoniporide]20040581
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased activity of AOX1 protein20040581
C059514resveratrolresveratrol affects the expression of AOX1 mRNA23525482
C059514resveratrolresveratrol inhibits the reaction [Estradiol results in decreased expression of AOX1]24894866
C059514resveratrolresveratrol inhibits the reaction [Estradiol results in decreased expression of AOX1 mRNA]24894866
C116926rofecoxibrofecoxib results in decreased expression of AOX1 mRNA17070997
C059590RS 8359AOX1 protein affects the metabolism of RS 835920444863
C064116S-(1,1,2,2-tetrafluoroethyl)cysteine"S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of AOX1 mRNA"16678137
D012643SeleniumSelenium deficiency results in decreased expression of and results in decreased activity of AOX1 protein19182374
D012643SeleniumSelenium deficiency results in decreased expression of AOX1 mRNA19182374
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of AOX1 mRNA23806026
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of AOX1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of AOX1 mRNA25351596
D012834SilverSilver results in increased expression of AOX1 mRNA27131904
C025451sodium bisulfidesodium bisulfide inhibits the reaction [Galactose results in increased expression of AOX1 mRNA]23274001
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of AOX1 mRNA26378955
C013698tallowtallow affects the expression of AOX1 mRNA19680557
D013739TestosteroneTestosterone results in increased expression of AOX1 mRNA21669218
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in increased expression of AOX1 mRNA]20032058
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of AOX1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AOX1 mRNA23669205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AOX1 mRNA19619570
D013749Tetrachlorodibenzodioxin"2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of AOX1 mRNA]"21851831
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AOX1 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of AOX1 mRNA25975270
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Vitamin A] results in increased activity of AOX1 protein16292751
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Vitamin A] results in increased expression of AOX1 mRNA16292751
D013749Tetrachlorodibenzodioxin"Tetrachlorodibenzodioxin promotes the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of AOX1 mRNA]"21851831
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased activity of AOX1 protein16292751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AOX1 mRNA15664268|1629275
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AOX1 protein15664268
D013749Tetrachlorodibenzodioxintungstate inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AOX1 protein]15664268
D013749TetrachlorodibenzodioxinVitamin A inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AOX1 protein]16292751
D013749TetrachlorodibenzodioxinVitamin A inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AOX1 mRNA]16292751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AOX1 mRNA21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AOX1 mRNA20558275
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of AOX1 mRNA25613284
D013875ThiophanateThiophanate results in increased expression of AOX1 protein17329170
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of AOX1 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of AOX1 mRNA28111298
D019772TopotecanAOX1 protein affects the susceptibility to Topotecan16217747
C012589trichostatin Atrichostatin A results in decreased expression of AOX1 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of AOX1 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of AOX1 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of AOX1 mRNA29024780
C045951tungstatetungstate inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AOX1 protein]15664268
C045951tungstatetungstate results in decreased expression of AOX1 protein15664268
D014520UrethaneUrethane results in decreased expression of AOX1 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of AOX1 mRNA24383497|2493525
D014635Valproic AcidValproic Acid results in decreased methylation of AOX1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of AOX1 mRNA17292431
D014638VanadatesVanadates results in increased expression of AOX1 mRNA22714537
D014747VinblastineAOX1 protein affects the susceptibility to Vinblastine16217747
C029297vinylidene chloridevinylidene chloride results in increased expression of AOX1 mRNA26682919
D014801Vitamin A[Tetrachlorodibenzodioxin co-treated with Vitamin A] results in increased activity of AOX1 protein16292751
D014801Vitamin A[Tetrachlorodibenzodioxin co-treated with Vitamin A] results in increased expression of AOX1 mRNA16292751
D014801Vitamin AVitamin A inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AOX1 protein]16292751
D014801Vitamin AVitamin A inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AOX1 mRNA]16292751
D024483Vitamin K 3Vitamin K 3 inhibits the reaction [AOX1 protein results in increased metabolism of zoniporide]20040581
D024483Vitamin K 3Vitamin K 3 results in decreased activity of AOX1 protein20040581
D024483Vitamin K 3Vitamin K 3 results in decreased activity of AOX1 protein3741414
C118180XK 469AOX1 protein affects the metabolism of XK 46920444863
C085665zaleplonAOX1 protein affects the metabolism of zaleplon20444863
D015032ZincZinc deficiency results in decreased expression of AOX1 mRNA12672911
C424422zoniporideAOX1 protein affects the metabolism of zoniporide20444863
C424422zoniporideAOX1 protein results in increased hydrolysis of zoniporide20040581
C424422zoniporideAOX1 protein results in increased metabolism of zoniporide20040581
C424422zoniporideRaloxifene Hydrochloride inhibits the reaction [AOX1 protein results in increased metabolism of zoniporide]20040581
C424422zoniporideVitamin K 3 inhibits the reaction [AOX1 protein results in increased metabolism of zoniporide]20040581

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004031aldehyde oxidase activity-IDA22279051  26842593  
GO:0004031aldehyde oxidase activity-TAS-  
GO:0004854xanthine dehydrogenase activity-IBA21873635  
GO:0005506iron ion binding-IDA26322824  26842593  
GO:0009055electron transfer activity-IEA-  
GO:0016614oxidoreductase activity, acting on CH-OH group of donors-IEA-  
GO:0016903oxidoreductase activity, acting on the aldehyde or oxo group of donors-IBA21873635  
GO:0042802identical protein binding-IPI26322824  
GO:0042803protein homodimerization activity-IDA26322824  26842593  
GO:0043546molybdopterin cofactor binding-IDA26322824  26842593  
GO:0050660flavin adenine dinucleotide binding-IBA21873635  
GO:0050660flavin adenine dinucleotide binding-IDA26322824  26842593  
GO:0051287NAD binding-IEA-  
GO:00515372 iron, 2 sulfur cluster binding-IDA26322824  26842593  
GO:0102797geranial:oxygen oxidoreductase activity-IEA-  
GO:0102798heptaldehyde:oxygen oxidoreductase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0009115xanthine catabolic process-IBA21873635  
GO:0017144drug metabolic process-IDA20444863  22031625  22522748  23857892  
GO:0022900electron transport chain-IEA-  
GO:0042816vitamin B6 metabolic process-TAS-  
GO:0055114oxidation-reduction process-IDA22279051  22996261  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA20444863  23857892  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa00280Valine, leucine and isoleucine degradation
hsa00350Tyrosine metabolism
hsa00380Tryptophan metabolism
hsa00750Vitamin B6 metabolism
hsa00760Nicotinate and nicotinamide metabolism
hsa00982Drug metabolism - cytochrome P450
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-964975Vitamins B6 activation to pyridoxal phosphateTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27142338Prostate tumor DNA methylation is associated with cigarette smoking and adverse prostate cancer outcomes. (2016 Jul 15)Shui IMCancer
19184652Molecular genetics of nicotine metabolism. (2009)Mwenifumbo JCHandb Exp Pharmacol