Gene: HMMR

3161
CD168|IHABP|RHAMM
hyaluronan mediated motility receptor
protein-coding
5q34
Ensembl:ENSG00000072571 MIM:600936 Vega:OTTHUMG00000130381 UniprotKB:O75330
NG_023309.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.582e-1 (AD)  6.956e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
XRN10.555
LETM20.541
EGF0.533
PAQR30.525
RC3H10.523
JAK20.521
ZNF4510.52
PPAT0.514
ATAD20.514
STK38L0.511

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COL9A1-0.296
RSPO1-0.291
MTRNR2L9-0.291
OR4F16-0.273
PTGDR2-0.272
CACNG4-0.269
MTRNR2L6-0.269
HIGD1B-0.268
WSCD1-0.266
RERGL-0.257

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB08818Hyaluronic acidSmall Molecule9004-61-9ApprovedTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of HMMR mRNA"28903501
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HMMR mRNA"25510870
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of HMMR mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HMMR mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HMMR mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HMMR mRNA"25510870
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of HMMR mRNA"20713471
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HMMR mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of HMMR mRNA"20406850
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in increased expression of HMMR mRNA25088246
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of HMMR mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of HMMR mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of HMMR mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 affects the expression of HMMR protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of HMMR mRNA23630614
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HMMR mRNA16483693
C000228aristolochic acid Iaristolochic acid I results in decreased expression of HMMR mRNA17483316
D001241AspirinAspirin results in increased expression of HMMR mRNA11906190
D001379AzathioprineAzathioprine results in decreased expression of HMMR mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HMMR mRNA20064835|2010694
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HMMR mRNA"20018196|2038263
D004958EstradiolEstradiol results in decreased expression of HMMR mRNA23019147
D004958EstradiolEstradiol results in increased expression of HMMR mRNA19167446
C044887beta-methylcholinebeta-methylcholine affects the expression of HMMR mRNA21179406
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in decreased expression of HMMR mRNA15912405
C006780bisphenol Abisphenol A affects the expression of HMMR mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of HMMR mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of HMMR mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of HMMR gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of HMMR mRNA25993096
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of HMMR mRNA17484886
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of HMMR mRNA28472532
C031180chrysenechrysene results in decreased expression of HMMR mRNA26377693
C018021cobaltous chloridecobaltous chloride results in decreased expression of HMMR mRNA19376846
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of HMMR mRNA20971185
D003300CopperCopper results in increased expression of HMMR mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of HMMR mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of HMMR mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with ESR1 protein] results in increased expression of HMMR mRNA18310284
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of HMMR mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of HMMR mRNA19167446
D003375CoumestrolESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of HMMR mRNA]18310284
C029892cupric chloridecupric chloride results in decreased expression of HMMR mRNA24650576
D003471CuprizoneCuprizone results in decreased expression of HMMR mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of HMMR mRNA20106945|2163298
D000069439DasatinibDasatinib results in decreased expression of HMMR mRNA20579391
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HMMR mRNA28973377
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HMMR mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HMMR mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of HMMR mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of HMMR mRNA27392435
D002945CisplatinCisplatin results in decreased expression of HMMR mRNA27392435|2759478
D002945Cisplatin[Piroxicam co-treated with Cisplatin] results in increased expression of HMMR mRNA21858171
D002945CisplatinCisplatin results in increased expression of HMMR mRNA21151649
C000944dicrotophosdicrotophos results in decreased expression of HMMR mRNA28302478
D004026DieldrinDieldrin results in increased expression of HMMR mRNA23041725
D002117CalcitriolCalcitriol results in decreased expression of HMMR mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of HMMR mRNA21592394
C472511dimethylarsinous aciddimethylarsinous acid results in increased expression of HMMR mRNA23876855
D004317DoxorubicinHMMR protein affects the susceptibility to Doxorubicin16217747
D004317DoxorubicinDoxorubicin results in decreased expression of HMMR mRNA19073829
D004317DoxorubicinDoxorubicin results in increased oxidation of HMMR protein28818578
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HMMR mRNA22079256
D004918Erythromycin EstolateErythromycin Estolate results in decreased expression of HMMR mRNA24412560
D004918Erythromycin EstolateErythromycin Estolate results in increased expression of HMMR mRNA24412560
D005419FlavonoidsFlavonoids results in decreased expression of HMMR mRNA18035473
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of HMMR mRNA]15016801
D005557FormaldehydeFormaldehyde results in decreased expression of HMMR mRNA23649840
D005944GlucosamineGlucosamine results in decreased expression of HMMR mRNA17109745
D006820Hyaluronic AcidHyaluronic Acid binds to and results in increased activity of HMMR protein16864594
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of HMMR mRNA21179406
C051890irinotecanirinotecan metabolite results in decreased expression of HMMR mRNA15956246
C051890irinotecanirinotecan results in decreased expression of HMMR mRNA15956246
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of HMMR mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HMMR mRNA25961927
C011890kojic acidkojic acid results in decreased expression of HMMR mRNA16595896
D007840LatexLatex analog results in increased expression of HMMR mRNA24768652
D007854LeadLead affects the expression of HMMR mRNA28903495
C008261lead acetatelead acetate results in increased expression of HMMR mRNA22609695
C045463leflunomideleflunomide results in decreased expression of HMMR mRNA28988120
C533894LG 100815LG 100815 results in decreased expression of HMMR mRNA16951191
D008154LucanthoneLucanthone results in decreased expression of HMMR mRNA21148553
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of HMMR mRNA21641980
D008627Mercuric ChlorideMercuric Chloride results in increased expression of HMMR mRNA16507785
D008727MethotrexateMethotrexate results in decreased expression of HMMR mRNA24657277
D008748MethylcholanthreneMethylcholanthrene results in increased expression of HMMR mRNA20713471
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of HMMR mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of HMMR mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of HMMR promoter"26251327
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of HMMR mRNA24810058
D009151Mustard GasMustard Gas results in decreased expression of HMMR mRNA25102026
C017096n-butoxyethanoln-butoxyethanol results in increased expression of HMMR mRNA19812364
C028007nickel monoxidenickel monoxide results in decreased expression of HMMR mRNA19167457
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of HMMR mRNA19074003
C570897NSC668394NSC668394 results in decreased expression of HMMR mRNA27137931
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of HMMR mRNA20971185
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in decreased expression of HMMR mRNA"16951191
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of HMMR mRNA25729387
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of HMMR mRNA25658374
D017239PaclitaxelPaclitaxel results in decreased expression of HMMR protein15907983
C500026palbociclibpalbociclib results in decreased expression of HMMR mRNA22869556
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HMMR mRNA"25510870
D010634PhenobarbitalPhenobarbital results in increased expression of HMMR mRNA19363144|2309116
C006253pirinixic acidpirinixic acid results in increased expression of HMMR mRNA18301758|2381119
C006253pirinixic acidpirinixic acid results in increased expression of HMMR mRNA19162173|2248451
D010894Piroxicam[Piroxicam co-treated with Cisplatin] results in increased expression of HMMR mRNA21858171
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HMMR mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of HMMR mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of HMMR mRNA19162173
D011374ProgesteroneProgesterone results in decreased expression of HMMR mRNA21795739
D011374ProgesteroneProgesterone results in increased expression of HMMR mRNA18070364
C045950propiconazolepropiconazole results in increased expression of HMMR mRNA21278054
C005556propionaldehydepropionaldehyde results in decreased expression of HMMR mRNA26079696
D011794QuercetinQuercetin results in decreased expression of HMMR mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of HMMR mRNA19167446
D012822Silicon DioxideSilicon Dioxide results in increased expression of HMMR mRNA25351596
D012969Sodium FluorideSodium Fluoride results in decreased expression of HMMR mRNA27862939
C561322sparstolonin Bsparstolonin B results in decreased expression of HMMR mRNA23940584
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of HMMR mRNA21641980
D013467SulindacSulindac results in decreased expression of HMMR mRNA11906190
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of HMMR mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of HMMR mRNA21592394
D013739TestosteroneTestosterone results in increased expression of HMMR mRNA19693291
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of HMMR mRNA19074003
C010792testosterone undecanoatetestosterone undecanoate results in increased expression of HMMR mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HMMR mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HMMR mRNA21802500
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HMMR mRNA21570461|2637764
D013853ThioacetamideThioacetamide results in increased expression of HMMR mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of HMMR mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of HMMR mRNA25729387
D019772TopotecanTopotecan results in decreased expression of HMMR mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of HMMR mRNA"19682533
D014241TrichloroethyleneTrichloroethylene results in increased expression of HMMR mRNA19109764
D014241TrichloroethyleneTrichloroethylene results in increased expression of HMMR protein19109764
C012589trichostatin Atrichostatin A affects the expression of HMMR mRNA28542535
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of HMMR mRNA19042947
D014415TunicamycinTunicamycin results in decreased expression of HMMR mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of HMMR mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of HMMR mRNA23179753|2718838
D014635Valproic AcidValproic Acid affects the expression of HMMR mRNA17292431
D014747VinblastineHMMR protein affects the susceptibility to Vinblastine16217747
C029297vinylidene chloridevinylidene chloride results in increased expression of HMMR mRNA26682919
C111237vorinostatvorinostat results in increased expression of HMMR mRNA27188386
C088658zoledronic acidzoledronic acid results in decreased expression of HMMR mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI22110403  22666460  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0010389regulation of G2/M transition of mitotic cell cycle-TAS-  
GO:0030214hyaluronan catabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005813centrosome-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0009986cell surface-IEA-  
GO:0015630microtubule cytoskeleton-IDA-  
GO:0016020membrane-HDA19946888  
KEGG ID KEGG Term
hsa04512ECM-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1630316Glycosaminoglycan metabolismTAS
R-HSA-1640170Cell CycleTAS
R-HSA-2142845Hyaluronan metabolismTAS
R-HSA-2160916Hyaluronan uptake and degradationTAS
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-69275G2/M TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-71387Metabolism of carbohydratesTAS
R-HSA-8854518AURKA Activation by TPX2TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26439031Identification of potential therapeutic target genes and mechanisms in non-small-cell lung carcinoma in non-smoking women based on bioinformatics analysis. (2015 Sep)Zhou WEur Rev Med Pharmacol Sci