Gene: HMOX2

3163
HO-2
heme oxygenase 2
protein-coding
16p13.3
Ensembl:ENSG00000103415 MIM:141251 Vega:OTTHUMG00000129473 UniprotKB:P30519
NC_000016.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.864e-1 (AD)  8.352e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP6V0D10.963
DCTN30.958
LCMT10.958
UCHL10.956
BSCL20.954
ACOT70.954
BABAM10.952
MAEA0.952
FARSA0.952
TUBA4A0.952

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.577
OR4F29-0.538
EBF1-0.476
REST-0.475
MAGEA12-0.47
IL18RAP-0.463
WEE1-0.461
LATS2-0.459
RNF135-0.458
CXCR2-0.457

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB04912StannsoporfinSmall Molecule106344-20-1InvestigationalTarget
ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of HMOX2 protein"25670856
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HMOX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HMOX2 mRNA"27188386
C512352abexinostatabexinostat promotes the reaction [Bortezomib results in decreased expression of HMOX2 mRNA]19417023
C512352abexinostatabexinostat results in decreased expression of HMOX2 mRNA19417023
D000082AcetaminophenAcetaminophen affects the expression of HMOX2 mRNA17562736
D000108AcetylcarnitineAcetylcarnitine affects the reaction [Dexamethasone results in increased expression of HMOX2 mRNA]21986892
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of HMOX2 gene28458013
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HMOX2 mRNA16483693
D001151ArsenicArsenic results in increased expression of HMOX2 mRNA24706384
C006632arsenic trioxidearsenic trioxide results in increased expression of HMOX2 mRNA20458559
D001414BacitracinBacitracin results in increased expression of HMOX2 mRNA18289764
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HMOX2 mRNA22228805
D004958EstradiolEstradiol affects the expression of HMOX2 mRNA21826169
D001623BetamethasoneBetamethasone results in increased expression of HMOX2 protein11698254
D001663BilirubinHMOX2 affects the abundance of Bilirubin16181104
D001663BilirubinHMOX2 protein results in increased chemical synthesis of Bilirubin21448202
C006780bisphenol Abisphenol A affects the expression of HMOX2 mRNA21826169
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of HMOX2 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of HMOX2 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of HMOX2 mRNA28628672
D000069286Bortezomibabexinostat promotes the reaction [Bortezomib results in decreased expression of HMOX2 mRNA]19417023
D019328Buthionine SulfoximineHMOX2 affects the susceptibility to Buthionine Sulfoximine16181104
D020122tert-ButylhydroperoxideHMOX2 protein results in decreased susceptibility to tert-Butylhydroperoxide15589375
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of HMOX2 mRNA27509014
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased methylation of HMOX2 gene27509014
C584509C646 compoundC646 compound results in decreased expression of HMOX2 mRNA26191083
D002104CadmiumCadmium results in increased expression of HMOX2 mRNA24706384
C028031cadmium acetatecadmium acetate affects the expression of HMOX2 mRNA16249259
D019256Cadmium ChlorideCadmium Chloride affects the expression of HMOX2 mRNA21442002
D019256Cadmium Chloride[Cadmium Chloride co-treated with Melatonin] results in decreased expression of HMOX2 mRNA21442002
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of HMOX2 promoter22457795
D019256Cadmium ChlorideCadmium Chloride results in increased expression of HMOX2 mRNA20107868
D002248Carbon MonoxideCarbon Monoxide deficiency promotes the reaction [HMOX2 mutant form results in increased expression of EDN1 protein]12969895
D002248Carbon MonoxideHMOX2 protein affects the abundance of Carbon Monoxide12969895
D002248Carbon MonoxideHMOX2 protein affects the chemical synthesis of Carbon Monoxide11342580
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of HMOX2 mRNA16644059
D002259Carbonyl Cyanide p-TrifluoromethoxyphenylhydrazoneCarbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of HMOX2 mRNA16039398
C499843chromium histidinatechromium histidinate results in increased expression of HMOX2 mRNA19902159
C427471chromium mesoporphyrinchromium mesoporphyrin results in decreased activity of HMOX2 protein21448202
C427471chromium mesoporphyrinchromium mesoporphyrin results in decreased activity of HMOX2 protein21448202
C036937chromium protoporphyrin IXchromium protoporphyrin IX results in decreased activity of HMOX2 protein21448202
C007095cobaltiprotoporphyrincobaltiprotoporphyrin inhibits the reaction [HMOX2 gene mutant form results in increased susceptibility to Streptozocin]16524951
D019327Copper SulfateCopper Sulfate results in decreased expression of HMOX2 mRNA19549813
D003520CyclophosphamideCyclophosphamide results in decreased expression of HMOX2 mRNA11906922
D003905DeuteroporphyrinsDeuteroporphyrins results in decreased activity of HMOX2 protein21448202
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of HMOX2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of HMOX2 mRNA28628672
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of HMOX2 mRNA16054899
D003907DexamethasoneAcetylcarnitine affects the reaction [Dexamethasone results in increased expression of HMOX2 mRNA]21986892
D003907DexamethasoneDexamethasone results in increased expression of HMOX2 mRNA21986892
D003907DexamethasoneMelatonin affects the reaction [Dexamethasone results in increased expression of HMOX2 mRNA]21986892
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HMOX2 mRNA18544905
D004148DioxolanesDioxolanes results in decreased activity of HMOX2 protein16331285
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of HMOX2 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HMOX2 mRNA22079256
D000431Ethanol[Fish Oils co-treated with Ethanol] results in increased expression of HMOX2 mRNA17347304
D000431Ethanol[tricarbonyldichlororuthenium (II) dimer co-treated with Ethanol] results in decreased expression of HMOX2 protein26460608
D018683Excitatory Amino Acid AgentsHMOX2 gene mutant form promotes the reaction [Excitatory Amino Acid Agents results in increased activity of CASP3 protein]16371440
D018683Excitatory Amino Acid AgentsHMOX2 gene mutant form promotes the reaction [Excitatory Amino Acid Agents results in increased localization of RELA protein]16371440
D018683Excitatory Amino Acid AgentsHMOX2 protein results in increased susceptibility to Excitatory Amino Acid Agents12176107
D018683Excitatory Amino Acid AgentsHMOX2 results in decreased susceptibility to Excitatory Amino Acid Agents16371440
D005395Fish Oils[Fish Oils co-treated with Ethanol] results in increased expression of HMOX2 mRNA17347304
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of HMOX2 mRNA22634610
D006152Cyclic GMPHMOX2 affects the abundance of Cyclic GMP16181104
D006427HeminHMOX2 protein results in decreased susceptibility to Hemin15589375
D006427HeminHMOX2 protein results in decreased susceptibility to Hemin16459095
D006861Hydrogen PeroxideHMOX2 protein results in decreased susceptibility to Hydrogen Peroxide15589375
C492448ICG 001ICG 001 results in decreased expression of HMOX2 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of HMOX2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of HMOX2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of HMOX2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of HMOX2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of HMOX2 mRNA16054899
D007538IsoniazidIsoniazid results in increased expression of HMOX2 mRNA12883083
D007649KetamineKetamine results in increased expression of HMOX2 mRNA20080153
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HMOX2 mRNA18544905
C008261lead acetatelead acetate results in increased expression of HMOX2 mRNA21891863
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX2 protein"12114211
C482199lipopolysaccharide, E coli O55-B5"NOS2 protein affects the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX2 protein]"12114211
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX2 protein"12114211
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of HMOX2 mRNA12057914
D008550Melatonin[Cadmium Chloride co-treated with Melatonin] results in decreased expression of HMOX2 mRNA21442002
D008550MelatoninMelatonin affects the reaction [Dexamethasone results in increased expression of HMOX2 mRNA]21986892
D008550MelatoninMelatonin results in decreased expression of HMOX2 mRNA21442002
D008767Methylmercury CompoundsHMOX2 protein results in decreased susceptibility to Methylmercury Compounds20807546
D008825MiconazoleMiconazole results in decreased expression of HMOX2 mRNA22262564
D009020MorphineMorphine results in decreased activity of HMOX2 protein12812915
D009020MorphineMorphine results in increased activity of HMOX2 protein12812915
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of HMOX2 mRNA"15585362
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of HMOX2 mRNA"17450800
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of HMOX2 mRNA"25554681
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of HMOX2 mRNA"12888634
C025589ochratoxin Aochratoxin A results in decreased expression of HMOX2 mRNA16251485
C016340o,p'-DDT"o,p'-DDT affects the expression of HMOX2 mRNA"18925944
D010269ParaquatParaquat results in increased expression of HMOX2 mRNA17935786
D052638Particulate MatterParticulate Matter analog results in increased expression of HMOX2 mRNA12011483
D052638Particulate MatterParticulate Matter results in increased expression of HMOX2 mRNA24216475
C049032pinosylvinpinosylvin results in increased expression of HMOX2 mRNA23333577
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HMOX2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of HMOX2 mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of HMOX2 mRNA28903501
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in increased expression of HMOX2 mRNA25800948
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of HMOX2 mRNA16054899
C017947sodium arsenitesodium arsenite results in increased expression of HMOX2 mRNA21396911
D018038Sodium SeleniteSodium Selenite results in increased expression of HMOX2 mRNA18175754
D053260SootSoot results in decreased expression of HMOX2 mRNA21914721
D013311Streptozocincobaltiprotoporphyrin inhibits the reaction [HMOX2 gene mutant form results in increased susceptibility to Streptozocin]16524951
D013311StreptozocinHMOX2 gene mutant form results in increased susceptibility to Streptozocin16524951
D013311Streptozocintin mesoporphyrin promotes the reaction [HMOX2 gene mutant form results in increased susceptibility to Streptozocin]16524951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HMOX2 mRNA16039398
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HMOX2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HMOX2 mRNA28213091
C055421tin mesoporphyrintin mesoporphyrin promotes the reaction [HMOX2 gene mutant form results in increased susceptibility to Streptozocin]16524951
C055421tin mesoporphyrintin mesoporphyrin results in decreased activity of HMOX2 protein21448202
C055421tin mesoporphyrintin mesoporphyrin results in decreased activity of HMOX2 protein21448202
C032628tin protoporphyrin IXtin protoporphyrin IX results in decreased activity of HMOX2 protein21448202
C032628tin protoporphyrin IXtin protoporphyrin IX results in decreased expression of HMOX2 protein25824035
C009495titanium dioxidetitanium dioxide results in increased expression of HMOX2 mRNA19695317
D014212Tretinoin[Tretinoin co-treated with zoledronic acid] results in increased expression of HMOX2 protein20349282
C447082tricarbonyldichlororuthenium (II) dimer[tricarbonyldichlororuthenium (II) dimer co-treated with Ethanol] results in decreased expression of HMOX2 protein26460608
C447082tricarbonyldichlororuthenium (II) dimertricarbonyldichlororuthenium (II) dimer results in decreased expression of HMOX2 protein26460608
C012589trichostatin Atrichostatin A results in increased expression of HMOX2 mRNA24935251
D014501UraniumUranium results in increased expression of HMOX2 mRNA18375546
D014520UrethaneUrethane results in increased expression of HMOX2 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HMOX2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of HMOX2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of HMOX2 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased methylation of HMOX2 gene29154799
D014638VanadatesVanadates results in increased expression of HMOX2 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of HMOX2 gene25560391
D001335Vehicle EmissionsVehicle Emissions analog results in increased expression of HMOX2 mRNA12011483
D001335Vehicle EmissionsVehicle Emissions results in increased expression of HMOX2 mRNA24216475
C025643vinclozolinvinclozolin results in increased expression of HMOX2 mRNA23034163
C058069zinc mesoporphyrinzinc mesoporphyrin results in decreased activity of HMOX2 protein21448202
C017803zinc protoporphyrinzinc protoporphyrin results in decreased activity of HMOX2 protein21448202
C017803zinc protoporphyrinzinc protoporphyrin results in decreased activity of HMOX2 protein21448202
C017803zinc protoporphyrinzinc protoporphyrin results in decreased expression of HMOX2 protein25824035
C088658zoledronic acid[Tretinoin co-treated with zoledronic acid] results in increased expression of HMOX2 protein20349282

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004392heme oxygenase (decyclizing) activity-IBA21873635  
GO:0004392heme oxygenase (decyclizing) activity-IDA1575508  
GO:0004392heme oxygenase (decyclizing) activity-TAS-  
GO:0005515protein binding-IPI15528406  
GO:0020037heme binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001666response to hypoxia-IDA15528406  
GO:0006788heme oxidation-IBA21873635  
GO:0006879cellular iron ion homeostasis-TAS-  
GO:0006979response to oxidative stress-IBA21873635  
GO:0042167heme catabolic process-IBA21873635  
GO:0042167heme catabolic process-TAS-  
GO:0043312neutrophil degranulation-TAS-  
GO:0055072iron ion homeostasis-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005886plasma membrane-IDA15528406  
GO:0005886plasma membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016020membrane-IBA21873635  
GO:0035579specific granule membrane-TAS-  
KEGG ID KEGG Term
hsa00860Porphyrin and chlorophyll metabolism
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-189445Metabolism of porphyrinsTAS
R-HSA-189483Heme degradationTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-917937Iron uptake and transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21804464Lack of association between the c.544G>A polymorphism of the heme oxygenase-2 gene and age-related macular degeneration. (2011 Aug)Wysokinski DMed Sci Monit