Gene: FOXA1

3169
HNF3A|TCF3A
forkhead box A1
protein-coding
14q21.1
Ensembl:ENSG00000129514 MIM:602294 Vega:OTTHUMG00000140253 UniprotKB:P55317
NG_033028.1
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.258e-1 (AD)  4.940e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC44A40.507
FANCD2OS0.473
HAL0.473
LEP0.472
OR11H120.464
G6PC0.456
ACTL7B0.453
TAAR10.452
GPR1410.45
ELF30.449

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPIL6-0.258
RAB41-0.254
C16orf46-0.237
GDF10-0.231
SPR-0.219
TMEM97-0.217
TIMM21-0.216
SNX31-0.214
GALR3-0.21
CHRNA5-0.21

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of FOXA1 mRNA"28903501
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of FOXA1 mRNA"21724226
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in decreased expression of FOXA1 protein]26363213
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of FOXA1 mRNA]25712622
C0022024-oxoretinoic acid4-oxoretinoic acid results in increased expression of FOXA1 mRNA17034753
C0418194-oxoretinol4-oxoretinol results in increased expression of FOXA1 mRNA17034753
D000082AcetaminophenAcetaminophen results in decreased expression of FOXA1 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FOXA1 mRNA22100608
C103303alitretinoinalitretinoin results in increased expression of FOXA1 mRNA17034753
D013196DihydrotestosteroneCurcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to KLK3 enhancer]]22258452
D013196DihydrotestosteroneCurcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to TMPRSS2 enhancer]]22258452
D013196DihydrotestosteroneDihydrotestosterone promotes the reaction [FOXA1 protein binds to KLK3 enhancer]22258452
D013196DihydrotestosteroneDihydrotestosterone promotes the reaction [FOXA1 protein binds to TMPRSS2 enhancer]22258452
D000638AmiodaroneAmiodarone results in decreased expression of FOXA1 mRNA27089845
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FOXA1 mRNA16483693
C006632arsenic trioxidearsenic trioxide affects the methylation of FOXA1 promoter26046465
C006632arsenic trioxide[arsenic trioxide co-treated with Bortezomib] results in increased expression of FOXA1 mRNA25913414
D001379AzathioprineAzathioprine results in decreased expression of FOXA1 mRNA22623647
D001507BeclomethasoneBeclomethasone results in increased expression of FOXA1 mRNA23656298
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of FOXA1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FOXA1 mRNA26238291|2722105
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FOXA1 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FOXA1 mRNA19770486|2171566
D019207beta Carotenebeta Carotene results in increased expression of FOXA1 mRNA17034753
D004958EstradiolEstradiol results in increased expression of FOXA1 mRNA19484750
D004958EstradiolFOXA1 protein affects the reaction [Estradiol affects the activity of ESR1 protein]21151129
D004958EstradiolFOXA1 protein affects the reaction [[Estradiol binds to ESR1 protein] which results in decreased expression of CCNG2 mRNA]22596188
D004958EstradiolFOXA1 protein affects the reaction [Tetrachlorodibenzodioxin inhibits the reaction [[Estradiol binds to ESR1 protein] which results in decreased expression of CCNG2 mRNA]]22596188
D004958EstradiolEstradiol results in increased expression of FOXA1 mRNA19484750
C095105bexarotenebexarotene results in increased expression of FOXA1 mRNA16648578
C006780bisphenol A2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in decreased expression of FOXA1 protein]26363213
C006780bisphenol Abisphenol A results in decreased expression of FOXA1 mRNA26363213
C006780bisphenol Abisphenol A results in decreased expression of FOXA1 protein26363213
C006780bisphenol AFOXA1 protein affects the reaction [bisphenol A results in decreased expression of CDH1 protein]26363213
C006780bisphenol AFOXA1 protein affects the reaction [bisphenol A results in increased expression of FN1 protein]26363213
C006780bisphenol AFOXA1 protein affects the reaction [bisphenol A results in increased expression of VIM protein]26363213
C006780bisphenol Abisphenol A affects the methylation of FOXA1 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of FOXA1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of FOXA1 gene28505145
D000069286Bortezomib[arsenic trioxide co-treated with Bortezomib] results in increased expression of FOXA1 mRNA25913414
D000069286BortezomibBortezomib results in decreased expression of FOXA1 mRNA20471514
C018475butyraldehydebutyraldehyde results in decreased expression of FOXA1 mRNA26079696
D002211CapsaicinCapsaicin results in decreased expression of FOXA1 mRNA18533110
D002220CarbamazepineCarbamazepine affects the expression of FOXA1 mRNA24752500|2597931
D002220CarbamazepineCarbamazepine affects the expression of FOXA1 mRNA22634333
D002794Choline2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of FOXA1 mRNA]25712622
D002794CholineCholine affects the expression of FOXA1 mRNA17616785
D002794Choline[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of FOXA1 mRNA25712622
D002794CholineQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of FOXA1 mRNA]25712622
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FOXA1 gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of FOXA1 mRNA25712622
D002794CholineQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of FOXA1 mRNA]25712622
D002994ClofibrateClofibrate results in increased expression of FOXA1 mRNA22300585
D019327Copper SulfateCopper Sulfate results in decreased expression of FOXA1 mRNA19549813
D003474CurcuminCurcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to KLK3 enhancer]]22258452
D003474CurcuminCurcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to TMPRSS2 enhancer]]22258452
D016572CyclosporineCyclosporine results in decreased expression of FOXA1 mRNA20106945|2798913
C014347decitabine[decitabine co-treated with trichostatin A] results in decreased expression of FOXA1 mRNA17891453
D004008DiclofenacDiclofenac affects the expression of FOXA1 mRNA24752500
C000944dicrotophosdicrotophos results in increased expression of FOXA1 mRNA28302478
D004041Dietary FatsDietary Fats affects the expression of FOXA1 mRNA19680557
C061365flusilazoleflusilazole affects the expression of FOXA1 mRNA22634333
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FOXA1 gene20938992
D004397FonofosFonofos results in increased methylation of FOXA1 promoter22847954
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of FOXA1 mRNA20044591
C051890irinotecanirinotecan affects the expression of FOXA1 mRNA20097248
C045463leflunomideleflunomide results in decreased expression of FOXA1 mRNA28988120
D001556LindaneLindane results in decreased expression of FOXA1 mRNA17785943
D008627Mercuric ChlorideMercuric Chloride affects the expression of FOXA1 mRNA20353558
D008715Methionine2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of FOXA1 mRNA]25712622
D008715Methionine[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of FOXA1 mRNA25712622
D008715MethionineQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of FOXA1 mRNA]25712622
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FOXA1 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of FOXA1 mRNA25712622
D008715MethionineQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of FOXA1 mRNA]25712622
D008752Methylene ChlorideMethylene Chloride results in decreased expression of FOXA1 mRNA28392392
D008770MethylnitrosoureaMethylnitrosourea results in decreased expression of FOXA1 mRNA27221058
C008493methylselenic acidmethylselenic acid results in decreased expression of FOXA1 mRNA12517777|1854812
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate affects the expression of FOXA1 mRNA21195148
C028577monobutyl phthalatemonobutyl phthalate affects the expression of FOXA1 mRNA21195148
D009151Mustard GasMustard Gas results in increased expression of FOXA1 mRNA15674844
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FOXA1 mRNA"23634900
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FOXA1 mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of FOXA1 protein16239640
D000073878Palm OilPalm Oil affects the expression of FOXA1 mRNA19680557
D010278ParathionParathion results in increased methylation of FOXA1 promoter22847954
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in decreased expression of FOXA1 mRNA18593933
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of FOXA1 mRNA25868421
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of FOXA1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of FOXA1 mRNA18445702|2381119
D011192Potassium DichromatePotassium Dichromate results in decreased expression of FOXA1 mRNA23608068
D011794QuercetinQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of FOXA1 mRNA]25712622
D011794QuercetinQuercetin results in decreased expression of FOXA1 mRNA21632981
D011794QuercetinQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of FOXA1 mRNA]25712622
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in decreased expression of FOXA1 mRNA25800948
C059514resveratrolFOXA1 protein promotes the reaction [resveratrol results in increased activity of ESR1 protein]17513867
C059514resveratrolFOXA1 protein promotes the reaction [resveratrol results in increased expression of BMP2 protein]17513867
C059514resveratrolresveratrol results in increased phosphorylation of FOXA1 protein25311616
D012293Rifampin[Rifampin co-treated with NR1I2 protein] results in decreased expression of FOXA1 mRNA21127053
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of FOXA1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of FOXA1 mRNA23221170
C013698tallowtallow affects the expression of FOXA1 mRNA19680557
D013629TamoxifenFOXA1 protein affects the reaction [Tamoxifen affects the activity of ESR1 protein]21151129
D013629TamoxifenTamoxifen results in decreased expression of FOXA1 mRNA27089845
C012568terbufosterbufos results in increased methylation of FOXA1 promoter22847954
D013739TestosteroneTestosterone results in increased expression of FOXA1 mRNA21669218
D013749TetrachlorodibenzodioxinFOXA1 protein affects the reaction [Tetrachlorodibenzodioxin inhibits the reaction [[Estradiol binds to ESR1 protein] which results in decreased expression of CCNG2 mRNA]]22596188
D013749TetrachlorodibenzodioxinFOXA1 protein affects the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CCNG2 promoter]]22596188
D013749TetrachlorodibenzodioxinFOXA1 protein affects the reaction [Tetrachlorodibenzodioxin promotes the reaction [NCOA3 protein binds to CCNG2 promoter]]22596188
D013749TetrachlorodibenzodioxinFOXA1 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CCNG2 mRNA]22596188
D013749TetrachlorodibenzodioxinFOXA1 protein affects the susceptibility to Tetrachlorodibenzodioxin22596188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to FOXA1 protein]22596188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to FOXA1 protein binds to NR3C1 protein]22596188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[[AHR protein binds to FOXA1 protein] which binds to CCNG2 promoter] which results in increased expression of CCNG2 mRNA]22596188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[[AHR protein binds to NCOA3 protein binds to FOXA1 protein] which binds to CCNG2 promoter] which results in increased expression of CCNG2 mRNA]22596188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[[AHR protein binds to NCOA3 protein binds to FOXA1 protein] which binds to CCNG2 promoter] which results in increased expression of CCNG2 protein]22596188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [FOXA1 protein binds to CCNG2 enhancer]22596188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [FOXA1 protein binds to CCNG2 promoter]22596188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [FOXA1 protein binds to NR3C1 protein]22596188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FOXA1 mRNA21632981|2623829
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FOXA1 mRNA21570461|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FOXA1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FOXA1 mRNA20959002|2121527
D013752TetracyclineTetracycline results in decreased expression of FOXA1 mRNA24469900
D014212TretinoinTretinoin results in increased expression of FOXA1 mRNA17034753|2193413
D014212TretinoinTretinoin results in increased expression of FOXA1 mRNA16604517
C012589trichostatin A[decitabine co-treated with trichostatin A] results in decreased expression of FOXA1 mRNA17891453
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of FOXA1 mRNA"26179874
C406224valdecoxibvaldecoxib results in decreased expression of FOXA1 mRNA24136188
D014635Valproic AcidValproic Acid results in increased expression of FOXA1 mRNA27089845
D014635Valproic AcidValproic Acid results in increased methylation of FOXA1 gene29154799
C025643vinclozolinvinclozolin affects the expression of FOXA1 mRNA19015723
D014801Vitamin AVitamin A results in increased expression of FOXA1 mRNA17034753
D024483Vitamin K 3Vitamin K 3 affects the expression of FOXA1 mRNA20044591
D015032Zinc[PCI 5002 co-treated with Zinc] results in decreased expression of FOXA1 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-ISS-  
GO:0003677DNA binding-IDA9931457  
GO:0003700DNA-binding transcription factor activity-TAS8652662  
GO:0005515protein binding-IPI22722839  23260764  
GO:0008134transcription factor binding-IEA-  
GO:0019904protein domain specific binding-IEA-  
GO:0043565sequence-specific DNA binding-IEA-  
GO:0044212transcription regulatory region DNA binding-IDA16087863  16331276  19127412  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0006338chromatin remodeling-ISS-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007219Notch signaling pathway-IEA-  
GO:0009653anatomical structure morphogenesis-IBA21873635  
GO:0010719negative regulation of epithelial to mesenchymal transition-IMP20160041  
GO:0021904dorsal/ventral neural tube patterning-IEA-  
GO:0030154cell differentiation-IBA21873635  
GO:0032355response to estradiol-IDA16087863  
GO:0033148positive regulation of intracellular estrogen receptor signaling pathway-IMP16087863  
GO:0042445hormone metabolic process-IEA-  
GO:0042593glucose homeostasis-IEA-  
GO:0043065positive regulation of apoptotic process-IDA19127412  
GO:0045666positive regulation of neuron differentiation-IEA-  
GO:0045880positive regulation of smoothened signaling pathway-IEA-  
GO:0045931positive regulation of mitotic cell cycle-IMP16087863  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA16331276  19127412  20160041  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP16087863  
GO:0048646anatomical structure formation involved in morphogenesis-IEA-  
GO:0048665neuron fate specification-IEA-  
GO:0051091positive regulation of DNA-binding transcription factor activity-IMP16087863  
GO:0060441epithelial tube branching involved in lung morphogenesis-IEA-  
GO:0060487lung epithelial cell differentiation-IEA-  
GO:0060528secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development-IEA-  
GO:0060738epithelial-mesenchymal signaling involved in prostate gland development-IEA-  
GO:0060740prostate gland epithelium morphogenesis-IEA-  
GO:0060741prostate gland stromal morphogenesis-IEA-  
GO:0060743epithelial cell maturation involved in prostate gland development-IEA-  
GO:0061144alveolar secondary septum development-IEA-  
GO:0071542dopaminergic neuron differentiation-TAS24431302  
GO:1902691respiratory basal cell differentiation-IEA-  
GO:2000049positive regulation of cell-cell adhesion mediated by cadherin-IC20160041  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA9931457  20160041  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005902microvillus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-8939211ESR-mediated signalingTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS
R-HSA-9018519Estrogen-dependent gene expressionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27835577A functional variant rs4442975 modulating FOXA1-binding affinity does not influence the risk or progression of breast cancer in Chinese Han population. (2016 Dec 6)Zhang YOncotarget
25701738Interactions Between Nuclear Receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice. (2015 May)Tsuchiya HGastroenterology