Gene: APAF1

317
APAF-1|CED4
apoptotic peptidase activating factor 1
protein-coding
12q23.1
Ensembl:ENSG00000120868 MIM:602233 Vega:OTTHUMG00000170214 UniprotKB:O14727
NG_029094.1
PubMed
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.633e-1 (AD)  8.894e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RC3H20.932
KRIT10.932
TOPBP10.931
UBXN2B0.925
RAPGEF20.922
DCP20.922
HEATR5B0.921
HERC30.919
CEP1700.919
SENP20.916

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.454
OR4F29-0.432
S100A14-0.413
PLA2G5-0.394
MTRNR2L10-0.392
S100A1-0.387
MTRNR2L6-0.375
RBP1-0.37
AQP5-0.363
LRAT-0.36

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00171ATPSmall Molecule56-65-5Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether affects the expression of APAF1 mRNA"27589474
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of APAF1 mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of APAF1 mRNA"20816883
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of APAF1 mRNA"20816883
C4824923,4,5,4'-tetramethoxystilbene"3,4,5,4'-tetramethoxystilbene results in increased expression of APAF1 mRNA"22687606
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of APAF1 mRNA16788091
C0909373-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole[cobaltous chloride co-treated with 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole] results in increased expression of APAF1 mRNA24265542
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of APAF1 mRNA24140754
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of APAF1 mRNA"25380136
C0415944-nonylphenol4-nonylphenol affects the expression of APAF1 mRNA27109770
C0415944-nonylphenol4-nonylphenol results in increased expression of APAF1 protein26804764|2710977
C5805985-OH-BDE-475-OH-BDE-47 results in decreased expression of APAF1 mRNA27589474
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased expression of APAF1 mRNA]"19477266
C5805996-OH-BDE-476-OH-BDE-47 results in decreased expression of APAF1 mRNA27589474
D000082AcetaminophenAcetaminophen results in increased expression of APAF1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of APAF1 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of APAF1 mRNA11752693
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of APAF1 mRNA]19477266
D000111AcetylcysteineAcetylcysteine inhibits the reaction [tert-Butylhydroperoxide results in increased expression of APAF1 protein]15877105
D020106AcrylamideAcrylamide results in decreased expression of APAF1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of APAF1 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of APAF1 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of APAF1 mRNA21757418
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of APAF1 mRNA"23195993
D000496AlloxanAlloxan results in decreased expression of APAF1 protein21982801
D000496AlloxanAlloxan results in increased expression of APAF1 protein23092809
D000496AlloxanTaurine inhibits the reaction [Alloxan results in increased expression of APAF1 protein]23092809
D047310Apigenin[polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased expression of APAF1 protein24070738
D001151ArsenicArsenic affects the reaction [GSTO1 gene alternative form results in increased expression of APAF1 mRNA]22293942
D001151ArsenicArsenic results in increased expression of APAF1 mRNA19945496
D001152ArsenicalsArsenicals analog results in increased expression of APAF1 mRNA16778962
C006632arsenic trioxidearsenic trioxide results in increased expression of APAF1 protein25258189
C006632arsenic trioxidearsenic trioxide results in increased expression of APAF1 mRNA19730151
D001241AspirinAspirin results in increased expression of APAF1 mRNA20457246
D001241AspirinAPAF1 results in increased susceptibility to Aspirin11228543
C010329azadirachtinazadirachtin results in increased expression of APAF1 protein20429769
C040929bafilomycin A1bafilomycin A1 results in increased expression of APAF1 protein28483490
C580697BDMC-ABDMC-A results in increased expression of APAF1 protein24365254
D001554BenzeneBenzene results in increased expression of APAF1 protein17171516
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of APAF1 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of APAF1 mRNA21393351
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with sodium bichromate] results in increased expression of APAF1 mRNA22613061
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of APAF1 mRNA19770486|2196490
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of APAF1 mRNA"28593498
C103712benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethanebenzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane results in increased expression of APAF1 protein28483490
D004958EstradiolEstradiol affects the expression of APAF1 mRNA21826169
D004958Estradiol[Estradiol co-treated with EGF protein] results in decreased expression of APAF1 mRNA24758408
D004958EstradiolEstradiol results in decreased expression of APAF1 mRNA23373633
C044887beta-methylcholinebeta-methylcholine affects the expression of APAF1 mRNA21179406
C099952bifenthrinbifenthrin results in increased expression of APAF1 mRNA26071804
C006780bisphenol Abisphenol A results in decreased expression of APAF1 mRNA23557687
C006780bisphenol Abisphenol A results in increased expression of APAF1 mRNA29027980
C006780bisphenol Abisphenol A results in decreased expression of APAF1 mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of APAF1 protein21277958
C006780bisphenol Abisphenol A affects the expression of APAF1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of APAF1 mRNA25181051|2909715
C006780bisphenol Abisphenol A results in increased expression of APAF1 protein23328667
C006780bisphenol Abisphenol A results in increased methylation of APAF1 gene28505145
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of APAF1 mRNA22434021
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of APAF1 mRNA22079614
C022777bufalinbufalin results in increased expression of APAF1 protein27444971
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of APAF1 protein17419000
D020122tert-ButylhydroperoxideAcetylcysteine inhibits the reaction [tert-Butylhydroperoxide results in increased expression of APAF1 protein]15877105
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of APAF1 protein15877105
D020148Butyric Acid"[Butyric Acid co-treated with Niacinamide co-treated with Glucaric Acid] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 mRNA]"25478867
D020148Butyric Acid"[Butyric Acid co-treated with Niacinamide co-treated with Glucaric Acid] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein]"25478867
D020148Butyric Acid"Butyric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 mRNA]"25478867
D020148Butyric Acid"Butyric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein]"25478867
D019256Cadmium ChlorideCadmium Chloride results in increased expression of APAF1 protein24291162
C034939cadmium sulfidecadmium sulfide results in increased expression of APAF1 mRNA27866839
D002211CapsaicinCapsaicin results in increased expression of APAF1 mRNA19502594
D002220CarbamazepineCarbamazepine affects the expression of APAF1 mRNA24752500
C006698carbendazimcarbendazim results in decreased expression of APAF1 mRNA25304545
C006698carbendazimcarbendazim results in increased expression of APAF1 mRNA26055223
C054133casticincasticin results in increased expression of APAF1 protein27862857
C030583ceric oxideceric oxide results in increased expression of APAF1 protein24987704
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of APAF1 protein22406624
D004390ChlorpyrifosChlorpyrifos results in increased expression of APAF1 protein26435000
D004390ChlorpyrifosMitoTEMPO inhibits the reaction [Chlorpyrifos results in increased expression of APAF1 protein]26435000
D004390ChlorpyrifosChlorpyrifos results in decreased expression of APAF1 mRNA20350560
D002784Cholesterol"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased expression of APAF1 mRNA]"19477266
D002784CholesterolAcetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of APAF1 mRNA]19477266
D002784CholesterolCholesterol analog results in increased expression of APAF1 mRNA19477266
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of APAF1 mRNA20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of APAF1 gene20938992
D002927CimetidineCimetidine results in increased activity of APAF1 protein17273750
C018021cobaltous chloride[cobaltous chloride co-treated with 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole] results in increased expression of APAF1 mRNA24265542
C018021cobaltous chloridecobaltous chloride results in increased expression of APAF1 mRNA24265542
D003300Copper[[Ditiocarb binds to Copper] which affects the localization of CYCS protein] promotes the reaction [[[CYCS protein binds to APAF1 protein binds to CASP9 protein] which results in increased metabolism of and results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein]22951949
D003300CopperCopper analog results in decreased expression of APAF1 protein21319953
D003300CopperCopper analog results in increased expression of APAF1 protein22000994
D003474CurcuminCurcumin results in increased expression of APAF1 protein17277231
D003474CurcuminCurcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of APAF1 mRNA]20869986
D003513CycloheximideCycloheximide results in decreased expression of APAF1 mRNA19684285
D003513Cycloheximide[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in decreased expression of APAF1 mRNA19684285
C089595cylindrospermopsincylindrospermopsin results in decreased expression of APAF1 mRNA23726867
C017160cypermethrincypermethrin results in increased expression of APAF1 mRNA20965546|2131646
C017160cypermethrincypermethrin results in increased expression of APAF1 mRNA27704156
C014347decitabinedecitabine affects the expression of APAF1 mRNA17133271
C014347decitabinedecitabine results in increased expression of APAF1 mRNA15972851|1966237
C014347decitabinedecitabine results in increased expression of APAF1 protein19662370
C014347decitabineTP53 protein affects the reaction [decitabine affects the expression of APAF1 mRNA]17133271
C014347decitabinedecitabine results in increased expression of APAF1 mRNA27915011
D003976DiazinonDiazinon affects the expression of APAF1 mRNA22546817
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of APAF1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of APAF1 mRNA27392435
D002945Cisplatin[trichostatin A results in increased activity of APAF1 protein] which results in increased susceptibility to Cisplatin20925046
D002945CisplatinCisplatin results in increased expression of APAF1 mRNA20883750|2527062
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased expression of APAF1 mRNA25410718
D004008DiclofenacDiclofenac affects the expression of APAF1 mRNA24752500
D004026DieldrinDieldrin affects the expression of APAF1 mRNA22546817
D004041Dietary FatsDietary Fats results in decreased expression of APAF1 mRNA18503570
D004041Dietary Fats[Fructose co-treated with Dietary Fats] results in increased expression of APAF1 mRNA28916335
D004041Dietary Fatstroxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of APAF1 mRNA]28916335
C014476diethyl maleatediethyl maleate results in increased expression of APAF1 mRNA11875189
D004052DiethylnitrosamineAHR protein affects the reaction [Diethylnitrosamine affects the expression of APAF1 mRNA]19996281
D004052DiethylnitrosamineAHR protein inhibits the reaction [Diethylnitrosamine results in decreased expression of APAF1 mRNA]19996281
D004052DiethylnitrosamineDiethylnitrosamine affects the expression of APAF1 mRNA19996281|2115964
D004052Diethylnitrosamine[DMU-212 co-treated with Diethylnitrosamine co-treated with Phenobarbital] affects the expression of APAF1 mRNA27048571
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 mRNA"21294050
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein"21294050
D0151279,10-Dimethyl-1,2-benzanthracene"Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 mRNA]"21294050
D0151279,10-Dimethyl-1,2-benzanthracene"Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein]"21294050
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 mRNA"25478867
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein"18791811|2547886
D0151279,10-Dimethyl-1,2-benzanthracene"[Butyric Acid co-treated with Niacinamide co-treated with Glucaric Acid] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 mRNA]"25478867
D0151279,10-Dimethyl-1,2-benzanthracene"[Butyric Acid co-treated with Niacinamide co-treated with Glucaric Acid] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein]"25478867
D0151279,10-Dimethyl-1,2-benzanthracene"Butyric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 mRNA]"25478867
D0151279,10-Dimethyl-1,2-benzanthracene"Butyric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein]"25478867
D0151279,10-Dimethyl-1,2-benzanthracene"Glucaric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 mRNA]"25478867
D0151279,10-Dimethyl-1,2-benzanthracene"Glucaric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein]"25478867
D0151279,10-Dimethyl-1,2-benzanthracene"Niacinamide inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 mRNA]"25478867
D0151279,10-Dimethyl-1,2-benzanthracene"Niacinamide inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein]"25478867
D0151279,10-Dimethyl-1,2-benzanthracene"resveratrol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein]"18791811
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of APAF1 mRNA25380136
D004050Ditiocarb[[Ditiocarb binds to Copper] which affects the localization of CYCS protein] promotes the reaction [[[CYCS protein binds to APAF1 protein binds to CASP9 protein] which results in increased metabolism of and results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein]22951949
C521792DMU-212DMU-212 results in increased expression of APAF1 mRNA22687606|2405589
C521792DMU-212[DMU-212 co-treated with Diethylnitrosamine co-treated with Phenobarbital] affects the expression of APAF1 mRNA27048571
C521792DMU-212DMU-212 results in decreased expression of APAF1 mRNA27048571
D0192972,4-Dinitrophenol"2,4-Dinitrophenol results in increased expression of APAF1 mRNA alternative form"17064354
D004317DoxorubicinDoxorubicin results in increased expression of APAF1 mRNA15939500|1600197
D004317Doxorubicinpluronic block copolymer p85 promotes the reaction [Doxorubicin results in increased expression of APAF1 mRNA]15939500
D004317DoxorubicinDoxorubicin results in increased expression of APAF1 protein22015447|2516900
D004317DoxorubicinPropofol inhibits the reaction [Doxorubicin results in increased expression of APAF1 protein]22015447
D004610Ellagic AcidEllagic Acid results in decreased expression of APAF1 mRNA12002526
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of APAF1 protein15657356
D000431EthanolEthanol results in increased expression of APAF1 mRNA23273579
C002994ethylene dimethanesulfonateethylene dimethanesulfonate results in increased expression of APAF1 mRNA22711419
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of APAF1 mRNA23649840
D005047EtoposideEtoposide results in increased expression of APAF1 mRNA25270620
D005054EugenolEugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of APAF1 protein]20434464
D005411Flame RetardantsFlame Retardants results in increased expression of APAF1 mRNA19356805
C043562flavoneflavone results in increased expression of APAF1 protein14750173
D005419FlavonoidsFlavonoids results in increased expression of APAF1 mRNA18035473
D005472FluorouracilFluorouracil results in increased expression of APAF1 mRNA16557594
D005485FlutamideFlutamide results in decreased expression of APAF1 mRNA24793618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of APAF1 mRNA20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of APAF1 gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of APAF1 mRNA23649840
D005632Fructose[Fructose co-treated with Dietary Fats] results in increased expression of APAF1 mRNA28916335
D005632Fructosetroxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of APAF1 mRNA]28916335
C039281furanfuran results in increased expression of APAF1 mRNA22079235
D005665FurosemideFurosemide affects the expression of APAF1 mRNA17497460
D019833GenisteinGenistein results in increased expression of APAF1 mRNA15256057
D019833GenisteinGenistein results in increased expression of APAF1 mRNA24967385
D005839GentamicinsGentamicins results in increased expression of APAF1 mRNA22061828
C007845gingerolgingerol results in increased expression of APAF1 mRNA19481070
C007845gingerolgingerol results in increased expression of APAF1 protein19481070
C010974glyphosateglyphosate results in decreased expression of APAF1 protein24073338
D006046Gold[Polyethyleneimine binds to Gold] which results in decreased expression of APAF1 mRNA28433809
D006046Gold[Quercetin analog co-treated with Gold analog] results in increased expression of APAF1 protein27470402
D005937Glucaric Acid"[Butyric Acid co-treated with Niacinamide co-treated with Glucaric Acid] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 mRNA]"25478867
D005937Glucaric Acid"[Butyric Acid co-treated with Niacinamide co-treated with Glucaric Acid] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein]"25478867
D005937Glucaric Acid"Glucaric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 mRNA]"25478867
D005937Glucaric Acid"Glucaric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein]"25478867
C401311GW 7845APAF1 protein affects the susceptibility to GW 784517400580
C500810GW8510GW8510 results in increased expression of APAF1 mRNA22242153
C539481HCV 796HCV 796 results in increased expression of APAF1 protein19098685
C089796hexabromocyclododecanehexabromocyclododecane results in increased expression of APAF1 mRNA19356805
D017313FenretinideFenretinide results in increased expression of APAF1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of APAF1 mRNA26846883
D006918HydroxyureaHydroxyurea results in increased expression of APAF1 mRNA27208086
C492448ICG 001ICG 001 results in decreased expression of APAF1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of APAF1 mRNA25613284
D058085Iron CompoundsIron Compounds results in increased expression of APAF1 protein28483490
D058085Iron CompoundsL 709049 promotes the reaction [Iron Compounds results in increased expression of APAF1 protein]28483490
D007530IsofluraneIsoflurane results in decreased expression of APAF1 mRNA16978161
D007545IsoproterenolIsoproterenol results in increased expression of APAF1 mRNA24286936
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of APAF1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of APAF1 mRNA27392435
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with vemurafenib] results in decreased expression of APAF1 mRNA27169980
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of APAF1 mRNA23430699
D007608Kainic AcidKainic Acid results in increased expression of APAF1 mRNA17997037
C410027KNK 437KNK 437 results in increased expression of APAF1 protein19913524
C410027KNK 437Scorpion Venoms results in increased susceptibility to [KNK 437 results in increased expression of APAF1 protein]19913524
C096429L 709049L 709049 promotes the reaction [Iron Compounds results in increased expression of APAF1 protein]28483490
C096429L 709049L 709049 results in increased expression of APAF1 protein28483490
C008261lead acetatelead acetate results in increased expression of APAF1 mRNA20542052
C017461lead nitratelead nitrate results in decreased expression of APAF1 protein23451106
C017461lead nitratemangiferin inhibits the reaction [lead nitrate results in decreased expression of APAF1 protein]23451106
C038753leptomycin B[leptomycin B co-treated with TP53 gene mutant form] results in increased expression of APAF1 mRNA20803015
D008044LinuronLinuron results in increased expression of APAF1 mRNA28705778
C013099mancozebmancozeb results in increased expression of APAF1 protein22289270
C013592mangiferinmangiferin inhibits the reaction [lead nitrate results in decreased expression of APAF1 protein]23451106
D008555MelittenMelitten affects the reaction [TGFB1 protein affects the localization of APAF1 protein]21871910
D008555MelittenMelitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of APAF1 protein]21354845
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of APAF1 mRNA20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of APAF1 gene20938992
D008727MethotrexateMethotrexate results in increased expression of APAF1 mRNA21678067|2444957
D008748MethylcholanthreneMethylcholanthrene results in increased expression of APAF1 mRNA23273579
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of APAF1 mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of APAF1 mRNA21664453
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of APAF1 mRNA21664453
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of APAF1 mRNA23649840
D008741Methyl MethanesulfonateAPAF1 protein affects the susceptibility to Methyl Methanesulfonate16019050
D008769MethylnitronitrosoguanidineAPAF1 protein affects the susceptibility to Methylnitronitrosoguanidine16019050
D008769MethylnitronitrosoguanidineEugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of APAF1 protein]20434464
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in decreased expression of APAF1 protein20434464
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of APAF1 mRNA25270620
D016685MitomycinMitomycin results in increased expression of APAF1 mRNA25270620
C555916MitoTEMPOMitoTEMPO inhibits the reaction [Chlorpyrifos results in increased expression of APAF1 protein]26435000
C008548morinmorin results in increased expression of APAF1 mRNA28689916
C500085muraglitazarmuraglitazar results in decreased expression of APAF1 mRNA21515302
D009151Mustard GasMustard Gas results in increased expression of APAF1 mRNA15674843|1895507
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of APAF1 mRNA"15585362
C005273naringeninnaringenin results in increased expression of APAF1 protein27838343
C546012N-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamideN-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide results in increased expression of APAF1 protein27470402
D009532NickelNickel results in decreased expression of APAF1 mRNA23195993
C042198nimbolidenimbolide results in increased expression of APAF1 protein20429769
C025589ochratoxin Aochratoxin A results in decreased expression of APAF1 mRNA17316727
C025589ochratoxin Aochratoxin A results in increased expression of APAF1 mRNA19562491
C000594117ON123300ON123300 results in decreased expression of APAF1 mRNA26873845
C016340o,p'-DDT"o,p'-DDT analog results in decreased expression of APAF1 mRNA"22937105
D010100OxygenOxygen deficiency results in increased expression of APAF1 protein21468576
D017239PaclitaxelPaclitaxel results in increased expression of APAF1 protein14749477
D017239PaclitaxelAPAF1 protein affects the reaction [Paclitaxel results in increased activity of and results in increased cleavage of CASP3 protein]17652622
D010269ParaquatParaquat affects the splicing of APAF1 mRNA23613995
D010269ParaquatParaquat results in decreased expression of APAF1 mRNA17064354
D010269ParaquatParaquat results in increased expression of APAF1 mRNA alternative form17064354
D010269ParaquatParaquat affects the splicing of APAF1 exon27111068
D010424PentobarbitalPentobarbital results in decreased expression of APAF1 mRNA16978161
D030421Peroxynitrous AcidCurcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of APAF1 mRNA]20869986
D030421Peroxynitrous AcidPeroxynitrous Acid results in increased expression of APAF1 mRNA20869986
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in increased expression of APAF1 protein16054126
D010634PhenobarbitalPhenobarbital affects the expression of APAF1 mRNA23091169
D010634Phenobarbital[DMU-212 co-treated with Diethylnitrosamine co-treated with Phenobarbital] affects the expression of APAF1 mRNA27048571
D010634PhenobarbitalPhenobarbital results in increased expression of APAF1 mRNA23273579
C121565pifithrinpifithrin results in increased expression of APAF1 protein28483490
C006253pirinixic acidpirinixic acid results in decreased expression of APAF1 mRNA17426115
D010936Plant ExtractsPlant Extracts results in increased expression of APAF1 protein26122529
D028321Plant PreparationsPlant Preparations results in increased expression of APAF1 mRNA24973489
C422648pluronic block copolymer p85pluronic block copolymer p85 promotes the reaction [Doxorubicin results in increased expression of APAF1 mRNA]15939500
D011094Polyethyleneimine[Polyethyleneimine binds to Gold] which results in decreased expression of APAF1 mRNA28433809
C043435polylactic acid-polyglycolic acid copolymer[polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased expression of APAF1 protein24070738
D015742PropofolPropofol inhibits the reaction [Doxorubicin results in increased expression of APAF1 protein]22015447
D015742PropofolPropofol results in decreased expression of APAF1 protein21468576
D011441PropylthiouracilPropylthiouracil results in increased expression of APAF1 mRNA24780913
C009131pyrimidin-2-one beta-ribofuranosidepyrimidin-2-one beta-ribofuranoside affects the expression of APAF1 mRNA17133271
D011794Quercetin[Quercetin analog co-treated with Gold analog] results in increased expression of APAF1 protein27470402
D011794QuercetinQuercetin results in decreased expression of APAF1 mRNA15309432
D011794QuercetinQuercetin results in increased expression of APAF1 protein14750173
D011794Quercetin"Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 mRNA]"21294050
D011794Quercetin"Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein]"21294050
C059514resveratrolresveratrol results in decreased expression of APAF1 mRNA12002526
C059514resveratrolresveratrol results in decreased expression of APAF1 protein14749477
C059514resveratrolresveratrol results in increased expression of APAF1 mRNA12569576
C059514resveratrol"resveratrol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein]"18791811
C059514resveratrolresveratrol results in increased expression of APAF1 protein18201729
C089730rosiglitazonerosiglitazone results in decreased expression of APAF1 mRNA17639046
C089730rosiglitazonerosiglitazone results in decreased expression of APAF1 mRNA21515302
D012402RotenoneRotenone results in increased expression of APAF1 mRNA alternative form17064354
C039961S-(1,2-dichlorovinyl)cysteine"S-(1,2-dichlorovinyl)cysteine results in increased expression of APAF1 protein"15967204
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of APAF1 mRNA21427059
D012451SafroleSafrole results in increased expression of APAF1 protein21591240
D012604Scorpion VenomsScorpion Venoms results in increased expression of APAF1 protein19913524
D012604Scorpion VenomsScorpion Venoms results in increased susceptibility to [KNK 437 results in increased expression of APAF1 protein]19913524
D012604Scorpion VenomsScorpion Venoms results in increased susceptibility to [tanespimycin results in increased expression of APAF1 protein]19913524
C002979selenomethylselenocysteineselenomethylselenocysteine metabolite results in increased expression of APAF1 mRNA25321483
C017947sodium arsenitesodium arsenite results in increased expression of APAF1 protein20830294
C017947sodium arseniteTaurine inhibits the reaction [sodium arsenite results in increased expression of APAF1 protein]20830294
C016104sodium bichromate[Benzo(a)pyrene co-treated with sodium bichromate] results in increased expression of APAF1 mRNA22613061
C112765tanespimycinScorpion Venoms results in increased susceptibility to [tanespimycin results in increased expression of APAF1 protein]19913524
C112765tanespimycintanespimycin results in increased expression of APAF1 protein19913524
D013654TaurineTaurine inhibits the reaction [Alloxan results in increased expression of APAF1 protein]23092809
D013654TaurineTaurine inhibits the reaction [sodium arsenite results in increased expression of APAF1 protein]20830294
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid affects the expression of APAF1 mRNA15885361
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid affects the expression of APAF1 protein15885361
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in decreased expression of APAF1 mRNA15885361
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in decreased expression of APAF1 mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of APAF1 mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of APAF1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of APAF1 mRNA23864506
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of APAF1 mRNA19520675
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate affects the expression of APAF1 protein11139146
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of APAF1 mRNA25613284
C026995thallium acetatethallium acetate results in increased expression of APAF1 protein15965099
D019772TopotecanAPAF1 promotes the reaction [Topotecan results in increased cleavage of BID protein]19812371
D019772TopotecanAPAF1 promotes the reaction [Topotecan results in increased cleavage of CASP2 protein]19812371
D019772TopotecanAPAF1 promotes the reaction [Topotecan results in increased cleavage of CASP3 protein]19812371
D019772TopotecanAPAF1 promotes the reaction [Topotecan results in increased cleavage of CASP9 protein]19812371
D019772TopotecanAPAF1 promotes the reaction [Topotecan results in increased degradation of BCL2L1 protein]19812371
D019772TopotecanAPAF1 promotes the reaction [Topotecan results in increased phosphorylation of H2AFX protein]19812371
D014241TrichloroethyleneTrichloroethylene results in increased methylation of APAF1 gene27618143
C012589trichostatin Atrichostatin A results in increased activity of APAF1 protein20925046
C012589trichostatin A[trichostatin A results in increased activity of APAF1 protein] which results in increased susceptibility to Cisplatin20925046
C001899triptolidetriptolide results in increased expression of APAF1 protein25169008|2699090
C001899triptolideNFE2L2 protein inhibits the reaction [triptolide results in increased expression of APAF1 protein]25169008
C001899triptolidetriptolide results in increased expression of APAF1 protein25169008
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of APAF1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of APAF1 mRNA21515302
C005865troxerutintroxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of APAF1 mRNA]28916335
D014520UrethaneUrethane results in increased expression of APAF1 mRNA28818685
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of APAF1 mRNA15885361
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of APAF1 protein15885361
D014635Valproic AcidValproic Acid results in increased expression of APAF1 mRNA24935251
C551177vemurafenib[(+)-JQ1 compound co-treated with vemurafenib] results in decreased expression of APAF1 mRNA27169980
C025643vinclozolinvinclozolin results in decreased expression of APAF1 mRNA23869203
C029297vinylidene chloridevinylidene chloride results in increased expression of APAF1 mRNA26682919
D009536Niacinamide"[Butyric Acid co-treated with Niacinamide co-treated with Glucaric Acid] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 mRNA]"25478867
D009536Niacinamide"[Butyric Acid co-treated with Niacinamide co-treated with Glucaric Acid] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein]"25478867
D009536Niacinamide"Niacinamide inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 mRNA]"25478867
D009536Niacinamide"Niacinamide inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein]"25478867
D015034Zinc OxideZinc Oxide affects the expression of APAF1 mRNA28648595
C088658zoledronic acidzoledronic acid results in increased expression of APAF1 mRNA28871336
C088658zoledronic acidzoledronic acid results in increased expression of APAF1 mRNA28871336

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000166nucleotide binding-TAS10383829  
GO:0005515protein binding-IPI9267021  9390557  9829980  9922454  10206961  10376594  
10949025  11112785  11550094  11821383  15735003  17274640  
19494828  20462491  21371431  21827945  22246185  
GO:0005524ATP binding-IEA-  
GO:0008656cysteine-type endopeptidase activator activity involved in apoptotic process-IBA21873635  
GO:0008656cysteine-type endopeptidase activator activity involved in apoptotic process-NAS15009102  
GO:0031072heat shock protein binding-IEA-  
GO:0042802identical protein binding-IEA-  
GO:0043531ADP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001666response to hypoxia-IEA-  
GO:0001843neural tube closure-IEA-  
GO:0006915apoptotic process-TAS9753320  
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process-IDA21827945  
GO:0007399nervous system development-TAS9753320  
GO:0007568aging-IEA-  
GO:0007584response to nutrient-IEA-  
GO:0008635activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c-IBA21873635  
GO:0008635activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c-IDA9267021  
GO:0010659cardiac muscle cell apoptotic process-IEA-  
GO:0030154cell differentiation-IEA-  
GO:0030900forebrain development-IEA-  
GO:0034349glial cell apoptotic process-IEA-  
GO:0042981regulation of apoptotic process-TAS10441496  
GO:0043065positive regulation of apoptotic process-TAS18309324  
GO:0043312neutrophil degranulation-TAS-  
GO:0051260protein homooligomerization-IEA-  
GO:0051402neuron apoptotic process-IEA-  
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress-IEA-  
GO:0070317negative regulation of G0 to G1 transition-TAS-  
GO:0071560cellular response to transforming growth factor beta stimulus-IEA-  
GO:0072432response to G1 DNA damage checkpoint signaling-TAS18309324  
GO:0097193intrinsic apoptotic signaling pathway-TAS18309324  
GO:1902510regulation of apoptotic DNA fragmentation-IEA-  
GO:2001235positive regulation of apoptotic signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005634nucleus-IEA-  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0032991protein-containing complex-IDA11821383  
GO:0034774secretory granule lumen-TAS-  
GO:0043293apoptosome-IBA21873635  
GO:0043293apoptosome-IDA21827945  
GO:0043293apoptosome-TAS18309324  
GO:0070062extracellular exosome-HDA19056867  
GO:1904813ficolin-1-rich granule lumen-TAS-  
KEGG ID KEGG Term
hsa04115p53 signaling pathway
hsa04210Apoptosis
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05016Huntington's disease
hsa05222Small cell lung cancer
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisTAS
R-HSA-109606Intrinsic Pathway for ApoptosisTAS
R-HSA-111458Formation of apoptosomeTAS
R-HSA-111459Activation of caspases through apoptosome-mediated cleavageTAS
R-HSA-111461Cytochrome c-mediated apoptotic responseTAS
R-HSA-111471Apoptotic factor-mediated responseTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5357801Programmed Cell DeathTAS
R-HSA-5633008TP53 Regulates Transcription of Cell Death GenesTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-6803207TP53 Regulates Transcription of Caspase Activators and CaspasesTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8953750Transcriptional Regulation by E2F6TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26116372MiR-21: an environmental driver of malignant melanoma? (2015 Jun 27)Melnik BCJ Transl Med
28700107Cigarette smoke induces rat testicular injury via mitochondrial apoptotic pathway. (2017 Oct)He LMol Reprod Dev