Gene info: ID 317

Gene: APAF1

GENE ID: 317

Synonyms: APAF-1|CED4

Description: apoptotic peptidase activating factor 1

Gene type: protein-coding

Location: 12q23.1

dbXrefs: Ensembl:ENSG00000120868 MIM:602233 Vega:OTTHUMG00000170214 UniprotKB:O14727

RefSeq: NG_029094.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.633e-1 (AD) 8.894e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RC3H2	0.932
KRIT1	0.932
TOPBP1	0.931
UBXN2B	0.925
RAPGEF2	0.922
DCP2	0.922
HEATR5B	0.921
HERC3	0.919
CEP170	0.919
SENP2	0.916

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.454
OR4F29	-0.432
S100A14	-0.413
PLA2G5	-0.394
MTRNR2L10	-0.392
S100A1	-0.387
MTRNR2L6	-0.375
RBP1	-0.37
AQP5	-0.363
LRAT	-0.36

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00171	ATP	Small Molecule	56-65-5	Investigational\|Nutraceutical	Target

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether affects the expression of APAF1 mRNA"	27589474
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of APAF1 mRNA"	21346803
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of APAF1 mRNA"	20816883
C036990	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of APAF1 mRNA"	20816883
C482492	3,4,5,4'-tetramethoxystilbene	"3,4,5,4'-tetramethoxystilbene results in increased expression of APAF1 mRNA"	22687606
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of APAF1 mRNA	16788091
C090937	3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole	[cobaltous chloride co-treated with 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole] results in increased expression of APAF1 mRNA	24265542
C017906	3-dinitrobenzene	3-dinitrobenzene results in increased expression of APAF1 mRNA	24140754
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of APAF1 mRNA"	25380136
C041594	4-nonylphenol	4-nonylphenol affects the expression of APAF1 mRNA	27109770
C041594	4-nonylphenol	4-nonylphenol results in increased expression of APAF1 protein	26804764\|2710977
C580598	5-OH-BDE-47	5-OH-BDE-47 results in decreased expression of APAF1 mRNA	27589474
C010643	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased expression of APAF1 mRNA]"	19477266
C580599	6-OH-BDE-47	6-OH-BDE-47 results in decreased expression of APAF1 mRNA	27589474
D000082	Acetaminophen	Acetaminophen results in increased expression of APAF1 mRNA	22230336
D000082	Acetaminophen	Acetaminophen affects the expression of APAF1 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of APAF1 mRNA	11752693
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of APAF1 mRNA]	19477266
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide results in increased expression of APAF1 protein]	15877105
D020106	Acrylamide	Acrylamide results in decreased expression of APAF1 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of APAF1 mRNA	22100608
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of APAF1 mRNA	19770486
D000393	Air Pollutants	Air Pollutants analog results in decreased expression of APAF1 mRNA	21757418
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in decreased expression of APAF1 mRNA"	23195993
D000496	Alloxan	Alloxan results in decreased expression of APAF1 protein	21982801
D000496	Alloxan	Alloxan results in increased expression of APAF1 protein	23092809
D000496	Alloxan	Taurine inhibits the reaction [Alloxan results in increased expression of APAF1 protein]	23092809
D047310	Apigenin	[polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased expression of APAF1 protein	24070738
D001151	Arsenic	Arsenic affects the reaction [GSTO1 gene alternative form results in increased expression of APAF1 mRNA]	22293942
D001151	Arsenic	Arsenic results in increased expression of APAF1 mRNA	19945496
D001152	Arsenicals	Arsenicals analog results in increased expression of APAF1 mRNA	16778962
C006632	arsenic trioxide	arsenic trioxide results in increased expression of APAF1 protein	25258189
C006632	arsenic trioxide	arsenic trioxide results in increased expression of APAF1 mRNA	19730151
D001241	Aspirin	Aspirin results in increased expression of APAF1 mRNA	20457246
D001241	Aspirin	APAF1 results in increased susceptibility to Aspirin	11228543
C010329	azadirachtin	azadirachtin results in increased expression of APAF1 protein	20429769
C040929	bafilomycin A1	bafilomycin A1 results in increased expression of APAF1 protein	28483490
C580697	BDMC-A	BDMC-A results in increased expression of APAF1 protein	24365254
D001554	Benzene	Benzene results in increased expression of APAF1 protein	17171516
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of APAF1 mRNA	20064835
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of APAF1 mRNA	21393351
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with sodium bichromate] results in increased expression of APAF1 mRNA	22613061
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of APAF1 mRNA	19770486\|2196490
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of APAF1 mRNA"	28593498
C103712	benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane	benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane results in increased expression of APAF1 protein	28483490
D004958	Estradiol	Estradiol affects the expression of APAF1 mRNA	21826169
D004958	Estradiol	[Estradiol co-treated with EGF protein] results in decreased expression of APAF1 mRNA	24758408
D004958	Estradiol	Estradiol results in decreased expression of APAF1 mRNA	23373633
C044887	beta-methylcholine	beta-methylcholine affects the expression of APAF1 mRNA	21179406
C099952	bifenthrin	bifenthrin results in increased expression of APAF1 mRNA	26071804
C006780	bisphenol A	bisphenol A results in decreased expression of APAF1 mRNA	23557687
C006780	bisphenol A	bisphenol A results in increased expression of APAF1 mRNA	29027980
C006780	bisphenol A	bisphenol A results in decreased expression of APAF1 mRNA	27685785
C006780	bisphenol A	bisphenol A results in decreased expression of APAF1 protein	21277958
C006780	bisphenol A	bisphenol A affects the expression of APAF1 mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of APAF1 mRNA	25181051\|2909715
C006780	bisphenol A	bisphenol A results in increased expression of APAF1 protein	23328667
C006780	bisphenol A	bisphenol A results in increased methylation of APAF1 gene	28505145
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of APAF1 mRNA	22434021
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of APAF1 mRNA	22079614
C022777	bufalin	bufalin results in increased expression of APAF1 protein	27444971
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of APAF1 protein	17419000
D020122	tert-Butylhydroperoxide	Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide results in increased expression of APAF1 protein]	15877105
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of APAF1 protein	15877105
D020148	Butyric Acid	"[Butyric Acid co-treated with Niacinamide co-treated with Glucaric Acid] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 mRNA]"	25478867
D020148	Butyric Acid	"[Butyric Acid co-treated with Niacinamide co-treated with Glucaric Acid] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein]"	25478867
D020148	Butyric Acid	"Butyric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 mRNA]"	25478867
D020148	Butyric Acid	"Butyric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein]"	25478867
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of APAF1 protein	24291162
C034939	cadmium sulfide	cadmium sulfide results in increased expression of APAF1 mRNA	27866839
D002211	Capsaicin	Capsaicin results in increased expression of APAF1 mRNA	19502594
D002220	Carbamazepine	Carbamazepine affects the expression of APAF1 mRNA	24752500
C006698	carbendazim	carbendazim results in decreased expression of APAF1 mRNA	25304545
C006698	carbendazim	carbendazim results in increased expression of APAF1 mRNA	26055223
C054133	casticin	casticin results in increased expression of APAF1 protein	27862857
C030583	ceric oxide	ceric oxide results in increased expression of APAF1 protein	24987704
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of APAF1 protein	22406624
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of APAF1 protein	26435000
D004390	Chlorpyrifos	MitoTEMPO inhibits the reaction [Chlorpyrifos results in increased expression of APAF1 protein]	26435000
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of APAF1 mRNA	20350560
D002784	Cholesterol	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased expression of APAF1 mRNA]"	19477266
D002784	Cholesterol	Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of APAF1 mRNA]	19477266
D002784	Cholesterol	Cholesterol analog results in increased expression of APAF1 mRNA	19477266
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of APAF1 mRNA	20938992
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of APAF1 gene	20938992
D002927	Cimetidine	Cimetidine results in increased activity of APAF1 protein	17273750
C018021	cobaltous chloride	[cobaltous chloride co-treated with 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole] results in increased expression of APAF1 mRNA	24265542
C018021	cobaltous chloride	cobaltous chloride results in increased expression of APAF1 mRNA	24265542
D003300	Copper	[[Ditiocarb binds to Copper] which affects the localization of CYCS protein] promotes the reaction [[[CYCS protein binds to APAF1 protein binds to CASP9 protein] which results in increased metabolism of and results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein]	22951949
D003300	Copper	Copper analog results in decreased expression of APAF1 protein	21319953
D003300	Copper	Copper analog results in increased expression of APAF1 protein	22000994
D003474	Curcumin	Curcumin results in increased expression of APAF1 protein	17277231
D003474	Curcumin	Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of APAF1 mRNA]	20869986
D003513	Cycloheximide	Cycloheximide results in decreased expression of APAF1 mRNA	19684285
D003513	Cycloheximide	[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in decreased expression of APAF1 mRNA	19684285
C089595	cylindrospermopsin	cylindrospermopsin results in decreased expression of APAF1 mRNA	23726867
C017160	cypermethrin	cypermethrin results in increased expression of APAF1 mRNA	20965546\|2131646
C017160	cypermethrin	cypermethrin results in increased expression of APAF1 mRNA	27704156
C014347	decitabine	decitabine affects the expression of APAF1 mRNA	17133271
C014347	decitabine	decitabine results in increased expression of APAF1 mRNA	15972851\|1966237
C014347	decitabine	decitabine results in increased expression of APAF1 protein	19662370
C014347	decitabine	TP53 protein affects the reaction [decitabine affects the expression of APAF1 mRNA]	17133271
C014347	decitabine	decitabine results in increased expression of APAF1 mRNA	27915011
D003976	Diazinon	Diazinon affects the expression of APAF1 mRNA	22546817
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of APAF1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of APAF1 mRNA	27392435
D002945	Cisplatin	[trichostatin A results in increased activity of APAF1 protein] which results in increased susceptibility to Cisplatin	20925046
D002945	Cisplatin	Cisplatin results in increased expression of APAF1 mRNA	20883750\|2527062
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene results in increased expression of APAF1 mRNA	25410718
D004008	Diclofenac	Diclofenac affects the expression of APAF1 mRNA	24752500
D004026	Dieldrin	Dieldrin affects the expression of APAF1 mRNA	22546817
D004041	Dietary Fats	Dietary Fats results in decreased expression of APAF1 mRNA	18503570
D004041	Dietary Fats	[Fructose co-treated with Dietary Fats] results in increased expression of APAF1 mRNA	28916335
D004041	Dietary Fats	troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of APAF1 mRNA]	28916335
C014476	diethyl maleate	diethyl maleate results in increased expression of APAF1 mRNA	11875189
D004052	Diethylnitrosamine	AHR protein affects the reaction [Diethylnitrosamine affects the expression of APAF1 mRNA]	19996281
D004052	Diethylnitrosamine	AHR protein inhibits the reaction [Diethylnitrosamine results in decreased expression of APAF1 mRNA]	19996281
D004052	Diethylnitrosamine	Diethylnitrosamine affects the expression of APAF1 mRNA	19996281\|2115964
D004052	Diethylnitrosamine	[DMU-212 co-treated with Diethylnitrosamine co-treated with Phenobarbital] affects the expression of APAF1 mRNA	27048571
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 mRNA"	21294050
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein"	21294050
D015127	9,10-Dimethyl-1,2-benzanthracene	"Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 mRNA]"	21294050
D015127	9,10-Dimethyl-1,2-benzanthracene	"Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein]"	21294050
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 mRNA"	25478867
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein"	18791811\|2547886
D015127	9,10-Dimethyl-1,2-benzanthracene	"[Butyric Acid co-treated with Niacinamide co-treated with Glucaric Acid] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 mRNA]"	25478867
D015127	9,10-Dimethyl-1,2-benzanthracene	"[Butyric Acid co-treated with Niacinamide co-treated with Glucaric Acid] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein]"	25478867
D015127	9,10-Dimethyl-1,2-benzanthracene	"Butyric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 mRNA]"	25478867
D015127	9,10-Dimethyl-1,2-benzanthracene	"Butyric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein]"	25478867
D015127	9,10-Dimethyl-1,2-benzanthracene	"Glucaric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 mRNA]"	25478867
D015127	9,10-Dimethyl-1,2-benzanthracene	"Glucaric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein]"	25478867
D015127	9,10-Dimethyl-1,2-benzanthracene	"Niacinamide inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 mRNA]"	25478867
D015127	9,10-Dimethyl-1,2-benzanthracene	"Niacinamide inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein]"	25478867
D015127	9,10-Dimethyl-1,2-benzanthracene	"resveratrol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein]"	18791811
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of APAF1 mRNA	25380136
D004050	Ditiocarb	[[Ditiocarb binds to Copper] which affects the localization of CYCS protein] promotes the reaction [[[CYCS protein binds to APAF1 protein binds to CASP9 protein] which results in increased metabolism of and results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein]	22951949
C521792	DMU-212	DMU-212 results in increased expression of APAF1 mRNA	22687606\|2405589
C521792	DMU-212	[DMU-212 co-treated with Diethylnitrosamine co-treated with Phenobarbital] affects the expression of APAF1 mRNA	27048571
C521792	DMU-212	DMU-212 results in decreased expression of APAF1 mRNA	27048571
D019297	2,4-Dinitrophenol	"2,4-Dinitrophenol results in increased expression of APAF1 mRNA alternative form"	17064354
D004317	Doxorubicin	Doxorubicin results in increased expression of APAF1 mRNA	15939500\|1600197
D004317	Doxorubicin	pluronic block copolymer p85 promotes the reaction [Doxorubicin results in increased expression of APAF1 mRNA]	15939500
D004317	Doxorubicin	Doxorubicin results in increased expression of APAF1 protein	22015447\|2516900
D004317	Doxorubicin	Propofol inhibits the reaction [Doxorubicin results in increased expression of APAF1 protein]	22015447
D004610	Ellagic Acid	Ellagic Acid results in decreased expression of APAF1 mRNA	12002526
C045651	epigallocatechin gallate	epigallocatechin gallate results in increased expression of APAF1 protein	15657356
D000431	Ethanol	Ethanol results in increased expression of APAF1 mRNA	23273579
C002994	ethylene dimethanesulfonate	ethylene dimethanesulfonate results in increased expression of APAF1 mRNA	22711419
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of APAF1 mRNA	23649840
D005047	Etoposide	Etoposide results in increased expression of APAF1 mRNA	25270620
D005054	Eugenol	Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of APAF1 protein]	20434464
D005411	Flame Retardants	Flame Retardants results in increased expression of APAF1 mRNA	19356805
C043562	flavone	flavone results in increased expression of APAF1 protein	14750173
D005419	Flavonoids	Flavonoids results in increased expression of APAF1 mRNA	18035473
D005472	Fluorouracil	Fluorouracil results in increased expression of APAF1 mRNA	16557594
D005485	Flutamide	Flutamide results in decreased expression of APAF1 mRNA	24793618
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of APAF1 mRNA	20938992
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of APAF1 gene	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of APAF1 mRNA	23649840
D005632	Fructose	[Fructose co-treated with Dietary Fats] results in increased expression of APAF1 mRNA	28916335
D005632	Fructose	troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of APAF1 mRNA]	28916335
C039281	furan	furan results in increased expression of APAF1 mRNA	22079235
D005665	Furosemide	Furosemide affects the expression of APAF1 mRNA	17497460
D019833	Genistein	Genistein results in increased expression of APAF1 mRNA	15256057
D019833	Genistein	Genistein results in increased expression of APAF1 mRNA	24967385
D005839	Gentamicins	Gentamicins results in increased expression of APAF1 mRNA	22061828
C007845	gingerol	gingerol results in increased expression of APAF1 mRNA	19481070
C007845	gingerol	gingerol results in increased expression of APAF1 protein	19481070
C010974	glyphosate	glyphosate results in decreased expression of APAF1 protein	24073338
D006046	Gold	[Polyethyleneimine binds to Gold] which results in decreased expression of APAF1 mRNA	28433809
D006046	Gold	[Quercetin analog co-treated with Gold analog] results in increased expression of APAF1 protein	27470402
D005937	Glucaric Acid	"[Butyric Acid co-treated with Niacinamide co-treated with Glucaric Acid] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 mRNA]"	25478867
D005937	Glucaric Acid	"[Butyric Acid co-treated with Niacinamide co-treated with Glucaric Acid] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein]"	25478867
D005937	Glucaric Acid	"Glucaric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 mRNA]"	25478867
D005937	Glucaric Acid	"Glucaric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein]"	25478867
C401311	GW 7845	APAF1 protein affects the susceptibility to GW 7845	17400580
C500810	GW8510	GW8510 results in increased expression of APAF1 mRNA	22242153
C539481	HCV 796	HCV 796 results in increased expression of APAF1 protein	19098685
C089796	hexabromocyclododecane	hexabromocyclododecane results in increased expression of APAF1 mRNA	19356805
D017313	Fenretinide	Fenretinide results in increased expression of APAF1 mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of APAF1 mRNA	26846883
D006918	Hydroxyurea	Hydroxyurea results in increased expression of APAF1 mRNA	27208086
C492448	ICG 001	ICG 001 results in decreased expression of APAF1 mRNA	26191083
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of APAF1 mRNA	25613284
D058085	Iron Compounds	Iron Compounds results in increased expression of APAF1 protein	28483490
D058085	Iron Compounds	L 709049 promotes the reaction [Iron Compounds results in increased expression of APAF1 protein]	28483490
D007530	Isoflurane	Isoflurane results in decreased expression of APAF1 mRNA	16978161
D007545	Isoproterenol	Isoproterenol results in increased expression of APAF1 mRNA	24286936
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of APAF1 mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of APAF1 mRNA	27392435
C561695	(+)-JQ1 compound	[(+)-JQ1 compound co-treated with vemurafenib] results in decreased expression of APAF1 mRNA	27169980
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of APAF1 mRNA	23430699
D007608	Kainic Acid	Kainic Acid results in increased expression of APAF1 mRNA	17997037
C410027	KNK 437	KNK 437 results in increased expression of APAF1 protein	19913524
C410027	KNK 437	Scorpion Venoms results in increased susceptibility to [KNK 437 results in increased expression of APAF1 protein]	19913524
C096429	L 709049	L 709049 promotes the reaction [Iron Compounds results in increased expression of APAF1 protein]	28483490
C096429	L 709049	L 709049 results in increased expression of APAF1 protein	28483490
C008261	lead acetate	lead acetate results in increased expression of APAF1 mRNA	20542052
C017461	lead nitrate	lead nitrate results in decreased expression of APAF1 protein	23451106
C017461	lead nitrate	mangiferin inhibits the reaction [lead nitrate results in decreased expression of APAF1 protein]	23451106
C038753	leptomycin B	[leptomycin B co-treated with TP53 gene mutant form] results in increased expression of APAF1 mRNA	20803015
D008044	Linuron	Linuron results in increased expression of APAF1 mRNA	28705778
C013099	mancozeb	mancozeb results in increased expression of APAF1 protein	22289270
C013592	mangiferin	mangiferin inhibits the reaction [lead nitrate results in decreased expression of APAF1 protein]	23451106
D008555	Melitten	Melitten affects the reaction [TGFB1 protein affects the localization of APAF1 protein]	21871910
D008555	Melitten	Melitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of APAF1 protein]	21354845
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of APAF1 mRNA	20938992
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of APAF1 gene	20938992
D008727	Methotrexate	Methotrexate results in increased expression of APAF1 mRNA	21678067\|2444957
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of APAF1 mRNA	23273579
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of APAF1 mRNA	28001369
D008767	Methylmercury Compounds	Methylmercury Compounds affects the expression of APAF1 mRNA	21664453
D008767	Methylmercury Compounds	Methylmercury Compounds affects the expression of APAF1 mRNA	21664453
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of APAF1 mRNA	23649840
D008741	Methyl Methanesulfonate	APAF1 protein affects the susceptibility to Methyl Methanesulfonate	16019050
D008769	Methylnitronitrosoguanidine	APAF1 protein affects the susceptibility to Methylnitronitrosoguanidine	16019050
D008769	Methylnitronitrosoguanidine	Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of APAF1 protein]	20434464
D008769	Methylnitronitrosoguanidine	Methylnitronitrosoguanidine results in decreased expression of APAF1 protein	20434464
D008770	Methylnitrosourea	Methylnitrosourea results in increased expression of APAF1 mRNA	25270620
D016685	Mitomycin	Mitomycin results in increased expression of APAF1 mRNA	25270620
C555916	MitoTEMPO	MitoTEMPO inhibits the reaction [Chlorpyrifos results in increased expression of APAF1 protein]	26435000
C008548	morin	morin results in increased expression of APAF1 mRNA	28689916
C500085	muraglitazar	muraglitazar results in decreased expression of APAF1 mRNA	21515302
D009151	Mustard Gas	Mustard Gas results in increased expression of APAF1 mRNA	15674843\|1895507
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of APAF1 mRNA"	15585362
C005273	naringenin	naringenin results in increased expression of APAF1 protein	27838343
C546012	N-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide	N-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide results in increased expression of APAF1 protein	27470402
D009532	Nickel	Nickel results in decreased expression of APAF1 mRNA	23195993
C042198	nimbolide	nimbolide results in increased expression of APAF1 protein	20429769
C025589	ochratoxin A	ochratoxin A results in decreased expression of APAF1 mRNA	17316727
C025589	ochratoxin A	ochratoxin A results in increased expression of APAF1 mRNA	19562491
C000594117	ON123300	ON123300 results in decreased expression of APAF1 mRNA	26873845
C016340	o,p'-DDT	"o,p'-DDT analog results in decreased expression of APAF1 mRNA"	22937105
D010100	Oxygen	Oxygen deficiency results in increased expression of APAF1 protein	21468576
D017239	Paclitaxel	Paclitaxel results in increased expression of APAF1 protein	14749477
D017239	Paclitaxel	APAF1 protein affects the reaction [Paclitaxel results in increased activity of and results in increased cleavage of CASP3 protein]	17652622
D010269	Paraquat	Paraquat affects the splicing of APAF1 mRNA	23613995
D010269	Paraquat	Paraquat results in decreased expression of APAF1 mRNA	17064354
D010269	Paraquat	Paraquat results in increased expression of APAF1 mRNA alternative form	17064354
D010269	Paraquat	Paraquat affects the splicing of APAF1 exon	27111068
D010424	Pentobarbital	Pentobarbital results in decreased expression of APAF1 mRNA	16978161
D030421	Peroxynitrous Acid	Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of APAF1 mRNA]	20869986
D030421	Peroxynitrous Acid	Peroxynitrous Acid results in increased expression of APAF1 mRNA	20869986
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in increased expression of APAF1 protein	16054126
D010634	Phenobarbital	Phenobarbital affects the expression of APAF1 mRNA	23091169
D010634	Phenobarbital	[DMU-212 co-treated with Diethylnitrosamine co-treated with Phenobarbital] affects the expression of APAF1 mRNA	27048571
D010634	Phenobarbital	Phenobarbital results in increased expression of APAF1 mRNA	23273579
C121565	pifithrin	pifithrin results in increased expression of APAF1 protein	28483490
C006253	pirinixic acid	pirinixic acid results in decreased expression of APAF1 mRNA	17426115
D010936	Plant Extracts	Plant Extracts results in increased expression of APAF1 protein	26122529
D028321	Plant Preparations	Plant Preparations results in increased expression of APAF1 mRNA	24973489
C422648	pluronic block copolymer p85	pluronic block copolymer p85 promotes the reaction [Doxorubicin results in increased expression of APAF1 mRNA]	15939500
D011094	Polyethyleneimine	[Polyethyleneimine binds to Gold] which results in decreased expression of APAF1 mRNA	28433809
C043435	polylactic acid-polyglycolic acid copolymer	[polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased expression of APAF1 protein	24070738
D015742	Propofol	Propofol inhibits the reaction [Doxorubicin results in increased expression of APAF1 protein]	22015447
D015742	Propofol	Propofol results in decreased expression of APAF1 protein	21468576
D011441	Propylthiouracil	Propylthiouracil results in increased expression of APAF1 mRNA	24780913
C009131	pyrimidin-2-one beta-ribofuranoside	pyrimidin-2-one beta-ribofuranoside affects the expression of APAF1 mRNA	17133271
D011794	Quercetin	[Quercetin analog co-treated with Gold analog] results in increased expression of APAF1 protein	27470402
D011794	Quercetin	Quercetin results in decreased expression of APAF1 mRNA	15309432
D011794	Quercetin	Quercetin results in increased expression of APAF1 protein	14750173
D011794	Quercetin	"Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 mRNA]"	21294050
D011794	Quercetin	"Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein]"	21294050
C059514	resveratrol	resveratrol results in decreased expression of APAF1 mRNA	12002526
C059514	resveratrol	resveratrol results in decreased expression of APAF1 protein	14749477
C059514	resveratrol	resveratrol results in increased expression of APAF1 mRNA	12569576
C059514	resveratrol	"resveratrol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein]"	18791811
C059514	resveratrol	resveratrol results in increased expression of APAF1 protein	18201729
C089730	rosiglitazone	rosiglitazone results in decreased expression of APAF1 mRNA	17639046
C089730	rosiglitazone	rosiglitazone results in decreased expression of APAF1 mRNA	21515302
D012402	Rotenone	Rotenone results in increased expression of APAF1 mRNA alternative form	17064354
C039961	S-(1,2-dichlorovinyl)cysteine	"S-(1,2-dichlorovinyl)cysteine results in increased expression of APAF1 protein"	15967204
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of APAF1 mRNA	21427059
D012451	Safrole	Safrole results in increased expression of APAF1 protein	21591240
D012604	Scorpion Venoms	Scorpion Venoms results in increased expression of APAF1 protein	19913524
D012604	Scorpion Venoms	Scorpion Venoms results in increased susceptibility to [KNK 437 results in increased expression of APAF1 protein]	19913524
D012604	Scorpion Venoms	Scorpion Venoms results in increased susceptibility to [tanespimycin results in increased expression of APAF1 protein]	19913524
C002979	selenomethylselenocysteine	selenomethylselenocysteine metabolite results in increased expression of APAF1 mRNA	25321483
C017947	sodium arsenite	sodium arsenite results in increased expression of APAF1 protein	20830294
C017947	sodium arsenite	Taurine inhibits the reaction [sodium arsenite results in increased expression of APAF1 protein]	20830294
C016104	sodium bichromate	[Benzo(a)pyrene co-treated with sodium bichromate] results in increased expression of APAF1 mRNA	22613061
C112765	tanespimycin	Scorpion Venoms results in increased susceptibility to [tanespimycin results in increased expression of APAF1 protein]	19913524
C112765	tanespimycin	tanespimycin results in increased expression of APAF1 protein	19913524
D013654	Taurine	Taurine inhibits the reaction [Alloxan results in increased expression of APAF1 protein]	23092809
D013654	Taurine	Taurine inhibits the reaction [sodium arsenite results in increased expression of APAF1 protein]	20830294
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid affects the expression of APAF1 mRNA	15885361
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid affects the expression of APAF1 protein	15885361
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid results in decreased expression of APAF1 mRNA	15885361
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in decreased expression of APAF1 mRNA	19684285
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of APAF1 mRNA	19684285
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of APAF1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of APAF1 mRNA	23864506
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of APAF1 mRNA	19520675
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate affects the expression of APAF1 protein	11139146
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of APAF1 mRNA	25613284
C026995	thallium acetate	thallium acetate results in increased expression of APAF1 protein	15965099
D019772	Topotecan	APAF1 promotes the reaction [Topotecan results in increased cleavage of BID protein]	19812371
D019772	Topotecan	APAF1 promotes the reaction [Topotecan results in increased cleavage of CASP2 protein]	19812371
D019772	Topotecan	APAF1 promotes the reaction [Topotecan results in increased cleavage of CASP3 protein]	19812371
D019772	Topotecan	APAF1 promotes the reaction [Topotecan results in increased cleavage of CASP9 protein]	19812371
D019772	Topotecan	APAF1 promotes the reaction [Topotecan results in increased degradation of BCL2L1 protein]	19812371
D019772	Topotecan	APAF1 promotes the reaction [Topotecan results in increased phosphorylation of H2AFX protein]	19812371
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of APAF1 gene	27618143
C012589	trichostatin A	trichostatin A results in increased activity of APAF1 protein	20925046
C012589	trichostatin A	[trichostatin A results in increased activity of APAF1 protein] which results in increased susceptibility to Cisplatin	20925046
C001899	triptolide	triptolide results in increased expression of APAF1 protein	25169008\|2699090
C001899	triptolide	NFE2L2 protein inhibits the reaction [triptolide results in increased expression of APAF1 protein]	25169008
C001899	triptolide	triptolide results in increased expression of APAF1 protein	25169008
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of APAF1 mRNA"	26179874
C057693	troglitazone	troglitazone results in decreased expression of APAF1 mRNA	21515302
C005865	troxerutin	troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of APAF1 mRNA]	28916335
D014520	Urethane	Urethane results in increased expression of APAF1 mRNA	28818685
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in decreased expression of APAF1 mRNA	15885361
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in decreased expression of APAF1 protein	15885361
D014635	Valproic Acid	Valproic Acid results in increased expression of APAF1 mRNA	24935251
C551177	vemurafenib	[(+)-JQ1 compound co-treated with vemurafenib] results in decreased expression of APAF1 mRNA	27169980
C025643	vinclozolin	vinclozolin results in decreased expression of APAF1 mRNA	23869203
C029297	vinylidene chloride	vinylidene chloride results in increased expression of APAF1 mRNA	26682919
D009536	Niacinamide	"[Butyric Acid co-treated with Niacinamide co-treated with Glucaric Acid] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 mRNA]"	25478867
D009536	Niacinamide	"[Butyric Acid co-treated with Niacinamide co-treated with Glucaric Acid] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein]"	25478867
D009536	Niacinamide	"Niacinamide inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 mRNA]"	25478867
D009536	Niacinamide	"Niacinamide inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APAF1 protein]"	25478867
D015034	Zinc Oxide	Zinc Oxide affects the expression of APAF1 mRNA	28648595
C088658	zoledronic acid	zoledronic acid results in increased expression of APAF1 mRNA	28871336
C088658	zoledronic acid	zoledronic acid results in increased expression of APAF1 mRNA	28871336

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000166	nucleotide binding	-	TAS	10383829
GO:0005515	protein binding	-	IPI	9267021 9390557 9829980 9922454 10206961 10376594 10949025 11112785 11550094 11821383 15735003 17274640 19494828 20462491 21371431 21827945 22246185
GO:0005524	ATP binding	-	IEA	-
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	-	IBA	21873635
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	-	NAS	15009102
GO:0031072	heat shock protein binding	-	IEA	-
GO:0042802	identical protein binding	-	IEA	-
GO:0043531	ADP binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001666	response to hypoxia	-	IEA	-
GO:0001843	neural tube closure	-	IEA	-
GO:0006915	apoptotic process	-	TAS	9753320
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	-	IDA	21827945
GO:0007399	nervous system development	-	TAS	9753320
GO:0007568	aging	-	IEA	-
GO:0007584	response to nutrient	-	IEA	-
GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	-	IBA	21873635
GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	-	IDA	9267021
GO:0010659	cardiac muscle cell apoptotic process	-	IEA	-
GO:0030154	cell differentiation	-	IEA	-
GO:0030900	forebrain development	-	IEA	-
GO:0034349	glial cell apoptotic process	-	IEA	-
GO:0042981	regulation of apoptotic process	-	TAS	10441496
GO:0043065	positive regulation of apoptotic process	-	TAS	18309324
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0051260	protein homooligomerization	-	IEA	-
GO:0051402	neuron apoptotic process	-	IEA	-
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	-	IEA	-
GO:0070317	negative regulation of G0 to G1 transition	-	TAS	-
GO:0071560	cellular response to transforming growth factor beta stimulus	-	IEA	-
GO:0072432	response to G1 DNA damage checkpoint signaling	-	TAS	18309324
GO:0097193	intrinsic apoptotic signaling pathway	-	TAS	18309324
GO:1902510	regulation of apoptotic DNA fragmentation	-	IEA	-
GO:2001235	positive regulation of apoptotic signaling pathway	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005634	nucleus	-	IEA	-
GO:0005829	cytosol	-	IBA	21873635
GO:0005829	cytosol	-	TAS	-
GO:0032991	protein-containing complex	-	IDA	11821383
GO:0034774	secretory granule lumen	-	TAS	-
GO:0043293	apoptosome	-	IBA	21873635
GO:0043293	apoptosome	-	IDA	21827945
GO:0043293	apoptosome	-	TAS	18309324
GO:0070062	extracellular exosome	-	HDA	19056867
GO:1904813	ficolin-1-rich granule lumen	-	TAS	-

KEGG ID	KEGG Term
hsa04115	p53 signaling pathway
hsa04210	Apoptosis
hsa05010	Alzheimer's disease
hsa05012	Parkinson's disease
hsa05014	Amyotrophic lateral sclerosis (ALS)
hsa05016	Huntington's disease
hsa05222	Small cell lung cancer

Reactome ID	Reactome Term	Evidence
R-HSA-109581	Apoptosis	TAS
R-HSA-109606	Intrinsic Pathway for Apoptosis	TAS
R-HSA-111458	Formation of apoptosome	TAS
R-HSA-111459	Activation of caspases through apoptosome-mediated cleavage	TAS
R-HSA-111461	Cytochrome c-mediated apoptotic response	TAS
R-HSA-111471	Apoptotic factor-mediated response	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-3700989	Transcriptional Regulation by TP53	TAS
R-HSA-5357801	Programmed Cell Death	TAS
R-HSA-5633008	TP53 Regulates Transcription of Cell Death Genes	TAS
R-HSA-6798695	Neutrophil degranulation	TAS
R-HSA-6803207	TP53 Regulates Transcription of Caspase Activators and Caspases	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-8953750	Transcriptional Regulation by E2F6	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26116372	MiR-21: an environmental driver of malignant melanoma? (2015 Jun 27)	Melnik BC	J Transl Med
28700107	Cigarette smoke induces rat testicular injury via mitochondrial apoptotic pathway. (2017 Oct)	He L	Mol Reprod Dev