Gene: FOXA2

3170
HNF3B|TCF3B
forkhead box A2
protein-coding
20p11.21
Ensembl:ENSG00000125798 MIM:600288 Vega:OTTHUMG00000191876 UniprotKB:Q9Y261
NC_000020.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.149e-1 (AD)  7.701e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR2B60.563
ODF40.502
PPIAL4E0.5
MUC170.476
OTOR0.447
LINC006680.444
CTRC0.431
KLK10.424
C18orf630.424
HSD17B20.405

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARRB1-0.219
EFR3B-0.208
PCDHGB1-0.203
ZNF843-0.201
SV2C-0.201
SHISA6-0.198
COLCA1-0.196
ERBB4-0.19
PHACTR1-0.186
ADCYAP1R1-0.185

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of FOXA2 mRNA"26377693
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of FOXA2 mRNA19933214
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of FOXA2 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of FOXA2 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of FOXA2 mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of FOXA2 mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of FOXA2 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXA2 mRNA"27188386
D000079AcetaldehydeAcetaldehyde affects the expression of FOXA2 mRNA22634333
D000082AcetaminophenAcetaminophen results in decreased expression of FOXA2 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of FOXA2 mRNA15606129|1756273
D019342Acetic AcidAcetic Acid affects the expression of FOXA2 protein21296659
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FOXA2 gene27153756
C000188alachloralachlor results in increased expression of FOXA2 mRNA12419858
D013196DihydrotestosteroneFOXA2 protein inhibits the reaction [Dihydrotestosterone results in increased expression of LCN5 mRNA]16740652
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FOXA2 mRNA16483693
C015001arsenitearsenite results in increased methylation of FOXA2 promoter23974009
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [nitrofen results in decreased expression of FOXA2 protein]16863852
C547126AZM551248AZM551248 results in decreased expression of FOXA2 mRNA22323515
D001507BeclomethasoneBeclomethasone results in increased expression of FOXA2 mRNA23656298
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of FOXA2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of FOXA2 mRNA21714911
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FOXA2 mRNA26238291|2722105
D004958EstradiolEstradiol results in increased expression of FOXA2 mRNA23184660
C095105bexarotenebexarotene results in decreased expression of FOXA2 mRNA16648578
C006780bisphenol Abisphenol A affects the methylation of FOXA2 promoter27334623
C006780bisphenol Abisphenol A affects the methylation of FOXA2 promoter27415467
C006780bisphenol Abisphenol A results in increased expression of FOXA2 mRNA25181051
C099813bromochloroacetic acidbromochloroacetic acid affects the expression of FOXA2 protein21296659
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of FOXA2 mRNA19010381
D002220CarbamazepineCarbamazepine affects the expression of FOXA2 mRNA25979313
D002220CarbamazepineCarbamazepine affects the expression of FOXA2 mRNA22634333
C006698carbendazimcarbendazim results in increased expression of FOXA2 mRNA26071454
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FOXA2 gene20938992
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of FOXA2 mRNA20971185
C030865copper bis(3,5-diisopropylsalicylate)"copper bis(3,5-diisopropylsalicylate) inhibits the reaction [Streptozocin results in decreased expression of FOXA2]"23795780
D003474CurcuminCurcumin results in decreased expression of FOXA2 mRNA27237783
D016572CyclosporineCyclosporine results in decreased expression of FOXA2 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of FOXA2 mRNA19770486
C089595cylindrospermopsincylindrospermopsin results in increased expression of FOXA2 mRNA24921660
C093628cyproconazolecyproconazole results in increased expression of FOXA2 mRNA22045034
D003907DexamethasoneDexamethasone affects the reaction [G6PC2 promoter SNP affects the reaction [FOXA2 protein binds to G6PC2 promoter]]27653037
D004126DimethylformamideDimethylformamide results in decreased expression of FOXA2 mRNA22169935
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of FOXA2 mRNA25380136
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in decreased expression of FOXA2 mRNA22105179
D004964EstriolEstriol results in increased expression of FOXA2 mRNA23184660
D005472FluorouracilFluorouracil results in decreased expression of FOXA2 protein21296659
C061365flusilazoleflusilazole affects the expression of FOXA2 mRNA22634333
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FOXA2 gene20938992
C056933fumonisin B1fumonisin B1 results in decreased expression of FOXA2 mRNA16221962
D019833GenisteinGenistein results in increased expression of FOXA2 mRNA21810550
D005897GlafenineGlafenine results in decreased expression of FOXA2 mRNA24136188
D005947Glucose[Metformin co-treated with Glucose] affects the localization of FOXA2 protein16489446
C409722hexaconazolehexaconazole results in increased expression of FOXA2 mRNA22045034
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of FOXA2 mRNA23391216
D006861Hydrogen PeroxideHydrogen Peroxide results in increased methylation of FOXA2 promoter23391216
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FOXA2 mRNA25307878
C017461lead nitratelead nitrate affects the reaction [FOXA2 affects the expression of MT1 mRNA]11891201
C017461lead nitratelead nitrate affects the reaction [FOXA2 affects the expression of MT2 mRNA]11891201
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of FOXA2 protein16002565
D008687Metformin[Metformin co-treated with Glucose] affects the localization of FOXA2 protein16489446
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FOXA2 gene20938992
D008770MethylnitrosoureaMethylnitrosourea results in decreased expression of FOXA2 mRNA27221058
C091888monoisoamyl-2,3-dimercaptosuccinate"monoisoamyl-2,3-dimercaptosuccinate results in decreased expression of FOXA2 mRNA"19615344
C091888monoisoamyl-2,3-dimercaptosuccinate"[sodium arsenite co-treated with monoisoamyl-2,3-dimercaptosuccinate] results in decreased expression of FOXA2 mRNA"19615344
D009151Mustard GasMustard Gas results in increased expression of FOXA2 mRNA15674843
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FOXA2 mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of FOXA2 protein16239640
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of FOXA2 mRNA25380136
C051752nefazodonenefazodone results in decreased expression of FOXA2 mRNA24136188
C007350nitrofennitrofen results in decreased expression of FOXA2 mRNA16490937
C007350nitrofenVitamin E inhibits the reaction [nitrofen results in decreased expression of FOXA2 mRNA]16490937
C007350nitrofenAscorbic Acid inhibits the reaction [nitrofen results in decreased expression of FOXA2 protein]16863852
C007350nitrofennitrofen results in decreased expression of FOXA2 protein16863852
C007350nitrofenVitamin A inhibits the reaction [nitrofen results in decreased expression of FOXA2 protein]16863852
C007350nitrofenVitamin E inhibits the reaction [nitrofen results in decreased expression of FOXA2 protein]16863852
C570897NSC668394NSC668394 results in decreased expression of FOXA2 mRNA27137931
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of FOXA2 mRNA20971185
C016340o,p'-DDT"o,p'-DDT results in increased expression of FOXA2 mRNA"20686349
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of FOXA2 mRNA25510869
D010634PhenobarbitalPhenobarbital affects the expression of FOXA2 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXA2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of FOXA2 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FOXA2 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of FOXA2 mRNA18445702
D011374ProgesteroneProgesterone results in decreased expression of FOXA2 mRNA22238285
C043680ptaquilosideptaquiloside results in decreased expression of FOXA2 mRNA23274088
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of FOXA2 mRNA23184660
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in decreased expression of FOXA2 mRNA25800948
C059514resveratrolresveratrol results in decreased expression of FOXA2 mRNA20878097
C059514resveratrolresveratrol results in increased expression of FOXA2 mRNA20878097
C089730rosiglitazonerosiglitazone affects the localization of FOXA2 protein16489446
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of FOXA2 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of FOXA2 mRNA23221170
C017947sodium arsenitesodium arsenite results in decreased expression of FOXA2 mRNA20308225
C017947sodium arsenite"[sodium arsenite co-treated with monoisoamyl-2,3-dimercaptosuccinate] results in decreased expression of FOXA2 mRNA"19615344
C017947sodium arsenitesodium arsenite results in decreased expression of FOXA2 mRNA19615344
D053260SootSoot results in decreased expression of FOXA2 mRNA26551751
D013311Streptozocin"copper bis(3,5-diisopropylsalicylate) inhibits the reaction [Streptozocin results in decreased expression of FOXA2]"23795780
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FOXA2 mRNA21570461|2405805
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of FOXA2 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FOXA2 mRNA24052564
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FOXA2 mRNA19933214|2597527
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FOXA2 mRNA19490992
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of FOXA2 mRNA27237783
D014212TretinoinTretinoin results in increased expression of FOXA2 mRNA21934132
D014212TretinoinTretinoin results in decreased expression of FOXA2 mRNA12834868
D014241TrichloroethyleneTrichloroethylene results in decreased expression of FOXA2 mRNA25549359
D014520UrethaneUrethane results in decreased expression of FOXA2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of FOXA2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of FOXA2 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased methylation of FOXA2 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of FOXA2 mRNA27237783
D014635Valproic AcidValproic Acid results in increased expression of FOXA2 mRNA22045034
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of FOXA2 gene25560391
D014801Vitamin AVitamin A inhibits the reaction [nitrofen results in decreased expression of FOXA2 protein]16863852
D014810Vitamin EVitamin E inhibits the reaction [nitrofen results in decreased expression of FOXA2 mRNA]16490937
D014810Vitamin EVitamin E inhibits the reaction [nitrofen results in decreased expression of FOXA2 protein]16863852
D015032ZincZinc deficiency results in increased degradation of FOXA2 protein12107072
C016837zinc chloridezinc chloride results in decreased expression of FOXA2 mRNA21540303

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA12642491  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003677DNA binding-IDA9931457  
GO:0003700DNA-binding transcription factor activity-IDA9931457  12124776  12911579  
GO:0008134transcription factor binding-IEA-  
GO:0019904protein domain specific binding-IEA-  
GO:0044212transcription regulatory region DNA binding-IMP15737987  
GO ID GO Term Qualifier Evidence PubMed
GO:0000432positive regulation of transcription from RNA polymerase II promoter by glucose-ISS-  
GO:0001708cell fate specification-ISS-  
GO:0006325chromatin organization-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006357regulation of transcription by RNA polymerase II-IDA12911579  
GO:0008344adult locomotory behavior-ISS-  
GO:0009653anatomical structure morphogenesis-IBA21873635  
GO:0010719negative regulation of epithelial to mesenchymal transition-IMP20160041  
GO:0030154cell differentiation-IBA21873635  
GO:0030193regulation of blood coagulation-IDA12911579  
GO:0031018endocrine pancreas development-IDA12124776  
GO:0033132negative regulation of glucokinase activity-ISS-  
GO:0040019positive regulation of embryonic development-ISS-  
GO:0043433negative regulation of DNA-binding transcription factor activity-IMP12642491  
GO:0045893positive regulation of transcription, DNA-templated-IDA9931457  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA12124776  20160041  
GO:0045944positive regulation of transcription by RNA polymerase II-TAS24431302  
GO:0061178regulation of insulin secretion involved in cellular response to glucose stimulus-ISS-  
GO:0061987negative regulation of transcription from RNA polymerase II promoter by glucose-ISS-  
GO:0070741response to interleukin-6-TAS15737987  
GO:0071542dopaminergic neuron differentiation-IGI19951692  
GO:0071542dopaminergic neuron differentiation-ISS-  
GO:0071542dopaminergic neuron differentiation-TAS24431302  
GO:0090009primitive streak formation-ISS-  
GO:2000049positive regulation of cell-cell adhesion mediated by cadherin-IC20160041  
GO:2000543positive regulation of gastrulation-ISS-  
GO:2000971negative regulation of detection of glucose-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA9931457  20160041  24399192  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IEA-  
GO:0030054cell junction-IDA-  
KEGG ID KEGG Term
hsa04950Maturity onset diabetes of the young
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-186712Regulation of beta-cell developmentIEA
R-HSA-210745Regulation of gene expression in beta cellsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28852427Seven-CpG-based prognostic signature coupled with gene expression predicts survival of oral squamous cell carcinoma. (2017)Shen SClin Epigenetics