Gene info: ID 3172

Gene: HNF4A

GENE ID: 3172

Synonyms: FRTS4|HNF4|HNF4a7|HNF4a8|HNF4a9|HNF4alpha|MODY|MODY1|NR2A1|NR2A21|TCF|TCF14

Description: hepatocyte nuclear factor 4 alpha

Gene type: protein-coding

Location: 20q13.12

dbXrefs: Ensembl:ENSG00000101076 MIM:600281 Vega:OTTHUMG00000032531 UniprotKB:P41235

RefSeq: NG_009818.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.112e-1 (AD) 2.008e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
AMPH	0.777
GRM1	0.775
GFOD1	0.769
KSR2	0.767
LSM11	0.766
PIP4K2C	0.765
CDKL1	0.765
LMTK2	0.761
FBXO40	0.761
ZDHHC22	0.76

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
YES1	-0.49
BCL7C	-0.488
HEY2	-0.487
ALDH3B1	-0.464
MBNL3	-0.46
RAI14	-0.459
LRAT	-0.456
ASB4	-0.452
AQP5	-0.448
PLA2G5	-0.442

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB03017	Lauric Acid	Small Molecule	143-07-7	Approved\|Experimental	Target
DB05447	AVI-4557	Small Molecule	-	Investigational	Target
DB08231	Myristic acid	Small Molecule	544-63-8	Experimental	Target

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of HNF4A mRNA"	19162173
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [HNF4A protein results in increased expression of UGT2B7 mRNA]"	21415305
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [HNF4A protein binds to MIR122 promoter]"	26171734
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"Androstanols inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [HNF4A protein binds to MIR122 promoter]]"	26171734
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of HNF4A mRNA"	19114083
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of HNF4A mRNA"	20959002
C054589	2,4,6-triphenyl-1,3-dioxane	"2,4,6-triphenyl-1,3-dioxane inhibits the reaction [HNF4A protein binds to G6PC promoter]"	23231652
C054589	2,4,6-triphenyl-1,3-dioxane	"2,4,6-triphenyl-1,3-dioxane inhibits the reaction [HNF4A protein binds to PCK1 promoter]"	23231652
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HNF4A mRNA"	20959002
C486184	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	"4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in decreased expression of HNF4A mRNA"	23184660
C000592353	4-(4,6-diphenyl-1,3-dioxan-2-yl)-N,N-dimethylaniline	"4-(4,6-diphenyl-1,3-dioxan-2-yl)-N,N-dimethylaniline inhibits the reaction [HNF4A protein binds to G6PC promoter]"	23231652
C000592353	4-(4,6-diphenyl-1,3-dioxan-2-yl)-N,N-dimethylaniline	"4-(4,6-diphenyl-1,3-dioxan-2-yl)-N,N-dimethylaniline inhibits the reaction [HNF4A protein binds to PCK1 promoter]"	23231652
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of HNF4A mRNA	12419474
C521334	5-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate	5-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate results in increased expression of HNF4A protein	20932894
C475093	6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime	"6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime inhibits the reaction [HNF4A protein binds to PCK1 promoter]"	21768169
C475093	6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime	"6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]"	21768169
C475093	6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime	"Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime inhibits the reaction [HNF4A protein binds to PCK1 promoter]]"	21768169
C475093	6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime	"Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]"	21768169
C475093	6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime	"[Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]"	21768169
C475093	6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime	"Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime inhibits the reaction [HNF4A protein binds to PCK1 promoter]]"	21768169
C475093	6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime	"Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]"	21768169
C475093	6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime	"Progesterone promotes the reaction [Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime inhibits the reaction [HNF4A protein binds to PCK1 promoter]]]"	21768169
D000082	Acetaminophen	Acetaminophen results in decreased expression of HNF4A mRNA	29067470
D000082	Acetaminophen	Acetaminophen results in decreased expression of HNF4A protein	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of HNF4A mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in decreased activity of HNF4A protein	25858767
D000242	Cyclic AMP	Cyclic AMP promotes the reaction [HNF4A protein binds to CYP2A5 promoter]	18602936
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of HNF4A protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of HNF4A mRNA	22100608
C031143	AICA ribonucleotide	AICA ribonucleotide results in decreased expression of HNF4A mRNA	24428821
D000393	Air Pollutants	Air Pollutants analog results in decreased expression of HNF4A mRNA	21757418
C103303	alitretinoin	alitretinoin results in decreased expression of HNF4A mRNA	21115832
C004471	allyl isothiocyanate	allyl isothiocyanate inhibits the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]	25069801
C004471	allyl isothiocyanate	allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]	25069801
D000638	Amiodarone	Amiodarone results in increased expression of HNF4A mRNA	24489787
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of HNF4A mRNA	16483693
D000732	Androstanols	"Androstanols inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [HNF4A protein binds to MIR122 promoter]]"	26171734
D001374	Azacitidine	Azacitidine results in increased expression of HNF4A mRNA	27590069
D001507	Beclomethasone	Beclomethasone results in increased expression of HNF4A mRNA	23656298
D001554	Benzene	Benzene results in increased expression of HNF4A mRNA	15878777
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of HNF4A mRNA	20106945
D001599	Berberine	Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]	18563319
D001599	Berberine	Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A protein]	18563319
D004958	Estradiol	"Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime inhibits the reaction [HNF4A protein binds to PCK1 promoter]]"	21768169
D004958	Estradiol	"Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]"	21768169
D004958	Estradiol	Estradiol results in decreased expression of HNF4A mRNA	23184660
D004958	Estradiol	fulvestrant inhibits the reaction [Estradiol results in decreased expression of HNF4A mRNA]	23184660
D004958	Estradiol	"[Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]"	21768169
D004958	Estradiol	"Progesterone promotes the reaction [Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime inhibits the reaction [HNF4A protein binds to PCK1 promoter]]]"	21768169
D001647	Bile Acids and Salts	Bile Acids and Salts affects the activity of HNF4A protein	15576845
D001647	Bile Acids and Salts	Bile Acids and Salts results in decreased activity of HNF4A protein	20699090
D001647	Bile Acids and Salts	[[Bile Acids and Salts results in increased activity of NR0B2 protein] co-treated with [Bile Acids and Salts results in decreased activity of HNF4A protein]] results in decreased expression of CYP7A1 mRNA	20699090
C006780	bisphenol A	bisphenol A results in decreased expression of HNF4A mRNA	23184660
C006780	bisphenol A	bisphenol A results in decreased expression of HNF4A mRNA	27502578
C006780	bisphenol A	bisphenol A results in decreased expression of HNF4A mRNA	25181051
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in decreased phosphorylation of HNF4A protein	22174045
C018475	butyraldehyde	butyraldehyde results in decreased expression of HNF4A mRNA	26079696
D002118	Calcium	Calcium affects the expression of HNF4A mRNA	15913539
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of HNF4A protein	25566828
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased activity of HNF4A protein	25858767
D002569	Cerulenin	Cerulenin inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]	17992261
D002569	Cerulenin	Cerulenin inhibits the reaction [Glucose results in decreased expression of HNF4A mRNA]	17992261
D002635	Chenodeoxycholic Acid	Chenodeoxycholic Acid results in decreased expression of HNF4A mRNA	15629111
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of HNF4A mRNA	11163329
D002994	Clofibrate	Clofibrate results in decreased expression of HNF4A mRNA	17585979
D003022	Clotrimazole	Clotrimazole results in decreased expression of HNF4A mRNA	15629111
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of HNF4A mRNA	24386269
D003300	Copper	Copper results in decreased expression of HNF4A mRNA	20875833
D003300	Copper	Copper results in decreased expression of HNF4A protein	20875833
C057862	cyanoginosin LR	cyanoginosin LR results in decreased expression of HNF4A mRNA	25497113
D016572	Cyclosporine	Cyclosporine results in decreased expression of HNF4A mRNA	20106945\|2556210
D016572	Cyclosporine	Cyclosporine results in decreased expression of HNF4A mRNA	19770486
D013759	Dronabinol	Dronabinol results in increased expression of HNF4A mRNA	17578508
C007262	deoxynivalenol	[deoxynivalenol co-treated with Zearalenone] affects the expression of HNF4A mRNA	28865950
C007262	deoxynivalenol	deoxynivalenol results in increased expression of HNF4A mRNA	28865950
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of HNF4A mRNA]	27941970
D003907	Dexamethasone	[Mifepristone co-treated with Dexamethasone] results in decreased expression of HNF4A mRNA	15629111
D003907	Dexamethasone	Dexamethasone promotes the reaction [HNF4A protein binds to CYP2A6 promoter]	17978169
D003907	Dexamethasone	Dexamethasone results in increased activity of HNF4A protein	17978169
D003907	Dexamethasone	Dexamethasone results in increased expression of HNF4A mRNA	17978169\|1902223
D003907	Dexamethasone	Dexamethasone results in increased expression of HNF4A protein	24399729
D003907	Dexamethasone	Mifepristone inhibits the reaction [Dexamethasone results in increased expression of HNF4A mRNA]	19022236
D003907	Dexamethasone	Dexamethasone results in decreased expression of HNF4A mRNA	20888898
D003907	Dexamethasone	Dexamethasone results in increased expression of HNF4A mRNA	12837037
D003907	Dexamethasone	Dexamethasone results in increased expression of HNF4A protein	15965953
C042577	diallyl trisulfide	diallyl trisulfide results in increased expression of HNF4A mRNA	16382202
D004008	Diclofenac	Diclofenac results in decreased expression of HNF4A mRNA	19022234
C000944	dicrotophos	dicrotophos results in increased expression of HNF4A mRNA	28302478
D004041	Dietary Fats	Dietary Fats results in increased expression of HNF4A mRNA	24275070
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of HNF4A protein	25280772
D004052	Diethylnitrosamine	HNF4A gene mutant form results in increased susceptibility to Diethylnitrosamine	23315968
D004052	Diethylnitrosamine	[HNF4A gene mutant form results in increased susceptibility to Diethylnitrosamine] which results in increased expression of MYC	23315968
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of HNF4A mRNA	19638242
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of HNF4A protein	27565560
D002117	Calcitriol	[Calcitriol binds to and results in increased activity of VDR protein] results in decreased activity of [HNF4A protein co-treated with PPARGC1A protein]	19106115
D002117	Calcitriol	Calcitriol inhibits the reaction [HNF4A protein binds to CYP7A1 mRNA]	20371703
D002117	Calcitriol	Calcitriol inhibits the reaction [HNF4A protein binds to CYP7A1 promoter]	19106115
D002117	Calcitriol	Calcitriol promotes the reaction [HNF4A protein binds to CYP24A1 mRNA]	20371703
D002117	Calcitriol	Calcitriol promotes the reaction [MAPK1 protein results in increased phosphorylation of HNF4A protein]	20371703
D002117	Calcitriol	Calcitriol promotes the reaction [MAPK3 protein results in increased phosphorylation of HNF4A protein]	20371703
D002117	Calcitriol	Calcitriol promotes the reaction [VDR protein binds to HNF4A protein]	20371703
D002117	Calcitriol	MAPK1 protein promotes the reaction [Calcitriol promotes the reaction [VDR protein binds to HNF4A protein]]	20371703
D002117	Calcitriol	MAPK3 protein promotes the reaction [Calcitriol promotes the reaction [VDR protein binds to HNF4A protein]]	20371703
D002117	Calcitriol	NCOA1 protein promotes the reaction [Calcitriol promotes the reaction [VDR protein binds to HNF4A protein]]	20371703
D002117	Calcitriol	NCOR1 protein inhibits the reaction [Calcitriol promotes the reaction [VDR protein binds to HNF4A protein]]	20371703
D002117	Calcitriol	NCOR2 protein inhibits the reaction [Calcitriol promotes the reaction [VDR protein binds to HNF4A protein]]	20371703
D002117	Calcitriol	PPARGC1A protein promotes the reaction [Calcitriol promotes the reaction [VDR protein binds to HNF4A protein]]	20371703
D002117	Calcitriol	U 0126 inhibits the reaction [Calcitriol inhibits the reaction [HNF4A protein binds to CYP7A1 mRNA]]	20371703
D002117	Calcitriol	U 0126 inhibits the reaction [Calcitriol promotes the reaction [MAPK1 protein results in increased phosphorylation of HNF4A protein]]	20371703
D002117	Calcitriol	U 0126 inhibits the reaction [Calcitriol promotes the reaction [MAPK3 protein results in increased phosphorylation of HNF4A protein]]	20371703
D002117	Calcitriol	U 0126 inhibits the reaction [MAPK1 protein promotes the reaction [Calcitriol promotes the reaction [VDR protein binds to HNF4A protein]]]	20371703
D002117	Calcitriol	U 0126 inhibits the reaction [MAPK3 protein promotes the reaction [Calcitriol promotes the reaction [VDR protein binds to HNF4A protein]]]	20371703
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in decreased expression of HNF4A mRNA"	23262642
D004964	Estriol	Estriol results in decreased expression of HNF4A mRNA	23184660
D000431	Ethanol	[Ethanol co-treated with Zinc] results in increased expression of HNF4A mRNA	19637192
D000431	Ethanol	Ethanol results in decreased activity of HNF4A protein	19637192
D000431	Ethanol	Zinc inhibits the reaction [Ethanol results in decreased activity of HNF4A protein]	19637192
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of HNF4A mRNA	16872691\|2022741
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of HNF4A mRNA	17555576
D015025	Zearalenone	[deoxynivalenol co-treated with Zearalenone] affects the expression of HNF4A mRNA	28865950
D005231	Fatty Acids, Unsaturated	"Fatty Acids, Unsaturated inhibits the reaction [HNF4A protein binds to PKLR promoter]"	16644726
D005485	Flutamide	Flutamide results in decreased expression of HNF4A mRNA	24793618
D005485	Flutamide	Flutamide results in increased expression of HNF4A mRNA	24136188
D004397	Fonofos	Fonofos results in increased methylation of HNF4A promoter	22847954
D005620	Freund's Adjuvant	Freund's Adjuvant results in increased expression of HNF4A mRNA	20846436
D005632	Fructose	Cerulenin inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]	17992261
D005632	Fructose	Fructose results in decreased expression of HNF4A mRNA	17992261
D005632	Fructose	Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]	18563319
D005632	Fructose	Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A protein]	18563319
D005632	Fructose	Fructose results in decreased expression of HNF4A mRNA	18563319\|1919655
D005632	Fructose	Fructose results in decreased expression of HNF4A protein	18563319
D005632	Fructose	rosiglitazone inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]	19196556
C069837	fullerene C60	fullerene C60 results in decreased expression of HNF4A mRNA	19167457
C070081	fulvestrant	fulvestrant inhibits the reaction [Estradiol results in decreased expression of HNF4A mRNA]	23184660
C070081	fulvestrant	fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in decreased expression of HNF4A mRNA]	23184660
C039281	furan	furan results in increased methylation of HNF4A gene	22079235
D005947	Glucose	Cerulenin inhibits the reaction [Glucose results in decreased expression of HNF4A mRNA]	17992261
D005947	Glucose	Glucose affects the reaction [HNF4A protein binds to SHBG promoter]	17992261
D005947	Glucose	Glucose results in decreased expression of HNF4A mRNA	17992261
D005978	Glutathione	Glutathione deficiency results in increased expression of HNF4A mRNA	15345336
C412815	GW 4064	GW 4064 results in increased expression of HNF4A mRNA	26655953
D017313	Fenretinide	Fenretinide results in increased expression of HNF4A mRNA	28973697
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of HNF4A	26505118
D007654	Ketoconazole	Ketoconazole inhibits the reaction [[NR1I2 binds to HNF4A] which results in increased expression of CYP3A4]	19077665
C017461	lead nitrate	lead nitrate results in decreased expression of HNF4A mRNA	16049268
D001556	Lindane	Lindane affects the expression of HNF4A mRNA	17785943
C482199	lipopolysaccharide, E coli O55-B5	"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of HNF4A mRNA"	20371263
D008070	Lipopolysaccharides	HNF4A protein results in increased susceptibility to Lipopolysaccharides	21131441
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of HNF4A protein	16002565
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of HNF4A mRNA	16415329
D008095	Lithocholic Acid	[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of HNF4A mRNA	20359477
D008095	Lithocholic Acid	Lithocholic Acid results in decreased expression of HNF4A mRNA	20359477
D008095	Lithocholic Acid	Lithocholic Acid results in decreased expression of HNF4A mRNA	20888898
C502354	lithocholic acid acetate	lithocholic acid acetate inhibits the reaction [HNF4A protein binds to CYP7A1 mRNA]	20371703
C502354	lithocholic acid acetate	lithocholic acid acetate inhibits the reaction [HNF4A protein binds to CYP7A1 promoter]	19106115
C502354	lithocholic acid acetate	lithocholic acid acetate promotes the reaction [HNF4A protein binds to CYP24A1 mRNA]	20371703
C502354	lithocholic acid acetate	lithocholic acid acetate promotes the reaction [MAPK1 protein results in increased phosphorylation of HNF4A protein]	20371703
C502354	lithocholic acid acetate	lithocholic acid acetate promotes the reaction [MAPK3 protein results in increased phosphorylation of HNF4A protein]	20371703
C502354	lithocholic acid acetate	lithocholic acid acetate promotes the reaction [VDR protein binds to HNF4A protein]	20371703
C502354	lithocholic acid acetate	MAPK1 protein promotes the reaction [lithocholic acid acetate promotes the reaction [VDR protein binds to HNF4A protein]]	20371703
C502354	lithocholic acid acetate	MAPK3 protein promotes the reaction [lithocholic acid acetate promotes the reaction [VDR protein binds to HNF4A protein]]	20371703
C502354	lithocholic acid acetate	NCOA1 protein promotes the reaction [lithocholic acid acetate promotes the reaction [VDR protein binds to HNF4A protein]]	20371703
C502354	lithocholic acid acetate	NCOR1 protein inhibits the reaction [lithocholic acid acetate promotes the reaction [VDR protein binds to HNF4A protein]]	20371703
C502354	lithocholic acid acetate	NCOR2 protein inhibits the reaction [lithocholic acid acetate promotes the reaction [VDR protein binds to HNF4A protein]]	20371703
C502354	lithocholic acid acetate	PPARGC1A protein promotes the reaction [lithocholic acid acetate promotes the reaction [VDR protein binds to HNF4A protein]]	20371703
C502354	lithocholic acid acetate	U 0126 inhibits the reaction [lithocholic acid acetate promotes the reaction [MAPK1 protein results in increased phosphorylation of HNF4A protein]]	20371703
C502354	lithocholic acid acetate	U 0126 inhibits the reaction [lithocholic acid acetate promotes the reaction [MAPK3 protein results in increased phosphorylation of HNF4A protein]]	20371703
C502354	lithocholic acid acetate	U 0126 inhibits the reaction [MAPK1 protein promotes the reaction [lithocholic acid acetate promotes the reaction [VDR protein binds to HNF4A protein]]]	20371703
C502354	lithocholic acid acetate	U 0126 inhibits the reaction [MAPK3 protein promotes the reaction [lithocholic acid acetate promotes the reaction [VDR protein binds to HNF4A protein]]]	20371703
D008687	Metformin	Metformin results in decreased expression of HNF4A mRNA	24428821
D008687	Metformin	Metformin results in decreased expression of HNF4A protein	24428821
D008687	Metformin	Metformin results in decreased expression of HNF4A mRNA	19022234
D008701	Methapyrilene	Methapyrilene inhibits the reaction [HNF4A protein binds to TF promoter]	28935588
D008701	Methapyrilene	Methapyrilene results in decreased expression of HNF4A protein	28935588
D008727	Methotrexate	HNF4A protein results in increased secretion of Methotrexate	27160211
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of HNF4A mRNA	21527772
D015735	Mifepristone	[Mifepristone co-treated with Dexamethasone] results in decreased expression of HNF4A mRNA	15629111
D015735	Mifepristone	Mifepristone results in decreased expression of HNF4A mRNA	15629111
D015735	Mifepristone	Mifepristone inhibits the reaction [Dexamethasone results in increased expression of HNF4A mRNA]	19022236
C028007	nickel monoxide	nickel monoxide results in decreased expression of HNF4A mRNA	19167457
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased activity of HNF4A protein"	19637192
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased activity of HNF4A protein]"	19637192
C025589	ochratoxin A	ochratoxin A results in decreased expression of HNF4A mRNA	16251485\|2335814
C025589	ochratoxin A	ochratoxin A results in decreased expression of HNF4A protein	16251485
D019301	Oleic Acid	Oleic Acid results in increased expression of HNF4A protein	23395669
D019301	Oleic Acid	sophocarpine inhibits the reaction [Oleic Acid results in increased expression of HNF4A protein]	23395669
D010171	Palmitoyl Coenzyme A	Palmitoyl Coenzyme A results in decreased expression of HNF4A mRNA	17992261
D010171	Palmitoyl Coenzyme A	Palmitoyl Coenzyme A results in decreased expression of HNF4A protein	17992261
D010278	Parathion	Parathion results in increased methylation of HNF4A promoter	22847954
D020881	Enkephalin, D-Penicillamine (2,5)-	"HNF4A protein results in increased secretion of Enkephalin, D-Penicillamine (2,5)-"	27160211
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of HNF4A protein	27153767
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of HNF4A protein	27153767
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of HNF4A mRNA	18692542
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased activity of HNF4A protein	22609092
C023036	perfluorooctanoic acid	[perfluorooctanoic acid results in decreased activity of HNF4A protein] which results in decreased expression of HNF1A mRNA	22609092
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of HNF4A mRNA	25868421
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of HNF4A protein	22609092\|2687931
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of HNF4A mRNA	25092180
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of HNF4A protein	27153767
D010634	Phenobarbital	Phenobarbital results in decreased expression of HNF4A mRNA	15629111
C014153	pirimiphos methyl	pirimiphos methyl results in increased expression of HNF4A mRNA	27845199
C006253	pirinixic acid	pirinixic acid results in decreased expression of HNF4A mRNA	15629111
C006253	pirinixic acid	HNF4A protein affects the reaction [pirinixic acid results in decreased expression of ACMSD mRNA]	16807375
C006253	pirinixic acid	pirinixic acid results in decreased expression of HNF4A mRNA	23811191
C006253	pirinixic acid	pirinixic acid results in decreased expression of HNF4A protein	16807375
C006253	pirinixic acid	PPARA protein affects the reaction [pirinixic acid results in decreased expression of HNF4A protein]	16807375
C006253	pirinixic acid	pirinixic acid results in increased expression of HNF4A mRNA	19162173
D010936	Plant Extracts	Plant Extracts results in decreased expression of HNF4A mRNA	23262642
D028321	Plant Preparations	Plant Preparations results in decreased expression of HNF4A mRNA	24973489
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of HNF4A mRNA	23608068
D011285	Pregnenolone Carbonitrile	[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of HNF4A mRNA	20359477
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of HNF4A mRNA	20888898
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of HNF4A mRNA	19162173
C035988	procymidone	procymidone results in decreased expression of HNF4A mRNA	15686871
D011374	Progesterone	"[Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]"	21768169
D011374	Progesterone	"Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime inhibits the reaction [HNF4A protein binds to PCK1 promoter]]"	21768169
D011374	Progesterone	"Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]"	21768169
D011374	Progesterone	"Progesterone promotes the reaction [Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime inhibits the reaction [HNF4A protein binds to PCK1 promoter]]]"	21768169
C005556	propionaldehyde	propionaldehyde results in decreased expression of HNF4A mRNA	26079696
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [TNF protein results in decreased expression of HNF4A mRNA]	19883121
C432165	pyrazolanthrone	pyrazolanthrone results in increased expression of HNF4A mRNA	19883121
C012526	quercitrin	quercitrin results in decreased expression of HNF4A mRNA	25193878
D020849	Raloxifene Hydrochloride	fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in decreased expression of HNF4A mRNA]	23184660
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in decreased expression of HNF4A mRNA	23184660
D011899	Ranitidine	[Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of HNF4A mRNA	16415329
C059514	resveratrol	FOXO1 protein promotes the reaction [resveratrol inhibits the reaction [HNF4A protein binds to GCK promoter]]	19740748
C059514	resveratrol	resveratrol affects the reaction [HNF4A protein binds to GCK promoter]	19740748
C059514	resveratrol	resveratrol promotes the reaction [FOXO1 protein binds to HNF4A protein]	19740748
C059514	resveratrol	[resveratrol promotes the reaction [FOXO1 protein binds to HNF4A protein]] which results in decreased expression of GCK mRNA	19740748
D012293	Rifampin	allyl isothiocyanate inhibits the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]	25069801
D012293	Rifampin	allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]	25069801
D012293	Rifampin	[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA	25069801
D012293	Rifampin	NCOA6 promotes the reaction [Rifampin promotes the reaction [[HNF4A co-treated with NR1I2] results in increased expression of CYP2C9 mRNA]]	21292004
D012293	Rifampin	NR1I2 protein promotes the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]	25069801
D012293	Rifampin	[Rifampin co-treated with NR1I2 protein] results in decreased expression of HNF4A mRNA	21127053
D012293	Rifampin	Rifampin inhibits the reaction [HNF4A protein binds to SULT1E1 enhancer]	21764778
D012293	Rifampin	Rifampin promotes the reaction [[HNF4A co-treated with NCOA6] results in increased expression of CYP2C9 mRNA]	21292004
D012293	Rifampin	Rifampin promotes the reaction [[HNF4A co-treated with NCOA6] results in increased expression of CYP3A4 mRNA]	21292004
D012293	Rifampin	Rifampin promotes the reaction [[HNF4A co-treated with NR1I2] results in increased expression of CYP2C9 mRNA]	21292004
D012293	Rifampin	Rifampin promotes the reaction [[HNF4A co-treated with NR1I2] results in increased expression of CYP3A4 mRNA]	21292004
D012293	Rifampin	Rifampin promotes the reaction [MED1 protein binds to HNF4A protein]	21292004
D012293	Rifampin	Rifampin promotes the reaction [NCOA1 protein binds to HNF4A protein]	21292004
D012293	Rifampin	Rifampin promotes the reaction [NCOA2 protein binds to HNF4A protein]	21292004
D012293	Rifampin	Rifampin promotes the reaction [NCOA6 protein binds to HNF4A protein]	21292004
D012293	Rifampin	Rifampin promotes the reaction [NR1I2 protein binds to HNF4A protein]	21764778
D012293	Rifampin	Rifampin promotes the reaction [PPARGC1A protein binds to HNF4A protein]	21292004
D012293	Rifampin	[Rifampin results in increased activity of NR1I2 protein] inhibits the reaction [HNF4A protein binds to SULT1E1 enhancer]	21764778
C089730	rosiglitazone	rosiglitazone inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]	19196556
D000068718	Rosuvastatin Calcium	HNF4A protein results in increased secretion of Rosuvastatin Calcium	27160211
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of HNF4A mRNA	25895662
C017947	sodium arsenite	sodium arsenite results in decreased expression of HNF4A	23052196
C017947	sodium arsenite	sodium arsenite results in decreased expression of HNF4A mRNA	19822182\|2561088
C016104	sodium bichromate	sodium bichromate results in decreased expression of HNF4A mRNA	24612858
C035933	sophocarpine	sophocarpine inhibits the reaction [Oleic Acid results in increased expression of HNF4A protein]	23395669
D013467	Sulindac	"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of HNF4A mRNA"	20371263
D013501	Surface-Active Agents	Surface-Active Agents results in decreased expression of HNF4A mRNA	22467014
D013629	Tamoxifen	Tamoxifen affects the expression of HNF4A mRNA	17555576
D013629	Tamoxifen	Tamoxifen results in decreased activity of HNF4A protein	20937368
D013656	Taurocholic Acid	HNF4A protein results in increased secretion of Taurocholic Acid	27160211
C012568	terbufos	terbufos results in increased methylation of HNF4A promoter	22847954
D013739	Testosterone	Testosterone results in decreased expression of HNF4A mRNA	21669218
D013739	Testosterone	Testosterone results in increased expression of HNF4A mRNA	20844152
C045037	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of HNF4A mRNA	20189893
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of HNF4A mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of HNF4A mRNA	19770486\|2405805
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HNF4A mRNA	20959002
D013752	Tetracycline	Tetracycline results in decreased expression of HNF4A mRNA	24489787
D013752	Tetracycline	Tetracycline results in decreased expression of HNF4A mRNA	24469900
D019284	Thapsigargin	Thapsigargin promotes the reaction [HNF4A protein binds to NR1I2 promoter]	25616597
D019284	Thapsigargin	Thapsigargin results in decreased expression of HNF4A mRNA	25616597
D019284	Thapsigargin	Thapsigargin results in decreased expression of HNF4A protein	25616597
D013853	Thioacetamide	Thioacetamide results in decreased expression of HNF4A mRNA	26222700
D014212	Tretinoin	Tretinoin results in increased expression of HNF4A mRNA	24977338
D014236	Trichlorfon	Trichlorfon results in increased activity of HNF4A protein	20143881
C012589	trichostatin A	trichostatin A results in decreased expression of HNF4A mRNA	15901671
C016805	tris(1,3-dichloro-2-propyl)phosphate	"HNF4A protein affects the susceptibility to tris(1,3-dichloro-2-propyl)phosphate"	24407104
C031324	tris(chloroethyl)phosphate	tris(chloroethyl)phosphate results in increased expression of HNF4A mRNA	27776230
C057693	troglitazone	troglitazone results in decreased expression of HNF4A mRNA	19022234
C113580	U 0126	U 0126 inhibits the reaction [Calcitriol inhibits the reaction [HNF4A protein binds to CYP7A1 mRNA]]	20371703
C113580	U 0126	U 0126 inhibits the reaction [Calcitriol promotes the reaction [MAPK1 protein results in increased phosphorylation of HNF4A protein]]	20371703
C113580	U 0126	U 0126 inhibits the reaction [Calcitriol promotes the reaction [MAPK3 protein results in increased phosphorylation of HNF4A protein]]	20371703
C113580	U 0126	U 0126 inhibits the reaction [lithocholic acid acetate promotes the reaction [MAPK1 protein results in increased phosphorylation of HNF4A protein]]	20371703
C113580	U 0126	U 0126 inhibits the reaction [lithocholic acid acetate promotes the reaction [MAPK3 protein results in increased phosphorylation of HNF4A protein]]	20371703
C113580	U 0126	U 0126 inhibits the reaction [MAPK1 protein promotes the reaction [Calcitriol promotes the reaction [VDR protein binds to HNF4A protein]]]	20371703
C113580	U 0126	U 0126 inhibits the reaction [MAPK1 protein promotes the reaction [lithocholic acid acetate promotes the reaction [VDR protein binds to HNF4A protein]]]	20371703
C113580	U 0126	U 0126 inhibits the reaction [MAPK3 protein promotes the reaction [Calcitriol promotes the reaction [VDR protein binds to HNF4A protein]]]	20371703
C113580	U 0126	U 0126 inhibits the reaction [MAPK3 protein promotes the reaction [lithocholic acid acetate promotes the reaction [VDR protein binds to HNF4A protein]]]	20371703
C113580	U 0126	U 0126 results in increased expression of HNF4A mRNA	24819614
D014501	Uranium	Uranium results in increased expression of HNF4A mRNA	17118558
D014520	Urethane	Urethane results in decreased expression of HNF4A mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in decreased expression of HNF4A mRNA	15901671
D014640	Vancomycin	Vancomycin results in increased expression of HNF4A mRNA	18930951
D015032	Zinc	"Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased activity of HNF4A protein]"	19637192
D015032	Zinc	[Ethanol co-treated with Zinc] results in increased expression of HNF4A mRNA	19637192
D015032	Zinc	Zinc inhibits the reaction [Ethanol results in decreased activity of HNF4A protein]	19637192

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IEA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	ISS	-
GO:0001102	RNA polymerase II activating transcription factor binding	-	ISS	-
GO:0003677	DNA binding	-	IDA	7615825 10551874
GO:0003700	DNA-binding transcription factor activity	-	IDA	7615825 10330009 12911579 16488887
GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	-	IEA	-
GO:0003707	steroid hormone receptor activity	-	IEA	-
GO:0004879	nuclear receptor activity	-	IEA	-
GO:0005102	signaling receptor binding	-	IDA	12220494
GO:0005504	fatty acid binding	-	IDA	12220494
GO:0005515	protein binding	-	IPI	12855700 16488887 17932483 17978169 19549071 19846556 21532585 23714182 23714368
GO:0008270	zinc ion binding	-	IEA	-
GO:0042803	protein homodimerization activity	-	IDA	12220494
GO:0044212	transcription regulatory region DNA binding	-	IDA	16488887

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006357	regulation of transcription by RNA polymerase II	-	IDA	10330009 12911579
GO:0006357	regulation of transcription by RNA polymerase II	-	IMP	18163890
GO:0006367	transcription initiation from RNA polymerase II promoter	-	TAS	-
GO:0006591	ornithine metabolic process	-	IMP	17827783
GO:0006629	lipid metabolic process	-	IEA	-
GO:0006805	xenobiotic metabolic process	-	IMP	17827783
GO:0007548	sex differentiation	-	IEA	-
GO:0007596	blood coagulation	-	IDA	12911579
GO:0008285	negative regulation of cell proliferation	-	IMP	18163890
GO:0009749	response to glucose	-	ISS	-
GO:0010470	regulation of gastrulation	-	IEA	-
GO:0019216	regulation of lipid metabolic process	-	IDA	10551874
GO:0023019	signal transduction involved in regulation of gene expression	-	IEA	-
GO:0030308	negative regulation of cell growth	-	IMP	18163890
GO:0030522	intracellular receptor signaling pathway	-	IEA	-
GO:0042593	glucose homeostasis	-	ISS	-
GO:0042632	cholesterol homeostasis	-	ISS	-
GO:0043401	steroid hormone mediated signaling pathway	-	IEA	-
GO:0045893	positive regulation of transcription, DNA-templated	-	IDA	16488887
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	7615825
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IMP	17827783
GO:0050796	regulation of insulin secretion	-	ISS	-
GO:0055088	lipid homeostasis	-	IMP	17827783
GO:0055091	phospholipid homeostasis	-	ISS	-
GO:0060395	SMAD protein signal transduction	-	IEA	-
GO:0070328	triglyceride homeostasis	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	7615825 14563941 15574752
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	IDA	14563941

KEGG ID	KEGG Term
hsa04950	Maturity onset diabetes of the young

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	IEA
R-HSA-186712	Regulation of beta-cell development	IEA
R-HSA-210745	Regulation of gene expression in beta cells	IEA
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-383280	Nuclear Receptor transcription pathway	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28583088	Uncovering the transcriptomic and epigenomic landscape of nicotinic receptor genes in non-neuronal tissues. (2017 Jun 5)	Zhang B	BMC Genomics
16838170	Single nucleotide polymorphisms of the HNF4alpha gene are associated with the conversion to type 2 diabetes mellitus: the STOP-NIDDM trial. (2006 Aug)	Andrulionyte L	J Mol Med (Berl)