Gene: HNMT

3176
HMT|HNMT-S1|HNMT-S2|MRT51
histamine N-methyltransferase
protein-coding
2q22.1
Ensembl:ENSG00000150540 MIM:605238 Vega:OTTHUMG00000131751 UniprotKB:P50135
NG_012966.1
PubMed
0   ANCO-SNPs
AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.169e-1 (AD)  1.381e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FPGT0.782
RCBTB20.777
STAM20.756
ARHGAP120.745
CREB10.734
UBTD20.731
ZFP900.726
SMAD20.723
AGPS0.721
PDCD40.719

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.495
OR4F29-0.465
UTF1-0.248
CRYBB2-0.248
LBP-0.245
IFNA5-0.244
NTN5-0.235
SLC25A47-0.233
ALPI-0.229
NANOS2-0.229

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00613AmodiaquineSmall Molecule86-42-0Approved|InvestigationalTarget
DB01752S-adenosyl-L-homocysteineSmall Molecule979-92-0ExperimentalTarget
DB04655MetoprineSmall Molecule7761-45-7ExperimentalTarget
DB071064-(DIMETHYLAMINO)BUTYL IMIDOTHIOCARBAMATESmall MoleculeExperimentalTarget
DB13875HarmalineSmall Molecule304-21-2ExperimentalTarget
DB00878ChlorhexidineSmall Molecule55-56-1ApprovedEnzyme
DB01103QuinacrineSmall Molecule83-89-6Approved|InvestigationalEnzyme
DB01752S-adenosyl-L-homocysteineSmall Molecule979-92-0ExperimentalEnzyme
DB05381HistamineSmall Molecule51-45-6Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of HNMT mRNA"26377693
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of HNMT mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of HNMT mRNA"20406850
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HNMT mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HNMT mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HNMT mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HNMT mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HNMT mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HNMT mRNA"27188386
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to HNMT protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to HNMT protein]26598702
C0652504-hydroxy-equilenin4-hydroxy-equilenin results in decreased expression of HNMT mRNA15135645
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HNMT mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HNMT mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HNMT mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HNMT mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HNMT mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HNMT mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of HNMT mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of HNMT mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of HNMT mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of HNMT mRNA19770486
C103505AM 251AM 251 results in increased expression of HNMT mRNA16500647
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HNMT mRNA16483693
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to HNMT protein]26598702
C015001arsenitearsenite results in increased methylation of HNMT promoter23974009
D001241AspirinHNMT gene SNP affects the susceptibility to Aspirin20485159
D001280AtrazineAtrazine results in increased expression of HNMT mRNA25929836
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of HNMT mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HNMT protein22138271
D001564Benzo(a)pyreneMethionine inhibits the reaction [Benzo(a)pyrene results in increased expression of HNMT protein]22138271
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HNMT mRNA19770486
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HNMT mRNA19619570
D004958EstradiolEstradiol results in increased expression of HNMT mRNA19619570|2118537
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of HNMT mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of HNMT mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of HNMT mRNA26794494
C018475butyraldehydebutyraldehyde results in decreased expression of HNMT mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of HNMT mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of HNMT promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of HNMT mRNA27339419
C105417caspofungincaspofungin results in decreased activity of HNMT protein12921242
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of HNMT mRNA18804290
D003300CopperCopper results in decreased expression of HNMT mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of HNMT mRNA19549813
C000541cyclopaminecyclopamine results in decreased expression of HNMT mRNA22265815
D016572CyclosporineCyclosporine results in decreased expression of HNMT mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of HNMT mRNA19770486
D016572CyclosporineCyclosporine results in decreased expression of HNMT mRNA21865292
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of HNMT mRNA24317228
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of HNMT mRNA28628672
C000944dicrotophosdicrotophos results in decreased expression of HNMT mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of HNMT mRNA18042831
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of HNMT mRNA21527772
C024565ethylene dichlorideethylene dichloride results in decreased expression of HNMT mRNA28189721
D005419FlavonoidsFlavonoids results in decreased expression of HNMT mRNA18035473
C039281furanfuran results in increased expression of HNMT mRNA27387713
C412815GW 4064GW 4064 results in decreased expression of HNMT mRNA26655953
C010178heliotrineheliotrine results in decreased expression of HNMT mRNA26100227
D006632HistamineHNMT protein results in increased methylation of Histamine7943261
D006632HistamineSK&F 91488 inhibits the reaction [HNMT protein results in increased methylation of Histamine]7943261
D017313FenretinideFenretinide results in decreased expression of HNMT mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of HNMT mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HNMT mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of HNMT mRNA28628672
C410337K 7174K 7174 results in decreased expression of HNMT mRNA24086573
D048628KetolidesKetolides analog results in increased expression of HNMT mRNA24967691
D001556LindaneLindane results in increased expression of HNMT mRNA18804290
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of HNMT mRNA25613284
C042720mercuric bromidemercuric bromide results in increased expression of HNMT mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HNMT mRNA"27188386
D008715MethionineMethionine inhibits the reaction [Benzo(a)pyrene results in increased expression of HNMT protein]22138271
D008748MethylcholanthreneMethylcholanthrene results in increased expression of HNMT mRNA18804290
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of HNMT mRNA28001369
C006308metoprinemetoprine results in decreased activity of HNMT protein10869801
C006308metoprinemetoprine results in decreased activity of HNMT protein9050021
D009151Mustard GasMustard Gas results in increased expression of HNMT mRNA25102026
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of HNMT mRNA"29244179
D009529NicardipineNicardipine results in decreased activity of HNMT protein2408645
D009532NickelNickel results in decreased expression of HNMT mRNA24768652|2558310
D009543NifedipineNifedipine results in decreased activity of HNMT protein2408645
D009585Nitrogen DioxideNitrogen Dioxide affects the activity of HNMT protein8534489
D009585Nitrogen DioxideNitrogen Dioxide results in increased expression of HNMT mRNA8534489
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of HNMT mRNA"12756304
D000073878Palm OilPalm Oil results in decreased expression of HNMT mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HNMT mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of HNMT mRNA26272509
D052638Particulate MatterParticulate Matter results in decreased expression of HNMT mRNA24769257
C046012pentanalpentanal results in decreased expression of HNMT mRNA26079696
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of HNMT mRNA18804290
D010634PhenobarbitalPhenobarbital affects the expression of HNMT mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of HNMT mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of HNMT mRNA19270015
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HNMT mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of HNMT mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of HNMT mRNA19710929
D010936Plant ExtractsPlant Extracts results in increased expression of HNMT mRNA23557933
D059808PolyphenolsPolyphenols results in decreased expression of HNMT mRNA16293270
C045950propiconazolepropiconazole results in decreased expression of HNMT mRNA21278054
C513428pyrachlostrobinpyrachlostrobin results in decreased expression of HNMT mRNA27029645
D011763Pyrrolizidine AlkaloidsPyrrolizidine Alkaloids results in decreased expression of HNMT mRNA26100227
D011794QuercetinQuercetin results in decreased expression of HNMT mRNA21632981
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of HNMT mRNA19244175
D012643SeleniumSelenium results in decreased expression of HNMT mRNA19244175
C009237senecioninesenecionine results in decreased expression of HNMT mRNA26100227
C009238senkirkinesenkirkine results in decreased expression of HNMT mRNA26100227
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of HNMT mRNA25895662
C024535SK&F 91488SK&F 91488 results in decreased activity of HNMT protein11445272
C024535SK&F 91488SK&F 91488 inhibits the reaction [HNMT protein results in increased methylation of Histamine]7943261
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HNMT mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HNMT mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HNMT mRNA24680724
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HNMT mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HNMT mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HNMT mRNA25613284
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HNMT mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of HNMT mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of HNMT mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate affects the expression of HNMT mRNA"26179874
D014520UrethaneUrethane results in decreased expression of HNMT mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HNMT mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of HNMT mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of HNMT mRNA23179753|2438349
D014640VancomycinVancomycin results in increased expression of HNMT mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of HNMT gene25560391
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of HNMT mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of HNMT mRNA19244175
D024483Vitamin K 3Vitamin K 3 affects the expression of HNMT mRNA20044591
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HNMT mRNA"27188386
C111237vorinostatvorinostat results in increased expression of HNMT mRNA26272509
D015032ZincZinc deficiency results in decreased expression of HNMT mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0046539histamine N-methyltransferase activity-IBA21873635  
GO:0046539histamine N-methyltransferase activity-IDA26206890  
GO:0046539histamine N-methyltransferase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001695histamine catabolic process-IDA26206890  
GO:0006548histidine catabolic process-TAS-  
GO:0007420brain development-IBA21873635  
GO:0007585respiratory gaseous exchange-TAS7943261  
GO:0032259methylation-IBA21873635  
GO:0032259methylation-IDA26206890  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA26206890  
GO:0005829cytosol-TAS-  
GO:0043005neuron projection-IBA21873635  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa00340Histidine metabolism
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-2408508Metabolism of ingested SeMet, Sec, MeSec into H2SeIEA
R-HSA-2408522Selenoamino acid metabolismIEA
R-HSA-6788656Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismTAS
R-HSA-70921Histidine catabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS
R-HSA-71291Metabolism of amino acids and derivativesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15770103Thr105Ile, a functional polymorphism of histamine N-methyltransferase, is associated with alcoholism in two independent populations. (2005 Mar)Oroszi GAlcohol Clin Exp Res
21138759No association between histamine N-methyltransferase functional polymorphism Thr105Ile and Alzheimer's disease. (2011 Feb 4)Marasovic-Susnjara INeurosci Lett
16950574Association of THR105Ile, a functional polymorphism of histamine N-methyltransferase (HNMT), with alcoholism in German Caucasians. (2007 Feb 23)Reuter MDrug Alcohol Depend