Gene: HNRNPL

3191
HNRPL|P/OKcl.14|hnRNP-L
heterogeneous nuclear ribonucleoprotein L
protein-coding
19q13.2
Ensembl:ENSG00000104824 MIM:603083 Vega:OTTHUMG00000182612 UniprotKB:P14866
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.579e-1 (AD)  6.584e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg00747152chr19:39339713HNRNPL4.200e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACTB0.941
SF3B20.939
CSNK2B0.939
TRIM280.938
PHF10.936
PCBP20.933
MARK30.933
VPS4A0.926
EWSR10.925
DEDD0.924

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.86
OR4F29-0.824
HMHB1-0.209
OR6C74-0.191
FCRL1-0.164
KLRB1-0.157
FAM25A-0.151
TTLL10-0.148
MTRNR2L6-0.147
OR4F16-0.147

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of HNRNPL mRNA"21394737
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in decreased expression of HNRNPL protein26194647
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HNRNPL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HNRNPL mRNA"27188386
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of HNRNPL mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HNRNPL mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of HNRNPL protein25419056
D001280AtrazineAtrazine results in increased expression of HNRNPL mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HNRNPL protein20097212
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of HNRNPL mRNA"20018196
C006780bisphenol Abisphenol A affects the expression of HNRNPL mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of HNRNPL mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of HNRNPL mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of HNRNPL mRNA28628672
C013418bromfenacoumbromfenacoum results in decreased expression of HNRNPL protein28903499
C515564bromovaninbromovanin results in decreased expression of HNRNPL protein21419150
D002220CarbamazepineCarbamazepine affects the expression of HNRNPL mRNA25979313
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HNRNPL mRNA"27188386
D002737ChloropreneChloroprene results in decreased expression of HNRNPL mRNA23125180
D004390Chlorpyrifos[Copper co-treated with Chlorpyrifos] results in increased expression of HNRNPL mRNA21356183
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of HNRNPL mRNA17602206
D003300Copper[Copper co-treated with Chlorpyrifos] results in increased expression of HNRNPL mRNA21356183
D003300CopperCopper results in increased expression of HNRNPL mRNA21356183
D003300CopperHNRNPL protein binds to Copper15359738
C030973cupric oxidecupric oxide results in decreased expression of HNRNPL protein25470785
D013759DronabinolDronabinol results in decreased expression of HNRNPL mRNA21955143
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of HNRNPL mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of HNRNPL mRNA28628672
D003976DiazinonDiazinon results in increased methylation of HNRNPL gene22964155
D002945Cisplatin[Piroxicam co-treated with Cisplatin] results in increased expression of HNRNPL mRNA21858171
D004041Dietary FatsDietary Fats results in increased expression of HNRNPL mRNA25016146
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of HNRNPL mRNA17602206
D004147DioxinsDioxins affects the expression of HNRNPL mRNA20463971
D004221DisulfiramDisulfiram results in decreased expression of HNRNPL mRNA20530235
D004317DoxorubicinHNRNPL protein results in decreased susceptibility to Doxorubicin24675091
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of HNRNPL protein23301498
D000431EthanolEthanol results in decreased expression of HNRNPL mRNA21955143
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of HNRNPL mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of HNRNPL mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HNRNPL mRNA17942748
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of HNRNPL mRNA]15016801
D005485FlutamideFlutamide results in decreased expression of HNRNPL mRNA21126777
C010974glyphosateglyphosate results in increased expression of HNRNPL mRNA26302742
C492448ICG 001ICG 001 results in decreased expression of HNRNPL mRNA26191083
C428264indioside Dindioside D results in decreased expression of HNRNPL protein18376857
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of HNRNPL mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of HNRNPL mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HNRNPL mRNA23086925
C410337K 7174K 7174 results in decreased expression of HNRNPL mRNA24086573
D008727MethotrexateMethotrexate affects the expression of HNRNPL mRNA18502557
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of HNRNPL protein26558463
D009020MorphineMorphine results in increased expression of HNRNPL mRNA21955143
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of HNRNPL protein"22001959
D009538NicotineNicotine results in decreased expression of HNRNPL mRNA21955143
D010894Piroxicam[Piroxicam co-treated with Cisplatin] results in increased expression of HNRNPL mRNA21858171
C037219quinolinequinoline analog results in decreased expression of HNRNPL protein18645022
C080703SK&F 83959SK&F 83959 results in decreased expression of HNRNPL protein25852303
D013629TamoxifenTamoxifen affects the expression of HNRNPL mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HNRNPL mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HNRNPL mRNA17942748
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine affects the expression of HNRNPL protein"25852303
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in decreased expression of HNRNPL protein"25852303
D013893ThiramThiram results in decreased expression of HNRNPL mRNA20530235
C012589trichostatin Atrichostatin A affects the expression of HNRNPL mRNA28542535
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of HNRNPL mRNA"26179874
D014635Valproic AcidValproic Acid results in decreased expression of HNRNPL mRNA23179753|2915479

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003730mRNA 3'-UTR binding-IEA-  
GO:0005515protein binding-IPI11809897  18669861  23976881  
GO:0044212transcription regulatory region DNA binding-IDA11809897  
GO:0097157pre-mRNA intronic binding-IDA25623890  
GO:1990715mRNA CDS binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000381regulation of alternative mRNA splicing, via spliceosome-IMP25623890  
GO:0000398mRNA splicing, via spliceosome-TAS-  
GO:0006396RNA processing-TAS2687284  
GO:0007623circadian rhythm-IEA-  
GO:0016070RNA metabolic process-TAS-  
GO:0034198cellular response to amino acid starvation-IEA-  
GO:0045727positive regulation of translation-IEA-  
GO:0048025negative regulation of mRNA splicing, via spliceosome-IEA-  
GO:1901652response to peptide-IEA-  
GO:1902416positive regulation of mRNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA15798186  
GO:0005654nucleoplasm-IDA2687284  
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-IEA-  
GO:0016020membrane-HDA19946888  
GO:0035770ribonucleoprotein granule-IDA17289661  
GO:0045120pronucleus-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
GO:0070062extracellular exosome-HDA19056867  
GO:1990904ribonucleoprotein complex-IDA2687284  17289661  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-72163mRNA Splicing - Major PathwayTAS
R-HSA-72172mRNA SplicingTAS
R-HSA-72203Processing of Capped Intron-Containing Pre-mRNATAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25821920Sperm mRNAs and microRNAs as candidate markers for the impact of toxicants on human spermatogenesis: an application to tobacco smoking. (2015 Jun)Metzler-Guillemain CSyst Biol Reprod Med