Gene: TAAR6

319100
TA4|TAR4|TAR6|TRAR4|taR-4|taR-6
trace amine associated receptor 6
protein-coding
6q23.2
Ensembl:ENSG00000146383 MIM:608923 Vega:OTTHUMG00000015579 UniprotKB:Q96RI8
NG_016544.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.957e-1 (AD)  2.383e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPACA70.457
KRT200.436
HYAL40.409
GPR1410.408
VENTX0.395
CCL150.392
SPANXN50.382
PRAM10.376
DAZ40.372
ACE20.369

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP2C2-0.241
SMN2-0.238
ARSF-0.232
MMD2-0.23
DHRS4L2-0.216
CPLX3-0.214
WIF1-0.214
WNT7B-0.211
FDXACB1-0.21
HES5-0.206

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of TAAR6 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TAAR6 mRNA16483693
C006780bisphenol Abisphenol A results in decreased expression of TAAR6 mRNA25181051
C045463leflunomideleflunomide results in decreased expression of TAAR6 mRNA28988120
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of TAAR6 mRNA21334430
D014241TrichloroethyleneTrichloroethylene results in increased methylation of TAAR6 gene27618143

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001594trace-amine receptor activity-IBA21873635  
GO:0004930G-protein coupled receptor activity-TAS15718104  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375280Amine ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25919112Association between TAAR6 polymorphisms and airway responsiveness to inhaled corticosteroids in asthmatic patients. (2015 Jul)Chang HSPharmacogenet Genomics