Gene: KRT73

319101
IRT6IRS3|K6IRS3|KRT6IRS3
keratin 73
protein-coding
12q13.13
Ensembl:ENSG00000186049 MIM:608247 Vega:OTTHUMG00000169746 UniprotKB:Q86Y46
NG_012319.1
SNP Mapped
1   ANCO-SNPs
CD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.269e-1 (AD)  5.388e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs670142chr12:52607203 (GRCh38.p7)A>Ccocaine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KRT720.826
GPR1710.772
DPPA40.756
IGF2BP30.74
ATP6V0D20.738
OR56A30.716
IL2RB0.709
MROH90.706
NPHS20.702
HOXC90.7

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KLHDC9-0.431
TMEM53-0.419
HDAC11-0.406
SPAG8-0.406
ABHD14A-0.404
B9D2-0.404
HDDC3-0.402
TACO1-0.401
TM7SF2-0.401
FAM43B-0.399

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D020106AcrylamideAcrylamide results in increased expression of KRT73 mRNA28959563
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of KRT73 mRNA21298039
D001280AtrazineAtrazine results in increased expression of KRT73 mRNA22378314
C006780bisphenol Abisphenol A results in decreased expression of KRT73 mRNA25181051
D003471CuprizoneCuprizone results in increased expression of KRT73 mRNA27523638
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of KRT73 mRNA]27941970
D004041Dietary FatsDietary Fats results in increased expression of KRT73 mRNA25016146
D004052Diethylnitrosamine[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of KRT73 gene23968726
D004397FonofosFonofos results in increased methylation of KRT73 promoter22847954
C039281furanfuran results in increased methylation of KRT73 gene22079235
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of KRT73 mRNA23086925
C028577monobutyl phthalatemonobutyl phthalate results in increased expression of KRT73 protein20553848
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of KRT73 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of KRT73 mRNA"25620056
D010278ParathionParathion results in increased methylation of KRT73 promoter22847954
D010882Piperonyl Butoxide[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of KRT73 gene23968726
D011441PropylthiouracilPropylthiouracil affects the expression of KRT73 mRNA24780913
C012568terbufosterbufos results in increased methylation of KRT73 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KRT73 mRNA21570461

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005198structural molecule activity-IEA-  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO:0031424keratinization-TAS-  
GO:0070268cornification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-HDA21630459  
GO:0005829cytosol-TAS-  
GO:0045095keratin filament-IEA-  
GO:0070062extracellular exosome-HDA19199708  23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-6805567KeratinizationTAS
R-HSA-6809371Formation of the cornified envelopeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal