Gene: HOXA5

3202
HOX1|HOX1.3|HOX1C
homeobox A5
protein-coding
7p15.2
Ensembl:ENSG00000106004 MIM:142952 Vega:OTTHUMG00000023214 UniprotKB:P20719
NC_000007.14
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.737e-1 (AD)  6.902e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg04863892chr7:27183375HOXA5Promoter1.208e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
USP260.44
OR52R10.43
POF1B0.429
S100A7A0.424
SERPINA120.424
MYOC0.413
TNS40.412
CEACAM180.405
LEP0.394
OR1A10.391

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RRP7A-0.28
ACTR3C-0.276
FAM86B1-0.253
PNMA5-0.251
TMEM53-0.246
LRRC37A2-0.246
HTR6-0.242
FLRT1-0.24
NKAIN1-0.24
PABPC1L2A-0.237

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of HOXA5 mRNA16788091
D000082AcetaminophenAcetaminophen affects the expression of HOXA5 mRNA17562736
C103303alitretinoinalitretinoin results in increased expression of HOXA5 mRNA28689802
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of HOXA5 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HOXA5 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of HOXA5 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of HOXA5 mRNA21461292
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HOXA5 mRNA21569818
D004958EstradiolEstradiol results in increased expression of HOXA5 mRNA21632981
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of HOXA5 mRNA25912373
C006780bisphenol Abisphenol A results in increased expression of HOXA5 mRNA29275510
C584509C646 compoundC646 compound results in increased expression of HOXA5 mRNA26191083
D016572CyclosporineCyclosporine results in decreased expression of HOXA5 mRNA25562108
D003561CytarabineCytarabine results in increased expression of HOXA5 mRNA21198554
C014347decitabine[decitabine co-treated with trichostatin A] results in increased expression of HOXA5 mRNA17891453
D002945CisplatinCisplatin results in increased expression of HOXA5 mRNA27392435
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of HOXA5 mRNA21658437
D002117CalcitriolCalcitriol results in decreased expression of HOXA5 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of HOXA5 mRNA21592394
D004237DiuronDiuron results in decreased expression of HOXA5 mRNA21551480
D005047EtoposideHOXA5 protein affects the susceptibility to Etoposide16217747
D005419FlavonoidsFlavonoids results in decreased expression of HOXA5 mRNA18035473
C492448ICG 001ICG 001 results in increased expression of HOXA5 mRNA26191083
C544151jinfukangjinfukang results in decreased expression of HOXA5 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HOXA5 mRNA26254443
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of HOXA5 mRNA16415329
D008942MitoxantroneHOXA5 protein affects the susceptibility to Mitoxantrone16217747
C523799MRK 003MRK 003 results in decreased expression of HOXA5 mRNA21169257
D009151Mustard GasMustard Gas results in increased expression of HOXA5 mRNA15674843
C017096n-butoxyethanoln-butoxyethanol results in increased expression of HOXA5 mRNA19812364
D009532NickelNickel results in decreased expression of HOXA5 mRNA24768652|2558310
C007350nitrofennitrofen results in increased expression of HOXA5 mRNA18351244
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of HOXA5 mRNA25729387
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of HOXA5 mRNA28973697
D010705PhosgenePhosgene affects the expression of HOXA5 mRNA16300373
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of HOXA5 mRNA19710929
D011794QuercetinQuercetin results in decreased expression of HOXA5 mRNA21632981
D011899Ranitidine[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of HOXA5 mRNA16415329
D012906SmokeSmoke results in decreased expression of HOXA5 mRNA21095227
C017947sodium arsenitesodium arsenite results in increased expression of HOXA5 mRNA12760830
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of HOXA5 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of HOXA5 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HOXA5 mRNA21570461|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HOXA5 mRNA19897914
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HOXA5 mRNA15328365
C009495titanium dioxidetitanium dioxide results in decreased expression of HOXA5 mRNA23409001
C009495titanium dioxidetitanium dioxide results in increased expression of HOXA5 mRNA23131501
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of HOXA5 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of HOXA5 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of HOXA5 mRNA21934132
D014212TretinoinTretinoin results in increased expression of HOXA58838863
D014212TretinoinTretinoin results in increased expression of HOXA5 mRNA16604517|1678809
D014212TretinoinTretinoin results in increased expression of HOXA5 mRNA20488242
D014212TretinoinTretinoin results in increased expression of HOXA5 mRNA28689802
C012589trichostatin A[decitabine co-treated with trichostatin A] results in increased expression of HOXA5 mRNA17891453
D014520UrethaneUrethane results in increased expression of HOXA5 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of HOXA5 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of HOXA5 mRNA24896083
C025643vinclozolinvinclozolin affects the expression of HOXA5 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of HOXA5 mRNA15686871
D015034Zinc OxideZinc Oxide analog results in decreased expression of HOXA5 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA10879542  
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA10879542  
GO:0003677DNA binding-IDA8657138  
GO:0003700DNA-binding transcription factor activity-IDA10879542  16756717  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-IBA21873635  
GO:0005515protein binding-IPI15545268  
GO ID GO Term Qualifier Evidence PubMed
GO:0003016respiratory system process-IEA-  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0009952anterior/posterior pattern specification-IBA21873635  
GO:0009952anterior/posterior pattern specification-IEA-  
GO:0010870positive regulation of receptor biosynthetic process-IDA10875927  
GO:0016477cell migration-IEA-  
GO:0016525negative regulation of angiogenesis-IMP17957028  23136161  
GO:0030878thyroid gland development-IEA-  
GO:0033599regulation of mammary gland epithelial cell proliferation-IEA-  
GO:0035264multicellular organism growth-IEA-  
GO:0043065positive regulation of apoptotic process-IDA10879542  
GO:0045639positive regulation of myeloid cell differentiation-IDA10397719  
GO:0045647negative regulation of erythrocyte differentiation-IDA10397719  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA10879542  16756717  
GO:0048286lung alveolus development-IEA-  
GO:0048704embryonic skeletal system morphogenesis-IEA-  
GO:0060435bronchiole development-IEA-  
GO:0060441epithelial tube branching involved in lung morphogenesis-IEA-  
GO:0060480lung goblet cell differentiation-IEA-  
GO:0060484lung-associated mesenchyme development-IEA-  
GO:0060535trachea cartilage morphogenesis-IEA-  
GO:0060574intestinal epithelial cell maturation-IEA-  
GO:0060638mesenchymal-epithelial cell signaling-IEA-  
GO:0060644mammary gland epithelial cell differentiation-IEA-  
GO:0060749mammary gland alveolus development-IEA-  
GO:0060764cell-cell signaling involved in mammary gland development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA15545268  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20625274Expression of miRNA-130a in nonsmall cell lung cancer. (2010 Nov)Wang XCAm J Med Sci