Gene: HOXA7

3204
ANTP|HOX1|HOX1.1|HOX1A
homeobox A7
protein-coding
7p15.2
Ensembl:ENSG00000122592 MIM:142950 Vega:OTTHUMG00000023217 UniprotKB:P31268
NC_000007.14
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.178e-1 (AD)  6.594e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg25727671chr7:27193351HOXA75.700e-8Smoking27651444
cg24389054chr7:27194013HOXA76.730e-14Smoking28686328
cg08396193chr7:27193709HOXA72.250e-9Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRAMEF70.463
FSHB0.425
PRAMEF60.402
OR5D180.391
GGTLC10.385
FGF30.384
OR8B80.381
SPINT40.379
OR11G20.369
UNC93A0.365

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HHATL-0.227
BPIFB4-0.199
CA14-0.198
TESK2-0.19
FAM69C-0.19
PRR18-0.189
HNRNPCL1-0.188
CARNS1-0.188
SEMA3B-0.187
GPIHBP1-0.186

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of HOXA7 mRNA"21346803
C412373AG 1879AG 1879 inhibits the reaction [deoxynivalenol results in increased expression of HOXA7 mRNA]19438726
C004984apocarotenalapocarotenal results in increased expression of HOXA7 mRNA17034753
D019207beta Carotenebeta Carotene results in increased expression of HOXA7 mRNA17034753
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HOXA7 mRNA28628672
D002104CadmiumCadmium results in decreased expression of HOXA7 mRNA24284285
D002104CadmiumCadmium results in increased expression of HOXA7 mRNA24376830
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of HOXA7 mRNA26472689
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HOXA7 gene20938992
D002922CiguatoxinsCiguatoxins affects the expression of HOXA7 mRNA18353800
C007262deoxynivalenolAG 1879 inhibits the reaction [deoxynivalenol results in increased expression of HOXA7 mRNA]19438726
C007262deoxynivalenoldeoxynivalenol results in increased expression of HOXA7 mRNA19438726
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HOXA7 mRNA28628672
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HOXA7 gene20938992
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of HOXA7 mRNA20044591
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HOXA7 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HOXA7 mRNA28628672
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HOXA7 gene20938992
C523799MRK 003MRK 003 results in decreased expression of HOXA7 mRNA21169257
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of HOXA7 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of HOXA7 mRNA"25554681
D009532NickelNickel results in decreased expression of HOXA7 mRNA24768652|2558310
D010634PhenobarbitalPhenobarbital results in decreased expression of HOXA7 mRNA19084549
D012834SilverSilver results in decreased expression of HOXA7 mRNA27131904
C004648testosterone enanthatetestosterone enanthate affects the expression of HOXA7 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HOXA7 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HOXA7 mRNA24058054
C009495titanium dioxidetitanium dioxide affects the expression of HOXA7 mRNA23557971
D014212TretinoinTretinoin results in increased expression of HOXA7 mRNA17185360
D014212TretinoinTretinoin affects the expression of HOXA7 mRNA14708090
D014635Valproic AcidValproic Acid results in increased expression of HOXA7 mRNA23179753
D014810Vitamin EVitamin E results in decreased expression of HOXA7 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA11435435  
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA11435435  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-IBA21873635  
GO:0008134transcription factor binding-IPI18973687  
GO:0043565sequence-specific DNA binding-IDA11435435  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA11435435  14704364  
GO:0001525angiogenesis-IEP17972163  
GO:0001953negative regulation of cell-matrix adhesion-IDA14704364  
GO:0002686negative regulation of leukocyte migration-IDA14704364  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0009952anterior/posterior pattern specification-IBA21873635  
GO:0009952anterior/posterior pattern specification-IEA-  
GO:0045617negative regulation of keratinocyte differentiation-IDA11435435  
GO:0045656negative regulation of monocyte differentiation-IDA14704364  
GO:0045892negative regulation of transcription, DNA-templated-IDA11435435  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA11435435  
GO:0048704embryonic skeletal system morphogenesis-IEA-  
GO:0048863stem cell differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IC11435435  
GO:0005654nucleoplasm-IDA-  
GO:0031965nuclear membrane-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27142338Prostate tumor DNA methylation is associated with cigarette smoking and adverse prostate cancer outcomes. (2016 Jul 15)Shui IMCancer