Gene: HOXA9

3205
ABD-B|HOX1|HOX1.7|HOX1G
homeobox A9
protein-coding
7p15.2
Ensembl:ENSG00000078399 MIM:142956 Vega:OTTHUMG00000023220 UniprotKB:P31269
NG_029923.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLEKHG60.557
LILRB20.552
TMEM1540.55
TCN10.543
TREML10.54
CEACAM40.539
TRIM100.535
TGFBI0.528
TLR100.528
CLECL10.519

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP2C2-0.333
HHATL-0.328
RNFT2-0.32
PLA2G6-0.308
ASTN2-0.307
DBP-0.288
ASPDH-0.286
ZNF835-0.285
OMG-0.284
HS3ST5-0.284

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased expression of HOXA9 mRNA"24821986
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HOXA9 gene27153756
C096920AGN 193109AGN 193109 results in increased expression of HOXA9 mRNA24821986
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HOXA9 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of HOXA9 mRNA22541086
C006632arsenic trioxidearsenic trioxide results in increased expression of HOXA9 protein22541086
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HOXA9 mRNA]16964424
D004958EstradiolEstradiol promotes the reaction [Lipopolysaccharides results in increased expression of HOXA9 mRNA]16977382
C006780bisphenol Abisphenol A affects the methylation of HOXA9 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of HOXA9 mRNA25181051
C584509C646 compoundC646 compound results in increased expression of HOXA9 mRNA26191083
C018021cobaltous chloridecobaltous chloride results in increased expression of HOXA9 mRNA17553155
C014347decitabinedecitabine results in increased expression of HOXA9 mRNA19194470
D002945CisplatinCisplatin results in increased expression of HOXA9 mRNA19561079
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of HOXA9 mRNA16632680
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of HOXA9 mRNA16632680
D004237DiuronDiuron results in decreased expression of HOXA9 mRNA21551480
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of HOXA9 mRNA17557909
D004397FonofosFonofos results in increased methylation of HOXA9 promoter22847954
C070081fulvestrantfulvestrant inhibits the reaction [Genistein results in decreased expression of HOXA9 mRNA]21810550
C039281furanfuran results in increased methylation of HOXA9 gene22079235
D019833Genisteinfulvestrant inhibits the reaction [Genistein results in decreased expression of HOXA9 mRNA]21810550
D019833GenisteinGenistein results in decreased expression of HOXA9 mRNA21810550
C014026hexamethylene bisacetamidehexamethylene bisacetamide results in increased expression of HOXA9 protein16973558
C492448ICG 001ICG 001 results in increased expression of HOXA9 mRNA26191083
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HOXA9 mRNA26752646
D008070LipopolysaccharidesEstradiol promotes the reaction [Lipopolysaccharides results in increased expression of HOXA9 mRNA]16977382
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of HOXA9 mRNA16977382
C008493methylselenic acidmethylselenic acid results in decreased expression of HOXA9 mRNA18548127
C523799MRK 003MRK 003 results in decreased expression of HOXA9 mRNA21169257
D009151Mustard GasMustard Gas results in increased expression of HOXA9 mRNA15674843
C570897NSC668394NSC668394 results in increased expression of HOXA9 mRNA27137931
D010278ParathionParathion results in increased methylation of HOXA9 promoter22847954
D010894PiroxicamPiroxicam results in decreased expression of HOXA9 mRNA21858171
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of HOXA9 mRNA23806026
D020123SirolimusSirolimus inhibits the reaction [TP73 protein affects the activity of HOXA9 protein]21245298
C012568terbufosterbufos results in increased methylation of HOXA9 promoter22847954
D013739TestosteroneTestosterone affects the expression of HOXA9 mRNA17138648
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HOXA9 mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HOXA9 mRNA19897914
D014118Toxins, Biological"Toxins, Biological affects the expression of HOXA9 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of HOXA9 mRNA22541086
D014212TretinoinTretinoin results in increased expression of HOXA9 protein22541086
D014212TretinoinTretinoin affects the expression of HOXA9 mRNA22262565

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0005515protein binding-IPI16189514  19060904  22269951  
GO:0019899enzyme binding-IPI22269951  
GO:0043565sequence-specific DNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0007275multicellular organism development-IEA-  
GO:0042118endothelial cell activation-IMP22269951  
GO:0045638negative regulation of myeloid cell differentiation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19472401The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history: a target for risk diagnosis and prevention of esophageal cancers. (2009 Aug 1)Oka DCancer