Gene: HOXA10

3206
HOX1|HOX1.8|HOX1H|PL
homeobox A10
protein-coding
7p15.2
Ensembl:ENSG00000253293 MIM:142957 Vega:OTTHUMG00000023436 UniprotKB:P31260
NC_000007.14
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.361e-1 (AD)  7.039e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C10orf710.477
ADIPOQ0.476
KCNA70.464
KRTAP24-10.431
OPN1LW0.431
GALNT50.419
HES20.413
HOXC100.413
GAGE10.411
ACTA10.411

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZBTB3-0.304
HHATL-0.258
NTSR2-0.25
SPATA3-0.23
SLC22A6-0.229
FAM69C-0.226
LAIR2-0.225
CRB2-0.222
GPR37L1-0.219
MLYCD-0.218

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00136CalcitriolSmall Molecule32222-06-3Approved|NutraceuticalTarget
ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HOXA10 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of HOXA10 mRNA24449571
C015001arsenitearsenite results in increased methylation of HOXA10 promoter23974009
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to HOXA10 gene]15890768
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to HOXA10 promoter]15236964
D004958EstradiolEstradiol promotes the reaction [ESR2 protein binds to HOXA10 promoter]15236964
D004958EstradiolEstradiol promotes the reaction [NCOA1 protein binds to HOXA10 promoter]15236964
D004958EstradiolEstradiol results in increased expression of HOXA10 mRNA15236964|1589076
D004958EstradiolMethoxychlor inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to HOXA10 gene]]15890768
D004958EstradiolEstradiol results in decreased expression of HOXA10 mRNA16985261
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of HOXA10 mRNA18653720
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of HOXA10 protein18653720
D004958EstradiolEstradiol promotes the reaction [Progesterone results in increased expression of HOXA10 mRNA]21705055
D004958EstradiolEstradiol results in increased expression of HOXA10 mRNA21705055
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in increased expression of HOXA10 mRNA]21705055
C006780bisphenol Abisphenol A results in decreased methylation of HOXA10 gene23590724
C006780bisphenol Abisphenol A results in increased expression of HOXA10 mRNA16632680|1709313
C006780bisphenol Abisphenol A affects the methylation of HOXA10 promoter27334623
C006780bisphenol Abisphenol A promotes the reaction [ESR1 protein binds to HOXA10 promoter]20181937
C006780bisphenol Abisphenol A results in decreased expression of HOXA10 mRNA24769007|2702267
C006780bisphenol Abisphenol A results in decreased expression of HOXA10 protein24769007
C006780bisphenol Abisphenol A results in decreased methylation of HOXA10 intron20181937|2153225
C006780bisphenol Abisphenol A results in decreased methylation of HOXA10 promoter20181937
C006780bisphenol Abisphenol A results in increased expression of HOXA10 mRNA17093138|2018193
C006780bisphenol Abisphenol A results in increased expression of HOXA10 protein20181937
C006780bisphenol Abisphenol A results in decreased expression of HOXA10 mRNA18653720|2128532
C006780bisphenol Abisphenol A results in decreased expression of HOXA10 protein21285323
C006780bisphenol Abisphenol A results in increased expression of HOXA10 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of HOXA10 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of HOXA10 mRNA26472689
C018021cobaltous chloridecobaltous chloride results in increased expression of HOXA10 mRNA19376846
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of HOXA10 mRNA23914054
D002945CisplatinCisplatin results in increased expression of HOXA10 mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of HOXA10 mRNA18042831
D004054DiethylstilbestrolDiethylstilbestrol promotes the reaction [ESR1 protein binds to HOXA10 promoter]15236964
D004054DiethylstilbestrolDiethylstilbestrol promotes the reaction [ESR2 protein binds to HOXA10 promoter]15236964
D004054DiethylstilbestrolDiethylstilbestrol promotes the reaction [NCOA1 protein binds to HOXA10 promoter]15236964
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of HOXA10 mRNA15236964|1589076
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of HOXA10 mRNA15458790
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of HOXA10 mRNA16632680
D004054DiethylstilbestrolESR1 protein affects the reaction [Diethylstilbestrol results in decreased expression of HOXA10 mRNA]15458790
D004054DiethylstilbestrolWNT5A protein affects the reaction [Diethylstilbestrol results in decreased expression of HOXA10 mRNA]15073149
D004054DiethylstilbestrolWNT7A protein affects the reaction [Diethylstilbestrol results in decreased expression of HOXA10 mRNA]15070830
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of HOXA10 mRNA18653720|2128532
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of HOXA10 protein21285323
D002117Calcitriol[Calcitriol binds to VDR protein] which binds to HOXA10 promoter16632680
D002117Calcitriol[Calcitriol binds to VDR protein] which results in increased expression of HOXA10 mRNA16632680
D002117CalcitriolCalcitriol affects the expression of HOXA10 mRNA16632680
D052244Endocrine DisruptorsEndocrine Disruptors affects the expression of HOXA10 mRNA24056088
D052244Endocrine DisruptorsEndocrine Disruptors affects the methylation of HOXA10 promoter24056088
D052244Endocrine DisruptorsEndocrine Disruptors affects the expression of HOXA10 mRNA24056088
D052244Endocrine DisruptorsEndocrine Disruptors affects the methylation of HOXA10 promoter24056088
D004726EndosulfanEndosulfan results in decreased expression of HOXA10 protein25486513
D004964EstriolEstriol results in decreased expression of HOXA10 mRNA16402032
D004967EstrogensEstrogens results in increased expression of HOXA10 mRNA21670700
D004967Estrogens[Medroxyprogesterone Acetate co-treated with Estrogens] results in increased expression of HOXA10 mRNA21670700
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HOXA10 mRNA17942748
D015025ZearalenoneZearalenone results in decreased expression of HOXA10 mRNA27862621
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in increased expression of HOXA10 mRNA]21705055
C070081fulvestrantfulvestrant results in decreased expression of HOXA10 mRNA21705055
D019833GenisteinGenistein results in increased expression of HOXA10 mRNA16632680
D019833GenisteinGenistein results in increased expression of HOXA10 protein16632680
D019833GenisteinGenistein results in decreased expression of HOXA10 mRNA16402032|2181055
D019833GenisteinGenistein results in increased expression of HOXA10 mRNA16632680|1698526
C010974glyphosateglyphosate results in increased expression of HOXA10 protein27287056
C544151jinfukangjinfukang results in increased expression of HOXA10 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HOXA10 mRNA25307878
D017258Medroxyprogesterone Acetate[Medroxyprogesterone Acetate co-treated with Estrogens] results in increased expression of HOXA10 mRNA21670700
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of HOXA10 mRNA16632680|2167070
D017258Medroxyprogesterone AcetateMifepristone inhibits the reaction [Medroxyprogesterone Acetate results in increased expression of HOXA10 mRNA]21670700
D008731MethoxychlorMethoxychlor inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to HOXA10 gene]]15890768
D008731MethoxychlorMethoxychlor promotes the reaction [ESR1 protein binds to HOXA10 gene]15890768
D008731MethoxychlorMethoxychlor results in decreased expression of HOXA10 mRNA16632680
D008731MethoxychlorMethoxychlor results in increased expression of HOXA10 mRNA15890768
D008731MethoxychlorMethoxychlor results in increased expression of HOXA10 protein15890768
D008731MethoxychlorMethoxychlor results in decreased expression of HOXA10 mRNA15890768
D008731MethoxychlorMethoxychlor results in decreased expression of HOXA10 protein16632680
D015735MifepristoneMifepristone inhibits the reaction [Medroxyprogesterone Acetate results in increased expression of HOXA10 mRNA]21670700
C053238onapristoneonapristone results in decreased expression of HOXA10 mRNA17709569
C053238onapristoneonapristone results in decreased expression of HOXA10 protein17709569
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of HOXA10 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of HOXA10 mRNA25729387
D000073878Palm OilPalm Oil results in increased expression of HOXA10 mRNA18042831
D048789PhytoestrogensPhytoestrogens results in decreased expression of HOXA10 mRNA16402032
D011374ProgesteroneHOXA10 protein affects the reaction [Progesterone affects the localization of GABRP protein]20103740
D011374ProgesteroneHOXA10 protein affects the reaction [Progesterone results in increased expression of GABRP mRNA]20103740
D011374ProgesteroneProgesterone results in decreased expression of HOXA10 mRNA18037150
D011374ProgesteroneProgesterone results in increased expression of HOXA1015845616
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of HOXA10 mRNA18653720
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of HOXA10 protein18653720
D011374ProgesteroneEstradiol promotes the reaction [Progesterone results in increased expression of HOXA10 mRNA]21705055
D011374ProgesteroneProgesterone results in increased expression of HOXA10 mRNA21705055
C017947sodium arsenitesodium arsenite results in decreased expression of HOXA10 mRNA14989901|2037198
D013739TestosteroneTestosterone results in decreased expression of HOXA10 mRNA16632680
D013739TestosteroneTestosterone affects the expression of HOXA10 mRNA17138648
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HOXA10 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HOXA10 mRNA24058054
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of HOXA10 mRNA25729387
D019772TopotecanTopotecan results in increased expression of HOXA10 mRNA25729387
D014212TretinoinTretinoin results in increased expression of HOXA10 mRNA17218384
D014212TretinoinTretinoin results in decreased expression of HOXA10 mRNA22262565
D014635Valproic AcidValproic Acid results in decreased methylation of HOXA10 gene29154799
D014635Valproic AcidValproic Acid affects the expression of HOXA10 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions affects the methylation of HOXA10 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA21471217  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA21471217  
GO:0005515protein binding-IPI18692240  
GO:0042826histone deacetylase binding-IPI15213244  
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-IEA-  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007275multicellular organism development-TAS8972230  
GO:0007283spermatogenesis-IEA-  
GO:0007338single fertilization-IEA-  
GO:0008584male gonad development-IEA-  
GO:0009952anterior/posterior pattern specification-IEA-  
GO:0009954proximal/distal pattern formation-IEA-  
GO:0030326embryonic limb morphogenesis-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA21471217  
GO:0060065uterus development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA15213244  
GO:0005667transcription factor complex-IEA-  
GO:0005737cytoplasm-IDA15213244  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21325691Cigarette smoke increases progesterone receptor and homeobox A10 expression in human endometrium and endometrial cells: a potential role in the decreased prevalence of endometrial pathology in smokers. (2011 Jun)Zhou YBiol Reprod