Gene: HOXA11

3207
HOX1|HOX1I|RUSAT1
homeobox A11
protein-coding
7p15.2
Ensembl:ENSG00000005073 MIM:142958 Vega:OTTHUMG00000023437 UniprotKB:P31270
NG_012079.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.370e-1 (AD)  7.123e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C3orf840.622
TAS2R410.605
OR2A140.599
OR56A40.593
IFNB10.581
OR9Q20.58
AMPD10.572
PRAMEF170.571
DEFB108B0.57
PRDM140.569

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ALDH3A1-0.213
MOGAT1-0.209
B3GNT9-0.203
RAD9B-0.198
CNGA4-0.195
ADAMTS14-0.194
GGACT-0.192
PROK1-0.189
REG1A-0.185
HDDC3-0.18

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased expression of HOXA11 mRNA"24821986
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HOXA11 gene27153756
C096920AGN 193109AGN 193109 results in increased expression of HOXA11 mRNA24821986
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of HOXA11 mRNA"19446018
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HOXA11 mRNA"19150397
D004958EstradiolEstradiol results in increased expression of HOXA11 mRNA16632680
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of HOXA11 mRNA17404688
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of HOXA11 mRNA18653720
C006780bisphenol Abisphenol A results in decreased methylation of HOXA11 promoter27271280
C006780bisphenol Abisphenol A affects the methylation of HOXA11 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of HOXA11 mRNA18653720
D000069286BortezomibBortezomib results in decreased expression of HOXA11 mRNA20977926
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HOXA11 gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of HOXA11 mRNA24386269
D004041Dietary FatsDietary Fats results in increased expression of HOXA11 mRNA18042831
D004054DiethylstilbestrolDiethylstilbestrol affects the expression of HOXA11 mRNA16632680
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of HOXA11 mRNA15458790|1559153
D004054DiethylstilbestrolESR1 protein affects the reaction [Diethylstilbestrol results in decreased expression of HOXA11 mRNA]15458790
D004054DiethylstilbestrolWNT5A protein affects the reaction [Diethylstilbestrol results in decreased expression of HOXA11 mRNA]15073149
D004054DiethylstilbestrolWNT7A protein affects the reaction [Diethylstilbestrol results in decreased expression of HOXA11 mRNA]15070830
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of HOXA11 mRNA18653720
D004964EstriolEstriol results in decreased expression of HOXA11 mRNA16402032
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HOXA11 gene20938992
D019833GenisteinGenistein results in decreased expression of HOXA11 mRNA16402032|2181055
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of HOXA11 mRNA16632680
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HOXA11 gene20938992
D008727MethotrexateMethotrexate results in decreased expression of HOXA11 mRNA24449571
C028577monobutyl phthalatemonobutyl phthalate results in decreased expression of HOXA11 mRNA29162477
D009151Mustard GasMustard Gas results in increased expression of HOXA11 mRNA15674843
C053238onapristoneonapristone results in decreased expression of HOXA11 mRNA17709569
D000073878Palm OilPalm Oil results in increased expression of HOXA11 mRNA18042831
C011272perfosfamideperfosfamide results in decreased expression of HOXA11 mRNA19429390
D048789PhytoestrogensPhytoestrogens results in decreased expression of HOXA11 mRNA16402032
C006253pirinixic acidpirinixic acid results in increased expression of HOXA11 mRNA20813756
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of HOXA11 mRNA22714537
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of HOXA11 mRNA17404688
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of HOXA11 mRNA18653720
D013739TestosteroneTestosterone results in increased expression of HOXA11 mRNA20403060
D013739TestosteroneTestosterone affects the expression of HOXA11 mRNA17138648
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HOXA11 mRNA24058054
D014212TretinoinTretinoin results in decreased expression of HOXA11 mRNA19897914
D014635Valproic AcidValproic Acid results in decreased methylation of HOXA11 gene29154799
D014810Vitamin EVitamin E results in increased expression of HOXA11 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0043565sequence-specific DNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-ISS-  
GO:0001656metanephros development-IEA-  
GO:0001658branching involved in ureteric bud morphogenesis-ISS-  
GO:0001759organ induction-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0007275multicellular organism development-ISS-  
GO:0007283spermatogenesis-IEA-  
GO:0007338single fertilization-IEA-  
GO:0007501mesodermal cell fate specification-ISS-  
GO:0008584male gonad development-IEA-  
GO:0009653anatomical structure morphogenesis-TAS9745033  
GO:0009952anterior/posterior pattern specification-IEA-  
GO:0009953dorsal/ventral pattern formation-ISS-  
GO:0009954proximal/distal pattern formation-IEA-  
GO:0010720positive regulation of cell development-ISS-  
GO:0030326embryonic limb morphogenesis-ISS-  
GO:0032332positive regulation of chondrocyte differentiation-ISS-  
GO:0035115embryonic forelimb morphogenesis-IEA-  
GO:0042733embryonic digit morphogenesis-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0048589developmental growth-ISS-  
GO:0060065uterus development-IEA-  
GO:0060272embryonic skeletal joint morphogenesis-IEA-  
GO:0060351cartilage development involved in endochondral bone morphogenesis-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005667transcription factor complex-ISS-  
GO:0032991protein-containing complex-ISS-  
GO:0032993protein-DNA complex-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29796116Genome-wide analysis of DNA methylation in bronchial washings. (2018)Um SWClin Epigenetics