Gene: HOXA13

3209
HOX1|HOX1J
homeobox A13
protein-coding
7p15.2
Ensembl:ENSG00000106031 MIM:142959 Vega:OTTHUMG00000023438 UniprotKB:P31271
NG_008181.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.414e-1 (AD)  5.862e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR6N10.702
TAS2R160.695
HIST1H2AA0.681
OR10W10.677
RGS210.674
LMX1A0.673
OR7G20.671
C11orf440.671
TCHHL10.67
BAGE20.666

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HPN-0.235
HIST1H2AC-0.235
HHATL-0.227
FAM222A-0.225
TMEM229A-0.22
C1orf53-0.216
NTSR2-0.216
IGSF11-0.213
TMEM116-0.212
CRB2-0.212

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C496492abrineabrine results in decreased expression of HOXA13 mRNA22595364
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HOXA13 gene27153756
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HOXA13 mRNA22316170
C006780bisphenol Abisphenol A results in decreased expression of HOXA13 mRNA24465770
C006780bisphenol Abisphenol A results in decreased expression of HOXA13 mRNA25181051
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of HOXA13 mRNA20971185
D003976DiazinonDiazinon results in increased methylation of HOXA13 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HOXA13 mRNA25213187|2707974
D004041Dietary FatsDietary Fats results in increased expression of HOXA13 mRNA18042831
D005031EthylenethioureaEthylenethiourea results in decreased expression of HOXA13 mRNA17161201|1808271
D004397FonofosFonofos results in increased methylation of HOXA13 promoter22847954
C070081fulvestrantfulvestrant inhibits the reaction [Genistein results in decreased expression of HOXA13 mRNA]21810550
D019833Genisteinfulvestrant inhibits the reaction [Genistein results in decreased expression of HOXA13 mRNA]21810550
D019833GenisteinGenistein results in increased expression of HOXA13 mRNA21810550
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of HOXA13 mRNA18951874
C492448ICG 001ICG 001 results in decreased expression of HOXA13 mRNA26191083
D015122MercaptopurineMercaptopurine results in decreased expression of HOXA13 mRNA23358152
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of HOXA13 mRNA20971185
D000073878Palm OilPalm Oil results in increased expression of HOXA13 mRNA18042831
D010278ParathionParathion results in increased methylation of HOXA13 promoter22847954
C011272perfosfamideperfosfamide results in increased expression of HOXA13 mRNA19429390
D010936Plant ExtractsPlant Extracts results in decreased expression of HOXA13 mRNA23557933
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of HOXA13 mRNA23806026
C012568terbufosterbufos results in increased methylation of HOXA13 promoter22847954
D013739TestosteroneTestosterone affects the expression of HOXA13 mRNA17138648
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HOXA13 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HOXA13 mRNA24058054
D014118Toxins, Biological"Toxins, Biological affects the expression of HOXA13 mRNA"19682533
D014212TretinoinTretinoin results in decreased expression of HOXA13 mRNA16107473
D014212Tretinoin[DHRS3 gene mutant form results in increased abundance of Tretinoin] which results in decreased expression of HOXA13 mRNA24005908
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of HOXA13 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003677DNA binding-TAS9020844  
GO:0043565sequence-specific DNA binding-IDA23332764  
GO:0043565sequence-specific DNA binding-IMP23332764  
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-TAS9020844  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25888331A segregation index combining phenotypic (clinical characteristics) and genotypic (gene expression) biomarkers from a urine sample to triage out patients presenting with hematuria who have a low probability of urothelial carcinoma. (2015 Mar 27)Kavalieris LBMC Urol
19423998Diminished vaginal HOXA13 expression in women with pelvic organ prolapse. (2009 May-Jun)Connell KAMenopause