Gene: APBA2

321
D15S1518E|HsT16821|LIN-10|MGC:14091|MINT2|X11-BETA|X11L
amyloid beta precursor protein binding family A member 2
protein-coding
15q13.1
Ensembl:ENSG00000034053 MIM:602712 Vega:OTTHUMG00000129255 UniprotKB:Q99767
NC_000015.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.428e-1 (AD)  3.738e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs8037972chr15:29094390 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg10768063chr15:29213736APBA27.000e-11Smoking27651444
cg19847577chr15:29213748APBA27.100e-10Smoking27651444
cg21917349chr15:29213860APBA26.400e-8Smoking28686328
cg10768063chr15:29213736APBA27.600e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRKAR1B0.972
SV2A0.972
TOLLIP0.97
OTUB10.97
SCAMP50.97
DNM10.969
GSK3A0.968
PLD30.968
KLC20.967
C16orf450.967

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.645
OR4F29-0.601
REST-0.466
TFPI2-0.441
KCNJ15-0.432
RAI14-0.432
WWTR1-0.432
CNN2-0.428
ARHGEF5-0.427
EBF1-0.425

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of APBA2 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of APBA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of APBA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of APBA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of APBA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of APBA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of APBA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of APBA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of APBA2 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of APBA2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of APBA2 mRNA23630614
D000643Ammonium ChlorideAmmonium Chloride affects the expression of APBA2 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of APBA2 mRNA22378314
C006780bisphenol Abisphenol A affects the expression of APBA2 mRNA23557687
C006780bisphenol Abisphenol A results in decreased expression of APBA2 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of APBA2 mRNA26079696
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of APBA2 mRNA20971185
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of APBA2 mRNA21266533
D002117CalcitriolCalcitriol results in decreased expression of APBA2 mRNA26485663
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of APBA2 mRNA"27840820
C118739entinostatentinostat results in decreased expression of APBA2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of APBA2 mRNA"27188386
D005472FluorouracilAPBA2 protein affects the susceptibility to Fluorouracil16217747
C069837fullerene C60fullerene C60 results in increased expression of APBA2 mRNA19167457
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of APBA2 mRNA23430699
D007854LeadLead affects the splicing of APBA2 mRNA28903495
C042720mercuric bromidemercuric bromide results in decreased expression of APBA2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of APBA2 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of APBA2 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of APBA2 mRNA"20188158
C029938nickel sulfatenickel sulfate results in increased expression of APBA2 mRNA22714537
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of APBA2 mRNA20971185
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of APBA2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of APBA2 mRNA26272509
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of APBA2 mRNA22714537
D012906SmokeSmoke results in increased expression of APBA2 mRNA21095227
C009495titanium dioxidetitanium dioxide results in increased expression of APBA2 mRNA23557971
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of APBA2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of APBA2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of APBA2 mRNA23179753|2352703
D014638VanadatesVanadates results in decreased expression of APBA2 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions affects the methylation of APBA2 gene25560391
C111237vorinostatvorinostat results in decreased expression of APBA2 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001540amyloid-beta binding-IBA21873635  
GO:0001540amyloid-beta binding-IEA-  
GO:0005515protein binding-IPI10833507  17332754  
GO ID GO Term Qualifier Evidence PubMed
GO:0001701in utero embryonic development-IEA-  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0007268chemical synaptic transmission-IEA-  
GO:0007399nervous system development-TAS9890987  
GO:0007626locomotory behavior-IEA-  
GO:0010468regulation of gene expression-IEA-  
GO:0015031protein transport-IEA-  
GO:0023051regulation of signaling-IBA21873635  
GO:0035264multicellular organism growth-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IEA-  
GO:0008021synaptic vesicle-IEA-  
GO:0043197dendritic spine-IBA21873635  
GO:0045202synapse-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemIEA
R-HSA-6794361Neurexins and neuroliginsIEA
R-HSA-6794362Protein-protein interactions at synapsesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal