Gene: HOXB4

3214
HOX-2.6|HOX2|HOX2F
homeobox B4
protein-coding
17q21.32
Ensembl:ENSG00000182742 MIM:142965 Vega:OTTHUMG00000159920 UniprotKB:P17483
NC_000017.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.933e-1 (AD)  6.334e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg10953655chr17:46656664HOXB4Promoter3.875e-4Alcohol use disorders26763658
cg17144149chr17:46656572HOXB43.200e-12Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KRT80.673
HOXC120.652
HBG10.643
PRAME0.635
HOXB30.629
COMP0.626
CTCFL0.607
IGF2BP30.605
RHAG0.599
MROH90.578

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
E2F1-0.343
GSG1-0.323
PTGES3L-0.315
SLC25A10-0.309
CLEC2L-0.306
SMKR1-0.305
SYT12-0.3
CORT-0.295
ACRV1-0.295
CHCHD6-0.294

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000079AcetaldehydeAcetaldehyde affects the expression of HOXB4 mRNA22634333
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HOXB4 gene27153756
D001151ArsenicArsenic affects the methylation of HOXB4 gene25304211
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of HOXB4 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HOXB4 mRNA22228805
D002220CarbamazepineCarbamazepine affects the expression of HOXB4 mRNA22634333
C093628cyproconazolecyproconazole results in increased expression of HOXB4 mRNA22045034
D003561CytarabineCytarabine results in decreased expression of HOXB4 mRNA21198554
C014347decitabine[decitabine co-treated with trichostatin A] results in increased expression of HOXB4 mRNA17185465
C014347decitabine[decitabine co-treated with trichostatin A] results in increased expression of HOXB4 protein17185465
D004041Dietary FatsDietary Fats results in decreased expression of HOXB4 mRNA18042831
C039281furanfuran results in increased methylation of HOXB4 gene22079235
C409722hexaconazolehexaconazole results in increased expression of HOXB4 mRNA22045034
D017313FenretinideFenretinide results in increased expression of HOXB4 mRNA28973697
D008628MercuryMercury results in increased expression of HOXB4 mRNA19937285
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of HOXB4 mRNA22555245
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of HOXB4 mRNA22555245
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of HOXB4 mRNA21664453
D010126OzoneOzone results in decreased expression of HOXB4 mRNA12763052
D000073878Palm OilPalm Oil results in decreased expression of HOXB4 mRNA18042831
D010634PhenobarbitalPhenobarbital results in decreased expression of HOXB4 mRNA19363144
C004532quinonequinone results in increased expression of HOXB4 mRNA28986286
D012906SmokeSmoke results in increased expression of HOXB4 mRNA21095227
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HOXB4 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HOXB4 mRNA24058054
D014212TretinoinTretinoin results in increased expression of HOXB4 mRNA21934132
D014212TretinoinTretinoin results in increased expression of HOXB4 mRNA16604517|1678809
C012589trichostatin A[decitabine co-treated with trichostatin A] results in increased expression of HOXB4 mRNA17185465
C012589trichostatin A[decitabine co-treated with trichostatin A] results in increased expression of HOXB4 protein17185465
D014635Valproic AcidValproic Acid affects the expression of HOXB4 mRNA25979313
D014635Valproic AcidValproic Acid affects the expression of HOXB4 mRNA22045034
D014635Valproic AcidValproic Acid results in increased expression of HOXB4 mRNA24896083
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of HOXB4 gene25560391
C111237vorinostatvorinostat results in increased expression of HOXB4 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IBA21873635  
GO:0033613activating transcription factor binding-IBA21873635  
GO:0043565sequence-specific DNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0001501skeletal system development-IBA21873635  
GO:0002011morphogenesis of an epithelial sheet-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0008283cell proliferation-IEA-  
GO:0009952anterior/posterior pattern specification-IBA21873635  
GO:0009952anterior/posterior pattern specification-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA18932205  
GO:0048103somatic stem cell division-IEA-  
GO:0048536spleen development-IEA-  
GO:0048539bone marrow development-IEA-  
GO:0048704embryonic skeletal system morphogenesis-IBA21873635  
GO:0048704embryonic skeletal system morphogenesis-IEA-  
GO:0060216definitive hemopoiesis-IEA-  
GO:0060218hematopoietic stem cell differentiation-IDA18932205  
GO:2000738positive regulation of stem cell differentiation-IDA18932205  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA-  
GO:0005813centrosome-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesisIEA
R-HSA-5619507Activation of HOX genes during differentiationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28852427Seven-CpG-based prognostic signature coupled with gene expression predicts survival of oral squamous cell carcinoma. (2017)Shen SClin Epigenetics
28592245In silico identification of potential key regulatory factors in smoking-induced lung cancer. (2017 Jun 7)El-Aarag SABMC Med Genomics