Gene: APBB1

322
FE65|MGC:9072|RIR
amyloid beta precursor protein binding family B member 1
protein-coding
11p15.4
Ensembl:ENSG00000166313 MIM:602709 Vega:OTTHUMG00000165454 UniprotKB:O00213
NG_029615.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.414e-1 (AD)  1.114e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AP2M10.972
BABAM10.971
KLHDC30.97
OTUB10.967
SAE10.966
FXR20.965
MAP7D10.965
USP50.965
WIPI20.963
UBL70.961

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.716
OR4F29-0.692
TFPI2-0.423
KCNJ15-0.415
IL18RAP-0.407
EBF1-0.404
CST7-0.403
CXCR2-0.395
SIX1-0.392
FCGR3B-0.389

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of APBB1 mRNA"19162173
D000643Ammonium ChlorideAmmonium Chloride affects the expression of APBB1 mRNA16483693
D001151ArsenicArsenic affects the expression of APBB1 mRNA18414638
D001151ArsenicArsenic results in increased expression of APBB1 mRNA24019935
C006632arsenic trioxidearsenic trioxide results in decreased expression of APBB1 mRNA19128835|2252195
D001280AtrazineAtrazine results in increased expression of APBB1 mRNA22982499
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of APBB1 mRNA26377693
C006780bisphenol Abisphenol A results in increased expression of APBB1 mRNA25181051
C013418bromfenacoumbromfenacoum results in decreased expression of APBB1 protein28903499
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of APBB1 mRNA17484886
C018021cobaltous chloridecobaltous chloride results in decreased expression of APBB1 mRNA24386269
D013759DronabinolDronabinol results in decreased expression of APBB1 mRNA12237329
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of APBB1 mRNA]27941970
D003976DiazinonDiazinon affects the expression of APBB1 mRNA22546817
D004026DieldrinDieldrin affects the expression of APBB1 mRNA22546817
C044101endotoxin, Escherichia coli"endotoxin, Escherichia coli results in increased expression of APBB1 mRNA"15919760
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of APBB1 mRNA23550701
C039281furanfuran results in increased expression of APBB1 mRNA22079235
D017313FenretinideFenretinide results in decreased expression of APBB1 mRNA28973697
C016517indole-3-carbinolindole-3-carbinol affects the expression of APBB1 mRNA21396975
C045463leflunomideleflunomide results in decreased expression of APBB1 mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 affects the expression of APBB1 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of APBB1 mRNA15919760
D008344Maneb[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of APBB1 mRNA23017109
D008727MethotrexateMethotrexate affects the expression of APBB1 mRNA18502557
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of APBB1 mRNA"20188158
C022838nickel chloridenickel chloride affects the expression of APBB1 mRNA22546817
D010269Paraquat[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of APBB1 mRNA23017109
C006253pirinixic acidpirinixic acid results in decreased expression of APBB1 mRNA20813756
D011192Potassium DichromatePotassium Dichromate results in decreased expression of APBB1 mRNA23608068
C059514resveratrolresveratrol results in increased expression of APBB1 mRNA22610192
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of APBB1 mRNA21427059
D012969Sodium FluorideSodium Fluoride results in decreased expression of APBB1 mRNA27862939
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of APBB1 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of APBB1 mRNA21570461
D013853ThioacetamideThioacetamide results in increased expression of APBB1 mRNA23411599
D014212TretinoinTretinoin results in decreased expression of APBB1 mRNA20488242
D014501UraniumUranium affects the expression of APBB1 mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of APBB1 mRNA15672453
D014520UrethaneUrethane results in increased expression of APBB1 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of APBB1 mRNA21427059
D019287Zinc SulfateZinc Sulfate results in decreased expression of APBB1 mRNA12756304

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001540amyloid-beta binding-IBA21873635  
GO:0001540amyloid-beta binding-IPI18468999  
GO:0001540amyloid-beta binding-ISS-  
GO:0001540amyloid-beta binding-NAS8894693  
GO:0003682chromatin binding-IDA19343227  
GO:0005515protein binding-IPI8887653  9461550  12972431  16049941  16273093  17332754  
19234442  19343227  21968187  
GO:0008134transcription factor binding-IBA21873635  
GO:0008134transcription factor binding-ISS-  
GO:0042393histone binding-IPI19234442  
GO:0044877protein-containing complex binding-IEA-  
GO:0048156tau protein binding-IEA-  
GO:0070064proline-rich region binding-IPI17686488  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IGI21803450  
GO:0006302double-strand break repair-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IBA21873635  
GO:0006355regulation of transcription, DNA-templated-ISS-  
GO:0006915apoptotic process-IEA-  
GO:0006974cellular response to DNA damage stimulus-IDA18468999  
GO:0007050cell cycle arrest-ISS-  
GO:0007165signal transduction-NAS8894693  
GO:0007409axonogenesis-NAS12843239  
GO:0010039response to iron ion-IEA-  
GO:0010976positive regulation of neuron projection development-IEA-  
GO:0030308negative regulation of cell growth-ISS-  
GO:0043065positive regulation of apoptotic process-IDA18468999  
GO:0043967histone H4 acetylation-ISS-  
GO:0045739positive regulation of DNA repair-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IDA19343227  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0050714positive regulation of protein secretion-IEA-  
GO:0050760negative regulation of thymidylate synthase biosynthetic process-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA18468999  19343227  
GO:0005634nucleus-ISS-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA18468999  
GO:0005886plasma membrane-IDA18468999  
GO:0016607nuclear speck-IEA-  
GO:0030027lamellipodium-IDA12843239  
GO:0030426growth cone-IDA12843239  
GO:0032991protein-containing complex-IEA-  
GO:0042734presynaptic membrane-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0043197dendritic spine-IEA-  
GO:0044304main axon-IEA-  
GO:0045202synapse-IDA12843239  
GO:0045211postsynaptic membrane-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
GO:1990761growth cone lamellipodium-IEA-  
GO:1990812growth cone filopodium-IEA-  
KEGG ID KEGG Term
hsa05010Alzheimer's disease
Reactome ID Reactome Term Evidence
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693565Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksTAS
R-HSA-5693606DNA Double Strand Break ResponseTAS
R-HSA-73894DNA RepairTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18777128Association of amyloid precursor protein-binding protein, family B, member 1 with nicotine dependence in African and European American smokers. (2008 Nov)Chen GBHum Genet