Gene: HOXC4

3221
HOX3|HOX3E|cp19
homeobox C4
protein-coding
12q13.13
Ensembl:ENSG00000198353 MIM:142974 Vega:OTTHUMG00000160036 UniprotKB:P09017
NG_029818.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.419e-1 (AD)  7.795e-3 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg01946191chr12:54444463HOXC4Promoter3.073e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DEFB1320.497
FAM177B0.45
OR8B40.448
SLC17A20.439
PPIAL4E0.435
SCGB1D10.431
CPLX40.418
SIGLECL10.415
DEFB1250.413
ARL110.412

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FOXP3-0.275
MYOG-0.24
PEBP4-0.22
LRRC37A-0.196
IGFL2-0.194
SPDEF-0.19
C12orf54-0.188
SPRR2G-0.18
SOX3-0.18
PYY-0.178

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000079AcetaldehydeAcetaldehyde affects the expression of HOXC4 mRNA22634333
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HOXC4 gene27153756
D000638AmiodaroneAmiodarone results in increased expression of HOXC4 mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HOXC4 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of HOXC4 mRNA24449571
C015001arsenitearsenite results in increased methylation of HOXC4 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HOXC4 mRNA22316170
C044887beta-methylcholinebeta-methylcholine affects the expression of HOXC4 mRNA21179406
C006780bisphenol Abisphenol A results in increased methylation of HOXC4 gene28582417
C006780bisphenol Abisphenol A affects the methylation of HOXC4 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of HOXC4 mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HOXC4 gene20938992
C093628cyproconazolecyproconazole results in increased expression of HOXC4 mRNA22045034
D004041Dietary FatsDietary Fats results in decreased expression of HOXC4 mRNA18503570
C061365flusilazoleflusilazole affects the expression of HOXC4 mRNA22634333
C061365flusilazoleflusilazole results in increased expression of HOXC4 mRNA28263823
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HOXC4 gene20938992
C039281furanfuran results in increased methylation of HOXC4 gene22079235
C409722hexaconazolehexaconazole results in increased expression of HOXC4 mRNA22045034
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of HOXC4 mRNA21179406
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HOXC4 gene20938992
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of HOXC4 mRNA19710929
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HOXC4 mRNA21354282|2405805
D014212TretinoinTretinoin promotes the reaction [HOXC4 protein results in increased expression of CD14 mRNA]16019559
D014212TretinoinTretinoin results in increased expression of HOXC4 mRNA21934132
D014212TretinoinTretinoin results in increased expression of HOXC4 protein16019559
D014212TretinoinTretinoin results in increased expression of HOXC4 mRNA19897914
D014635Valproic AcidValproic Acid results in decreased methylation of HOXC4 gene29154799
D014635Valproic AcidValproic Acid affects the expression of HOXC4 mRNA22045034
D014635Valproic AcidValproic Acid results in increased expression of HOXC4 mRNA24896083

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding-IDA15252056  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001205transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding-IDA15252056  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IBA21873635  
GO:0005515protein binding-IPI23455924  
GO:0033613activating transcription factor binding-IBA21873635  
GO:0071837HMG box domain binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-IBA21873635  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0009952anterior/posterior pattern specification-IBA21873635  
GO:0009952anterior/posterior pattern specification-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA15252056  
GO:0048562embryonic organ morphogenesis-IEA-  
GO:0048704embryonic skeletal system morphogenesis-IBA21873635  
GO:0051216cartilage development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesisIEA
R-HSA-5619507Activation of HOX genes during differentiationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28852427Seven-CpG-based prognostic signature coupled with gene expression predicts survival of oral squamous cell carcinoma. (2017)Shen SClin Epigenetics