Gene: HOXC9

3225
HOX3|HOX3B
homeobox C9
protein-coding
12q13.13
Ensembl:ENSG00000180806 MIM:142971 Vega:OTTHUMG00000160033 UniprotKB:P31274
NC_000012.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.975e-1 (AD)  1.034e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
XIRP20.723
TTN0.722
KRT730.7
AMPD10.697
C10orf710.693
OR10A70.691
MROH90.684
IGF2BP30.683
NRAP0.671
OR56A30.671

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPAG8-0.388
HDDC3-0.36
TMEM53-0.339
BOLA1-0.333
GDF9-0.33
HDAC11-0.323
ZNF575-0.32
SHBG-0.311
CLDND2-0.306
TMEM187-0.305

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D020106AcrylamideAcrylamide results in increased expression of HOXC9 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HOXC9 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of HOXC9 mRNA24449571
C015001arsenitearsenite results in increased methylation of HOXC9 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HOXC9 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of HOXC9 mRNA22342234
C006780bisphenol Abisphenol A results in increased expression of HOXC9 mRNA24465770
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of HOXC9 mRNA28628672
C584509C646 compoundC646 compound results in increased expression of HOXC9 mRNA26191083
D002104CadmiumCadmium results in increased expression of HOXC9 mRNA24376830
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of HOXC9 mRNA18804290
D019327Copper SulfateCopper Sulfate results in decreased expression of HOXC9 mRNA19549813
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of HOXC9 mRNA28628672
D002945CisplatinCisplatin results in decreased expression of HOXC9 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of HOXC9 mRNA18042831|2501614
C492448ICG 001ICG 001 results in increased expression of HOXC9 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of HOXC9 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of HOXC9 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HOXC9 mRNA25307878
D008777MethyltestosteroneMethyltestosterone results in decreased expression of HOXC9 mRNA29191790
C523799MRK 003MRK 003 results in decreased expression of HOXC9 mRNA21169257
D009151Mustard GasMustard Gas results in increased expression of HOXC9 mRNA15674843
D009532NickelNickel results in decreased expression of HOXC9 mRNA25583101
C029938nickel sulfatenickel sulfate results in increased expression of HOXC9 mRNA22714537
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of HOXC9 mRNA25729387
D000073878Palm OilPalm Oil results in decreased expression of HOXC9 mRNA18042831
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of HOXC9 mRNA23948077
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of HOXC9 mRNA22714537
D053260SootSoot results in increased expression of HOXC9 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HOXC9 mRNA21570461|2405805
C009495titanium dioxidetitanium dioxide results in increased expression of HOXC9 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of HOXC9 mRNA25729387
D014212TretinoinTretinoin results in increased expression of HOXC9 mRNA23830798

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0005515protein binding-IPI18305892  22761572  25416956  
GO:0043565sequence-specific DNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0009952anterior/posterior pattern specification-IEA-  
GO:0048704embryonic skeletal system morphogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0016235aggresome-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19506903RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4A, DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-small cell lung cancer in China. (2009 Dec)Lin QJ Cancer Res Clin Oncol