Gene: HOXD8

3234
HOX4|HOX4E|HOX5.4
homeobox D8
protein-coding
2q31.1
Ensembl:ENSG00000175879 MIM:142985 Vega:OTTHUMG00000132513 UniprotKB:P13378
NC_000002.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.512e-1 (AD)  4.657e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LUM0.519
AOX10.514
FOXL10.513
S100A40.506
OSR20.503
COL3A10.5
COL6A30.5
CD480.495
IRF60.49
COL8A10.485

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM74-0.318
PLEKHA6-0.306
C4orf50-0.305
OPRD1-0.303
HTR1E-0.302
RNFT2-0.302
KSR2-0.301
TMEM81-0.297
ZNF835-0.296
SKIDA1-0.294

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of HOXD8 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HOXD8 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of HOXD8 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HOXD8 mRNA22228805
D004958EstradiolEstradiol results in decreased expression of HOXD8 mRNA15289156
D019327Copper SulfateCopper Sulfate results in decreased expression of HOXD8 mRNA19549813
D004041Dietary FatsDietary Fats results in increased expression of HOXD8 mRNA18042831
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of HOXD8 mRNA15289156
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of HOXD8 mRNA17555576
D004397FonofosFonofos results in increased methylation of HOXD8 promoter22847954
D019833GenisteinGenistein results in decreased expression of HOXD8 mRNA15289156
D017313FenretinideFenretinide results in decreased expression of HOXD8 mRNA28973697
D017313FenretinideFenretinide results in increased expression of HOXD8 mRNA28973697
C008493methylselenic acidmethylselenic acid results in increased expression of HOXD8 mRNA12517777
D000073878Palm OilPalm Oil results in increased expression of HOXD8 mRNA18042831
D010278ParathionParathion results in increased methylation of HOXD8 promoter22847954
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of HOXD8 mRNA25895662
C017947sodium arsenitesodium arsenite affects the methylation of HOXD8 gene28589171
C017947sodium arsenitesodium arsenite results in increased expression of HOXD8 mRNA16322246
D013629TamoxifenTamoxifen affects the expression of HOXD8 mRNA17555576
C012568terbufosterbufos results in increased methylation of HOXD8 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HOXD8 mRNA19897914
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HOXD8 mRNA17942748|2405805
D014212TretinoinTretinoin results in decreased expression of HOXD8 mRNA19897914
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HOXD8 mRNA"26179874
D014635Valproic AcidValproic Acid results in increased methylation of HOXD8 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of HOXD8 mRNA24896083
C029297vinylidene chloridevinylidene chloride results in decreased expression of HOXD8 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IDA1756725  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IDA1756725  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0008595anterior/posterior axis specification, embryo-NAS2568311  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA1756725  
GO:0048705skeletal system morphogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-NAS2568311  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24921089Epigenetic clustering of lung adenocarcinomas based on DNA methylation profiles in adjacent lung tissue: Its correlation with smoking history and chronic obstructive pulmonary disease. (2014 Jul 15)Sato TInt J Cancer