Gene info: ID 3240

Gene: HP

GENE ID: 3240

Synonyms: BP|HP2ALPHA2|HPA1S

Description: haptoglobin

Gene type: protein-coding

Location: 16q22.2

dbXrefs: Ensembl:ENSG00000257017 MIM:140100 Vega:OTTHUMG00000173009 UniprotKB:P00738

RefSeq: NG_012651.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 76

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.675e-1 (AD) 6.909e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FGA	0.793
FGB	0.78
FGG	0.774
ORM1	0.747
CRP	0.741
APOH	0.682
ORM2	0.646
AMBP	0.646
AGXT	0.635
APCS	0.634

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TOX3	-0.374
DCX	-0.347
CNGB1	-0.335
DLX6	-0.331
CALB1	-0.329
FSTL5	-0.326
YPEL1	-0.324
ENTPD3	-0.322
MYO16	-0.321
PCDH19	-0.319

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C517232	1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane	"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane results in increased expression of HP mRNA"	23958786
C014211	2,3,7,8-tetrachlorodibenzofuran	"2,3,7,8-tetrachlorodibenzofuran affects the expression of HP mRNA"	18343893
D000082	Acetaminophen	Acetaminophen results in decreased expression of HP mRNA	26690555
D000082	Acetaminophen	Acetaminophen affects the expression of HP mRNA	17562736
D000082	Acetaminophen	Acetaminophen affects the expression of HP protein	16687475
D000082	Acetaminophen	Acetaminophen results in increased expression of HP mRNA	15800402
D000082	Acetaminophen	Acetaminophen results in increased expression of HP protein	15800402
D000242	Cyclic AMP	Cyclic AMP inhibits the reaction [IL1B protein results in increased expression of HP mRNA]	22117073
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of HP mRNA	21641981\|2715375
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of HP gene	27153756
C084615	alclofenac	alclofenac results in decreased expression of HP protein	241598
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of HP protein	26072098
D024502	alpha-Tocopherol	alpha-Tocopherol affects the activity of HP protein polymorphism	19769483
D024502	alpha-Tocopherol	Ascorbic Acid inhibits the reaction [alpha-Tocopherol affects the activity of HP protein polymorphism]	19769483
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of HP mRNA	16483693
C030419	andrographolide	[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of HP mRNA	19737545
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in decreased expression of HP mRNA"	24160326
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of HP mRNA"	23917077
D001205	Ascorbic Acid	Ascorbic Acid affects the activity of HP protein polymorphism	19769483
D001205	Ascorbic Acid	HP gene polymorphism affects the susceptibility to Ascorbic Acid deficiency	20926521
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [alpha-Tocopherol affects the activity of HP protein polymorphism]	19769483
D001379	Azathioprine	[Carbon Tetrachloride co-treated with Azathioprine] results in increased expression of HP protein	8614026
C000609563	AZD8848	AZD8848 results in increased secretion of HP protein	29122671
D001554	Benzene	Benzene results in increased expression of HP mRNA	15120971\|1512265
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in decreased expression of HP mRNA	19737606
D019324	beta-Naphthoflavone	[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of HP mRNA	19737545
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of HP mRNA	19737606
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of HP mRNA	23735875
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of HP mRNA	16488489
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of HP mRNA	20061341
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of HP mRNA	20660070
D004958	Estradiol	Estradiol results in increased expression of HP mRNA	19484750\|1969329
C095105	bexarotene	bexarotene results in decreased expression of HP mRNA	16648578
C452139	BIRB 796	BIRB 796 results in decreased expression of HP mRNA	21328587
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HP mRNA	28628672
C006780	bisphenol A	bisphenol A results in increased expression of HP mRNA	26364221
C006780	bisphenol A	bisphenol A results in increased expression of HP mRNA	17989879
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HP mRNA	28628672
C006780	bisphenol A	[potassium bromate co-treated with bisphenol A] affects the expression of HP mRNA	27082013
C006780	bisphenol A	[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of HP mRNA]	27082013
C006780	bisphenol A	bisphenol A results in increased expression of HP mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of HP gene	28505145
C006780	bisphenol A	bisphenol A results in decreased expression of HP mRNA	26794494
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HP mRNA	28628672
D002104	Cadmium	HP protein binds to Cadmium	23896426
D002185	Cannabidiol	Cannabidiol results in increased expression of HP mRNA	21542829
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of HP mRNA	17484886
D002251	Carbon Tetrachloride	[Carbon Tetrachloride co-treated with Azathioprine] results in increased expression of HP protein	8614026
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of HP mRNA	21356183
D002994	Clofibrate	Clofibrate affects the expression of HP mRNA	16081524
D002994	Clofibrate	Clofibrate results in decreased expression of HP mRNA	12851107
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of HP mRNA	24386269
D003300	Copper	HP protein binds to Copper	23896426
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of HP mRNA	19549813
D016572	Cyclosporine	Cyclosporine affects the expression of HP mRNA	20106945\|2556210
D016572	Cyclosporine	Cyclosporine results in decreased expression of HP mRNA	27989131
D016572	Cyclosporine	Cyclosporine results in increased expression of HP mRNA	21632981
D013759	Dronabinol	Dronabinol results in increased expression of HP mRNA	21542829
D003907	Dexamethasone	Dexamethasone results in increased expression of HP mRNA	19853017\|2504701
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HP mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HP mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HP mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of HP mRNA	28628672
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of HP mRNA	16054899
D003907	Dexamethasone	Dexamethasone results in increased expression of HP mRNA	22733784
D003907	Dexamethasone	[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of HP mRNA]	16054899
D003907	Dexamethasone	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of HP mRNA]	16054899
D002945	Cisplatin	Cisplatin results in increased secretion of HP protein	28885000
D004008	Diclofenac	Diclofenac results in decreased expression of HP mRNA	26934552
D004008	Diclofenac	Diclofenac results in increased expression of HP mRNA	26934552
C000944	dicrotophos	dicrotophos results in decreased expression of HP mRNA	28302478
D004041	Dietary Fats	Dietary Fats results in decreased expression of HP mRNA	18042831\|2501614
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of HP mRNA	19850644
D004051	Diethylhexyl Phthalate	PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of HP mRNA]	19850644
D002117	Calcitriol	Calcitriol results in increased expression of HP protein	27107558
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of HP mRNA"	22485181
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in decreased expression of HP protein	17719030
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in increased expression of HP mRNA	14757319
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in increased expression of HP protein	14757319
D004317	Doxorubicin	Doxorubicin results in increased secretion of HP protein	28885000
D004785	Environmental Pollutants	Environmental Pollutants results in decreased expression of HP mRNA	24534155
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of HP mRNA	16940010
D005485	Flutamide	Flutamide results in increased expression of HP mRNA	19299419\|2152539
D005620	Freund's Adjuvant	Freund's Adjuvant results in increased expression of HP protein	12669191
C039281	furan	furan results in decreased expression of HP mRNA	26194646
D019833	Genistein	Genistein results in increased expression of HP protein	24552547
D005947	Glucose	Glucose deficiency affects the secretion of HP protein	24802182
D006569	Hesperidin	[Hesperidin co-treated with naringin] results in decreased expression of HP protein	22005428
D006581	Hexachlorobenzene	Hexachlorobenzene results in increased expression of HP mRNA	15159207
D006861	Hydrogen Peroxide	[HP gene polymorphism co-treated with GSTM1 gene polymorphism] affects the susceptibility to Hydrogen Peroxide	20444272
D006861	Hydrogen Peroxide	[HP gene polymorphism co-treated with GSTT1 gene polymorphism] affects the susceptibility to Hydrogen Peroxide	20444272
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of HP mRNA	26339600
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HP mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HP mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HP mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of HP mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HP mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HP mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HP mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HP mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of HP mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of HP mRNA	16054899
D015056	1-Methyl-3-isobutylxanthine	[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of HP mRNA]	16054899
D015056	1-Methyl-3-isobutylxanthine	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of HP mRNA]	16054899
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of HP mRNA]	25890327
C410337	K 7174	K 7174 results in decreased expression of HP mRNA	24086573
C060282	lariciresinol	lariciresinol results in decreased expression of HP protein	27417256
D007854	Lead	HP protein binds to Lead	23896426
D007854	Lead	Lead results in increased expression of HP protein	22923205
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of HP mRNA	22235868
D008070	Lipopolysaccharides	(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of HP mRNA]	25890327
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of HP mRNA	25890327
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of HP mRNA	20353558
D008713	Methimazole	Methimazole results in increased expression of HP mRNA	20144635
C004925	methylmercuric chloride	methylmercuric chloride affects the expression of HP protein	27012723
D009020	Morphine	Morphine results in decreased expression of HP protein	23056601
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of HP mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of HP mRNA"	19836432
C005274	naringin	[Hesperidin co-treated with naringin] results in decreased expression of HP protein	22005428
D009532	Nickel	HP protein binds to Nickel	23896426
D009532	Nickel	Nickel results in increased expression of HP mRNA	24768652\|2558310
D015525	Fatty Acids, Omega-3	"Fatty Acids, Omega-3 results in increased expression of HP mRNA"	23333450
D000073878	Palm Oil	Palm Oil results in decreased expression of HP mRNA	18042831
D010396	Penicillamine	Penicillamine results in decreased expression of HP protein	241598
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of HP mRNA	23948077
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of HP mRNA	18692542
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of HP mRNA	21061450
C006253	pirinixic acid	[pirinixic acid co-treated with PPARA] results in decreased expression of HP mRNA	20813756
C006253	pirinixic acid	pirinixic acid results in decreased expression of HP mRNA	20813756
C006253	pirinixic acid	pirinixic acid results in decreased expression of HP mRNA	16940010
D028321	Plant Preparations	Plant Preparations results in decreased expression of HP protein	28284660
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls results in decreased expression of HP mRNA	17396211
C019536	potassium bromate	potassium bromate affects the expression of HP mRNA	27082013
C019536	potassium bromate	[potassium bromate co-treated with bisphenol A] affects the expression of HP mRNA	27082013
C019536	potassium bromate	[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [potassium bromate affects the expression of HP mRNA]	27082013
C019536	potassium bromate	[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of HP mRNA]	27082013
C027373	potassium chromate(VI)	potassium chromate(VI) promotes the reaction [IL6 protein results in increased metabolism of HP protein]	23618972
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of HP protein	23618972
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of HP mRNA	28903501
C024273	profenofos	profenofos results in increased expression of HP mRNA	17569032
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of HP mRNA	20660070
D011374	Progesterone	Progesterone affects the expression of HP mRNA	17251523
D011441	Propylthiouracil	Propylthiouracil results in increased expression of HP mRNA	24780913
D011791	Quartz	Quartz results in increased expression of HP mRNA	19836432
D011794	Quercetin	Quercetin results in decreased expression of HP mRNA	21632981
C059514	resveratrol	resveratrol results in increased expression of HP mRNA	23419489
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of HP mRNA	16054899
C089730	rosiglitazone	[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of HP mRNA]	16054899
C089730	rosiglitazone	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of HP mRNA]	16054899
D012524	Sarin	Sarin results in decreased expression of HP protein	26778279
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in decreased expression of HP mRNA"	24160326
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of HP mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of HP mRNA	23806026
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of HP mRNA	22431001
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of HP protein	28918527
C016766	sulforafan	sulforafan results in increased expression of HP mRNA	26833863
D013605	T-2 Toxin	T-2 Toxin results in increased expression of HP mRNA	26141394
D013739	Testosterone	Testosterone results in decreased expression of HP mRNA	19693291
D013739	Testosterone	Testosterone results in increased expression of HP mRNA	19693291
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of HP mRNA	18343893\|2637764
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of HP mRNA]	16054899
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with EGF protein] results in decreased expression of HP mRNA	16054899
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of HP mRNA]	16054899
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HP gene]	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HP mRNA	16054899\|2629044
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HP protein	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of HP mRNA	16114106
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of HP protein	15822908
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HP mRNA	25613284
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of HP mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of and results in increased secretion of HP protein	27818348
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of HP protein	27793746
D014118	Toxins, Biological	"Toxins, Biological affects the expression of HP mRNA"	19682533
D014204	Trenbolone Acetate	Trenbolone Acetate results in increased expression of HP mRNA	16488489
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of HP gene	27618143
D014260	Triclosan	Triclosan results in decreased expression of HP mRNA	27538710
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of HP mRNA"	26179874
C057693	troglitazone	[troglitazone co-treated with TNF protein] results in increased expression of HP mRNA	12732648
D014425	Turpentine	Turpentine results in increased expression of HP mRNA	14757319
D014425	Turpentine	Turpentine results in increased expression of HP protein	14757319
D014520	Urethane	Urethane results in decreased expression of HP mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in decreased expression of HP mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in decreased methylation of HP gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of HP gene	25560391
C029297	vinylidene chloride	vinylidene chloride results in increased expression of HP mRNA	26682919
C029297	vinylidene chloride	vinylidene chloride results in increased expression of HP protein	14565772
D002762	Cholecalciferol	Cholecalciferol results in increased expression of HP mRNA	16508948
D024483	Vitamin K 3	Vitamin K 3 affects the expression of HP mRNA	20044591
D014859	Warfarin	Warfarin results in increased expression of HP protein	22342526
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in decreased expression of HP mRNA"	25475078
C499198	WAY-169916	WAY-169916 inhibits the reaction [IL1B protein results in increased expression of HP mRNA]	19903824
D015032	Zinc	Zinc deficiency results in increased expression of HP mRNA	20932299
D015032	Zinc	HP protein binds to Zinc	23896426

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004252	serine-type endopeptidase activity	-	IBA	21873635
GO:0005515	protein binding	-	IPI	19758344
GO:0016209	antioxidant activity	-	IEA	-
GO:0030492	hemoglobin binding	-	IDA	19740759

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002526	acute inflammatory response	-	IBA	21873635
GO:0006898	receptor-mediated endocytosis	-	TAS	-
GO:0006952	defense response	-	TAS	7036344
GO:0006953	acute-phase response	-	IEA	-
GO:0010033	response to organic substance	-	IBA	21873635
GO:0010942	positive regulation of cell death	-	IBA	21873635
GO:0010942	positive regulation of cell death	-	IDA	19740759
GO:0042542	response to hydrogen peroxide	-	IDA	19740759
GO:0042742	defense response to bacterium	-	IEA	-
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0051354	negative regulation of oxidoreductase activity	-	IDA	19740759
GO:0098869	cellular oxidant detoxification	-	IEA	-
GO:2000296	negative regulation of hydrogen peroxide catabolic process	-	IDA	19740759

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	NAS	14718574
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	HDA	16502470 22664934
GO:0005615	extracellular space	-	IBA	21873635
GO:0005615	extracellular space	-	IDA	19433579 21805676 25645918
GO:0031838	haptoglobin-hemoglobin complex	-	IDA	19740759
GO:0035580	specific granule lumen	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	19056867 23533145
GO:0071682	endocytic vesicle lumen	-	TAS	-
GO:0072562	blood microparticle	-	HDA	22516433
GO:1904724	tertiary granule lumen	-	TAS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-2168880	Scavenging of heme from plasma	TAS
R-HSA-2173782	Binding and Uptake of Ligands by Scavenger Receptors	TAS
R-HSA-5653656	Vesicle-mediated transport	TAS
R-HSA-6798695	Neutrophil degranulation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25557755	Risk Factors for Early Hemorrhagic Progression after Traumatic Brain Injury: A Focus on Lipid Profile. (2015 Jul 1)	Kim H	J Neurotrauma
26455281	Novel candidate genes for alcoholism--transcriptomic analysis of prefrontal medial cortex, hippocampus and nucleus accumbens of Warsaw alcohol-preferring and non-preferring rats. (2015 Dec)	Stankiewicz AM	Pharmacol Biochem Behav
23314068	Polycyclic aromatic hydrocarbons (PAHs) as determinants of various anthropometric measures of birth outcome. (2013 Feb 1)	Al-Saleh I	Sci Total Environ
25217401	Oxidative stress in the brain of cigarette smoke-induced noxiousness: neuroprotective role of Sesbania grandiflora. (2015 Apr)	Ramesh T	Metab Brain Dis
1902851	Difference in the phenotypes of bronchoalveolar lavage lymphocytes in patients with summer-type hypersensitivity pneumonitis, farmer's lung, ventilation pneumonitis, and bird fancier's lung: report of a nationwide epidemiologic study in Japan. (1991 May)	Ando M	J Allergy Clin Immunol
16782270	Effects of treatment with acamprosate on beta-endorphin plasma concentration in humans with high alcohol preference. (2006 Aug 14)	Kiefer F	Neurosci Lett
24523671	Selective increases of AMPA, NMDA, and kainate receptor subunit mRNAs in the hippocampus and orbitofrontal cortex but not in prefrontal cortex of human alcoholics. (2014)	Jin Z	Front Cell Neurosci
25575141	Smoking and the correlation between birth weight and placental weight. Evidence of interaction with maternal haptoglobin phenotype. (2015 Feb)	Gloria-Bottini F	Eur J Obstet Gynecol Reprod Biol
24084092	VEGF rescues cigarette smoking-induced human RPE cell death by increasing autophagic flux: implications of the role of autophagy in advanced age-related macular degeneration. (2013 Nov 8)	Chu YK	Invest Ophthalmol Vis Sci
20720373	Smokers are over-represented in subjects with ahaptoglobinemia in Ghana. (2010 Dec 26)	Quaye IK	J Atheroscler Thromb
9700114	Hypersensitivity pneumonitis in peat moss processing plant workers. (1998 Aug)	Cormier Y	Am J Respir Crit Care Med
12867276	Haptoglobin 2-2 phenotype is associated with decreased ferroxidase activity in smokers. (2003 Aug)	Awadallah SM	Clin Chim Acta
10217368	Associations between haptoglobin polymorphism, lipids, lipoproteins and inflammatory variables. (1999 Apr)	Braeckman L	Atherosclerosis
15529608	The prevalence of anti-Helicobacter pylori antibodies in the patients with ischemic heart disease. (2004)	Andreica V	Rom J Intern Med
19004324	[Molecular-genetic and epidemiologic examination of personnel subjected to occupational irradiation in Russian Federal Nuclear Center (Sarov). Report 1. Genome structural damage rate and radiosensitivity]. (2008 Sep-Oct)	Korzeneva IB	Radiats Biol Radioecol
15283927	Comparison of the effects of tibolone and estrogen replacement therapy on echocardiographic basic cardiac functions in post-menopausal women: a randomized placebo controlled study. (2004 Aug 20)	Taskin O	Maturitas
12848920	[Study on the correlation of between infection, inflammation and coronary artery disease]. (2003 Jun)	Cai XJ	Zhonghua Liu Xing Bing Xue Za Zhi
8228210	Haptoglobin polymorphism and complications in established essential arterial hypertension. (1993 Aug)	Delanghe JR	J Hypertens
18755888	The natural history of hereditary pancreatitis: a national series. (2009 Jan)	Rebours V	Gut
25197540	Pepsinogen I and II, Gastrin and Cag A Serum Levels in Shiraz. (2011 Sep)	Shamsdin SA	Middle East J Dig Dis
17918239	The functional polymorphism of the hemoglobin-binding protein haptoglobin influences susceptibility to idiopathic Parkinson's disease. (2008 Mar 5)	Costa-Mallen P	Am J Med Genet B Neuropsychiatr Genet
12690558	[Mast cells in bronchoalveolar lavage fluid of patients with interstitial lung diseases]. (2003 Apr)	Schildge J	Pneumologie
18184119	Risk of pancreatic adenocarcinoma in patients with hereditary pancreatitis: a national exhaustive series. (2008 Jan)	Rebours V	Am J Gastroenterol
15306193	Oxidized low-density lipoprotein, iron stores, and haptoglobin polymorphism. (2004 Sep)	Brouwers A	Atherosclerosis
24624459	Pancreatitis Overview (1993)	LaRusch J	-
27349967	Smoking and haptoglobin phenotype modulate serum ferritin and haptoglobin levels in Parkinson disease. (2016 Nov)	Costa-Mallen P	J Neural Transm (Vienna)
19570244	Smoking, haptoglobin and fertility in humans. (2002 Jan 15)	Bottini N	Tob Induc Dis
11221586	[Chlamydia pneumoniae and Helicobacter pylori infections in acute myocardial infarction]. (2000 Dec)	Di Tano G	Ital Heart J Suppl
22094928	Association of the 463G-A myeloperoxidase gene polymorphism with gastric cancer risk. (2012 May)	Jiang Z	Hepatogastroenterology
23290038	[Expression of beta-catenin in human pulmonary tissues of smokers with and without chronic obstructive pulmonary disease]. (2012 Nov)	Liu QX	Zhonghua Jie He He Hu Xi Za Zhi
12065097	Increased expression of heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP) in pancreatic tissue from smokers and pancreatic tumor cells. (2002 Sep 26)	Yan-Sanders Y	Cancer Lett
23935769	Significance of p16 in Site-specific HPV Positive and HPV Negative Head and Neck Squamous Cell Carcinoma. (2013)	Stephen JK	Cancer Clin Oncol
9869158	Contribution of acute-phase proteins and cardiovascular risk factors to erythrocyte aggregation in normolipidemic and hyperlipidemic individuals. (1998 Dec)	Weng X	Thromb Haemost
28558695	Azithromycin and risk of COPD exacerbations in patients with and without Helicobacter pylori. (2017 May 30)	Ra SW	Respir Res
15359537	Maternal cigarette smoking, metabolic enzyme polymorphism, and developmental events in the early stages of extrauterine life. (2004 Apr)	Bottini N	Hum Biol
27734519	A hybrid multibreath wash-in wash-out lung function quantification scheme in human subjects using hyperpolarized (3) He MRI for simultaneous assessment of specific ventilation, alveolar oxygen tension, oxygen uptake, and air trapping. (2017 Aug)	Hamedani H	Magn Reson Med
10488955	Haptoglobin polymorphism and peripheral arterial occlusive disease. (1999 Aug)	Delanghe J	Atherosclerosis
28457061	Association between Fatty Liver Disease and Hyperplastic Colonic Polyp. (2017 Feb)	Mahamid M	Isr Med Assoc J
19127818	[The effect of environmental and genetic factors in the pathogenesis of periodontitis]. (2008)	Drozdzik A	Ann Acad Med Stetin
9398872	Serum and gastric luminal epidermal growth factor in Helicobacter pylori-associated gastritis and peptic ulcer disease. (1996 Dec)	Lynch DA	Helicobacter
15528021	Genetic counseling for hereditary pancreatitis--the role of molecular genetics testing for the cationic trypsinogen gene, cystic fibrosis and serine protease inhibitor Kazal type 1. (2004 Dec)	Ellis I	Gastroenterol Clin North Am
21321788	N-nitrosamines are associated with shorter telomere length. (2011 Jul)	Li H	Scand J Work Environ Health
26122942	Haptoglobin genotype is associated with increased endothelial dysfunction serum markers in type 1 diabetes. (2015 Sep)	Llaurado G	Eur J Clin Invest
19182421	Modifiable risk factors for colorectal neoplasms and hyperplastic polyps. (2009)	Omata F	Intern Med
3759102	Haptoglobin groups and lung cancer. (1986)	Beckman G	Hum Hered
26467690	How Effective Is the Quadruple Concomitant Helicobacter Pylori Eradication Therapy for Obese Patients Undergoing Gastric Bypass Surgery? (2016 Jun)	Cerqueira RM	Obes Surg
7697272	Elastin and collagen degradation products in urine of smokers with and without chronic obstructive pulmonary disease. (1995 Apr)	Stone PJ	Am J Respir Crit Care Med
27000817	[Hereditary pancreatitis]. (2016 Feb)	Dyrla P	Pol Merkur Lekarski
11208460	Helicobacter pylori, gastrin and cyclooxygenase-2 in lung cancer. (2000 Nov-Dec)	Gocyk W	Med Sci Monit
21865138	APC and KRAS mutations in distal colorectal polyps are related to smoking habits in men: results of a cross-sectional study. (2011 Sep)	Martinez F	Clin Transl Oncol
29576550	Apolipoprotein-defined lipoprotein subclasses, serum apolipoproteins, and carotid intima-media thickness in T1D. (2018 May)	Basu A	J Lipid Res
16824064	Interleukin-8 gene polymorphism associated with susceptibility to non-cardia gastric carcinoma with microsatellite instability. (2006 Jul)	Shirai K	J Gastroenterol Hepatol
15812164	Helicobacter pylori seropositivity and atherosclerosis risk factors. (2004)	Koksal A	Dig Dis
20740111	Risk of proximal colonic neoplasms in asymptomatic adults older than 50 years found to have distal hyperplastic polyps on routine colorectal cancer screening. (2010 Summer)	Collins BD	Perm J
26794143	Mental performance in 8-year-old children fed reduced protein content formula during the 1st year of life: safety analysis of a randomised clinical trial. (2016 Jan 22)	Escribano J	Br J Nutr
11376556	Low expression myeloperoxidase genotype negatively associated with Helicobacter pylori infection. (2001 May)	Hamajima N	Jpn J Cancer Res
21674814	Bronchoalveolar lavage improves diagnostic accuracy in patients with diffuse lung disease. (2013 Jan)	Capelozzi VL	Diagn Cytopathol
25343257	Associated factors of atrophic gastritis diagnosed by double-contrast upper gastrointestinal barium X-ray radiography: a cross-sectional study analyzing 6,901 healthy subjects in Japan. (2014)	Yamamichi N	PLoS One
23238028	Prevalence of different subtypes of serrated polyps and risk of synchronous advanced colorectal neoplasia in average-risk population undergoing first-time colonoscopy. (2012 Jan 5)	Buda A	Clin Transl Gastroenterol
22379635	PRSS1-Related Hereditary Pancreatitis (1993)	Solomon S	-
10351927	Expression of costimulatory molecules on alveolar macrophages in hypersensitivity pneumonitis. (1999 Jun)	Israel-Assayag E	Am J Respir Crit Care Med
17509026	Aberrant DNA methylation in non-neoplastic gastric mucosa of H. Pylori infected patients and effect of eradication. (2007 Jul)	Perri F	Am J Gastroenterol
27117830	Treatment and monitoring of hypersensitivity pneumonitis. (2016 Sep)	Miyazaki Y	Expert Rev Clin Immunol
26228081	Haptoglobin phenotype modifies serum iron levels and the effect of smoking on Parkinson disease risk. (2015 Sep)	Costa-Mallen P	Parkinsonism Relat Disord
19150414	Genetic predisposition and environmental risk factors to pancreatic cancer: A review of the literature. (2009 Mar-Jun)	Landi S	Mutat Res
22579477	Clinical necessity of partitioning of human plasma haptoglobin reference intervals by recently-discovered rs2000999. (2012 Oct 9)	Shahabi P	Clin Chim Acta
8007474	[Pathogenesis of summer-type hypersensitivity pneumonitis]. (1993 Dec)	Ando M	Nihon Kyobu Shikkan Gakkai Zasshi
21792769	[Analysis for myeloperoxidase genetic polymorphism in gastric cancer]. (2011 Jul)	Wang Q	Zhonghua Wei Chang Wai Ke Za Zhi
28627459	Peripheral blood gene expression of acute phase proteins in people with first episode psychosis. (2017 Oct)	Yee JY	Brain Behav Immun
19468831	Prevention of nicotine and streptozotocin treatment induced circulatory oxidative stress by bis-1,7-(2-hydroxyphenyl)-hepta-1,6-diene-3,5-dione in diabetic rats. (2009 Nov)	Reddy BV	Mol Cell Biochem
11267933	Effect of smoking on serum pepsinogen I level depends on serological status of Helicobacter pylori. (2001 Mar)	Tatemichi M	Jpn J Cancer Res
11282449	Serum cytokine levels in alcohol-related liver cirrhosis. (2001 Jan)	Daniluk J	Alcohol
12810834	Helicobacter pylori seropositivity and the myeloperoxidase G-463A polymorphism in combination with interleukin-1B C-31T in Japanese health checkup examinees. (2003 Apr)	Katsuda N	Jpn J Clin Oncol
26790673	Resveratrol fails to affect cocaine conditioned place preference behavior, but alleviates anxiety-like behaviors in cocaine withdrawn rats. (2016 Apr)	Hu P	Psychopharmacology (Berl)
8912738	Urinary desmosine excretion in smokers with and without rapid decline of lung function: the Normative Aging Study. (1996 Nov)	Gottlieb DJ	Am J Respir Crit Care Med
23106957	In vitro characterization of the oxidation of a pyridinium metabolite of haloperidol by human placenta: the effect of smoking. (2012)	Fang J	J Pharm Pharm Sci