Gene: HPCAL1

3241
BDR1|HLP2|VILIP-3
hippocalcin like 1
protein-coding
2p25.1
Ensembl:ENSG00000115756 MIM:600207 Vega:OTTHUMG00000090451 UniprotKB:P37235
NC_000002.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.909e-1 (AD)  1.577e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HS6ST10.863
C2CD4C0.853
RBP40.824
ABHD80.823
FAM19A50.815
NRXN20.815
CHST10.812
VSTM2L0.81
ITPKA0.81
FAM213B0.809

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.587
OR4F29-0.535
CTNNA3-0.42
ZFP57-0.399
VRK2-0.375
SH2D1A-0.372
KCNJ15-0.363
DTHD1-0.363
FOLR3-0.357
IL18RAP-0.356

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of HPCAL1 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of HPCAL1 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of HPCAL1 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HPCAL1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HPCAL1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of HPCAL1 mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HPCAL1 mRNA16483693
D001151ArsenicArsenic affects the methylation of HPCAL1 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of HPCAL1 mRNA20458559
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in increased expression of HPCAL1 mRNA15894607
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HPCAL1 mRNA21569818|2222880
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HPCAL1 mRNA"19150397
D004958EstradiolEstradiol affects the expression of HPCAL1 mRNA22574217
D004958Estradiol[Dieldrin co-treated with Estradiol] results in increased expression of HPCAL1 mRNA23041725
D004958Estradiol[Testosterone co-treated with Estradiol] affects the reaction [estradiol-17 beta-benzoate results in increased methylation of HPCAL1 promoter]22109888
D004958Estradiol[[Testosterone co-treated with Estradiol] affects the reaction [estradiol-17 beta-benzoate results in increased methylation of HPCAL1 promoter]] which affects the expression of HPCAL1 protein22109888|2210988
D004958Estradiol[Testosterone co-treated with Estradiol] results in increased methylation of HPCAL1 promoter22109888
D004958Estradiol[[Testosterone co-treated with Estradiol] results in increased methylation of HPCAL1 promoter] which results in decreased expression of HPCAL1 mRNA22109888|2210988
C006780bisphenol Abisphenol A results in decreased expression of HPCAL1 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of HPCAL1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of HPCAL1 gene28505145
C006780bisphenol Abisphenol A results in increased methylation of HPCAL1 promoter22109888
C006780bisphenol A[bisphenol A results in increased methylation of HPCAL1 promoter] which results in decreased expression of HPCAL1 mRNA22109888|2210988
D002211CapsaicinCapsaicin results in increased expression of HPCAL1 mRNA16278290
D002994ClofibrateClofibrate results in decreased expression of HPCAL1 mRNA17585979
D003024ClozapineClozapine results in decreased expression of HPCAL1 mRNA12437575
C018021cobaltous chloridecobaltous chloride results in decreased expression of HPCAL1 mRNA19320972
D003042CocaineCocaine results in decreased expression of HPCAL1 mRNA15009677
D003300CopperCopper results in decreased expression of HPCAL1 mRNA18522721
D019327Copper SulfateCopper Sulfate results in increased expression of HPCAL1 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of HPCAL1 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of HPCAL1 mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of HPCAL1 mRNA25562108
C014347decitabinedecitabine results in decreased methylation of HPCAL1 promoter22109888
C014347decitabine[decitabine results in decreased methylation of HPCAL1 promoter] which results in increased expression of HPCAL1 mRNA22109888|2210988
D013759DronabinolDronabinol results in increased expression of HPCAL1 protein18584336
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of HPCAL1 mRNA]27941970
D002945CisplatinCisplatin results in decreased expression of HPCAL1 mRNA19561079
D002945CisplatinHPCAL1 protein affects the susceptibility to Cisplatin16217747
D002945CisplatinCisplatin results in increased expression of HPCAL1 mRNA25270620
D004026Dieldrin[Dieldrin co-treated with Estradiol] results in increased expression of HPCAL1 mRNA23041725
D004041Dietary FatsDietary Fats results in increased expression of HPCAL1 mRNA25016146
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of HPCAL1 mRNA17547211
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of HPCAL1 mRNA25380136
D004237DiuronDiuron results in decreased expression of HPCAL1 mRNA21551480
C010452estradiol-17 beta-benzoateestradiol-17 beta-benzoate results in increased methylation of HPCAL1 promoter22109888
C010452estradiol-17 beta-benzoate[estradiol-17 beta-benzoate results in increased methylation of HPCAL1 promoter] which results in decreased expression of HPCAL1 mRNA22109888|2210988
C010452estradiol-17 beta-benzoate[Testosterone co-treated with Estradiol] affects the reaction [estradiol-17 beta-benzoate results in increased methylation of HPCAL1 promoter]22109888
C010452estradiol-17 beta-benzoate[[Testosterone co-treated with Estradiol] affects the reaction [estradiol-17 beta-benzoate results in increased methylation of HPCAL1 promoter]] which affects the expression of HPCAL1 protein22109888|2210988
D005473FluoxetineFluoxetine results in increased expression of HPCAL1 mRNA20924750
C061365flusilazoleflusilazole results in increased expression of HPCAL1 mRNA28263823
C069837fullerene C60fullerene C60 results in increased expression of HPCAL1 mRNA19167457
D019833Genistein[Genistein co-treated with Methoxychlor] results in increased expression of HPCAL1 mRNA21782745
D019833GenisteinGenistein results in increased expression of HPCAL1 mRNA21782745
D005839GentamicinsGentamicins results in decreased expression of HPCAL1 mRNA22061828
D005839GentamicinsGentamicins results in increased expression of HPCAL1 mRNA22061828
D017313FenretinideFenretinide results in increased expression of HPCAL1 mRNA28973697
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of HPCAL1 mRNA19376150
C544151jinfukangjinfukang results in increased expression of HPCAL1 mRNA27392435
C410337K 7174K 7174 results in increased expression of HPCAL1 mRNA24086573
D007854LeadLead affects the expression of HPCAL1 mRNA28903495
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of HPCAL1 mRNA25613284
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in increased expression of HPCAL1 mRNA21782745
D008731MethoxychlorMethoxychlor results in increased expression of HPCAL1 mRNA21782745
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of HPCAL1 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of HPCAL1 mRNA"20188158
D016685MitomycinMitomycin results in increased expression of HPCAL1 mRNA25270620
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of HPCAL1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of HPCAL1 mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of HPCAL1 mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of HPCAL1 mRNA22714537
D010269ParaquatParaquat results in increased expression of HPCAL1 mRNA12595580
D010936Plant ExtractsPlant Extracts results in decreased expression of HPCAL1 mRNA23557933
D010936Plant ExtractsPlant Extracts results in increased expression of HPCAL1 mRNA20924750
D011192Potassium DichromatePotassium Dichromate results in increased expression of HPCAL1 protein23718831
D011441PropylthiouracilPropylthiouracil affects the expression of HPCAL1 mRNA24780913
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HPCAL1 mRNA19059307
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of HPCAL1 mRNA21427059
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of HPCAL1 mRNA19244175
D012643SeleniumSelenium results in increased expression of HPCAL1 mRNA19244175
C017947sodium arsenitesodium arsenite results in increased expression of HPCAL1 mRNA22714537
D053260SootSoot results in increased expression of HPCAL1 mRNA26551751
D010042OuabainOuabain affects the expression of HPCAL1 protein17268060
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of HPCAL1 mRNA19059307
D013739Testosterone[Testosterone co-treated with Estradiol] affects the reaction [estradiol-17 beta-benzoate results in increased methylation of HPCAL1 promoter]22109888
D013739Testosterone[[Testosterone co-treated with Estradiol] affects the reaction [estradiol-17 beta-benzoate results in increased methylation of HPCAL1 promoter]] which affects the expression of HPCAL1 protein22109888|2210988
D013739Testosterone[Testosterone co-treated with Estradiol] results in increased methylation of HPCAL1 promoter22109888
D013739Testosterone[[Testosterone co-treated with Estradiol] results in increased methylation of HPCAL1 promoter] which results in decreased expression of HPCAL1 mRNA22109888|2210988
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HPCAL1 mRNA21570461
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of HPCAL1 mRNA28065790
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in increased expression of HPCAL1 mRNA15894607
D014212TretinoinTretinoin results in increased expression of HPCAL1 mRNA15894607
D014212TretinoinTretinoin results in increased expression of HPCAL1 mRNA20488242
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HPCAL1 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of HPCAL1 mRNA29024780
D014520UrethaneUrethane results in increased expression of HPCAL1 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HPCAL1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of HPCAL1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of HPCAL1 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased expression of HPCAL1 mRNA21427059
D014638VanadatesVanadates results in increased expression of HPCAL1 mRNA22714537
C025643vinclozolinvinclozolin results in increased expression of HPCAL1 mRNA23034163
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of HPCAL1 mRNA19244175
D014810Vitamin EVitamin E results in increased expression of HPCAL1 mRNA19244175
C111237vorinostatvorinostat results in increased expression of HPCAL1 protein17593366
D015032ZincZinc deficiency results in increased expression of HPCAL1 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI16189514  25416956  25519916  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0016020membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15834280Hypertension susceptibility genes on chromosome 2p24-p25 in a general Japanese population. (2005 May)Kamide KJ Hypertens