Gene: HPGD

3248
15-PGDH|PGDH|PGDH1|PHOAR1|SDR36C1
15-hydroxyprostaglandin dehydrogenase
protein-coding
4q34.1
Ensembl:ENSG00000164120 MIM:601688 Vega:OTTHUMG00000160772 UniprotKB:P15428
NG_011689.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.483e-1 (AD)  1.848e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CYP4F80.61
CCR30.592
VCY0.587
TMEM710.585
HAL0.579
DPEP20.558
CLEC2D0.554
CYYR10.536
TUBAL30.536
CD1D0.535

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KLHL25-0.308
GGN-0.297
NXPH3-0.294
EFNA2-0.291
WNT7B-0.289
SDK2-0.274
GPR3-0.27
DERL3-0.266
FAM155B-0.262
KCNJ14-0.256

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C02735611-hydroxy-5,8,12,14-eicosatetraenoic acid"Phenylacetates inhibits the reaction [[HPGD protein results in increased metabolism of 11-hydroxy-5,8,12,14-eicosatetraenoic acid] which results in increased chemical synthesis of 11-oxoeicosatetraenoic acid]"21916491
C02735611-hydroxy-5,8,12,14-eicosatetraenoic acid"[Phenylacetates results in decreased activity of HPGD protein] which results in increased abundance of 11-hydroxy-5,8,12,14-eicosatetraenoic acid"21916491
C02735611-hydroxy-5,8,12,14-eicosatetraenoic acid"HPGD protein results in increased metabolism of 11-hydroxy-5,8,12,14-eicosatetraenoic acid"21916491
C02735611-hydroxy-5,8,12,14-eicosatetraenoic acid"HPGD protein results in increased metabolism of 11-hydroxy-5,8,12,14-eicosatetraenoic acid analog"25586183
C02735611-hydroxy-5,8,12,14-eicosatetraenoic acid"[HPGD protein results in increased metabolism of 11-hydroxy-5,8,12,14-eicosatetraenoic acid] which results in increased chemical synthesis of 11-oxoeicosatetraenoic acid"21916491
C57144811-oxoeicosatetraenoic acid"Phenylacetates inhibits the reaction [[HPGD protein results in increased metabolism of 11-hydroxy-5,8,12,14-eicosatetraenoic acid] which results in increased chemical synthesis of 11-oxoeicosatetraenoic acid]"21916491
C57144811-oxoeicosatetraenoic acidHPGD protein results in increased abundance of 11-oxoeicosatetraenoic acid25586183
C57144811-oxoeicosatetraenoic acidHPGD protein results in increased abundance of 11-oxoeicosatetraenoic acid analog25586183
C57144811-oxoeicosatetraenoic acid"[HPGD protein results in increased metabolism of 11-hydroxy-5,8,12,14-eicosatetraenoic acid] which results in increased chemical synthesis of 11-oxoeicosatetraenoic acid"21916491
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of HPGD mRNA"26377693
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"HPGD protein results in increased metabolism of 15-hydroxy-5,8,11,13-eicosatetraenoic acid analog"25586183
C02634615-ketoprostaglandin E2HPGD protein results in increased chemical synthesis of 15-ketoprostaglandin E220448048
C02634615-ketoprostaglandin E2HPGD protein results in increased abundance of 15-ketoprostaglandin E225586183
C0166141-nitronaphthalene1-nitronaphthalene metabolite binds to HPGD protein16453347
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in increased activity of HPGD protein19501039
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of HPGD mRNA"19114083
C0144643,4-dichloroaniline"3,4-dichloroaniline results in increased expression of HPGD mRNA"24172598
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of HPGD mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HPGD mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HPGD mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HPGD mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HPGD mRNA"27188386
C1052604-tert-octylphenol4-tert-octylphenol results in increased expression of HPGD mRNA23664861
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HPGD mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HPGD mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HPGD mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HPGD mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of HPGD mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of HPGD mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of HPGD mRNA11264010
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of HPGD mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of HPGD mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 affects the expression of HPGD protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of HPGD mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HPGD gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of HPGD mRNA26968497
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HPGD mRNA16483693
C030419andrographolide[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of HPGD mRNA19737545
C006632arsenic trioxidearsenic trioxide results in decreased expression of HPGD mRNA19128835
C006632arsenic trioxidearsenic trioxide results in increased expression of HPGD mRNA20458559
D001280AtrazineAtrazine results in increased expression of HPGD mRNA26891955
D001374AzacitidineAzacitidine results in decreased methylation of HPGD gene19584167
D001374AzacitidineAzacitidine results in increased expression of HPGD mRNA19584167
D001374Azacitidinetrichostatin A promotes the reaction [Azacitidine results in increased expression of HPGD mRNA]19584167
C487081belinostatbelinostat results in increased expression of HPGD mRNA26272509
D019324beta-Naphthoflavone[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of HPGD mRNA19737545
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of HPGD mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HPGD mRNA20064835
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of HPGD mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HPGD mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HPGD mRNA"20018196
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HPGD mRNA19619570
D004958EstradiolEstradiol results in decreased expression of HPGD mRNA20106945
D004958EstradiolEstradiol results in increased expression of HPGD mRNA19619570|2118537
D004958EstradiolRaloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of HPGD mRNA]21185374
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of HPGD mRNA26496021
D004958EstradiolEstradiol results in increased expression of HPGD mRNA23664861
D001623BetamethasoneBetamethasone results in increased expression of and results in increased activity of HPGD protein15680906
C006780bisphenol Abisphenol A affects the expression of HPGD mRNA27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of HPGD mRNA]27082013
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of HPGD mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of HPGD mRNA25181051
C001371boldenone undecylenate[boldenone undecylenate co-treated with estradiol 3-benzoate] results in decreased expression of HPGD mRNA16023321
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of HPGD mRNA23741332
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of HPGD mRNA27339419
D000068579Celecoxib[Celecoxib co-treated with NAD] binds to HPGD protein25526675
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of HPGD mRNA23650126
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of HPGD mRNA26272509
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of HPGD mRNA20938992
C039671ciglitazoneciglitazone results in decreased activity of HPGD protein21650226
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of HPGD mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of HPGD mRNA]17585979
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of HPGD mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of HPGD mRNA19376846
D009243NAD[Celecoxib co-treated with NAD] binds to HPGD protein25526675
D009243NAD[Diclofenac co-treated with NAD] binds to HPGD protein25526675
D009243NAD[Dinoprostone co-treated with NAD] binds to HPGD protein25526675
D009243NAD[Fenoprofen co-treated with NAD] binds to HPGD protein25526675
D009243NAD[Indomethacin co-treated with NAD] binds to HPGD protein25526675
D009243NAD[Ketoprofen co-treated with NAD] binds to HPGD protein25526675
D009243NADNAD binds to and results in increased activity of HPGD protein25526675
D009243NAD[Niflumic Acid co-treated with NAD] binds to HPGD protein25526675
D009243NAD[pioglitazone co-treated with NAD] binds to HPGD protein25526675
D009243NAD[rosiglitazone co-treated with NAD] binds to HPGD protein25526675
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of HPGD mRNA20971185
D003300CopperCopper deficiency results in decreased expression of HPGD mRNA19821111
D016572CyclosporineCyclosporine results in decreased expression of HPGD mRNA20106945|2798913
D016572CyclosporineCyclosporine results in decreased expression of HPGD mRNA19770486
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of HPGD mRNA23640034
D013759DronabinolDronabinol results in decreased expression of HPGD mRNA16616335
D003907DexamethasoneDexamethasone results in increased expression of and results in increased activity of HPGD protein15680906
D003907Dexamethasonegeldanamycin inhibits the reaction [Dexamethasone results in increased expression of and results in increased activity of HPGD protein]15680906
D003907DexamethasoneMifepristone inhibits the reaction [Dexamethasone results in increased expression of and results in increased activity of HPGD protein]15680906
D003907DexamethasoneTetradecanoylphorbol Acetate inhibits the reaction [Dexamethasone results in increased expression of and results in increased activity of HPGD protein]15680906
D003907DexamethasoneDexamethasone results in increased expression of HPGD mRNA22733784
D003907DexamethasoneDexamethasone results in decreased expression of HPGD protein6421564
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HPGD mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of HPGD mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of HPGD mRNA27392435
D004008Diclofenac[Diclofenac co-treated with NAD] binds to HPGD protein25526675
D004008DiclofenacDiclofenac results in increased activity of HPGD protein19501039
D004008DiclofenacDiclofenac results in increased expression of HPGD mRNA19501039
D004041Dietary FatsDietary Fats results in decreased expression of HPGD mRNA18042831
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of HPGD mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of HPGD mRNA17602206
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of HPGD mRNA21658437
D002117CalcitriolCalcitriol results in increased expression of HPGD mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of HPGD mRNA21592394
D01506416,16-Dimethylprostaglandin E2"16,16-Dimethylprostaglandin E2 results in increased activity of HPGD protein"14736730
D004237DiuronDiuron metabolite results in increased expression of HPGD mRNA24172598
D004237DiuronDiuron results in decreased expression of HPGD mRNA21551480
D004281Docosahexaenoic AcidsHPGD protein affects the metabolism of Docosahexaenoic Acids25586183
D052244Endocrine DisruptorsEndocrine Disruptors results in decreased expression of HPGD mRNA25198161
C118739entinostatentinostat results in increased expression of HPGD mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HPGD mRNA"27188386
C074283estradiol 3-benzoate[boldenone undecylenate co-treated with estradiol 3-benzoate] results in decreased expression of HPGD mRNA16023321
C074283estradiol 3-benzoate[Testosterone co-treated with estradiol 3-benzoate] results in decreased expression of HPGD mRNA16023321
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of HPGD mRNA17942748
D005279Fenoprofen[Fenoprofen co-treated with NAD] binds to HPGD protein25526675
D005395Fish OilsFish Oils inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of HPGD protein]21653731
D005480FlurbiprofenFlurbiprofen results in decreased degradation of HPGD protein19501039
D005480FlurbiprofenFlurbiprofen results in increased activity of HPGD protein19501039
D005480FlurbiprofenFlurbiprofen results in increased expression of HPGD mRNA19501039
D005480Flurbiprofen[[Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA] which results in decreased degradation of HPGD protein19501039
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of HPGD mRNA20938992
C039281furanfuran results in increased expression of HPGD mRNA27387713
C001277geldanamycingeldanamycin inhibits the reaction [Dexamethasone results in increased expression of and results in increased activity of HPGD protein]15680906
D005944GlucosamineGlucosamine results in decreased expression of HPGD mRNA17109745
D017313FenretinideFenretinide results in decreased expression of HPGD mRNA28973697
D007052IbuprofenIbuprofen affects the expression of HPGD mRNA17070997
D007052IbuprofenIbuprofen results in increased activity of HPGD protein19501039
D007052IbuprofenIbuprofen results in increased expression of HPGD mRNA19501039
D007213Indomethacin[Indomethacin co-treated with NAD] binds to HPGD protein25526675
D007213IndomethacinIndomethacin promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of HPGD mRNA]11237475
D007213IndomethacinIndomethacin results in increased activity of HPGD protein19501039
D007213IndomethacinIndomethacin results in increased expression of and results in increased activity of HPGD protein11352223|1473673
D007213IndomethacinIndomethacin results in increased expression of HPGD mRNA19501039
D007529IsoflavonesIsoflavones affects the expression of HPGD mRNA16365062
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of HPGD mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of HPGD mRNA26752646
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HPGD mRNA25982114
D007649KetamineKetamine results in decreased expression of HPGD mRNA20080153
D007660Ketoprofen[Ketoprofen co-treated with NAD] binds to HPGD protein25526675
D007854LeadLead results in increased expression of HPGD mRNA19921347
D008528Mefenamic AcidMefenamic Acid results in increased activity of HPGD protein19501039
D008528Mefenamic AcidMefenamic Acid results in increased expression of HPGD mRNA19501039
C065757meloxicammeloxicam inhibits the reaction [IFNE protein results in decreased expression of HPGD mRNA]21270428
C042720mercuric bromidemercuric bromide results in increased expression of HPGD mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HPGD mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of HPGD mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of HPGD mRNA17400583|2444957
D008748MethylcholanthreneMethylcholanthrene results in increased expression of HPGD mRNA25926378
C004925methylmercuric chloridemethylmercuric chloride affects the expression of HPGD mRNA20864626
C030957methylmercury IImethylmercury II results in decreased expression of HPGD mRNA17905399
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in decreased expression of HPGD mRNA15120970
C008493methylselenic acidmethylselenic acid results in increased expression of HPGD mRNA25187657
C008493methylselenic acidmethylselenic acid results in increased expression of HPGD protein25187657
D015735MifepristoneMifepristone inhibits the reaction [Dexamethasone results in increased expression of and results in increased activity of HPGD protein]15680906
D015735MifepristoneMifepristone results in decreased expression of HPGD mRNA17584828
D015735MifepristoneMifepristone results in decreased expression of HPGD mRNA25972201
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of HPGD mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of HPGD mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of HPGD mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of HPGD mRNA"25620056
C031721naphthalenenaphthalene metabolite binds to HPGD protein16453347
D019829NevirapineNevirapine metabolite results in increased expression of HPGD mRNA23947594
C029938nickel sulfatenickel sulfate results in decreased expression of HPGD mRNA18651567
D009544Niflumic Acid[Niflumic Acid co-treated with NAD] binds to HPGD protein25526675
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of HPGD mRNA20971185
D010100OxygenOxygen deficiency results in increased expression of HPGD mRNA20042640
D010100OxygenOxygen results in decreased expression of HPGD mRNA22911455
D010126OzoneOzone results in decreased expression of HPGD mRNA12763052
D000073878Palm OilPalm Oil results in decreased expression of HPGD mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HPGD mRNA"27188386
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of HPGD mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of HPGD mRNA27153767
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of HPGD mRNA17681415
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of HPGD mRNA16221955
D015232Dinoprostone[Dinoprostone co-treated with NAD] binds to HPGD protein25526675
D015232DinoprostoneHPGD protein affects the abundance of Dinoprostone19584167
D015232DinoprostoneHPGD protein results in increased metabolism of Dinoprostone18500342
D015232DinoprostoneHPGD protein results in increased metabolism of Dinoprostone20448048
D015232DinoprostoneHPGD protein results in increased metabolism of Dinoprostone25586183
D010634PhenobarbitalPhenobarbital affects the expression of HPGD mRNA23091169
D010648Phenylacetates"Phenylacetates inhibits the reaction [[HPGD protein results in increased metabolism of 11-hydroxy-5,8,12,14-eicosatetraenoic acid] which results in increased chemical synthesis of 11-oxoeicosatetraenoic acid]"21916491
D010648Phenylacetates"[Phenylacetates results in decreased activity of HPGD protein] which results in increased abundance of 11-hydroxy-5,8,12,14-eicosatetraenoic acid"21916491
D010648PhenylacetatesPhenylacetates results in decreased activity of HPGD protein21916491
D010795Phthalic AcidsPhthalic Acids results in decreased expression of HPGD mRNA15728792
C060836pioglitazone[pioglitazone co-treated with NAD] binds to HPGD protein25526675
C006253pirinixic acidpirinixic acid results in decreased expression of HPGD mRNA16985257|1844570
C006253pirinixic acidpirinixic acid results in increased expression of HPGD mRNA20059764
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of HPGD mRNA]20059764
C006253pirinixic acidpirinixic acid results in decreased expression of HPGD mRNA19162173
D028321Plant PreparationsPlant Preparations affects the expression of HPGD mRNA16046712|1625160
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of HPGD mRNA]27082013
D011192Potassium DichromatePotassium Dichromate results in increased expression of HPGD mRNA23608068
D011239PrednisolonePrednisolone results in increased expression of and results in increased activity of HPGD protein15680906
D011374ProgesteroneProgesterone results in increased expression of HPGD mRNA20876846
D011441PropylthiouracilPropylthiouracil results in increased expression of HPGD mRNA24780913
D011453ProstaglandinsHPGD protein results in increased degradation of Prostaglandins11352223|1473673
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of HPGD mRNA]21185374
C116926rofecoxibrofecoxib results in decreased expression of HPGD mRNA17070997
C089730rosiglitazone[rosiglitazone co-treated with NAD] binds to HPGD protein25526675
C541923sandostatinLARsandostatinLAR results in increased expression of HPGD mRNA17210224
D012822Silicon DioxideSilicon Dioxide results in decreased expression of HPGD mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in decreased expression of HPGD mRNA19073995|2322117
D012822Silicon DioxideSilicon Dioxide results in decreased expression of HPGD mRNA22431001
C009277sodium arsenatesodium arsenate results in increased expression of HPGD mRNA21795629
C016104sodium bichromatesodium bichromate results in decreased expression of HPGD mRNA22155349
D018038Sodium SeleniteN-TUTCA2 gene mutant form inhibits the reaction [Sodium Selenite results in increased expression of HPGD mRNA]25187657
D018038Sodium SeleniteN-TUTCA2 gene mutant form inhibits the reaction [Sodium Selenite results in increased expression of HPGD protein]25187657
D018038Sodium SeleniteSodium Selenite results in increased expression of HPGD mRNA25187657
D018038Sodium SeleniteSodium Selenite results in increased expression of HPGD protein25187657
C025463sulindac sulfonesulindac sulfone results in increased activity of HPGD protein19501039
C025463sulindac sulfonesulindac sulfone results in increased expression of HPGD mRNA19501039
C061133tamibarotenetamibarotene affects the expression of HPGD mRNA15498508
D013739Testosterone[Testosterone co-treated with estradiol 3-benzoate] results in decreased expression of HPGD mRNA16023321
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of HPGD mRNA21592394
D013739TestosteroneTestosterone results in increased expression of HPGD mRNA21592394
C010792testosterone undecanoatetestosterone undecanoate results in increased expression of HPGD mRNA19074003
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HPGD mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HPGD mRNA19619570
D013749TetrachlorodibenzodioxinFish Oils inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of HPGD protein]21653731
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HPGD mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of HPGD mRNA16214954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of HPGD mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of HPGD mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HPGD gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HPGD protein21653731
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HPGD mRNA15328365|1879615
D013752TetracyclineTetracycline results in decreased expression of HPGD mRNA24489787
D013755Tetradecanoylphorbol AcetateIndomethacin promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of HPGD mRNA]11237475
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate inhibits the reaction [Dexamethasone results in increased expression of and results in increased activity of HPGD protein]15680906
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of HPGD mRNA11237475
C009495titanium dioxidetitanium dioxide affects the expression of HPGD mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of HPGD mRNA23131501
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of HPGD mRNA20133372
D014212TretinoinTretinoin affects the expression of HPGD mRNA15498508
D014212TretinoinTretinoin results in increased expression of HPGD mRNA21934132|2383079
D014221TriamcinoloneTriamcinolone results in increased expression of and results in increased activity of HPGD protein15680906
C012589trichostatin Atrichostatin A promotes the reaction [Azacitidine results in increased expression of HPGD mRNA]19584167
C012589trichostatin Atrichostatin A results in increased expression of HPGD mRNA19584167
C009954trilostanetrilostane promotes the reaction [GNRH1 protein results in increased expression of HPGD mRNA]17332517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid affects the expression of HPGD mRNA25526689
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid affects the expression of HPGD mRNA25526689
C113580U 0126U 0126 results in increased activity of HPGD protein19501039
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HPGD mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of HPGD mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of HPGD mRNA23179753|2438349
D014640VancomycinVancomycin results in increased expression of HPGD mRNA18930951
C025643vinclozolinvinclozolin results in decreased expression of HPGD mRNA23034163
C029297vinylidene chloridevinylidene chloride results in decreased expression of HPGD mRNA26682919
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of HPGD mRNA"25198161
D015032ZincZinc deficiency results in increased expression of HPGD mRNA19111725
D015032ZincZinc inhibits the reaction [Zinc deficiency results in increased expression of HPGD mRNA]19111725
C088658zoledronic acidzoledronic acid results in decreased expression of HPGD mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003824catalytic activity-IDA2025296  
GO:0004957prostaglandin E receptor activity-IDA10198228  
GO:001640415-hydroxyprostaglandin dehydrogenase (NAD+) activity-IBA21873635  
GO:001640415-hydroxyprostaglandin dehydrogenase (NAD+) activity-IDA2025296  10198228  15581601  16828555  
GO:001640415-hydroxyprostaglandin dehydrogenase (NAD+) activity-NAS7557451  
GO:001640415-hydroxyprostaglandin dehydrogenase (NAD+) activity-TAS-  
GO:0042803protein homodimerization activity-TAS2025296  
GO:0051287NAD binding-IDA10198228  15581601  
GO:0070403NAD+ binding-IDA16828555  
GO ID GO Term Qualifier Evidence PubMed
GO:0001822kidney development-IEA-  
GO:0006693prostaglandin metabolic process-IBA21873635  
GO:0006693prostaglandin metabolic process-IDA16828555  
GO:0007165signal transduction-IBA21873635  
GO:0007179transforming growth factor beta receptor signaling pathway-IDA15574495  
GO:0007565female pregnancy-IBA21873635  
GO:0007565female pregnancy-IDA15531523  
GO:0007567parturition-IDA15531523  
GO:0019372lipoxygenase pathway-TAS15581601  
GO:0030728ovulation-ISS-  
GO:0032355response to estradiol-IEA-  
GO:0032496response to lipopolysaccharide-IEA-  
GO:0042759long-chain fatty acid biosynthetic process-TAS-  
GO:0043065positive regulation of apoptotic process-IEA-  
GO:0045471response to ethanol-IEA-  
GO:0045786negative regulation of cell cycle-IDA15574495  
GO:0055114oxidation-reduction process-IEA-  
GO:0070493thrombin-activated receptor signaling pathway-ISS-  
GO:0097070ductus arteriosus closure-ISS-  
GO:1904707positive regulation of vascular smooth muscle cell proliferation-IEA-  
GO:2001301lipoxin biosynthetic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-NAS15581601  
GO:0005829cytosol-TAS-  
GO:0016323basolateral plasma membrane-IEA-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismIEA
R-HSA-1430728MetabolismTAS
R-HSA-2142700Synthesis of Lipoxins (LX)TAS
R-HSA-2142753Arachidonic acid metabolismIEA
R-HSA-2162123Synthesis of Prostaglandins (PG) and Thromboxanes (TX)IEA
R-HSA-556833Metabolism of lipidsIEA
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8978868Fatty acid metabolismIEA
R-HSA-8978868Fatty acid metabolismTAS
R-HSA-9018676Biosynthesis of D-series resolvinsTAS
R-HSA-9018677Biosynthesis of DHA-derived SPMsTAS
R-HSA-9018678Biosynthesis of specialized proresolving mediators (SPMs)TAS
R-HSA-9018679Biosynthesis of EPA-derived SPMsTAS
R-HSA-9018896Biosynthesis of E-series 18(S)-resolvinsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24694755Genetic variability in key genes in prostaglandin E2 pathway (COX-2, HPGD, ABCC4 and SLCO2A1) and their involvement in colorectal cancer development. (2014)Pereira CPLoS One
27548026Colonic Saturated Fatty Acid Concentrations and Expression of COX-1, but not Diet, Predict Prostaglandin E2 in Normal Human Colon Tissue. (2016 Oct)Sidahmed ENutr Cancer