Gene info: ID 3249

Gene: HPN

GENE ID: 3249

Synonyms: TMPRSS1

Description: hepsin

Gene type: protein-coding

Location: 19q13.11

dbXrefs: Ensembl:ENSG00000105707 MIM:142440 Vega:OTTHUMG00000182474 UniprotKB:P05981

RefSeq: NC_000019.10

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.483e-1 (AD) 5.627e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg24715735	chr19:35531403	HPN		4.000e-18	Smoking	27651444
cg06151964	chr19:35531417	HPN		2.400e-10	Smoking	27651444
cg06672753	chr19:35531990	HPN		3.600e-10	Smoking	27651444
cg15234271	chr19:35531411	HPN		6.300e-10	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TFEB	0.832
SEMA3B	0.815
TTYH2	0.811
ELOVL1	0.81
SLC45A3	0.805
HSPA2	0.804
VWA1	0.796
KIAA1755	0.796
TMEM63A	0.792
CDC42EP1	0.791

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CERKL	-0.401
CNGB1	-0.378
CHRNA6	-0.375
CALB2	-0.373
GALNTL6	-0.371
PTHLH	-0.37
TP53I11	-0.369
CNTN5	-0.369
KCNG3	-0.366
SLC5A1	-0.365

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00036	Coagulation factor VIIa Recombinant Human	BiotechDrug	102786-61-8	Approved	Target
DB00522	Bentiromide	Small Molecule	37106-97-1	Investigational\|Withdrawn	Target
DB03297	Benzylsulfinic Acid	Small Molecule		Experimental	Target
DB03643	CRA_1144	Small Molecule		Experimental	Target
DB03865	6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of HPN mRNA"	19162173
C028451	3,4,3',4'-tetrachlorobiphenyl	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of HPN mRNA]"	19467301
D000082	Acetaminophen	Acetaminophen results in decreased expression of HPN mRNA	17175557
D000082	Acetaminophen	Acetaminophen affects the expression of HPN mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of HPN protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of HPN mRNA	27153756
D000638	Amiodarone	Amiodarone results in increased expression of HPN mRNA	15342952\|1756758
D000639	Amitriptyline	Amitriptyline results in increased expression of HPN mRNA	15342952\|1717555
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of HPN mRNA	16483693
C547126	AZM551248	AZM551248 results in decreased expression of HPN mRNA	22323515
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of HPN mRNA	20106945
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of HPN mRNA	22300585
C006780	bisphenol A	bisphenol A affects the expression of HPN mRNA	25181051
C084597	chlorcyclizine	chlorcyclizine results in increased expression of HPN mRNA	15342952
D002746	Chlorpromazine	Chlorpromazine results in increased expression of HPN mRNA	15342952\|1717555
C039671	ciglitazone	[ciglitazone binds to PPARG protein alternative form] which results in increased expression of HPN mRNA	16197558
D002922	Ciguatoxins	Ciguatoxins affects the expression of HPN mRNA	18353800
D002994	Clofibrate	Clofibrate results in decreased expression of HPN mRNA	17585979
D002997	Clomipramine	Clomipramine results in increased expression of HPN mRNA	15342952
D003024	Clozapine	Clozapine results in increased expression of HPN mRNA	15342952
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of HPN mRNA	24386269
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of HPN mRNA	19549813
D003471	Cuprizone	Cuprizone results in decreased expression of HPN mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in decreased expression of HPN mRNA	20106945\|2556210
D016572	Cyclosporine	Cyclosporine results in increased expression of HPN mRNA	22147139
D016572	Cyclosporine	Cyclosporine results in decreased expression of HPN mRNA	19224547
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of HPN mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of HPN mRNA	27392435
D004041	Dietary Fats	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of HPN mRNA]"	19467301
D004041	Dietary Fats	Dietary Fats results in increased expression of HPN mRNA	18042831\|1946730
D002117	Calcitriol	Calcitriol results in increased expression of HPN mRNA	26485663
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of HPN mRNA"	22485181
D004917	Erythromycin	Erythromycin results in increased expression of HPN mRNA	17175557
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of HPN mRNA	17108234
D005424	Flecainide	Flecainide results in increased expression of HPN mRNA	17175557
D005473	Fluoxetine	Fluoxetine results in increased expression of HPN mRNA	15342952
C069837	fullerene C60	fullerene C60 results in increased expression of HPN mRNA	19167457
D017313	Fenretinide	Fenretinide results in increased expression of HPN mRNA	28973697
D007099	Imipramine	Imipramine results in increased expression of HPN mRNA	15342952\|1756758
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of HPN mRNA	27392435
D007654	Ketoconazole	Ketoconazole results in increased expression of HPN mRNA	15342952
D017336	Loratadine	Loratadine results in increased expression of HPN mRNA	15342952
D008701	Methapyrilene	Methapyrilene results in decreased expression of HPN mRNA	16393664
C028007	nickel monoxide	nickel monoxide results in increased expression of HPN mRNA	19167457
D005996	Nitroglycerin	Nitroglycerin results in increased expression of HPN mRNA	12102619
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of HPN mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in decreased expression of HPN mRNA	25729387
D000073878	Palm Oil	Palm Oil results in increased expression of HPN mRNA	18042831
D010269	Paraquat	Paraquat results in decreased expression of HPN mRNA	16797015
D010419	Pentamidine	Pentamidine results in increased expression of HPN mRNA	15342952
D010480	Perhexiline	Perhexiline results in increased expression of HPN mRNA	15342952\|1717555
C006253	pirinixic acid	pirinixic acid results in increased expression of HPN mRNA	17426115
D010936	Plant Extracts	Plant Extracts results in decreased expression of HPN mRNA	23557933
D010936	Plant Extracts	Plant Extracts results in decreased expression of HPN mRNA	28533734
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of HPN mRNA	24780913
D011794	Quercetin	Quercetin results in increased expression of HPN mRNA	21632981
C089730	rosiglitazone	rosiglitazone results in decreased expression of HPN mRNA	25572481
D012643	Selenium	Selenium results in increased expression of HPN mRNA	19244175
D012645	Selenomethionine	Selenomethionine affects the expression of HPN mRNA	17222674
D020280	Sertraline	Sertraline results in increased expression of HPN mRNA	15342952
C017947	sodium arsenite	sodium arsenite affects the methylation of HPN gene	28589171
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of HPN mRNA	18175754
D013629	Tamoxifen	Tamoxifen results in increased expression of HPN mRNA	15342952
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid results in decreased expression of HPN mRNA	15885361
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of HPN mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HPN mRNA	21215274
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of HPN mRNA	18796159
D013752	Tetracycline	Tetracycline results in decreased expression of HPN mRNA	19224547
D013881	Thioridazine	Thioridazine results in increased expression of HPN mRNA	15342952
C009495	titanium dioxide	titanium dioxide results in increased expression of HPN mRNA	23557971
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of HPN mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of HPN mRNA	25729387
D001371	trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride	"trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride results in increased expression of HPN mRNA"	15342952
D014212	Tretinoin	Tretinoin results in increased expression of HPN mRNA	20488242
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in decreased expression of HPN mRNA	15885361
D014635	Valproic Acid	Valproic Acid affects the expression of HPN mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of HPN mRNA	29154799
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of HPN gene	25560391
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of HPN mRNA	26682919
D015031	Zimeldine	Zimeldine results in increased expression of HPN mRNA	15342952\|1717555

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004252	serine-type endopeptidase activity	-	IDA	16908524
GO:0004252	serine-type endopeptidase activity	-	TAS	-
GO:0005515	protein binding	-	IPI	15614436 19911255
GO:0008233	peptidase activity	-	IDA	16908524 19843851
GO:0008236	serine-type peptidase activity	-	IDA	19911255
GO:0015269	calcium-activated potassium channel activity	-	ISS	-
GO:0070008	serine-type exopeptidase activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006508	proteolysis	-	IDA	16908524 19843851 19911255 24227843
GO:0008360	regulation of cell shape	-	IBA	21873635
GO:0008360	regulation of cell shape	-	IMP	8346233
GO:0010628	positive regulation of gene expression	-	ISS	-
GO:0010719	negative regulation of epithelial to mesenchymal transition	-	IBA	21873635
GO:0010719	negative regulation of epithelial to mesenchymal transition	-	IDA	19843851
GO:0010756	positive regulation of plasminogen activation	-	IDA	16908524
GO:0030307	positive regulation of cell growth	-	IMP	8346233
GO:0034769	basement membrane disassembly	-	IDA	16908524
GO:0043066	negative regulation of apoptotic process	-	IDA	15614436
GO:0043923	positive regulation by host of viral transcription	-	IDA	15614436
GO:0048012	hepatocyte growth factor receptor signaling pathway	-	TAS	-
GO:0050680	negative regulation of epithelial cell proliferation	-	IDA	19843851
GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	-	ISS	-
GO:0071805	potassium ion transmembrane transport	-	ISS	-
GO:0090103	cochlea morphogenesis	-	ISS	-
GO:0097066	response to thyroid hormone	-	ISS	-
GO:0097195	pilomotor reflex	-	ISS	-
GO:2000347	positive regulation of hepatocyte proliferation	-	IDA	15614436
GO:2000611	positive regulation of thyroid hormone generation	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005789	endoplasmic reticulum membrane	-	IDA	17918732
GO:0005886	plasma membrane	-	IDA	8346233
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IDA	1885621
GO:0005911	cell-cell junction	-	ISS	-
GO:0009986	cell surface	-	IDA	8346233 16908524
GO:0016021	integral component of membrane	-	IDA	19843851
GO:0016324	apical plasma membrane	-	IEA	-
GO:0031965	nuclear membrane	colocalizes_with	IDA	15614436
GO:0043025	neuronal cell body	-	ISS	-
GO:0070062	extracellular exosome	-	HDA	23533145

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-6806834	Signaling by MET	TAS
R-HSA-6806942	MET Receptor Activation	TAS
R-HSA-8852405	Signaling by MST1	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
11903385	Lifestyle behaviors affect cardiovascular risk status in men 1 year after kidney transplantation. (2001)	Martin JC	Clin Transplant
25852128	Environmental Risk Factors for Developing Catheter-Related Bloodstream Infection in Home Parenteral Nutrition Patients: A 6-Year Follow-up Study. (2016 Sep)	Bech LF	JPEN J Parenter Enteral Nutr
20441232	Discovering disease-specific biomarker genes for cancer diagnosis and prognosis. (2010 Jun)	Huang HC	Technol Cancer Res Treat