Gene: HPN

3249
TMPRSS1
hepsin
protein-coding
19q13.11
Ensembl:ENSG00000105707 MIM:142440 Vega:OTTHUMG00000182474 UniprotKB:P05981
NC_000019.10
PubMed
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.483e-1 (AD)  5.627e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg24715735chr19:35531403HPN4.000e-18Smoking27651444
cg06151964chr19:35531417HPN2.400e-10Smoking27651444
cg06672753chr19:35531990HPN3.600e-10Smoking27651444
cg15234271chr19:35531411HPN6.300e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TFEB0.832
SEMA3B0.815
TTYH20.811
ELOVL10.81
SLC45A30.805
HSPA20.804
VWA10.796
KIAA17550.796
TMEM63A0.792
CDC42EP10.791

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CERKL-0.401
CNGB1-0.378
CHRNA6-0.375
CALB2-0.373
GALNTL6-0.371
PTHLH-0.37
TP53I11-0.369
CNTN5-0.369
KCNG3-0.366
SLC5A1-0.365

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00036Coagulation factor VIIa Recombinant HumanBiotechDrug102786-61-8ApprovedTarget
DB00522BentiromideSmall Molecule37106-97-1Investigational|WithdrawnTarget
DB03297Benzylsulfinic AcidSmall MoleculeExperimentalTarget
DB03643CRA_1144Small MoleculeExperimentalTarget
DB038656-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-CarboxamidineSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of HPN mRNA"19162173
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of HPN mRNA]"19467301
D000082AcetaminophenAcetaminophen results in decreased expression of HPN mRNA17175557
D000082AcetaminophenAcetaminophen affects the expression of HPN mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of HPN protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of HPN mRNA27153756
D000638AmiodaroneAmiodarone results in increased expression of HPN mRNA15342952|1756758
D000639AmitriptylineAmitriptyline results in increased expression of HPN mRNA15342952|1717555
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HPN mRNA16483693
C547126AZM551248AZM551248 results in decreased expression of HPN mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HPN mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HPN mRNA22300585
C006780bisphenol Abisphenol A affects the expression of HPN mRNA25181051
C084597chlorcyclizinechlorcyclizine results in increased expression of HPN mRNA15342952
D002746ChlorpromazineChlorpromazine results in increased expression of HPN mRNA15342952|1717555
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of HPN mRNA16197558
D002922CiguatoxinsCiguatoxins affects the expression of HPN mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of HPN mRNA17585979
D002997ClomipramineClomipramine results in increased expression of HPN mRNA15342952
D003024ClozapineClozapine results in increased expression of HPN mRNA15342952
C018021cobaltous chloridecobaltous chloride results in decreased expression of HPN mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of HPN mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of HPN mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of HPN mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of HPN mRNA22147139
D016572CyclosporineCyclosporine results in decreased expression of HPN mRNA19224547
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of HPN mRNA27392435
D002945CisplatinCisplatin results in increased expression of HPN mRNA27392435
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of HPN mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of HPN mRNA18042831|1946730
D002117CalcitriolCalcitriol results in increased expression of HPN mRNA26485663
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of HPN mRNA"22485181
D004917ErythromycinErythromycin results in increased expression of HPN mRNA17175557
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of HPN mRNA17108234
D005424FlecainideFlecainide results in increased expression of HPN mRNA17175557
D005473FluoxetineFluoxetine results in increased expression of HPN mRNA15342952
C069837fullerene C60fullerene C60 results in increased expression of HPN mRNA19167457
D017313FenretinideFenretinide results in increased expression of HPN mRNA28973697
D007099ImipramineImipramine results in increased expression of HPN mRNA15342952|1756758
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of HPN mRNA27392435
D007654KetoconazoleKetoconazole results in increased expression of HPN mRNA15342952
D017336LoratadineLoratadine results in increased expression of HPN mRNA15342952
D008701MethapyrileneMethapyrilene results in decreased expression of HPN mRNA16393664
C028007nickel monoxidenickel monoxide results in increased expression of HPN mRNA19167457
D005996NitroglycerinNitroglycerin results in increased expression of HPN mRNA12102619
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of HPN mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of HPN mRNA25729387
D000073878Palm OilPalm Oil results in increased expression of HPN mRNA18042831
D010269ParaquatParaquat results in decreased expression of HPN mRNA16797015
D010419PentamidinePentamidine results in increased expression of HPN mRNA15342952
D010480PerhexilinePerhexiline results in increased expression of HPN mRNA15342952|1717555
C006253pirinixic acidpirinixic acid results in increased expression of HPN mRNA17426115
D010936Plant ExtractsPlant Extracts results in decreased expression of HPN mRNA23557933
D010936Plant ExtractsPlant Extracts results in decreased expression of HPN mRNA28533734
D011441PropylthiouracilPropylthiouracil results in decreased expression of HPN mRNA24780913
D011794QuercetinQuercetin results in increased expression of HPN mRNA21632981
C089730rosiglitazonerosiglitazone results in decreased expression of HPN mRNA25572481
D012643SeleniumSelenium results in increased expression of HPN mRNA19244175
D012645SelenomethionineSelenomethionine affects the expression of HPN mRNA17222674
D020280SertralineSertraline results in increased expression of HPN mRNA15342952
C017947sodium arsenitesodium arsenite affects the methylation of HPN gene28589171
D018038Sodium SeleniteSodium Selenite results in decreased expression of HPN mRNA18175754
D013629TamoxifenTamoxifen results in increased expression of HPN mRNA15342952
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in decreased expression of HPN mRNA15885361
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HPN mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HPN mRNA21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HPN mRNA18796159
D013752TetracyclineTetracycline results in decreased expression of HPN mRNA19224547
D013881ThioridazineThioridazine results in increased expression of HPN mRNA15342952
C009495titanium dioxidetitanium dioxide results in increased expression of HPN mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of HPN mRNA25729387
D019772TopotecanTopotecan results in decreased expression of HPN mRNA25729387
D001371trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride"trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride results in increased expression of HPN mRNA"15342952
D014212TretinoinTretinoin results in increased expression of HPN mRNA20488242
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of HPN mRNA15885361
D014635Valproic AcidValproic Acid affects the expression of HPN mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of HPN mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of HPN gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of HPN mRNA26682919
D015031ZimeldineZimeldine results in increased expression of HPN mRNA15342952|1717555

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-IDA16908524  
GO:0004252serine-type endopeptidase activity-TAS-  
GO:0005515protein binding-IPI15614436  19911255  
GO:0008233peptidase activity-IDA16908524  19843851  
GO:0008236serine-type peptidase activity-IDA19911255  
GO:0015269calcium-activated potassium channel activity-ISS-  
GO:0070008serine-type exopeptidase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IDA16908524  19843851  19911255  24227843  
GO:0008360regulation of cell shape-IBA21873635  
GO:0008360regulation of cell shape-IMP8346233  
GO:0010628positive regulation of gene expression-ISS-  
GO:0010719negative regulation of epithelial to mesenchymal transition-IBA21873635  
GO:0010719negative regulation of epithelial to mesenchymal transition-IDA19843851  
GO:0010756positive regulation of plasminogen activation-IDA16908524  
GO:0030307positive regulation of cell growth-IMP8346233  
GO:0034769basement membrane disassembly-IDA16908524  
GO:0043066negative regulation of apoptotic process-IDA15614436  
GO:0043923positive regulation by host of viral transcription-IDA15614436  
GO:0048012hepatocyte growth factor receptor signaling pathway-TAS-  
GO:0050680negative regulation of epithelial cell proliferation-IDA19843851  
GO:0050910detection of mechanical stimulus involved in sensory perception of sound-ISS-  
GO:0071805potassium ion transmembrane transport-ISS-  
GO:0090103cochlea morphogenesis-ISS-  
GO:0097066response to thyroid hormone-ISS-  
GO:0097195pilomotor reflex-ISS-  
GO:2000347positive regulation of hepatocyte proliferation-IDA15614436  
GO:2000611positive regulation of thyroid hormone generation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-IDA17918732  
GO:0005886plasma membrane-IDA8346233  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IDA1885621  
GO:0005911cell-cell junction-ISS-  
GO:0009986cell surface-IDA8346233  16908524  
GO:0016021integral component of membrane-IDA19843851  
GO:0016324apical plasma membrane-IEA-  
GO:0031965nuclear membranecolocalizes_withIDA15614436  
GO:0043025neuronal cell body-ISS-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-6806834Signaling by METTAS
R-HSA-6806942MET Receptor ActivationTAS
R-HSA-8852405Signaling by MST1TAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
11903385Lifestyle behaviors affect cardiovascular risk status in men 1 year after kidney transplantation. (2001)Martin JCClin Transplant
25852128Environmental Risk Factors for Developing Catheter-Related Bloodstream Infection in Home Parenteral Nutrition Patients: A 6-Year Follow-up Study. (2016 Sep)Bech LFJPEN J Parenter Enteral Nutr
20441232Discovering disease-specific biomarker genes for cancer diagnosis and prognosis. (2010 Jun)Huang HCTechnol Cancer Res Treat