Gene: APCS

325
HEL-S-92n|PTX2|SAP
amyloid P component, serum
protein-coding
1q23.2
Ensembl:ENSG00000132703 MIM:104770 Vega:OTTHUMG00000022741 UniprotKB:P02743
NC_000001.11
PubMed
0   ANCO-SNPs
ND
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.298e-1 (AD)  4.979e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FGA0.711
APOC30.706
AGXT0.694
FGB0.658
FGG0.65
CRP0.639
HP0.634
ORM20.634
ORM10.585
APOH0.555

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GOLGA8N-0.237
TSSK4-0.206
ZNF157-0.2
NLRP14-0.186
TOX3-0.186
PCDHB11-0.186
GPR75-0.182
KRBA2-0.177
GOLGA6B-0.175
ZNF81-0.174

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB01651Methyl 4,6-O-[(1r)-1-Carboxyethylidene]-Beta-D-GalactopyranosideSmall MoleculeExperimentalTarget
DB07579BIS-1,2-{[(Z)-2-CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBAMOYL}-ETHANESmall MoleculeExperimentalTarget
DB07580BIS-1,2-{[(Z)-2CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBONYL}-PIPERAZINESmall MoleculeExperimentalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of APCS mRNA"19162173
C0211831,7-dimethylxanthine"1,7-dimethylxanthine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of APCS protein]"19962977
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of APCS mRNA"21346803
C5850042-monochloropropanediol2-monochloropropanediol results in increased expression of APCS mRNA28522335
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of APCS mRNA"19692669
C0293704-toluidine4-toluidine results in decreased expression of APCS mRNA27638505
D000082AcetaminophenAcetaminophen results in decreased expression of APCS mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of APCS mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of APCS mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of APCS mRNA]17585979
D020106AcrylamideAcrylamide results in decreased expression of APCS mRNA28959563
C096064acteinactein results in decreased expression of APCS mRNA19527300
D016604Aflatoxin B1Aflatoxin B1 affects the expression of APCS protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of APCS mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of APCS gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of APCS mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of APCS mRNA28522335
D000638AmiodaroneAmiodarone affects the expression of APCS mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of APCS mRNA16483693
D001151ArsenicArsenic affects the methylation of APCS gene25304211
D001280AtrazineAtrazine results in decreased expression of APCS mRNA22982499
D001553BenzbromaroneBenzbromarone affects the expression of APCS mRNA19483382
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of APCS mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of APCS mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of APCS mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of APCS mRNA19770486|2171566
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of APCS mRNA22228805
D004958EstradiolEstradiol results in decreased expression of APCS mRNA20106945
C006780bisphenol Abisphenol A results in increased methylation of APCS promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of APCS mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of APCS mRNA18958704
D002104CadmiumAPCS protein binds to Cadmium23896426
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of APCS mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of APCS mRNA15963578
D002351CarrageenanCarrageenan results in increased expression of APCS protein22330755
D002509CephaloridineCephaloridine results in decreased expression of APCS mRNA18500788
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of APCS mRNA20938992
C041167chromium nitratechromium nitrate results in increased expression of APCS protein23618972
C019304ciprofibrateciprofibrate results in increased expression of APCS mRNA12771043
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of APCS mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of APCS mRNA]17585979
D002994ClofibrateClofibrate affects the expression of APCS mRNA19483382
D002994ClofibrateClofibrate results in decreased expression of APCS mRNA12851107
D002995Clofibric AcidClofibric Acid affects the expression of APCS mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of APCS mRNA24386269
D003042CocaineCocaine results in increased expression of APCS protein12714198
D003300CopperAPCS protein binds to Copper23896426
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of APCS mRNA15467011
C030123coumarincoumarin results in decreased expression of APCS mRNA18480146
D016572CyclosporineCyclosporine results in decreased expression of APCS mRNA20106945|2798913
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of APCS mRNA28962523
D004008DiclofenacDiclofenac results in increased expression of APCS mRNA26934552
D004008DiclofenacDiclofenac results in increased expression of APCS protein26934552
D004008Diclofenac"[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of APCS protein"25772430
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of APCS mRNA28085963
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of APCS mRNA18164116
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of APCS mRNA27638505
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of APCS mRNA23550701
D005001EthionineEthionine affects the expression of APCS mRNA19483382
D005459FluoridesAPCS protein affects the metabolism of and affects the susceptibility to Fluorides23308176
D005485FlutamideFlutamide results in decreased expression of APCS mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of APCS mRNA20938992
C056933fumonisin B1fumonisin B1 results in decreased expression of APCS mRNA16221962
C039281furanfuran results in decreased expression of APCS mRNA25539665
C056507gemcitabinegemcitabine results in decreased expression of APCS protein20531411
D006493HeparinHeparin results in increased expression of APCS protein17162433
D048628KetolidesKetolides analog results in increased expression of APCS mRNA24967691
D007657Ketone BodiesKetone Bodies results in decreased expression of APCS mRNA16807920
D007854LeadAPCS protein binds to Lead23896426
C482199lipopolysaccharide, E coli O55-B5"1,7-dimethylxanthine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of APCS protein]"19962977
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of APCS protein"19962977
C482199lipopolysaccharide, E coli O55-B5"[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of APCS protein"25772430
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of APCS protein9205823
D008070LipopolysaccharidesAPCS protein affects the susceptibility to Lipopolysaccharides21731756
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of APCS mRNA17321000|2733941
D008466MechlorethamineMechlorethamine results in increased expression of APCS mRNA26273949
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of APCS mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of APCS protein24055825
D009151Mustard GasMustard Gas results in increased expression of APCS protein11428626
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of APCS mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of APCS"21654424
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of APCS mRNA"25620056
D009532NickelAPCS protein binds to Nickel23896426
C037473nickel hydroxide (II)nickel hydroxide (II) analog results in increased expression of APCS mRNA20864429|2427854
C037473nickel hydroxide (II)nickel hydroxide (II) analog results in increased expression of APCS protein24278546
D000069463Olive OilOlive Oil analog affects the expression of APCS mRNA17349074
D009853OmeprazoleOmeprazole affects the expression of APCS mRNA19483382
C016030pantogabpantogab results in increased expression of APCS mRNA17379144
D052638Particulate MatterParticulate Matter results in increased expression of APCS mRNA21708214|2427854
D052638Particulate MatterParticulate Matter results in increased expression of APCS protein24278546
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of APCS mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of APCS mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of APCS mRNA18467677|2093613
C023036perfluorooctanoic acidPPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of APCS mRNA]18467677
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of APCS mRNA19162173
D010634PhenobarbitalPhenobarbital results in increased expression of APCS mRNA19363144
C006253pirinixic acidpirinixic acid results in decreased expression of APCS mRNA16221962|1732100
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in decreased expression of APCS mRNA]17321000
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of APCS mRNA]20059764
C006253pirinixic acidpirinixic acid affects the expression of APCS mRNA19483382
C006253pirinixic acidpirinixic acid results in decreased expression of APCS mRNA19162173|2248451
D028321Plant PreparationsPlant Preparations results in increased expression of APCS mRNA24973489
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of APCS protein23618972
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of APCS mRNA28903501
D011441PropylthiouracilPropylthiouracil affects the expression of APCS mRNA19483382
D054328Proton Pump InhibitorsProton Pump Inhibitors results in decreased expression of APCS mRNA25626140
C030984pyrenepyrene results in increased expression of APCS mRNA15963578
D022641Shiga Toxin 2APCS protein binds to Shiga Toxin 221731756
D012969Sodium FluorideSodium Fluoride results in increased expression of APCS protein28918527
D013629TamoxifenTamoxifen results in decreased expression of APCS protein11156862
D013629TamoxifenTamoxifen results in decreased expression of APCS mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of APCS mRNA20106945
D013749TetrachlorodibenzodioxinAHR gene mutant form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of APCS mRNA]22978700
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of APCS mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of APCS mRNA22978700|2629044
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of APCS mRNA16054898|1879615
D013853ThioacetamideThioacetamide affects the expression of APCS mRNA19483382
D014028Tobacco Smoke Pollution[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of APCS protein24096154
D014028Tobacco Smoke PollutionTobacco Smoke Pollution deficiency inhibits the reaction [[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of APCS protein]24096154
C032910triadimefontriadimefon results in increased expression of APCS mRNA19363144
C057693troglitazonetroglitazone results in decreased expression of APCS mRNA25572481
D014415TunicamycinTunicamycin results in increased expression of APCS mRNA22414386
D000068756ValsartanValsartan results in decreased expression of APCS protein16129801
D015032ZincAPCS protein binds to Zinc23896426

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001849complement component C1q binding-IBA21873635  
GO:0001849complement component C1q binding-IDA23544079  
GO:0005509calcium ion binding-IDA23544079  
GO:0030169low-density lipoprotein particle binding-IBA21873635  
GO:0030246carbohydrate binding-IEA-  
GO:0042802identical protein binding-IPI19372378  23850452  
GO:0046790virion binding-IDA23544079  
GO:0051082unfolded protein binding-TAS10812074  
GO ID GO Term Qualifier Evidence PubMed
GO:0002674negative regulation of acute inflammatory response-IC14607961  
GO:0006457protein folding-TAS10812074  
GO:0006953acute-phase response-TAS2987268  
GO:0006958complement activation, classical pathway-IBA21873635  
GO:0044267cellular protein metabolic process-TAS-  
GO:0044793negative regulation by host of viral process-IBA21873635  
GO:0044869negative regulation by host of viral exo-alpha-sialidase activity-IDA23544079  
GO:0044871negative regulation by host of viral glycoprotein metabolic process-IDA23544079  
GO:0045087innate immune response-IBA21873635  
GO:0045087innate immune response-IDA23544079  
GO:0045656negative regulation of monocyte differentiation-IDA14607961  
GO:0046597negative regulation of viral entry into host cell-IDA23544079  
GO:0048525negative regulation of viral process-IDA23544079  
GO:0051131chaperone-mediated protein complex assembly-TAS10972085  
GO:0061045negative regulation of wound healing-IC14607961  
GO:1903016negative regulation of exo-alpha-sialidase activity-IDA23544079  
GO:1903019negative regulation of glycoprotein metabolic process-IDA23544079  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-HDA27068509  
GO:0005576extracellular region-NAS14718574  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA20551380  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA14607961  23544079  
GO:0005634nucleus-HDA21630459  
GO:0062023collagen-containing extracellular matrix-HDA27559042  
GO:0062023collagen-containing extracellular matrixcolocalizes_withHDA20551380  
GO:0070062extracellular exosome-HDA19056867  23533145  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-977225Amyloid fiber formationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22261033Cigarette smoke induction of osteopontin (SPP1) mediates T(H)17 inflammation in human and experimental emphysema. (2012 Jan 18)Shan MSci Transl Med
26437452Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema. (2015 Oct 5)You RElife
17458584Temporal patterns in lung cancer death rates in Ireland. (2007 Jul-Sep)Kabir ZIr J Med Sci
19635922Concomitant inhalation of cigarette smoke and aerosolized protein activates airway dendritic cells and induces allergic airway inflammation in a TLR-independent way. (2009 Aug 15)Robays LJJ Immunol
23527127Continuous and discontinuous cigarette smoke exposure differentially affects protective Th1 immunity against pulmonary tuberculosis. (2013)Shaler CRPLoS One
6465006Cigarette smoking and ventricular arrhythmia in coronary heart disease. (1984 Aug 1)Davis MJAm J Cardiol
26437241The microRNA miR-22 inhibits the histone deacetylase HDAC4 to promote T(H)17 cell-dependent emphysema. (2015 Nov)Lu WNat Immunol