Gene: HPR

3250
A-259H10.2|HP
haptoglobin-related protein
protein-coding
16q22.2
Ensembl:ENSG00000261701 MIM:140210 Vega:OTTHUMG00000173010 UniprotKB:P00739
NG_030311.1
PubMed
0   ANCO-SNPs
ND
8   
2.320e-1 (AD)  9.130e-2 (ND)   (Frontal_Cortex)
4.996e-1 (AD)  6.326e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC25A180.63
NWD10.587
LFNG0.583
MT1F0.576
GRTP10.567
SMOX0.566
PHYHD10.561
RLBP10.56
SLC39A120.557
MT1E0.556

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TC2N-0.489
CLVS1-0.433
AFP-0.412
ARHGAP20-0.41
KCNT2-0.409
ARNTL2-0.407
TXK-0.4
L3MBTL3-0.396
TRAF5-0.394
NPY5R-0.392

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 affects the expression of HPR protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of HPR mRNA21641981|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HPR gene27153756
D001379AzathioprineAzathioprine results in decreased expression of HPR mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HPR mRNA21632981
D002104CadmiumHPR protein binds to Cadmium23896426
D003300CopperHPR protein binds to Copper23896426
D019327Copper SulfateCopper Sulfate results in decreased expression of HPR mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of HPR mRNA20106945|2798913
D003907DexamethasoneDexamethasone results in increased expression of HPR mRNA25047013
C000944dicrotophosdicrotophos results in decreased expression of HPR mRNA28302478
D008727MethotrexateMethotrexate results in decreased expression of HPR mRNA24449571
D009532NickelHPR protein binds to Nickel23896426
C046012pentanalpentanal results in decreased expression of HPR mRNA26079696
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of HPR mRNA19710929
D011794QuercetinQuercetin results in decreased expression of HPR mRNA21632981
C016766sulforafansulforafan results in increased expression of HPR mRNA26833863
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HPR mRNA20106945|2163298
D014520UrethaneUrethane results in decreased expression of HPR mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of HPR mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of HPR gene29154799
D015032ZincHPR protein binds to Zinc23896426

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-IBA21873635  
GO:0030492hemoglobin binding-NAS2987228  
GO ID GO Term Qualifier Evidence PubMed
GO:0002526acute inflammatory response-IBA21873635  
GO:0006898receptor-mediated endocytosis-TAS-  
GO:0010033response to organic substance-IBA21873635  
GO:0010942positive regulation of cell death-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0034366spherical high-density lipoprotein particle-IDA16682745  
GO:0070062extracellular exosome-HDA23533145  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
hsa05143African trypanosomiasis
Reactome ID Reactome Term Evidence
R-HSA-2168880Scavenging of heme from plasmaTAS
R-HSA-2173782Binding and Uptake of Ligands by Scavenger ReceptorsTAS
R-HSA-5653656Vesicle-mediated transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26247099Predictors of high on-clopidogrel platelet reactivity in patients with acute coronary syndrome. (2016)Lee SPlatelets
15756035Effect of the synthetic retinoid fenretinide on circulating free prostate-specific antigen, insulin-like growth factor-I, and insulin-like growth factor binding protein-3 levels in men with superficial bladder cancer. (2005 Mar 1)Serrano DClin Cancer Res
22440495Cigarette smoking is associated with a dose-response effect in clopidogrel-treated patients with diabetes mellitus and coronary artery disease: results of a pharmacodynamic study. (2012 Mar)Ueno MJACC Cardiovasc Interv
23651444Factors affecting residual platelet aggregation in prasugrel treated patients. (2013)Alexopoulos DCurr Pharm Des
22507978Accelerated platelet inhibition by switching from atorvastatin to a non-CYP3A4-metabolized statin in patients with high platelet reactivity (ACCEL-STATIN) study. (2012 Sep)Park YEur Heart J
28877606Discordance Between VASP Phosphorylation and Platelet Aggregation in Defining High On-Clopidogrel Platelet Reactivity After ST-Segment Elevation Myocardial Infarction. (2018 Jan)Sun JClin Appl Thromb Hemost
25860557Correlation Between SNPs in Candidate Genes and VerifyNow-Detected Platelet Responsiveness to Aspirin and Clopidogrel Treatment. (2015 Apr)Cui HCardiovasc Drugs Ther
23602770The influence of smoking status on the pharmacokinetics and pharmacodynamics of clopidogrel and prasugrel: the PARADOX study. (2013 Aug 6)Gurbel PAJ Am Coll Cardiol