Gene: AIRE

326
AIRE1|APECED|APS1|APSI|PGA1
autoimmune regulator
protein-coding
21q22.3
Ensembl:ENSG00000160224 MIM:607358 Vega:OTTHUMG00000086921 UniprotKB:O43918
NG_009556.1
PubMed
0   ANCO-SNPs
CD|ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.342e-1 (AD)  3.908e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EMB0.638
PCBP30.629
SLC47A10.624
PCSK70.62
LTB4R0.608
CD163L10.604
PTP4A30.601
LTB4R20.588
FCHSD10.584
VSTM10.583

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RXRG-0.397
PYGM-0.377
ARSF-0.371
HSD17B6-0.37
SLC25A48-0.362
DIO2-0.355
HPSE2-0.347
NWD1-0.336
SLC13A5-0.323
GABRG1-0.322

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C496492abrineabrine results in increased expression of AIRE mRNA22595364
D000082AcetaminophenAcetaminophen results in decreased expression of AIRE mRNA22230336
D020106AcrylamideAcrylamide results in decreased expression of AIRE mRNA28959563
D001151ArsenicArsenic affects the expression of AIRE mRNA28793237
D001151Arsenic[Arsenic results in increased abundance of Cacodylic Acid] which affects the expression of AIRE mRNA28793237
C006780bisphenol Abisphenol A results in decreased expression of AIRE mRNA25181051
D002101Cacodylic Acid[Arsenic results in increased abundance of Cacodylic Acid] which affects the expression of AIRE mRNA28793237
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of AIRE promoter22457795
C100187chloropicrinchloropicrin results in increased expression of AIRE mRNA26352163
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of AIRE mRNA21179406
D008353MannitolMannitol results in decreased expression of AIRE mRNA25270620
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of AIRE mRNA26011545
D010936Plant ExtractsPlant Extracts results in decreased expression of AIRE mRNA23557933
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of AIRE mRNA19042947
D014635Valproic AcidValproic Acid results in increased methylation of AIRE gene29154799
D024483Vitamin K 3Vitamin K 3 results in decreased expression of AIRE mRNA25270620

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IDA11533054  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IC-  
GO:0003682chromatin binding-IDA18292755  
GO:0005515protein binding-IPI17474147  18292755  20085707  20185822  
GO:0008270zinc ion binding-IDA19446523  
GO:0042393histone binding-IDA18292755  19446523  
GO:0042802identical protein binding-IEA-  
GO:0044212transcription regulatory region DNA binding-IDA18292755  
GO:0045182translation regulator activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002458peripheral T cell tolerance induction-ISS-  
GO:0002509central tolerance induction to self antigen-IMP26084028  
GO:0006355regulation of transcription, DNA-templated-IDA18292755  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0006417regulation of translation-IEA-  
GO:0006955immune response-TAS9398840  
GO:0006959humoral immune response-IEA-  
GO:0032602chemokine production-ISS-  
GO:0045060negative thymic T cell selection-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IDA18292755  
GO:0045893positive regulation of transcription, DNA-templated-IMP26084028  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP11274163  
GO:0097536thymus epithelium morphogenesis-ISS-  
GO:2000410regulation of thymocyte migration-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-NAS9398840  
GO:0005737cytoplasm-IEA-  
GO:0016604nuclear body-ISS-  
KEGG ID KEGG Term
hsa04120Ubiquitin mediated proteolysis
hsa05340Primary immunodeficiency
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15330130Air pollution and respiratory status in asthmatic children: hints for a locally based preventive strategy. AIRE study. (2004)Ranzi AEur J Epidemiol
27242100[Indoor air pollution by fine particulate matter in the homes of newborns]. (2016 Sep - Oct)Barria RMRev Chil Pediatr
20489056Hypomorphic Rag mutations can cause destructive midline granulomatous disease. (2010 Aug 26)De Ravin SSBlood