Gene info: ID 3263

Gene: HPX

GENE ID: 3263

Synonyms: HX

Description: hemopexin

Gene type: protein-coding

Location: 11p15.4

dbXrefs: Ensembl:ENSG00000110169 MIM:142290 Vega:OTTHUMG00000133399 UniprotKB:P02790

RefSeq: NC_000011.10

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.996e-1 (AD) 1.256e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CFP	0.679
GNB3	0.606
ATF7IP2	0.577
NOP2	0.573
LRP2BP	0.569
PUS1	0.566
CEP95	0.56
AKR7L	0.559
KCNN4	0.557
LRRC37A3	0.556

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GSDMC	-0.297
PDE11A	-0.296
SMIM1	-0.284
TRDN	-0.268
BCHE	-0.255
CRYBG3	-0.246
HMSD	-0.227
OR9A2	-0.227
OR4F5	-0.22
KLRC3	-0.22

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of HPX mRNA"	25614096
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of HPX mRNA"	23962555
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of HPX mRNA"	21346803
D000082	Acetaminophen	Acetaminophen affects the expression of HPX mRNA	25064622
D000082	Acetaminophen	Acetaminophen results in decreased expression of HPX mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of HPX mRNA	17562736
D000082	Acetaminophen	Acetaminophen affects the expression of HPX protein	16099942
D000082	Acetaminophen	Acetaminophen results in increased expression of HPX protein	16687475
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of HPX protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of HPX gene	28458013
D000447	Aldehydes	Aldehydes results in decreased expression of HPX mRNA	25014914
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin analog results in decreased expression of HPX protein	26597043
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin analog results in increased expression of HPX protein	26072098
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of HPX protein	26597043
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of HPX protein	26072098
C061621	alpha-naphthyl isocyanate	alpha-naphthyl isocyanate affects the expression of HPX protein	16099942
D000638	Amiodarone	Amiodarone affects the expression of HPX mRNA	25064622
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of HPX mRNA	16483693
C028559	bathocuproine sulfonate	bathocuproine sulfonate inhibits the reaction [[cobaltiprotoporphyrin co-treated with HPX protein] affects the localization of MTF1 protein]	11213479
C028559	bathocuproine sulfonate	bathocuproine sulfonate inhibits the reaction [[cobaltiprotoporphyrin co-treated with HPX protein] results in increased expression of MTF1 mRNA]	11213479
C028559	bathocuproine sulfonate	bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein]	11213479
C487081	belinostat	belinostat results in decreased expression of HPX mRNA	27188386
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in decreased expression of HPX mRNA	19737606
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of HPX mRNA	20440473
D004958	Estradiol	Estradiol results in decreased expression of HPX mRNA	24223173
D004958	Estradiol	Estradiol results in decreased expression of HPX mRNA	21984479
C006780	bisphenol A	bisphenol A results in increased expression of HPX mRNA	26364221
C006780	bisphenol A	bisphenol A results in increased expression of HPX mRNA	24586524
C006780	bisphenol A	bisphenol A results in increased expression of HPX mRNA	24534842
C006780	bisphenol A	bisphenol A affects the expression of HPX mRNA	25181051
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of HPX mRNA	18958704
D001761	Bleomycin	Bleomycin results in increased expression of HPX protein	25933445
C053342	brevetoxin	brevetoxin analog results in decreased expression of HPX mRNA	14529743
C013418	bromfenacoum	bromfenacoum results in increased expression of HPX protein	28903499
C018475	butyraldehyde	butyraldehyde results in decreased expression of HPX mRNA	26079696
D002104	Cadmium	HPX protein binds to Cadmium	23896426
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of HPX mRNA	27671773
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of HPX mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of HPX mRNA	16239168
D002737	Chloroprene	Chloroprene results in increased expression of HPX mRNA	23125180
D002746	Chlorpromazine	Chlorpromazine affects the expression of HPX mRNA	25064622
D002922	Ciguatoxins	Ciguatoxins affects the expression of HPX mRNA	18353800
C007095	cobaltiprotoporphyrin	bathocuproine sulfonate inhibits the reaction [[cobaltiprotoporphyrin co-treated with HPX protein] affects the localization of MTF1 protein]	11213479
C007095	cobaltiprotoporphyrin	bathocuproine sulfonate inhibits the reaction [[cobaltiprotoporphyrin co-treated with HPX protein] results in increased expression of MTF1 mRNA]	11213479
C007095	cobaltiprotoporphyrin	cobaltiprotoporphyrin binds to HPX protein	19039664
C007095	cobaltiprotoporphyrin	[cobaltiprotoporphyrin binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]	19039664
C007095	cobaltiprotoporphyrin	[cobaltiprotoporphyrin binds to HPX protein] which results in increased degradation of CCS protein	19039664
C007095	cobaltiprotoporphyrin	[cobaltiprotoporphyrin binds to HPX protein] which results in increased expression of MT1 mRNA	12042074
C007095	cobaltiprotoporphyrin	[cobaltiprotoporphyrin binds to HPX protein] which results in increased expression of MT2 mRNA	12042074
C007095	cobaltiprotoporphyrin	[cobaltiprotoporphyrin co-treated with HPX protein] affects the activity of MT1 promoter	11213479
C007095	cobaltiprotoporphyrin	[cobaltiprotoporphyrin co-treated with HPX protein] affects the localization of MTF1 protein	11213479
C007095	cobaltiprotoporphyrin	[cobaltiprotoporphyrin co-treated with HPX protein] results in increased expression of MTF1 mRNA	11213479
C007095	cobaltiprotoporphyrin	hexamethylene bisacetamide promotes the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased expression of MT1 mRNA]	12042074
C007095	cobaltiprotoporphyrin	hexamethylene bisacetamide promotes the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased expression of MT2 mRNA]	12042074
C007095	cobaltiprotoporphyrin	lactacystin inhibits the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased degradation of CCS protein]	19039664
C007095	cobaltiprotoporphyrin	cobaltiprotoporphyrin binds to HPX protein	12042074
C018021	cobaltous chloride	cobaltous chloride results in increased expression of HPX mRNA	24612858
D003300	Copper	HPX protein binds to Copper	23896426
D003300	Copper	Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]	19039664
D003300	Copper	Copper inhibits the reaction [Heme binds to HPX protein]	19039664
D003300	Copper	Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]]	19039664
D003300	Copper	Copper results in increased expression of HPX protein	22480594
D003300	Copper	Copper results in decreased expression of HPX mRNA	22465980
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of HPX mRNA	19549813
C029892	cupric chloride	cupric chloride affects the expression of HPX mRNA	21072851
C029892	cupric chloride	cupric chloride results in increased expression of HPX mRNA	21072851
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of HPX protein	26984711
D016572	Cyclosporine	Cyclosporine affects the expression of HPX mRNA	25064622
D016572	Cyclosporine	Cyclosporine results in decreased expression of HPX mRNA	20106945
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in decreased expression of HPX mRNA	28962523
D002945	Cisplatin	Cisplatin results in increased expression of HPX mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased secretion of HPX protein	28885000
D004041	Dietary Fats	Dietary Fats results in decreased expression of HPX mRNA	25016146
D004147	Dioxins	Dioxins affects the expression of HPX mRNA	20463971
D004317	Doxorubicin	Doxorubicin results in increased secretion of HPX protein	28885000
C118739	entinostat	entinostat results in decreased expression of HPX mRNA	27188386
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of HPX protein	23301498
D000431	Ethanol	Ethanol results in increased expression of HPX protein	19609968
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of HPX mRNA	25064622
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of HPX mRNA	17555576
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HPX mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of HPX mRNA	16940010\|1710823
C054207	etomoxir	etomoxir results in decreased expression of HPX mRNA	19234235
C017690	fenvalerate	fenvalerate affects the expression of HPX mRNA	20003521
D005459	Fluorides	Fluorides results in increased expression of HPX protein	25556215
D005472	Fluorouracil	TP53 protein affects the reaction [Fluorouracil results in decreased expression of HPX mRNA]	15016801
D005473	Fluoxetine	Fluoxetine results in decreased expression of HPX mRNA	21852994
C056933	fumonisin B1	fumonisin B1 results in increased expression of HPX mRNA	16221962
C039281	furan	furan results in decreased expression of HPX mRNA	25539665\|2619464
D019833	Genistein	Genistein results in increased expression of HPX protein	22649256
C010974	glyphosate	glyphosate results in increased expression of HPX mRNA	16532367
D006418	Heme	bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein]	11213479
D006418	Heme	Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]	19039664
D006418	Heme	Copper inhibits the reaction [Heme binds to HPX protein]	19039664
D006418	Heme	Heme binds to HPX protein	19039664
D006418	Heme	[Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]	19039664
D006418	Heme	[Heme binds to HPX protein] which results in increased degradation of CCS protein	19039664
D006418	Heme	[Heme binds to HPX protein] which results in increased expression of HMOX1 protein	19039664
D006418	Heme	[Heme co-treated with HPX protein] affects the activity of MT1 promoter	11213479
D006418	Heme	[Heme co-treated with HPX protein] affects the localization of MTF1 protein	11213479
D006418	Heme	lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein]	19039664
D006418	Heme	Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]]	19039664
D006418	Heme	Heme binds to HPX protein	12042074
D006418	Heme	[Heme binds to HPX protein] which affects the expression of HMOX1	12042074
D006418	Heme	[Heme binds to HPX protein] which affects the expression of MT1	12042074
D006418	Heme	[Heme binds to HPX protein] which results in increased expression of HMOX1 mRNA	19039664
D006418	Heme	[[Heme binds to HPX protein] which results in increased expression of HMOX1 mRNA] which affects the expression of CCS mRNA	19039664
C014026	hexamethylene bisacetamide	hexamethylene bisacetamide inhibits the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of HMOX1 mRNA]	12042074
C014026	hexamethylene bisacetamide	hexamethylene bisacetamide promotes the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased expression of MT1 mRNA]	12042074
C014026	hexamethylene bisacetamide	hexamethylene bisacetamide promotes the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased expression of MT2 mRNA]	12042074
C014026	hexamethylene bisacetamide	hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT1 mRNA]	12042074
C014026	hexamethylene bisacetamide	hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT2 mRNA]	12042074
D017313	Fenretinide	Fenretinide results in increased expression of HPX mRNA	28973697
C029424	hydrazine	hydrazine results in increased expression of HPX mRNA	15282401
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of HPX mRNA	27432991
C067713	lactacystin	lactacystin inhibits the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased degradation of CCS protein]	19039664
C067713	lactacystin	lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein]	19039664
D007854	Lead	HPX protein binds to Lead	23896426
C052901	lemongrass oil	lemongrass oil affects the expression of HPX mRNA	25976427
D015122	Mercaptopurine	Mercaptopurine results in increased expression of HPX mRNA	23358152
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of HPX mRNA	20353558
D008628	Mercury	Mercury results in increased expression of HPX mRNA	21195448
D008628	Mercury	Mercury affects the expression of HPX protein	22030286
C031468	mesoporphyrin IX	hexamethylene bisacetamide inhibits the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of HMOX1 mRNA]	12042074
C031468	mesoporphyrin IX	hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT1 mRNA]	12042074
C031468	mesoporphyrin IX	hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT2 mRNA]	12042074
C031468	mesoporphyrin IX	[mesoporphyrin IX binds to HPX protein] which results in increased expression of HMOX1 mRNA	12042074
C031468	mesoporphyrin IX	[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT1 mRNA	12042074
C031468	mesoporphyrin IX	[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT2 mRNA	12042074
C031468	mesoporphyrin IX	mesoporphyrin IX binds to HPX protein	12042074
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of HPX mRNA	23103053
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of HPX protein	22265609
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of HPX mRNA"	23845593
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of HPX mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of HPX mRNA"	25554681\|2562005
D009532	Nickel	HPX protein binds to Nickel	23896426
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in decreased expression of HPX protein	19716841
C076029	olanzapine	olanzapine affects the phosphorylation of HPX protein	25821032
D010126	Ozone	[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of HPX mRNA	25658374
D010126	Ozone	[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of HPX mRNA	25658374
D010126	Ozone	Ozone results in increased expression of HPX mRNA	17460151
D010126	Ozone	pyrazolanthrone inhibits the reaction [Ozone results in increased expression of HPX mRNA]	17460151
D010269	Paraquat	Paraquat affects the expression of HPX mRNA	25064622
C046012	pentanal	pentanal results in decreased expression of HPX mRNA	26079696
C036567	perfluorodecanoic acid	perfluorodecanoic acid results in decreased expression of HPX mRNA	21984479
C522391	perfluorododecanoic acid	perfluorododecanoic acid results in increased expression of HPX protein	26168851
C101816	perfluoro-n-nonanoic acid	perfluoro-n-nonanoic acid results in decreased expression of HPX mRNA	21984479
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in decreased expression of HPX mRNA	23602845
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of HPX mRNA	21984479
C006253	pirinixic acid	[pirinixic acid co-treated with PPARA] results in decreased expression of HPX mRNA	20813756
C006253	pirinixic acid	pirinixic acid results in decreased expression of HPX mRNA	16221962\|2081375
C006253	pirinixic acid	pirinixic acid affects the expression of HPX protein	16099942
C006253	pirinixic acid	pirinixic acid results in decreased expression of HPX mRNA	16940010
D028321	Plant Preparations	Plant Preparations results in decreased expression of HPX protein	28284660
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of HPX mRNA	23608068
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of HPX mRNA	28903501
C005556	propionaldehyde	propionaldehyde results in decreased expression of HPX mRNA	26079696
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Ozone results in increased expression of HPX mRNA]	17460151
D012524	Sarin	Sarin results in decreased expression of HPX protein	26778279
C110822	SDZ CPI 975	SDZ CPI 975 results in decreased expression of HPX mRNA	19234235
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of HPX mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of HPX mRNA	22431001
C009277	sodium arsenate	sodium arsenate results in decreased expression of HPX mRNA	23922661
C017947	sodium arsenite	sodium arsenite affects the expression of HPX mRNA	20451245
C017947	sodium arsenite	sodium arsenite results in increased expression of HPX mRNA	16356559
C017947	sodium arsenite	sodium arsenite affects the expression of HPX mRNA	17450228
C016104	sodium bichromate	sodium bichromate results in decreased expression of HPX mRNA	24612858
D053260	Soot	Soot results in increased expression of HPX mRNA	22461453\|2655175
D013629	Tamoxifen	Tamoxifen affects the expression of HPX mRNA	17555576
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HPX mRNA	21632981
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of HPX mRNA	28922406
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HPX mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HPX gene]	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HPX mRNA	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HPX protein	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HPX mRNA	15703262
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of HPX mRNA	16267337
D013752	Tetracycline	Tetracycline affects the expression of HPX mRNA	25064622
D013853	Thioacetamide	Thioacetamide affects the expression of HPX mRNA	25064622
C009495	titanium dioxide	titanium dioxide results in increased expression of HPX mRNA	23557971\|2776080
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of HPX protein	19478969
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of HPX mRNA	20133372
D013721	Triethylenephosphoramide	[cobaltiprotoporphyrin binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]	19039664
D013721	Triethylenephosphoramide	[Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]	19039664
D013721	Triethylenephosphoramide	Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]]	19039664
C057693	troglitazone	troglitazone results in decreased expression of HPX mRNA	25572481
D014502	Uranyl Nitrate	Uranyl Nitrate results in increased expression of HPX protein	23261757
D014635	Valproic Acid	Valproic Acid affects the expression of HPX mRNA	25064622
D014635	Valproic Acid	Valproic Acid affects the expression of HPX mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of HPX mRNA	29154799
C025643	vinclozolin	vinclozolin results in increased expression of HPX mRNA	22570695
D015032	Zinc	HPX protein binds to Zinc	23896426
D015034	Zinc Oxide	Zinc Oxide analog results in decreased expression of HPX mRNA	27215404

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IBA	21873635
GO:0005515	protein binding	-	IPI	20610401
GO:0008237	metallopeptidase activity	-	IBA	21873635
GO:0008237	metallopeptidase activity	NOT	IBA	21873635
GO:0015232	heme transporter activity	-	IEA	-
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002639	positive regulation of immunoglobulin production	-	IEA	-
GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin	-	IEA	-
GO:0006879	cellular iron ion homeostasis	-	IEA	-
GO:0006898	receptor-mediated endocytosis	-	TAS	-
GO:0015886	heme transport	-	IEA	-
GO:0016032	viral process	-	IEA	-
GO:0020027	hemoglobin metabolic process	-	IBA	21873635
GO:0020027	hemoglobin metabolic process	-	IEA	-
GO:0042168	heme metabolic process	-	IBA	21873635
GO:0042168	heme metabolic process	-	IEA	-
GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	-	IEA	-
GO:0060335	positive regulation of interferon-gamma-mediated signaling pathway	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	NAS	14718574
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	HDA	16502470
GO:0005615	extracellular space	-	IDA	19433579
GO:0070062	extracellular exosome	-	HDA	19056867 23533145
GO:0071682	endocytic vesicle lumen	-	TAS	-
GO:0072562	blood microparticle	-	HDA	22516433

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-2168880	Scavenging of heme from plasma	TAS
R-HSA-2173782	Binding and Uptake of Ligands by Scavenger Receptors	TAS
R-HSA-5653656	Vesicle-mediated transport	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23681825	Heme-related gene expression signatures of meat intakes in lung cancer tissues. (2014 Jul)	Lam TK	Mol Carcinog
25683563	Are normolipidaemic patients with xanthelasma prone to atherosclerosis? (2015 Jun)	Esmat S	Clin Exp Dermatol