Gene: HRAS

3265
C-BAS/HAS|C-H-RAS|C-HA-RAS1|CTLO|H-RASIDX|HAMSV|HRAS1|RASH1|p21ras
HRas proto-oncogene, GTPase
protein-coding
11p15.5
Ensembl:ENSG00000174775 MIM:190020 Vega:OTTHUMG00000131919 UniprotKB:P01112
NG_007666.1
PubMed
ND|AD
12   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.026e-1 (AD)  8.202e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NDUFA130.946
NDUFB100.945
CCDC1240.945
GPX40.942
NDUFB70.94
C19orf700.94
HCFC1R10.94
AURKAIP10.936
EDF10.934
USE10.934

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.794
OR4F29-0.783
PZP-0.298
FCGR3B-0.297
KCNJ15-0.295
CXCR2-0.292
VNN1-0.287
VNN2-0.277
CXCR1-0.276
RAET1E-0.274

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02210Hexane-1,6-DiolSmall Molecule629-11-8ExperimentalTarget
DB03226TrifluoroethanolSmall MoleculeExperimentalTarget
DB04137Guanosine-5'-TriphosphateSmall Molecule86-01-1ExperimentalTarget
DB04315Guanosine-5'-DiphosphateSmall Molecule146-91-8ExperimentalTarget
DB08751N,N'-DIMETHYL-N-(ACETYL)-N'-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)ETHYLENEDIAMINESmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0979491,25-dihydroxyvitamin D"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [HRAS protein inhibits the reaction [1,25-dihydroxyvitamin D results in increased activity of VDR protein]]"18829283
C0979491,25-dihydroxyvitamin D"HRAS protein inhibits the reaction [1,25-dihydroxyvitamin D results in increased activity of VDR protein]"18829283
C0320411,2-diphenylhydrazine"[Copper co-treated with 1,2-diphenylhydrazine] results in increased mutagenesis of HRAS gene"10798712
C0320411,2-diphenylhydrazine"piperidine promotes the reaction [[Copper co-treated with 1,2-diphenylhydrazine] results in increased mutagenesis of HRAS gene]"10798712
C0317631,3-butadiene"1,3-butadiene results in increased mutagenesis of HRAS gene"11397402
C0477771-amino-2,4-dibromoanthraquinone"1-amino-2,4-dibromoanthraquinone results in increased mutagenesis of HRAS gene"11560247
C0326681-nitropyrene1-nitropyrene results in increased expression of HRAS mRNA11911274|9891514
C0326681-nitropyrene1-nitropyrene affects the expression of HRAS mRNA11201684
C0319031-UFT protocolHRAS protein results in decreased susceptibility to 1-UFT protocol16734730
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of HRAS mRNA"21346803
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [HRAS protein inhibits the reaction [1,25-dihydroxyvitamin D results in increased activity of VDR protein]]"18829283
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [HRAS protein results in increased activity of MMP2 protein]23877152
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased expression of ATF6 protein24898257
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased expression of HSPA5 protein24898257
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased phosphorylation of AKT1 protein24898257
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased phosphorylation of RPS6KB1 protein24898257
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased phosphorylation of RPS6 protein24898257
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Tunicamycin co-treated with HRAS protein] results in increased expression of PCNA protein]24898257
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of HRAS mRNA"21346803
C5022392-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct"[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct] which results in increased mutagenesis of HRAS gene"12507937
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HRAS mRNA"22307971
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HRAS protein"22307971
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HRAS gene"15132766
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"HRAS protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased abundance of Reactive Oxygen Species]"22307971
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"HRAS protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NOX1 protein]"22307971
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"HRAS protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of MAPK1 protein]"22307971
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"HRAS protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of MAPK3 protein]"22307971
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"HRAS protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"22307971
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct] which results in increased mutagenesis of HRAS gene"12507937
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of and results in increased activity of HRAS"8039140
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HRAS gene"11165753|9433479
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HRAS gene] which results in increased activity of HRAS protein"9433479|9433479
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"Dietary Fats affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HRAS gene]"9433479
C0369892-amino-3,4-dimethylimidazo(4,5-f)quinoline"2-amino-3,4-dimethylimidazo(4,5-f)quinoline results in increased activity of HRAS"1540938
C0369892-amino-3,4-dimethylimidazo(4,5-f)quinoline"2-amino-3,4-dimethylimidazo(4,5-f)quinoline results in increased mutagenesis of HRAS"1540938
C0369892-amino-3,4-dimethylimidazo(4,5-f)quinoline"2-amino-3,4-dimethylimidazo(4,5-f)quinoline results in increased mutagenesis of HRAS gene"8844820
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased mutagenesis of HRAS gene"2009133
C0292162-amino-3-methylimidazo(4,5-f)quinoline"2-amino-3-methylimidazo(4,5-f)quinoline results in increased mutagenesis of HRAS gene"2009133|8844820
C0047262-dichlorobenzene2-dichlorobenzene results in increased expression of HRAS mRNA10614693
C0043692-phenylphenol[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene10334203
C0043692-phenylphenolbathocuproine inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene]10334203
C0043692-phenylphenolCAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene]10334203
C0415253,3',4,5'-tetrahydroxystilbene"3,3',4,5'-tetrahydroxystilbene inhibits the reaction [HRAS protein results in increased activity of MMP2 protein]"23877152
C0251603-aminobenzamide3-aminobenzamide inhibits the reaction [hydroquinone results in increased expression of HRAS protein]26047893
C0888604-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead acetate results in increased activity of HRAS protein]"19133285
C0067574-biphenylamine4-biphenylamine results in increased mutagenesis of HRAS gene15761837
C0248364-nitrophenolHRAS protein affects the glucuronidation of 4-nitrophenol11695553
C0804174-octylphenol"4-octylphenol affects the reaction [HRAS protein results in increased susceptibility to 9,10-Dimethyl-1,2-benzanthracene]"12117780
C0671348-oxo-7-hydrodeoxyguanosineHRAS protein mutant form results in increased abundance of 8-oxo-7-hydrodeoxyguanosine27517622
C0671348-oxo-7-hydrodeoxyguanosinePRDX1 protein inhibits the reaction [HRAS protein mutant form results in increased abundance of 8-oxo-7-hydrodeoxyguanosine]27517622
C503142ABT-100ABT-100 results in decreased farnesylation of HRAS protein15930366
D000082AcetaminophenAcetaminophen affects the expression of HRAS mRNA17562736
D000082AcetaminophenAcetaminophen results in increased activity of HRAS protein19739265
D000082AcetaminophenGliotoxin inhibits the reaction [Acetaminophen results in increased activity of HRAS protein]19739265
D000082Acetaminophenmanumycin inhibits the reaction [Acetaminophen results in increased activity of HRAS protein]19739265
D000111AcetylcysteineAcetylcysteine inhibits the reaction [HRAS protein mutant form results in increased susceptibility to sodium arsenite]25199681
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of HRAS mRNA]15945272
D020106AcrylamideAcrylamide results in decreased expression of HRAS mRNA28959563
D000244Adenosine DiphosphateAdenosine Diphosphate binds to and affects the folding of HRAS protein16388579
D016604Aflatoxin B1Aflatoxin B1 affects the expression of HRAS protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of HRAS mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of HRAS mRNA19770486
D019386AlendronateAlendronate results in decreased prenylation of HRAS protein9556058
C010845aluminum chloridealuminum chloride results in increased expression of HRAS mRNA22079183
C000228aristolochic acid Iaristolochic acid I results in increased mutagenesis of HRAS gene21642617
D001151ArsenicArsenic affects the methylation of HRAS gene25304211
C006632arsenic trioxide[Tetradecanoylphorbol Acetate co-treated with arsenic trioxide] results in increased expression of HRAS mRNA18922899
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of HRAS protein"21570478
D001218AspartameAspartame results in increased expression of HRAS17354619
D001280AtrazineAtrazine results in decreased expression of HRAS mRNA22378314
D001397AzoxymethaneAzoxymethane results in increased activity of HRAS protein12839936
D001397AzoxymethaneUrsodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased activity of HRAS protein]12839936
C002478bathocuproinebathocuproine inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene]10334203
C002478bathocuproinebathocuproine inhibits the reaction [[phenylhydroquinone co-treated with Copper] results in increased mutagenesis of HRAS gene]10334203
C018003benzo(a)pyrene-3,6-quinone"benzo(a)pyrene-3,6-quinone results in increased expression of HRAS mRNA"11008122
C017228benzo(a)pyrene 7,8-dihydrodiol"benzo(a)pyrene 7,8-dihydrodiol results in increased expression of HRAS mRNA"11008122
C002615benzo(c)phenanthrenebenzo(c)phenanthrene analog results in increased mutagenesis of HRAS gene7955041
D001564Benzo(a)pyreneBenzo(a)pyrene metabolite results in increased expression of HRAS mRNA11008122
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HRAS mRNA11008122|2163298
D001564Benzo(a)pyreneHRAS mRNA results in increased susceptibility to Benzo(a)pyrene22048643
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with Tetradecanoylphorbol Acetate] affects the mutagenesis of HRAS gene11765016
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HRAS mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HRAS mRNA18656336|2050435
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HRAS protein18656336
D001564Benzo(a)pyrene[chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of HRAS mRNA25820237
D001564Benzo(a)pyreneepicatechin gallate inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS mRNA]18656336
D001564Benzo(a)pyreneepicatechin gallate inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS protein]18656336
D001564Benzo(a)pyreneepigallocatechin gallate inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS mRNA]18656336
D001564Benzo(a)pyreneepigallocatechin gallate inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS protein]18656336
D001564Benzo(a)pyrenetheaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS mRNA]18656336
D001564Benzo(a)pyrenetheaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS protein]18656336
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HRAS mRNA19408242|2006408
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HRAS protein19408242|2006408
D001564Benzo(a)pyrene[Sulfur Dioxide co-treated with Benzo(a)pyrene] results in increased expression of HRAS mRNA19408242
D001564Benzo(a)pyrene[Sulfur Dioxide co-treated with Benzo(a)pyrene] results in increased expression of HRAS protein19408242
D001564Benzo(a)pyreneSulfur Dioxide promotes the reaction [Benzo(a)pyrene results in increased expression of HRAS mRNA]20064080
D001564Benzo(a)pyreneSulfur Dioxide promotes the reaction [Benzo(a)pyrene results in increased expression of HRAS protein]20064080
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of HRAS mRNA"18567617
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of HRAS protein"18567617
D001585Benzoyl Peroxide"[9,10-Dimethyl-1,2-benzanthracene co-treated with Benzoyl Peroxide] results in increased expression of HRAS mRNA"3115617
D001585Benzoyl Peroxide"[9,10-Dimethyl-1,2-benzanthracene co-treated with Benzoyl Peroxide] results in increased mutagenesis of HRAS gene"11241758|3115617
D001585Benzoyl PeroxideBenzoyl Peroxide results in increased mutagenesis of HRAS gene11241758
D001608BerylliumBeryllium results in increased mutagenesis of HRAS gene7545909
D004958Estradioldibenzoylmethane inhibits the reaction [Estradiol results in increased expression of HRAS mRNA]16051634
D004958EstradiolEstradiol affects the expression of HRAS mRNA21826169
D004958Estradiol"Estradiol affects the reaction [HRAS protein results in increased susceptibility to 9,10-Dimethyl-1,2-benzanthracene]"12117780
D004958EstradiolEstradiol results in increased expression of HRAS mRNA16051634|2309414
D004958EstradiolEstradiol results in increased expression of HRAS mRNA22467019
C477843bicyclolbicyclol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HRAS mRNA]17106253
C006780bisphenol Abisphenol A affects the expression of HRAS mRNA21826169
C487933BMS225975BMS225975 results in decreased farnesylation of HRAS protein18230616
D000069286BortezomibATG5 gene mutant form inhibits the reaction [HRAS protein promotes the reaction [Bortezomib results in increased cleavage of and results in increased activity of CASP3 protein]]22842577
D000069286BortezomibHRAS protein promotes the reaction [Bortezomib results in increased cleavage of and results in increased activity of CASP3 protein]22842577
D002084Butylated HydroxytolueneHRAS protein results in increased susceptibility to Butylated Hydroxytoluene11599794
D002084Butylated HydroxytolueneButylated Hydroxytoluene results in decreased methylation of HRAS gene9780227
D019256Cadmium ChlorideCadmium Chloride affects the expression of HRAS protein23376331
D019256Cadmium ChlorideHRAS protein mutant form affects the reaction [Cadmium Chloride results in decreased activity of CASP3 protein]23376331
D019256Cadmium ChlorideHRAS protein mutant form affects the susceptibility to Cadmium Chloride23376331
D002110Caffeine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HRAS mRNA"20230807
D002110Caffeine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HRAS mRNA]"20230807
D000001CalcimycinCalcimycin promotes the reaction [RASGRF2 protein binds to HRAS protein]16000378
D000069287CapecitabineHRAS protein results in decreased susceptibility to Capecitabine16734730
D002211CapsaicinCapsaicin results in increased expression of HRAS mRNA9461043
D002220CarbamazepineCarbamazepine affects the expression of HRAS mRNA24752500
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of HRAS mRNA8847708
D002273CarcinogensCarcinogens results in increased expression of HRAS mRNA2228319
D002713Chlorine[Ozone co-treated with Chlorine] results in decreased expression of HRAS mRNA18636392
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of HRAS mRNA8471063
D002737ChloropreneChloroprene results in increased mutagenesis of HRAS gene11397402
C074702chromium hexavalent ion[chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of HRAS mRNA25820237
D002922CiguatoxinsCiguatoxins affects the expression of HRAS mRNA18353800
D009243NAD[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene10334203
D009243NADbathocuproine inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene]10334203
D009243NADCAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene]10334203
D003300Copper[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene10334203
D003300Copperbathocuproine inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene]10334203
D003300Copperbathocuproine inhibits the reaction [[phenylhydroquinone co-treated with Copper] results in increased mutagenesis of HRAS gene]10334203
D003300CopperCAT protein inhibits the reaction [[2-phenylphenol metabolite co-treated with NAD co-treated with Copper] results in increased mutagenesis of HRAS gene]10334203
D003300CopperCAT protein inhibits the reaction [[phenylhydroquinone co-treated with Copper] results in increased mutagenesis of HRAS gene]10334203
D003300Copper[N-hydroxy-4-aminobiphenyl co-treated with Copper] results in increased mutagenesis of HRAS gene11275476
D003300Copper[phenylhydroquinone co-treated with Copper] results in increased mutagenesis of HRAS gene10334203
D003300Copper"[Copper co-treated with 1,2-diphenylhydrazine] results in increased mutagenesis of HRAS gene"10798712
D003300Copper"piperidine promotes the reaction [[Copper co-treated with 1,2-diphenylhydrazine] results in increased mutagenesis of HRAS gene]"10798712
D019327Copper SulfateCopper Sulfate results in decreased expression of HRAS mRNA19549813
D003401CreatineCreatine results in decreased expression of HRAS protein modified form15578723
D016572CyclosporineCyclosporine results in decreased expression of HRAS mRNA25562108
D003609DactinomycinDactinomycin promotes the reaction [[Zinostatin co-treated with Glutathione] results in increased cleavage of HRAS gene]9345283
C014347decitabinedecitabine results in decreased expression of HRAS mRNA19027819
D003840Deoxycholic AcidDeoxycholic Acid results in increased activity of HRAS protein18444174
D003907DexamethasoneDexamethasone inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to HRAS protein]]10807665
D003907DexamethasoneMifepristone inhibits the reaction [Dexamethasone inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to HRAS protein]]]10807665
C061481dibenzoylmethanedibenzoylmethane inhibits the reaction [Estradiol results in increased expression of HRAS mRNA]16051634
D002945CisplatinCisplatin affects the splicing of HRAS mRNA23613995
D002945CisplatinCisplatin promotes the reaction [jinfukang results in increased expression of HRAS mRNA]27392435
D002945CisplatinHRAS results in decreased susceptibility to Cisplatin21849418
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in increased expression of HRAS mRNA]27392435
D002945CisplatinCisplatin results in increased expression of HRAS mRNA25270620
D002945CisplatinCisplatin results in increased expression of HRAS mRNA18172885
D004008DiclofenacDiclofenac affects the expression of HRAS mRNA24752500
D004041Dietary FatsDietary Fats results in decreased expression of HRAS mRNA25016146
D004041Dietary Fats"Dietary Fats affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HRAS gene]"9433479
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of HRAS mRNA28085963
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with HRAS protein] results in increased activity of GOT1 protein12499697
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with HRAS protein] results in increased activity of MDH1 protein12499697
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of HRAS mRNA26464624
D004052DiethylnitrosamineDiethylnitrosamine results in increased mutagenesis of HRAS gene15592514|2453584
D004052Diethylnitrosamine[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of HRAS mRNA18978307
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of HRAS mRNA7910516
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of HRAS mRNA27638505
D0151279,10-Dimethyl-1,2-benzanthracene"4-octylphenol affects the reaction [HRAS protein results in increased susceptibility to 9,10-Dimethyl-1,2-benzanthracene]"12117780
D0151279,10-Dimethyl-1,2-benzanthracene"Estradiol affects the reaction [HRAS protein results in increased susceptibility to 9,10-Dimethyl-1,2-benzanthracene]"12117780
D0151279,10-Dimethyl-1,2-benzanthracene"HRAS protein results in increased susceptibility to 9,10-Dimethyl-1,2-benzanthracene"11376698|1211778
D0151279,10-Dimethyl-1,2-benzanthracene"[9,10-Dimethyl-1,2-benzanthracene co-treated with Benzoyl Peroxide] results in increased expression of HRAS mRNA"3115617
D0151279,10-Dimethyl-1,2-benzanthracene"[9,10-Dimethyl-1,2-benzanthracene co-treated with Benzoyl Peroxide] results in increased mutagenesis of HRAS gene"11241758|3115617
D0151279,10-Dimethyl-1,2-benzanthracene"[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate co-treated with mezerein] results in increased expression of HRAS mRNA"3115617
D0151279,10-Dimethyl-1,2-benzanthracene"[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of HRAS mRNA"3115617
D0151279,10-Dimethyl-1,2-benzanthracene"[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in increased mutagenesis of HRAS gene"11241758|3115617
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased mutagenesis of HRAS gene"1375869|20103723
D0151279,10-Dimethyl-1,2-benzanthracene"[Ellagic Acid co-treated with Plant Extracts] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased mutagenesis of HRAS gene]"20103723
D0151279,10-Dimethyl-1,2-benzanthracene"[Ellagic Acid co-treated with resveratrol] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased mutagenesis of HRAS gene]"20103723
D0151279,10-Dimethyl-1,2-benzanthracene"[Glucaric Acid co-treated with Plant Extracts] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased mutagenesis of HRAS gene]"20103723
D0151279,10-Dimethyl-1,2-benzanthracene"[Glucaric Acid co-treated with resveratrol] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased mutagenesis of HRAS gene]"20103723
D0151279,10-Dimethyl-1,2-benzanthracene"[resveratrol co-treated with Plant Extracts] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased mutagenesis of HRAS gene]"20103723
D004121Dimethyl SulfoxideDimethyl Sulfoxide affects the expression of HRAS mRNA24834073
C067311docetaxeldocetaxel results in increased expression of and results in increased activity of HRAS protein15970518
C025034doxifluridineHRAS protein results in decreased susceptibility to doxifluridine16734730
D004317DoxorubicinDoxorubicin inhibits the reaction [hydroquinone results in decreased expression of HRAS protein]26047893
D004317DoxorubicinDoxorubicin results in increased expression of HRAS mRNA16001973
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in decreased mutagenesis of HRAS gene"23262642
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in decreased expression of HRAS mRNA"12747207
D004610Ellagic Acid"[Ellagic Acid co-treated with Plant Extracts] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased mutagenesis of HRAS gene]"20103723
D004610Ellagic Acid"[Ellagic Acid co-treated with resveratrol] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased mutagenesis of HRAS gene]"20103723
D004791Enzyme Inhibitors[Enzyme Inhibitors binds to and results in decreased activity of SOS1 protein] inhibits the reaction [HRAS protein binds to Guanosine Triphosphate]25825487
D004791Enzyme Inhibitors[Enzyme Inhibitors binds to and results in decreased activity of SOS1 protein] promotes the reaction [HRAS protein binds to Guanosine Diphosphate]25825487
D004791Enzyme InhibitorsEnzyme Inhibitors inhibits the reaction [SOS1 protein binds to [HRAS protein binds to Guanosine Diphosphate]]25825487
C062669epicatechin gallateepicatechin gallate inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS mRNA]18656336
C062669epicatechin gallateepicatechin gallate inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS protein]18656336
C045651epigallocatechin gallateepigallocatechin gallate inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS mRNA]18656336
C045651epigallocatechin gallateepigallocatechin gallate inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS protein]18656336
C500988estradiol-3,4-quinone"estradiol-3,4-quinone results in increased mutagenesis of HRAS gene"17261777
C500988estradiol-3,4-quinone"estradiol-3,4-quinone results in increased mutagenesis of HRAS gene"17261777
D004967Estrogens[Malathion co-treated with Estrogens] results in increased expression of HRAS mRNA18204794
D004967Estrogens[Parathion co-treated with Estrogens] results in increased expression of HRAS mRNA18204794
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of HRAS mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HRAS mRNA17942748
C024565ethylene dichlorideHRAS protein results in increased susceptibility to ethylene dichloride28421967
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of HRAS mRNA23649840
D005038EthylnitrosoureaHRAS protein results in increased susceptibility to Ethylnitrosourea11182032
D005038EthylnitrosoureaHRAS protein results in increased susceptibility to Ethylnitrosourea26558449
D005054EugenolEugenol results in decreased expression of HRAS protein20537511
D005200FANFTFANFT results in increased expression of HRAS mRNA3433577
C004808farnesyl pyrophosphatefarnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of HRAS protein]]18625914
C004808farnesyl pyrophosphatefarnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of HRAS protein]]18625914
C093323farnesylthiosalicylic acidfarnesylthiosalicylic acid results in decreased activity of HRAS protein15328380
C093323farnesylthiosalicylic acidfarnesylthiosalicylic acid results in decreased expression of HRAS protein16780807
D011345Fenofibrate[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of HRAS mRNA18978307
C020748ferrous sulfateferrous sulfate affects the localization of HRAS protein17172471
C020748ferrous sulfateferrous sulfate promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]17172471
C020748ferrous sulfateHRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]17172471
C020748ferrous sulfateHRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]17172471
C020748ferrous sulfateHRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]17172471
C020748ferrous sulfateHRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]17172471
D018120FinasterideFinasteride results in increased expression of HRAS mRNA24136188
C082360fipronilfipronil results in decreased expression of HRAS mRNA23962444
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of HRAS protein11350689
D005472FluorouracilFluorouracil results in increased expression of HRAS mRNA16557594
D005480FlurbiprofenHRAS protein affects the reaction [Flurbiprofen results in increased expression of PSCA mRNA]16949054
D005485FlutamideFlutamide results in increased expression of HRAS mRNA24136188
D005492Folic AcidFolic Acid results in increased expression of HRAS mRNA2566606
D005557FormaldehydeFormaldehyde results in increased expression of HRAS mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of HRAS mRNA9149109
C017338geranylgeraniolgeranylgeraniol promotes the reaction [Lovastatin results in decreased farnesylation of HRAS protein]9018116
C002963geranylgeranyl pyrophosphategeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of HRAS protein]]18625914
D005897GlafenineGlafenine results in increased expression of HRAS mRNA24136188
D005912GliotoxinGliotoxin inhibits the reaction [Acetaminophen results in increased activity of HRAS protein]19739265
D005947GlucoseGlucose results in increased activity of HRAS protein16572112
D005947Glucosemanumycin inhibits the reaction [Glucose results in increased activity of HRAS protein]16572112
D005978GlutathioneDactinomycin promotes the reaction [[Zinostatin co-treated with Glutathione] results in increased cleavage of HRAS gene]9345283
D005978Glutathione[Zinostatin co-treated with Glutathione] results in increased cleavage of HRAS gene9345283
D006034Glycyrrhetinic AcidGlycyrrhetinic Acid results in decreased expression of HRAS protein19958823
C081021Go 6976Go 6976 inhibits the reaction [lead acetate results in increased activity of HRAS protein]19133285
D006153Guanosine Diphosphate[Enzyme Inhibitors binds to and results in decreased activity of SOS1 protein] promotes the reaction [HRAS protein binds to Guanosine Diphosphate]25825487
D006153Guanosine DiphosphateEnzyme Inhibitors inhibits the reaction [SOS1 protein binds to [HRAS protein binds to Guanosine Diphosphate]]25825487
D006160Guanosine Triphosphate[Enzyme Inhibitors binds to and results in decreased activity of SOS1 protein] inhibits the reaction [HRAS protein binds to Guanosine Triphosphate]25825487
D005937Glucaric Acid"[Glucaric Acid co-treated with Plant Extracts] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased mutagenesis of HRAS gene]"20103723
D005937Glucaric Acid"[Glucaric Acid co-treated with resveratrol] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased mutagenesis of HRAS gene]"20103723
C479979GW0742[GW0742 binds to and results in increased activity of PPARD protein] inhibits the reaction [HRAS protein results in increased expression of CDK1 mRNA]22473992
C479979GW0742[GW0742 binds to and results in increased activity of PPARD protein] inhibits the reaction [HRAS protein results in increased expression of CDK1 protein]22473992
C479979GW0742[GW0742 binds to and results in increased activity of PPARD protein] inhibits the reaction [HRAS protein results in increased expression of CENPA protein]22473992
C479979GW0742[GW0742 binds to and results in increased activity of PPARD protein] inhibits the reaction [HRAS protein results in increased expression of CHEK1 mRNA]22473992
C479979GW0742[GW0742 binds to and results in increased activity of PPARD protein] inhibits the reaction [HRAS protein results in increased expression of CHEK1 protein]22473992
C479979GW0742[GW0742 binds to and results in increased activity of PPARD protein] inhibits the reaction [HRAS protein results in increased expression of H2AFZ mRNA]22473992
C479979GW0742[GW0742 binds to and results in increased activity of PPARD protein] inhibits the reaction [HRAS protein results in increased expression of H2AFZ protein]22473992
C479979GW0742[GW0742 binds to and results in increased activity of PPARD protein] inhibits the reaction [HRAS protein results in increased expression of NEK2 protein]22473992
D006533HeptachlorHeptachlor results in decreased expression of HRAS mRNA1771636
C089796hexabromocyclododecanehexabromocyclododecane results in increased expression of HRAS mRNA19027819
D017313FenretinideFenretinide results in decreased expression of HRAS mRNA16467112
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of HRAS mRNA11008122
D006861Hydrogen PeroxideHRAS protein affects the susceptibility to [Hydrogen Peroxide results in increased activity of MAPK1 protein]14975446
D006861Hydrogen PeroxideHRAS protein affects the susceptibility to [Hydrogen Peroxide results in increased activity of MAPK3 protein]14975446
C031927hydroquinone3-aminobenzamide inhibits the reaction [hydroquinone results in increased expression of HRAS protein]26047893
C031927hydroquinoneDoxorubicin inhibits the reaction [hydroquinone results in decreased expression of HRAS protein]26047893
C031927hydroquinonehydroquinone affects the expression of HRAS mRNA26047893
C031927hydroquinonehydroquinone affects the expression of HRAS protein26047893
C031927hydroquinonehydroquinone promotes the reaction [PARP1 protein binds to and results in increased ADP-ribosylation of and results in increased expression of HRAS protein]26047893
C031927hydroquinonePARP1 protein promotes the reaction [hydroquinone results in increased expression of HRAS protein]26047893
C073007ibandronic acidibandronic acid results in decreased prenylation of HRAS protein9556058
D019807Iodoacetic AcidHRAS protein modified form results in increased susceptibility to Iodoacetic Acid19923925
D007501IronHRAS protein affects the reaction [Iron results in increased phosphorylation of AKT1 protein]17172471
D007501IronHRAS protein affects the reaction [Iron results in increased phosphorylation of MAPK1 protein]17172471
D007501IronHRAS protein affects the reaction [Iron results in increased phosphorylation of MAPK3 protein]17172471
D007501IronHRAS protein affects the reaction [Iron results in increased phosphorylation of NFKBIA protein]17172471
D007501IronIron affects the localization of HRAS protein17172471
D007501IronIron promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]17172471
C005059isopreneisoprene results in increased mutagenesis of HRAS gene11397402|9111215
D007545IsoproterenolIsoproterenol results in increased activity of HRAS protein8484791
C544151jinfukangCisplatin promotes the reaction [jinfukang results in increased expression of HRAS mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in increased expression of HRAS mRNA]27392435
C410337K 7174K 7174 results in decreased expression of HRAS mRNA24086573
D007649KetamineKetamine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of HRAS protein]19540866
C096898L 744832L 744832 results in decreased prenylation of HRAS protein16156861
D007854LeadLead affects the splicing of HRAS mRNA28903495
D007854LeadLead inhibits the reaction [HSPA5 protein binds to HRAS enhancer]15111246
C008261lead acetate"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead acetate results in increased activity of HRAS protein]"19133285
C008261lead acetateGo 6976 inhibits the reaction [lead acetate results in increased activity of HRAS protein]19133285
C008261lead acetateHRAS mutant form inhibits the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]19133285
C008261lead acetateHRAS mutant form inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]19133285
C008261lead acetateHRAS mutant form inhibits the reaction [lead acetate results in increased phosphorylation of RAF1 protein]19133285
C008261lead acetatelead acetate results in increased activity of HRAS protein19133285
C008261lead acetatePRKCA mutant form inhibits the reaction [lead acetate results in increased activity of HRAS protein]19133285
C008261lead acetateSU 6656 inhibits the reaction [lead acetate results in increased activity of HRAS protein]19133285
C008261lead acetatelead acetate inhibits the reaction [HSPA5 protein binds to HRAS enhancer]15111246
C008281limonenelimonene inhibits the reaction [HRAS protein results in increased susceptibility to Methylnitrosourea]11802805
D008070Lipopolysaccharidesfarnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of HRAS protein]]18625914
D008070Lipopolysaccharidesfarnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of HRAS protein]]18625914
D008070Lipopolysaccharidesgeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of HRAS protein]]18625914
D008070LipopolysaccharidesLipopolysaccharides results in increased activity of HRAS protein18625914
D008070LipopolysaccharidesLipopolysaccharides results in increased localization of HRAS protein18625914
D008070LipopolysaccharidesLipopolysaccharides results in increased prenylation of HRAS protein18625914
D008070LipopolysaccharidesSimvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of HRAS protein]18625914
D008070LipopolysaccharidesSimvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of HRAS protein]18625914
D008070LipopolysaccharidesSimvastatin inhibits the reaction [Lipopolysaccharides results in increased prenylation of HRAS protein]18625914
D008070LipopolysaccharidesKetamine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of HRAS protein]19540866
D008070LipopolysaccharidesLipopolysaccharides results in increased phosphorylation of and results in increased activity of HRAS protein19540866
D008070LipopolysaccharidesTLR4 mutant form inhibits the reaction [Lipopolysaccharides results in increased activity of HRAS protein]19540866
C115354lonafarniblonafarnib inhibits the reaction [TNF protein results in increased activity of HRAS protein]15090542
D008148LovastatinLovastatin results in decreased prenylation of and results in decreased localization of HRAS protein19360310
D008148LovastatinLovastatin results in decreased prenylation of HRAS protein16156861
D008148Lovastatingeranylgeraniol promotes the reaction [Lovastatin results in decreased farnesylation of HRAS protein]9018116
D008148LovastatinLovastatin results in decreased farnesylation of HRAS protein9018116
D008294Malathion[Malathion co-treated with Estrogens] results in increased expression of HRAS mRNA18204794
D008294MalathionMalathion results in increased expression of HRAS mRNA18204794
D008294MalathionMalathion results in increased expression of HRAS protein19787260
C054474manumycinmanumycin results in decreased expression of HRAS protein19958823
C054474manumycinmanumycin inhibits the reaction [Acetaminophen results in increased activity of HRAS protein]19739265
C054474manumycinmanumycin inhibits the reaction [Glucose results in increased activity of HRAS protein]16572112
C054474manumycinmanumycin results in decreased farnesylation of HRAS protein21211511
D008627Mercuric ChlorideMercuric Chloride promotes the reaction [HSPA5 protein binds to HRAS enhancer]15111246
D008628MercuryMercury promotes the reaction [HSPA5 protein binds to HRAS enhancer]15111246
D008694MethamphetamineMethamphetamine results in decreased expression of HRAS mRNA15644446
D008731MethoxychlorMethoxychlor results in decreased expression of HRAS mRNA23303685
D008731MethoxychlorMethoxychlor results in increased methylation of HRAS gene23303685
D008767Methylmercury CompoundsMethylmercury Compounds results in increased activity of HRAS protein28837763
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of HRAS mRNA23649840
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine inhibits the reaction [EGF protein results in increased activity of HRAS protein]15708576
D008770MethylnitrosoureaHRAS protein results in increased susceptibility to Methylnitrosourea11182032|1137669
D008770Methylnitrosourealimonene inhibits the reaction [HRAS protein results in increased susceptibility to Methylnitrosourea]11802805
D008770MethylnitrosoureaHRAS protein results in increased susceptibility to Methylnitrosourea28421967
D008770MethylnitrosoureaHRAS protein results in decreased susceptibility to Methylnitrosourea11973638
D008770MethylnitrosoureaMethylnitrosourea results in increased mutagenesis of HRAS gene10767621|1568839
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HRAS mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HRAS mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HRAS mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HRAS mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HRAS mRNA]"20230807
C011309mezerein"[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate co-treated with mezerein] results in increased expression of HRAS mRNA"3115617
D015735MifepristoneMifepristone inhibits the reaction [Dexamethasone inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to HRAS protein]]]10807665
C040015myricetinmyricetin results in decreased activity of HRAS protein17693661
C058346N-(4-methoxyphenyl)retinamideN-(4-methoxyphenyl)retinamide results in decreased expression of HRAS mRNA16467112
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of HRAS mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of HRAS mRNA20551477
C005274naringinHRAS protein affects the reaction [naringin results in decreased expression of CDK2 protein]18296682
C005274naringinHRAS protein affects the reaction [naringin results in decreased expression of CDK4 protein]18296682
C005274naringinHRAS protein affects the reaction [naringin results in increased expression of CDKN1A protein]18296682
C005274naringinHRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]18296682
C005274naringinHRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]18296682
C005274naringinnaringin results in increased activity of HRAS protein18296682
C005274naringinHRAS protein affects the reaction [naringin results in decreased expression of CDK2 protein]18951945
C005274naringinHRAS protein affects the reaction [naringin results in decreased expression of CDK4 protein]18951945
C005274naringinHRAS protein affects the reaction [naringin results in increased expression of CDKN1A protein]18951945
C005274naringinHRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]18951945
C005274naringinHRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]18951945
C005274naringinnaringin results in increased activity of HRAS protein18951945
C014593N-hydroxy-4-aminobiphenyl[N-hydroxy-4-aminobiphenyl co-treated with Copper] results in increased mutagenesis of HRAS gene11275476
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HRAS mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HRAS mRNA]"20230807
D009538NicotineNicotine results in increased activity of HRAS protein15983034
C012655nimesulidenimesulide inhibits the reaction [[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of CCND1 mRNA]20043093
C012655nimesulidenimesulide inhibits the reaction [[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of PTGS2 mRNA]20043093
D009583NitrofurazoneAcetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of HRAS mRNA]15945272
D009583NitrofurazoneNitrofurazone results in increased expression of HRAS mRNA15945272
D0151124-Nitroquinoline-1-oxide[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of CCND1 mRNA20043093
D0151124-Nitroquinoline-1-oxide[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of PTGS2 mRNA20043093
D0151124-Nitroquinoline-1-oxidenimesulide inhibits the reaction [[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of CCND1 mRNA]20043093
D0151124-Nitroquinoline-1-oxidenimesulide inhibits the reaction [[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of PTGS2 mRNA]20043093
D009705NucleosidesNucleosides results in increased expression of HRAS mRNA15173389
C464660obeticholic acidobeticholic acid results in decreased expression of HRAS mRNA27939613
C025589ochratoxin Aochratoxin A results in increased expression of HRAS mRNA23358140
D010126Ozone[Ozone co-treated with Chlorine] results in decreased expression of HRAS mRNA18636392
D010269ParaquatParaquat affects the splicing of HRAS mRNA23613995
D010278Parathion[Parathion co-treated with Estrogens] results in increased expression of HRAS mRNA18204794
D010278ParathionParathion results in increased expression of HRAS protein19787260
C011272perfosfamideperfosfamide results in decreased expression of HRAS mRNA19429390
D010634PhenobarbitalPhenobarbital results in decreased mutagenesis of HRAS protein11753661
C066330phenylhydroquinonebathocuproine inhibits the reaction [[phenylhydroquinone co-treated with Copper] results in increased mutagenesis of HRAS gene]10334203
C066330phenylhydroquinoneCAT protein inhibits the reaction [[phenylhydroquinone co-treated with Copper] results in increased mutagenesis of HRAS gene]10334203
C066330phenylhydroquinone[phenylhydroquinone co-treated with Copper] results in increased mutagenesis of HRAS gene10334203
D010695PhlorhizinPhlorhizin results in increased expression of HRAS mRNA22538082
C032727piperidine"piperidine promotes the reaction [[Copper co-treated with 1,2-diphenylhydrazine] results in increased mutagenesis of HRAS gene]"10798712
D010936Plant Extracts"[Ellagic Acid co-treated with Plant Extracts] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased mutagenesis of HRAS gene]"20103723
D010936Plant Extracts"[Glucaric Acid co-treated with Plant Extracts] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased mutagenesis of HRAS gene]"20103723
D010936Plant ExtractsPlant Extracts results in decreased mutagenesis of HRAS gene23262642
D010936Plant Extracts"[resveratrol co-treated with Plant Extracts] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased mutagenesis of HRAS gene]"20103723
D011005PlutoniumPlutonium results in increased mutagenesis of HRAS gene9255578
D011374ProgesteroneProgesterone results in increased expression of HRAS mRNA21549006
D011765PyruvaldehydePyruvaldehyde results in increased activity of HRAS protein17635749
D011794QuercetinQuercetin results in decreased expression of HRAS mRNA10652438
D011794QuercetinQuercetin results in decreased expression of HRAS protein10652438
D011794QuercetinQuercetin results in increased expression of HRAS mRNA21632981
D017382Reactive Oxygen SpeciesHRAS protein affects the abundance of Reactive Oxygen Species22307971
D017382Reactive Oxygen Species"HRAS protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased abundance of Reactive Oxygen Species]"22307971
D017382Reactive Oxygen SpeciesHRAS protein mutant form results in increased abundance of Reactive Oxygen Species27517622
D017382Reactive Oxygen SpeciesPRDX1 protein inhibits the reaction [HRAS protein mutant form results in increased abundance of Reactive Oxygen Species]27517622
C059514resveratrolHRAS protein promotes the reaction [resveratrol results in increased activity of MAPK1 protein]11889192
C059514resveratrolHRAS protein promotes the reaction [resveratrol results in increased activity of MAPK3 protein]11889192
C059514resveratrolHRAS protein promotes the reaction [resveratrol results in increased expression of and results in increased phosphorylation of TP53 protein]11889192
C059514resveratrolHRAS protein promotes the reaction [resveratrol results in increased expression of CDKN1A mRNA]11889192
C059514resveratrolHRAS protein promotes the reaction [resveratrol results in increased expression of TP53 mRNA]11889192
C059514resveratrolHRAS protein promotes the reaction [resveratrol results in increased phosphorylation of and results in increased localization of and results in increased activity of MAPK1 protein]11889192
C059514resveratrolHRAS protein promotes the reaction [resveratrol results in increased phosphorylation of and results in increased localization of and results in increased activity of MAPK3 protein]11889192
C059514resveratrolHRAS protein promotes the reaction [TP53 protein results in increased susceptibility to resveratrol]11889192
C059514resveratrolresveratrol affects the expression of HRAS mRNA mutant form16369916
C059514resveratrolresveratrol affects the expression of HRAS protein mutant form16369916
C059514resveratrol"[Ellagic Acid co-treated with resveratrol] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased mutagenesis of HRAS gene]"20103723
C059514resveratrol"[Glucaric Acid co-treated with resveratrol] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased mutagenesis of HRAS gene]"20103723
C059514resveratrol"[resveratrol co-treated with Plant Extracts] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased mutagenesis of HRAS gene]"20103723
C059514resveratrolresveratrol results in decreased activity of HRAS protein mutant form10910059
D000068296Risedronate SodiumRisedronate Sodium results in decreased prenylation of HRAS protein9556058
D012402RotenoneRotenone results in decreased expression of HRAS mRNA10630619
C079198S 1 (combination)HRAS protein results in decreased susceptibility to S 1 (combination)16734730
C111350Sch 59228Sch 59228 results in decreased prenylation of HRAS protein9923541
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of HRAS mRNA19244175
D012643SeleniumSelenium results in increased expression of HRAS mRNA19244175
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of HRAS protein"10905503
D017632Asbestos, Serpentine"tobacco tar promotes the reaction [Asbestos, Serpentine results in increased expression of HRAS protein]"10905503
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of HRAS mRNA25895662
D019821Simvastatinfarnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of HRAS protein]]18625914
D019821Simvastatinfarnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of HRAS protein]]18625914
D019821Simvastatingeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of HRAS protein]]18625914
D019821SimvastatinSimvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of HRAS protein]18625914
D019821SimvastatinSimvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of HRAS protein]18625914
D019821SimvastatinSimvastatin inhibits the reaction [Lipopolysaccharides results in increased prenylation of HRAS protein]18625914
D019821SimvastatinSimvastatin results in decreased prenylation of and results in decreased localization of HRAS protein19360310
D019821SimvastatinSimvastatin results in decreased activity of HRAS11914545
C024711siomycin Asiomycin A inhibits the reaction [HRAS protein mutant form results in increased expression of CCND1 protein]27517622
C024711siomycin Asiomycin A inhibits the reaction [HRAS protein mutant form results in increased expression of FOXM1 protein]27517622
C024711siomycin Asiomycin A inhibits the reaction [HRAS protein mutant form results in increased expression of NFE2L2 protein]27517622
C024711siomycin Asiomycin A inhibits the reaction [HRAS protein mutant form results in increased expression of PRDX1 protein]27517622
D020123SirolimusPPARD protein affects the reaction [[Sirolimus co-treated with HRAS protein] results in decreased expression of ERN1 protein]24898257
D020123SirolimusPPARD protein affects the reaction [[Sirolimus co-treated with HRAS protein] results in decreased expression of HSPA5 protein]24898257
D020123Sirolimus[Sirolimus co-treated with HRAS protein] results in decreased expression of ERN1 protein24898257
D020123Sirolimus[Sirolimus co-treated with HRAS protein] results in decreased expression of HSPA5 protein24898257
C017947sodium arseniteAcetylcysteine inhibits the reaction [HRAS protein mutant form results in increased susceptibility to sodium arsenite]25199681
C017947sodium arseniteHRAS protein mutant form results in increased susceptibility to sodium arsenite25199681
C017947sodium arsenitesodium arsenite inhibits the reaction [HRAS protein mutant form results in increased activity of CAT protein]25199681
C017947sodium arsenitesodium arsenite results in increased expression of HRAS mRNA19464579
C017947sodium arsenitesodium arsenite results in increased expression of HRAS protein16039940
C017947sodium arseniteHRAS gene mutant form results in increased susceptibility to sodium arsenite22700541
C017947sodium arsenitesodium arsenite results in decreased expression of HRAS mRNA19822182
C017947sodium arsenitesodium arsenite results in decreased methylation of HRAS promoter12016150
C017947sodium arsenitesodium arsenite results in increased expression of HRAS mRNA14691202
C017947sodium arsenitesodium arsenite results in increased expression of HRAS mRNA11241755|1687621
C416927SU 6656SU 6656 inhibits the reaction [lead acetate results in increased activity of HRAS protein]19133285
D013458Sulfur Dioxide[Sulfur Dioxide co-treated with Benzo(a)pyrene] results in increased expression of HRAS mRNA19408242
D013458Sulfur Dioxide[Sulfur Dioxide co-treated with Benzo(a)pyrene] results in increased expression of HRAS protein19408242
D013458Sulfur DioxideSulfur Dioxide promotes the reaction [Benzo(a)pyrene results in increased expression of HRAS mRNA]20064080
D013458Sulfur DioxideSulfur Dioxide promotes the reaction [Benzo(a)pyrene results in increased expression of HRAS protein]20064080
D013458Sulfur DioxideSulfur Dioxide results in increased expression of HRAS mRNA19408242|2006408
D013458Sulfur DioxideSulfur Dioxide results in increased expression of HRAS protein19408242|2006408
C452601sulindac derivative IND 12HRAS protein affects the reaction [sulindac derivative IND 12 results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]11912145
C452601sulindac derivative IND 12HRAS protein affects the reaction [sulindac derivative IND 12 results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]11912145
D013481SuperoxidesHRAS protein mutant form results in increased abundance of Superoxides11313892
D013481Superoxides[HRAS protein mutant form results in increased abundance of Superoxides] which results in decreased susceptibility to TNF protein11313892
D013739TestosteroneTestosterone results in decreased expression of HRAS mRNA20403060
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HRAS protein9707505
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HRAS mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HRAS mRNA21354282
D013755Tetradecanoylphorbol AcetateHRAS protein affects the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of CDH5 protein]24211779
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with arsenic trioxide] results in increased expression of HRAS mRNA18922899
D013755Tetradecanoylphorbol Acetate"[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate co-treated with mezerein] results in increased expression of HRAS mRNA"3115617
D013755Tetradecanoylphorbol Acetate"[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of HRAS mRNA"3115617
D013755Tetradecanoylphorbol Acetate"[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in increased mutagenesis of HRAS gene"11241758|3115617
D013755Tetradecanoylphorbol Acetate[Benzo(a)pyrene co-treated with Tetradecanoylphorbol Acetate] affects the mutagenesis of HRAS gene11765016
D013755Tetradecanoylphorbol Acetatebicyclol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HRAS mRNA]17106253
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of HRAS mRNA17106253
D013755Tetradecanoylphorbol Acetate[Zidovudine co-treated with Tetradecanoylphorbol Acetate] results in increased mutagenesis of HRAS gene9766437
D013774TetranitromethaneTetranitromethane results in increased mutagenesis of HRAS gene9255578
D019284Thapsigargin[Thapsigargin co-treated with HRAS protein] results in decreased phosphorylation of MAPK1 protein24898257
D019284Thapsigargin[Thapsigargin co-treated with HRAS protein] results in decreased phosphorylation of MAPK3 protein24898257
D019284Thapsigargin[Thapsigargin co-treated with HRAS protein] results in increased expression of EIF2AK3 protein24898257
D019284Thapsigargin[Thapsigargin co-treated with HRAS protein] results in increased expression of ERN1 protein24898257
D019284Thapsigargin[Thapsigargin co-treated with HRAS protein] results in increased expression of HSPA5 protein24898257
D019284Thapsigargin[Thapsigargin co-treated with HRAS protein] results in increased phosphorylation of AKT1 protein24898257
C056068theaflavintheaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS mRNA]18656336
C056068theaflavintheaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS protein]18656336
C402769tipifarnibtipifarnib results in decreased metabolism of HRAS protein15728126
C402769tipifarnibHRAS gene mutant form results in increased susceptibility to tipifarnib16403772|1664857
C402769tipifarnibtipifarnib results in decreased activity of HRAS protein15970518
C024746tobacco tar"tobacco tar promotes the reaction [Asbestos, Serpentine results in increased expression of HRAS protein]"10905503
C113106tocopheryloxybutyric acidtocopheryloxybutyric acid inhibits the reaction [Urethane promotes the reaction [RAF1 protein binds to HRAS protein]]11062179
D014050TolueneToluene affects the expression of HRAS mRNA21827849
D014212TretinoinTretinoin results in decreased expression of HRAS mRNA16604517
C023764triciribinetriciribine inhibits the reaction [HRAS protein results in increased activity of MMP2 protein]23877152
C046488trimethyltintrimethyltin results in increased expression of HRAS mRNA21435392
C001899triptolidetriptolide results in decreased expression of HRAS mRNA23639586
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of HRAS mRNA"26179874
C057693troglitazonetroglitazone promotes the reaction [HRAS protein results in increased susceptibility to Urethane]26558449
C057693troglitazonetroglitazone results in increased expression of HRAS mRNA17569031
D014415Tunicamycin2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Tunicamycin co-treated with HRAS protein] results in increased expression of PCNA protein]24898257
D014415TunicamycinHSPA5 protein affects the reaction [[Tunicamycin co-treated with HRAS protein] results in increased phosphorylation of AKT1 protein]24898257
D014415TunicamycinHSPA5 protein affects the reaction [[Tunicamycin co-treated with HRAS protein] results in increased phosphorylation of RB1 protein]24898257
D014415Tunicamycin[Tunicamycin co-treated with HRAS protein] results in decreased phosphorylation of MAPK1 protein24898257
D014415Tunicamycin[Tunicamycin co-treated with HRAS protein] results in decreased phosphorylation of MAPK3 protein24898257
D014415Tunicamycin[Tunicamycin co-treated with HRAS protein] results in increased expression of EIF2AK3 protein24898257
D014415Tunicamycin[Tunicamycin co-treated with HRAS protein] results in increased expression of ERN1 protein24898257
D014415Tunicamycin[Tunicamycin co-treated with HRAS protein] results in increased expression of HSPA5 protein24898257
D014415Tunicamycin[Tunicamycin co-treated with HRAS protein] results in increased expression of PCNA protein24898257
D014415Tunicamycin[Tunicamycin co-treated with HRAS protein] results in increased phosphorylation of AKT1 protein24898257
D014415Tunicamycin[Tunicamycin co-treated with HRAS protein] results in increased phosphorylation of RB1 protein24898257
C113580U 0126U 0126 inhibits the reaction [HRAS protein results in increased expression of PMAIP1 protein]20802529
D014520UrethaneHRAS protein promotes the reaction [Urethane results in increased expression of CCND1 protein]11307925
D014520UrethaneHRAS protein results in increased susceptibility to Urethane10779650|1155229
D014520UrethaneUrethane results in increased mutagenesis of HRAS gene10779650|1276524
D014520UrethaneHRAS protein promotes the reaction [Urethane results in increased expression of AURKB mRNA]26558449
D014520UrethaneHRAS protein promotes the reaction [Urethane results in increased expression of CCNB1 mRNA]26558449
D014520UrethaneHRAS protein promotes the reaction [Urethane results in increased expression of EREG mRNA]26558449
D014520UrethaneHRAS protein results in increased susceptibility to Urethane15902970|2655844
D014520Urethanetocopheryloxybutyric acid inhibits the reaction [Urethane promotes the reaction [RAF1 protein binds to HRAS protein]]11062179
D014520Urethanetroglitazone promotes the reaction [HRAS protein results in increased susceptibility to Urethane]26558449
D014520UrethaneUrethane promotes the reaction [RAF1 protein binds to HRAS protein]11062179
D014520UrethaneUrethane results in increased expression of HRAS mRNA18465119
D014520UrethaneVitamin E inhibits the reaction [Urethane promotes the reaction [RAF1 protein binds to HRAS protein]]11062179
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased activity of HRAS protein]12839936
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid inhibits the reaction [EGF results in increased activity of HRAS protein]12839936
D014635Valproic AcidValproic Acid affects the expression of HRAS mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of HRAS mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of HRAS gene29154799
D014638VanadatesHRAS protein mutant form results in increased susceptibility to Vanadates19167484
D014638VanadatesHRAS protein results in decreased susceptibility to Vanadates19167484
D014638VanadatesVanadates results in increased expression of HRAS protein19167484
D001335Vehicle EmissionsHRAS protein results in increased susceptibility to Vehicle Emissions11516524
D014750VincristineVincristine results in increased expression of HRAS mRNA16001973
C017963vinyl carbamatevinyl carbamate results in increased mutagenesis of HRAS gene12765245
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of HRAS mRNA19244175
D014810Vitamin EVitamin E results in increased expression of HRAS mRNA19244175
D014810Vitamin EVitamin E inhibits the reaction [Urethane promotes the reaction [RAF1 protein binds to HRAS protein]]11062179
D014873Water PollutantsWater Pollutants results in increased expression of HRAS mRNA23591932
D015215Zidovudine[Zidovudine co-treated with Tetradecanoylphorbol Acetate] results in increased mutagenesis of HRAS gene9766437
D009353ZinostatinDactinomycin promotes the reaction [[Zinostatin co-treated with Glutathione] results in increased cleavage of HRAS gene]9345283
D009353Zinostatin[Zinostatin co-treated with Glutathione] results in increased cleavage of HRAS gene9345283
C088658zoledronic acidzoledronic acid results in decreased localization of HRAS protein11986784
C088658zoledronic acidzoledronic acid results in increased expression of HRAS protein28871336

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-IDA9178006  
GO:0003924GTPase activity-IMP9230043  
GO:0005515protein binding-IPI2122974  8332187  8332195  8621645  8670882  9144171  
9447984  9488663  9690470  10369681  10608844  11022048  
11335720  11598133  11857081  11980706  12620389  12628188  
14500341  14724641  15507210  15688026  15886098  16316996  
16698549  17084389  17540175  18073111  18273062  18454158  
18596699  19063885  19141281  19222999  19696784  20080631  
20133692  20133694  20178605  20936779  22020336  22169110  
23706742  24441586  24929361  25241761  25684575  26165597  
GO:0005525GTP binding-IDA14500341  17260967  
GO:0005525GTP binding-IMP9230043  
GO:0008022protein C-terminus binding-IPI9219684  
GO:0019003GDP binding-IMP8142349  9230043  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0001934positive regulation of protein phosphorylation-IDA22065586  
GO:0002223stimulatory C-type lectin receptor signaling pathway-TAS-  
GO:0006897endocytosis-IEA-  
GO:0006935chemotaxis-TAS10848592  
GO:0007050cell cycle arrest-IDA9054499  
GO:0007050cell cycle arrest-IMP9765203  
GO:0007093mitotic cell cycle checkpoint-IDA9054499  
GO:0007165signal transduction-NAS8607982  
GO:0007166cell surface receptor signaling pathway-TAS9020890  
GO:0007265Ras protein signal transduction-IDA23027131  
GO:0007265Ras protein signal transduction-TAS-  
GO:0008283cell proliferation-IEA-  
GO:0008284positive regulation of cell proliferation-IDA9765203  
GO:0008285negative regulation of cell proliferation-IDA9054499  
GO:0009887animal organ morphogenesis-TAS10848592  
GO:0010629negative regulation of gene expression-IDA23027131  
GO:0010863positive regulation of phospholipase C activity-IDA11022048  
GO:0030335positive regulation of cell migration-IDA23027131  
GO:0032729positive regulation of interferon-gamma production-IEA-  
GO:0034260negative regulation of GTPase activity-IDA23027131  
GO:0035900response to isolation stress-IEA-  
GO:0042088T-helper 1 type immune response-IEA-  
GO:0042832defense response to protozoan-IEA-  
GO:0043406positive regulation of MAP kinase activity-IDA23027131  
GO:0043410positive regulation of MAPK cascade-IDA9765203  
GO:0043524negative regulation of neuron apoptotic process-IEA-  
GO:0043547positive regulation of GTPase activity-IDA23027131  
GO:0045740positive regulation of DNA replication-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA22065586  23027131  
GO:0046330positive regulation of JNK cascade-IDA22065586  
GO:0046579positive regulation of Ras protein signal transduction-IEA-  
GO:0048013ephrin receptor signaling pathway-TAS-  
GO:0048169regulation of long-term neuronal synaptic plasticity-IEA-  
GO:0050679positive regulation of epithelial cell proliferation-IMP20154697  
GO:0050852T cell receptor signaling pathway-IEA-  
GO:0051291protein heterooligomerization-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IDA22065586  
GO:0071480cellular response to gamma radiation-IDA16213212  
GO:0090303positive regulation of wound healing-IDA23027131  
GO:0090314positive regulation of protein targeting to membrane-IMP11022048  
GO:0090398cellular senescence-IDA9054499  
GO:0097193intrinsic apoptotic signaling pathway-IEA-  
GO:1900029positive regulation of ruffle assembly-IDA23027131  
GO:2000251positive regulation of actin cytoskeleton reorganization-IDA23027131  
GO:2000630positive regulation of miRNA metabolic process-IDA23027131  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-TAS10842192  
GO:0005794Golgi apparatus-IDA14500341  21968647  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA14500341  17724343  21968647  
GO:0005886plasma membrane-TAS-  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04062Chemokine signaling pathway
hsa04144Endocytosis
hsa04360Axon guidance
hsa04370VEGF signaling pathway
hsa04510Focal adhesion
hsa04530Tight junction
hsa04540Gap junction
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04720Long-term potentiation
hsa04722Neurotrophin signaling pathway
hsa04730Long-term depression
hsa04810Regulation of actin cytoskeleton
hsa04910Insulin signaling pathway
hsa04912GnRH signaling pathway
hsa04916Melanogenesis
hsa05160Hepatitis C
hsa05200Pathways in cancer
hsa05211Renal cell carcinoma
hsa05213Endometrial cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05216Thyroid cancer
hsa05218Melanoma
hsa05219Bladder cancer
hsa05220Chronic myeloid leukemia
hsa05221Acute myeloid leukemia
hsa05223Non-small cell lung cancer
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-112399IRS-mediated signallingIEA
R-HSA-112412SOS-mediated signallingIEA
R-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)TAS
R-HSA-1169092Activation of RAS in B cellsTAS
R-HSA-1226099Signaling by FGFR in diseaseTAS
R-HSA-1227986Signaling by ERBB2IEA
R-HSA-1227986Signaling by ERBB2TAS
R-HSA-1236382Constitutive Signaling by Ligand-Responsive EGFR Cancer VariantsTAS
R-HSA-1236394Signaling by ERBB4TAS
R-HSA-1250196SHC1 events in ERBB2 signalingIEA
R-HSA-1250347SHC1 events in ERBB4 signalingTAS
R-HSA-1266738Developmental BiologyTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1433557Signaling by SCF-KITTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-1643713Signaling by EGFR in CancerTAS
R-HSA-166520Signaling by NTRKsIEA
R-HSA-166520Signaling by NTRKsTAS
R-HSA-167044Signalling to RASIEA
R-HSA-167044Signalling to RASTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-171007p38MAPK eventsTAS
R-HSA-171007p38MAPK eventsIEA
R-HSA-177929Signaling by EGFRTAS
R-HSA-179812GRB2 events in EGFR signalingTAS
R-HSA-180336SHC1 events in EGFR signalingTAS
R-HSA-186763Downstream signal transductionTAS
R-HSA-186797Signaling by PDGFTAS
R-HSA-187037Signaling by NTRK1 (TRKA)IEA
R-HSA-187037Signaling by NTRK1 (TRKA)TAS
R-HSA-187687Signalling to ERKsIEA
R-HSA-187687Signalling to ERKsTAS
R-HSA-190236Signaling by FGFRTAS
R-HSA-194138Signaling by VEGFTAS
R-HSA-1963640GRB2 events in ERBB2 signalingTAS
R-HSA-1963640GRB2 events in ERBB2 signalingIEA
R-HSA-202733Cell surface interactions at the vascular wallTAS
R-HSA-210993Tie2 SignalingTAS
R-HSA-2172127DAP12 interactionsTAS
R-HSA-2179392EGFR Transactivation by GastrinTAS
R-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)IEA
R-HSA-2424491DAP12 signalingTAS
R-HSA-2428924IGF1R signaling cascadeIEA
R-HSA-2428928IRS-related events triggered by IGF1RIEA
R-HSA-2428933SHC-related events triggered by IGF1RIEA
R-HSA-2454202Fc epsilon receptor (FCERI) signalingTAS
R-HSA-2682334EPH-Ephrin signalingTAS
R-HSA-2871796FCERI mediated MAPK activationTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-375165NCAM signaling for neurite out-growthTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-3928662EPHB-mediated forward signalingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-422475Axon guidanceTAS
R-HSA-438064Post NMDA receptor activation eventsTAS
R-HSA-4420097VEGFA-VEGFR2 PathwayTAS
R-HSA-442742CREB phosphorylation through the activation of RasTAS
R-HSA-442755Activation of NMDA receptor and postsynaptic eventsTAS
R-HSA-442982Ras activation upon Ca2+ influx through NMDA receptorTAS
R-HSA-5218921VEGFR2 mediated cell proliferationTAS
R-HSA-5621481C-type lectin receptors (CLRs)TAS
R-HSA-5621575CD209 (DC-SIGN) signalingTAS
R-HSA-5637810Constitutive Signaling by EGFRvIIITAS
R-HSA-5637812Signaling by EGFRvIII in CancerTAS
R-HSA-5637815Signaling by Ligand-Responsive EGFR Variants in CancerTAS
R-HSA-5654687Downstream signaling of activated FGFR1TAS
R-HSA-5654688SHC-mediated cascade:FGFR1TAS
R-HSA-5654693FRS-mediated FGFR1 signalingTAS
R-HSA-5654696Downstream signaling of activated FGFR2TAS
R-HSA-5654699SHC-mediated cascade:FGFR2TAS
R-HSA-5654700FRS-mediated FGFR2 signalingTAS
R-HSA-5654704SHC-mediated cascade:FGFR3TAS
R-HSA-5654706FRS-mediated FGFR3 signalingTAS
R-HSA-5654708Downstream signaling of activated FGFR3TAS
R-HSA-5654712FRS-mediated FGFR4 signalingTAS
R-HSA-5654716Downstream signaling of activated FGFR4TAS
R-HSA-5654719SHC-mediated cascade:FGFR4TAS
R-HSA-5654736Signaling by FGFR1TAS
R-HSA-5654738Signaling by FGFR2TAS
R-HSA-5654741Signaling by FGFR3TAS
R-HSA-5654743Signaling by FGFR4TAS
R-HSA-5655253Signaling by FGFR2 in diseaseTAS
R-HSA-5655291Signaling by FGFR4 in diseaseTAS
R-HSA-5655302Signaling by FGFR1 in diseaseTAS
R-HSA-5655332Signaling by FGFR3 in diseaseTAS
R-HSA-5658442Regulation of RAS by GAPsTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673000RAF activationTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5674135MAP2K and MAPK activationTAS
R-HSA-5675221Negative regulation of MAPK pathwayTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6802946Signaling by moderate kinase activity BRAF mutantsTAS
R-HSA-6802948Signaling by high-kinase activity BRAF mutantsTAS
R-HSA-6802949Signaling by RAS mutantsTAS
R-HSA-6802952Signaling by BRAF and RAF fusionsTAS
R-HSA-6802953RAS signaling downstream of NF1 loss-of-function variantsTAS
R-HSA-6802955Paradoxical activation of RAF signaling by kinase inactive BRAFTAS
R-HSA-6802957Oncogenic MAPK signalingTAS
R-HSA-6806834Signaling by METTAS
R-HSA-74751Insulin receptor signalling cascadeIEA
R-HSA-74752Signaling by Insulin receptorIEA
R-HSA-881907Gastrin-CREB signalling pathway via PKC and MAPKTAS
R-HSA-8848021Signaling by PTK6TAS
R-HSA-8849471PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinasesTAS
R-HSA-8851805MET activates RAS signalingTAS
R-HSA-8853334Signaling by FGFR3 fusions in cancerTAS
R-HSA-8853338Signaling by FGFR3 point mutants in cancerTAS
R-HSA-9006115Signaling by NTRK2 (TRKB)IEA
R-HSA-9006927Signaling by Non-Receptor Tyrosine KinasesTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA
R-HSA-9026519Activated NTRK2 signals through RASIEA
R-HSA-9028731Activated NTRK2 signals through FRS2 and FRS3IEA
R-HSA-983705Signaling by the B Cell Receptor (BCR)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28799801Cross-generational effects of alcohol dependence in humans on HRAS and TP53 methylation in offspring. (2017 Sep)Hill SYEpigenomics
21772844Molecular mechanisms of cigarette smoke-induced proliferation of lung cells and prevention by vitamin C. (2011)Dey NJ Oncol
11424140Smoking, folate and methylenetetrahydrofolate reductase status as interactive determinants of adenomatous and hyperplastic polyps of colorectum. (2001 Jul 1)Ulvik AAm J Med Genet
19750961Factors associated with incidental sickness absence among employees in one health care system. (2009 Sep-Oct)Pai CWAm J Health Promot
25631445Comprehensive genomic characterization of head and neck squamous cell carcinomas. (2015 Jan 29)-Nature
23435205Genome-wide methylation profiling and the PI3K-AKT pathway analysis associated with smoking in urothelial cell carcinoma. (2013 Apr 1)Brait MCell Cycle
20578566Health savings accounts and health reimbursement arrangements: assets, account balances, and rollovers, 2006-2009. (2010 Jun)Fronstin PEBRI Issue Brief
26683928Genomic Copy Number Variations Characterize the Prognosis of Both P16-Positive and P16-Negative Oropharyngeal Squamous Cell Carcinoma After Curative Resection. (2015 Dec)Rhie AMedicine (Baltimore)
28240520Roles of Signal Transducer Pathways in Investigation of Biopsies from Patients with Bladder Tumors (2017 Jan 1)Bayrak AAsian Pac J Cancer Prev
27352265Bladder Cancer and Genetic Mutations. (2015 Sep)Zhang XCell Biochem Biophys
12766628The reliability and validity of the self-reported drinking measures in the Army's Health Risk Appraisal survey. (2003 May)Bell NSAlcohol Clin Exp Res
24834262Study on association between H-ras gene polymorphism and gastric adenocarcinoma risk. (2013 Summer)Rostami MGastroenterol Hepatol Bed Bench