Gene: ERAS

3266
HRAS2|HRASP
ES cell expressed Ras
protein-coding
Xp11.23
Ensembl:ENSG00000187682 MIM:300437 Vega:OTTHUMG00000059533 UniprotKB:Q7Z444
NC_000023.11
PubMed
0   ANCO-SNPs
OD|ND|AD
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYNE40.621
MUC120.596
ZFAND2A0.594
IFT430.573
ALKBH20.57
HSPE10.567
C19orf240.551
TSSC40.55
TMIE0.548
NXT10.537

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CYSLTR2-0.422
P2RY14-0.331
LY75-0.325
CX3CR1-0.307
OLFML2A-0.301
HMCN1-0.293
TRIM6-0.285
PDE5A-0.283
LEPR-0.282
UNC13C-0.281

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D019342Acetic AcidAcetic Acid results in increased expression of ERAS protein21296659
C006780bisphenol Abisphenol A affects the expression of ERAS mRNA25181051
C099813bromochloroacetic acidbromochloroacetic acid results in increased expression of ERAS protein21296659
C014476diethyl maleatediethyl maleate results in decreased expression of ERAS mRNA25270620
D005472FluorouracilFluorouracil results in decreased expression of ERAS protein21296659
C008261lead acetatelead acetate results in decreased expression of ERAS mRNA25270620
C008261lead acetatelead acetate results in increased expression of ERAS mRNA22609695
C006253pirinixic acidpirinixic acid results in decreased expression of ERAS mRNA25270620
D011374ProgesteroneProgesterone results in increased expression of ERAS mRNA23012394
D011441PropylthiouracilPropylthiouracil results in increased expression of ERAS mRNA24780913
D014635Valproic AcidValproic Acid results in increased methylation of ERAS gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ERAS gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-IEA-  
GO:0005525GTP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27060849New scale for predicting mortality in ruptured abdominal aortic aneurysms. (2016 Jun-Jul)San Norberto EMCir Esp
15654781The effect of HIV coinfection on the risk of cirrhosis and hepatocellular carcinoma in U.S. veterans with hepatitis C. (2005 Jan)Kramer JRAm J Gastroenterol
17469097Association of DRB1 shared epitope genotypes with early mortality in rheumatoid arthritis: results of eighteen years of followup from the early rheumatoid arthritis study. (2007 May)Mattey DLArthritis Rheum
27831953Life expectancy in HIV-positive persons in Switzerland: matched comparison with general population. (2017 Jan 28)Gueler AAIDS
29225618Influence of Enhanced Recovery Pathway on Surgical Site Infection after Colonic Surgery. (2017)Gronnier CGastroenterol Res Pract
26526351Endothelin receptor-antagonists suppress lipopolysaccharide-induced cytokine release from alveolar macrophages of non-smokers, smokers and COPD subjects. (2015 Dec 5)Gerlach KEur J Pharmacol