Gene: RAB37

326624
-
RAB37, member RAS oncogene family
protein-coding
17q25.1
Ensembl:ENSG00000172794 MIM:609956 Vega:OTTHUMG00000134282 UniprotKB:Q96AX2
NC_000017.11
SNP Mapped
1   ANCO-SNPs
AD
0   
1.181e-2 (AD)  7.958e-1 (ND)   (Frontal_Cortex)
5.149e-1 (AD)  6.027e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs16978166chr17:74677410 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CBLN20.909
NCALD0.906
FAM81A0.905
ADAM110.904
EIF4E1B0.902
SRRM40.9
NEFM0.899
TESPA10.899
ABCG40.898
SPTSSB0.897

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WWTR1-0.597
YES1-0.581
REST-0.567
RAI14-0.566
LRAT-0.552
HEY2-0.541
CNN2-0.534
TGIF1-0.525
RAB13-0.524
CARD8-0.522

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in increased expression of RAB37 mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in increased expression of RAB37 mRNA]28655636
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of RAB37 mRNA16788091
D000082AcetaminophenAcetaminophen results in decreased expression of RAB37 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RAB37 mRNA21641981
D001151ArsenicArsenic affects the methylation of RAB37 gene25304211
C015001arsenitearsenite results in increased methylation of RAB37 promoter23974009
C547126AZM551248AZM551248 results in decreased expression of RAB37 mRNA22323515
C551172bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV)"bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV) results in increased expression of RAB37 mRNA"20162321
D016572CyclosporineCyclosporine results in decreased expression of RAB37 mRNA20106945
D003561CytarabineCytarabine results in decreased expression of RAB37 mRNA21198554
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of RAB37 mRNA27392435
D002945CisplatinCisplatin results in increased expression of RAB37 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of RAB37 mRNA18457598
C118739entinostatentinostat results in increased expression of RAB37 mRNA26272509|2718838
D004397FonofosFonofos results in increased methylation of RAB37 promoter22847954
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RAB37 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of RAB37 mRNA27392435
C544151jinfukangjinfukang results in increased expression of RAB37 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RAB37 mRNA23086925
D010278ParathionParathion results in increased methylation of RAB37 promoter22847954
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in increased expression of RAB37 mRNA]28655636
D052638Particulate MatterParticulate Matter results in increased expression of RAB37 mRNA28655636
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of RAB37 mRNA25895662
D012969Sodium FluorideSodium Fluoride results in increased expression of RAB37 protein27548804
C012568terbufosterbufos results in increased methylation of RAB37 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RAB37 mRNA21354282
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RAB37 mRNA25613284
C012589trichostatin Atrichostatin A results in increased expression of RAB37 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased methylation of RAB37 promoter24675093
D014635Valproic AcidValproic Acid affects the expression of RAB37 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of RAB37 mRNA28001369|2915479
D014635Valproic AcidValproic Acid results in increased methylation of RAB37 gene29154799
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in increased expression of RAB37 mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in increased expression of RAB37 mRNA28655636

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-IBA21873635  
GO:0003924GTPase activity-IEA-  
GO:0005515protein binding-IPI25416956  
GO:0005525GTP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-IBA21873635  
GO:0032482Rab protein signal transduction-IBA21873635  
GO:0043312neutrophil degranulation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005793endoplasmic reticulum-Golgi intermediate compartment-IDA15308636  
GO:0005886plasma membrane-TAS-  
GO:0012505endomembrane system-IBA21873635  
GO:0035577azurophil granule membrane-TAS-  
GO:0035579specific granule membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-8873719RAB geranylgeranylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal