Gene: HRG

3273
HPRG|HRGP|THPH11
histidine rich glycoprotein
protein-coding
3q27.3
Ensembl:ENSG00000113905 MIM:142640 Vega:OTTHUMG00000156578 UniprotKB:P04196
NG_021485.2
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.761e-1 (AD)  6.385e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RDH120.501
SPAG40.494
SLC29A10.487
RASSF50.484
ECM10.483
INSM20.48
DNAJC5G0.479
NPBWR20.477
SGCG0.475
TRPM20.474

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM100-0.441
MBNL3-0.428
PARD3B-0.413
ZFHX4-0.412
RFTN2-0.405
PELI2-0.397
PDLIM5-0.396
MYOM1-0.395
MFAP5-0.394
PPARA-0.39

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of HRG mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of HRG mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of HRG mRNA29067470
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of HRG mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of HRG mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 affects the expression of HRG protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of HRG mRNA27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of HRG mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HRG mRNA16483693
D001151ArsenicArsenic affects the expression of HRG protein24675094
C006632arsenic trioxidearsenic trioxide results in increased expression of HRG mRNA27829220
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of HRG mRNA25412620
D004958EstradiolEstradiol results in decreased expression of HRG mRNA20106945
C006780bisphenol Abisphenol A results in decreased expression of HRG mRNA25181051
D002104CadmiumHRG protein binds to Cadmium23896426
D002509CephaloridineCephaloridine results in decreased expression of HRG mRNA18500788
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of HRG mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of HRG mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of HRG mRNA]17585979
D003300CopperCopper results in increased activity of HRG protein8690451
D003300CopperHRG protein binds to Copper23896426
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of HRG mRNA20971185
D003300CopperCopper results in decreased expression of HRG mRNA22465980
D016572CyclosporineCyclosporine results in decreased expression of HRG mRNA20106945|2798913
D003687DehydroepiandrosteroneDehydroepiandrosterone results in decreased expression of HRG mRNA22640920
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of HRG mRNA28943392
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HRG mRNA26159488
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of HRG protein7667832
C007738fluoranthene[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of HRG mRNA25412620
C039281furanfuran results in decreased expression of HRG mRNA26194646
C039281furanfuran results in increased methylation of HRG gene22079235
D005839GentamicinsGentamicins results in decreased expression of HRG mRNA22061828
C412815GW 4064GW 4064 results in decreased expression of HRG mRNA26655953
D006493HeparinHeparin inhibits the reaction [Zinc results in increased activity of HRG protein]8690451
C051890irinotecanirinotecan metabolite results in increased expression of HRG mRNA15956246
C051890irinotecanirinotecan results in increased expression of HRG mRNA15956246
D007854LeadHRG protein binds to Lead23896426
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of HRG mRNA26667767
D008070Lipopolysaccharidesresveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of HRG mRNA]26667767
D009532NickelHRG protein binds to Nickel23896426
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of HRG mRNA20971185
C076029olanzapineolanzapine affects the phosphorylation of HRG protein25821032
D052638Particulate MatterParticulate Matter results in increased expression of HRG protein17520064
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of HRG mRNA19710929
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of HRG mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of HRG mRNA20813756|2381119
C006253pirinixic acidpirinixic acid results in decreased expression of HRG mRNA16940010
D011192Potassium DichromatePotassium Dichromate results in increased expression of HRG mRNA23608068
D017035PravastatinPravastatin results in decreased expression of HRG mRNA27225895
D017035PravastatinPravastatin results in decreased expression of HRG mRNA27225895
D011374ProgesteroneProgesterone results in increased expression of HRG mRNA19690047
C059514resveratrolresveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of HRG mRNA]26667767
C075117squalestatin 1squalestatin 1 results in decreased expression of HRG mRNA27225895
C075117squalestatin 1squalestatin 1 results in decreased expression of HRG mRNA27225895
D010042OuabainOuabain affects the expression of HRG protein17268060
D013629TamoxifenHRG protein results in decreased susceptibility to Tamoxifen19552798
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in decreased expression of HRG mRNA15885361
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HRG mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HRG gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HRG mRNA28213091
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of HRG mRNA28943392
C057693troglitazonetroglitazone results in decreased expression of HRG mRNA25572481
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of HRG mRNA15885361
D014635Valproic AcidValproic Acid results in decreased expression of HRG mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of HRG gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased expression of HRG protein17520064
D015032ZincHeparin inhibits the reaction [Zinc results in increased activity of HRG protein]8690451
D015032ZincHRG protein binds to Zinc23896426
D015032ZincZinc results in increased activity of HRG protein8690451

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004866endopeptidase inhibitor activity-IBA21873635  
GO:0004867serine-type endopeptidase inhibitor activity-IBA21873635  
GO:0004869cysteine-type endopeptidase inhibitor activity-IEA-  
GO:0005102signaling receptor binding-IDA16436387  
GO:0005515protein binding-IPI11134179  15220341  19285951  19712047  20561914  21304106  
21988832  24825900  
GO:0008201heparin binding-IBA21873635  
GO:0008201heparin binding-IDA16436387  21304106  
GO:0008270zinc ion binding-IBA21873635  
GO:0008270zinc ion binding-IDA15138272  16436387  21304106  
GO:0019865immunoglobulin binding-IDA10514432  
GO:0020037heme binding-IDA678554  
GO:0043395heparan sulfate proteoglycan binding-IDA15138272  16436387  
GO:0046872metal ion binding-IDA678554  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0002576platelet degranulation-TAS-  
GO:0002839positive regulation of immune response to tumor cell-IDA21215706  
GO:0006935chemotaxis-IEA-  
GO:0007162negative regulation of cell adhesion-IDA14744774  
GO:0008285negative regulation of cell proliferation-IDA14744774  
GO:0010468regulation of gene expression-IDA21215706  
GO:0010543regulation of platelet activation-IBA21873635  
GO:0010543regulation of platelet activation-ISS-  
GO:0010593negative regulation of lamellipodium assembly-IDA16489009  
GO:0010951negative regulation of endopeptidase activity-IBA21873635  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0015886heme transport-IBA21873635  
GO:0016525negative regulation of angiogenesis-IDA14744774  16436387  16489009  19903770  
GO:0030168platelet activation-IDA19903770  
GO:0030193regulation of blood coagulation-IDA6740558  21304106  
GO:0030308negative regulation of cell growth-IDA21215706  
GO:0032956regulation of actin cytoskeleton organization-IDA16489009  
GO:0033629negative regulation of cell adhesion mediated by integrin-IDA16489009  
GO:0042730fibrinolysis-TAS-  
GO:0043065positive regulation of apoptotic process-IDA14744774  
GO:0043254regulation of protein complex assembly-IDA16489009  
GO:0043537negative regulation of blood vessel endothelial cell migration-ISS-  
GO:0050730regulation of peptidyl-tyrosine phosphorylation-IDA16489009  
GO:0050832defense response to fungus-IDA18797515  
GO:0051715cytolysis in other organism-IDA18797515  
GO:0051894positive regulation of focal adhesion assembly-IDA14744774  16436387  
GO:0051918negative regulation of fibrinolysis-IBA21873635  
GO:0061844antimicrobial humoral immune response mediated by antimicrobial peptide-IDA18797515  
GO:1900747negative regulation of vascular endothelial growth factor signaling pathway-IDA16489009  
GO:2000504positive regulation of blood vessel remodeling-IDA21215706  
GO:2001027negative regulation of endothelial cell chemotaxis-IDA14744774  16436387  16489009  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-HDA27068509  
GO:0005576extracellular region-IBA21873635  
GO:0005576extracellular region-IDA18797515  
GO:0005576extracellular region-NAS14718574  
GO:0005576extracellular region-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0009986cell surface-IDA15220341  
GO:0031093platelet alpha granule lumen-TAS-  
GO:0036019endolysosome-IBA21873635  
GO:0070062extracellular exosome-HDA19056867  23533145  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-75205Dissolution of Fibrin ClotTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16393673Expression of epidermal growth factors and their receptors in the bronchial epithelium of subjects with chronic obstructive pulmonary disease. (2006 Feb)de Boer WIAm J Clin Pathol
28434814Novel protein biomarkers associated with coronary artery disease in statin-treated patients with familial hypercholesterolemia. (2017 May - Jun)Bos SJ Clin Lipidol