Gene: SERPINA9

327657
GCET1|SERPINA11|SERPINA11b
serpin family A member 9
protein-coding
14q32.13
Ensembl:ENSG00000170054 MIM:615677 Vega:OTTHUMG00000167710 UniprotKB:Q86WD7
NC_000014.9
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.637e-2 (AD)  6.652e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12892340chr14:94467839 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg08593009chr14:94943184SERPINA9Promoter3.983e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GACAT10.893
OR4A150.883
KRTAP27-10.882
OR4C120.882
KRTAP6-20.882
CDY2A0.882
OR5M10.882
TSPY30.882
OR5F10.882
OR5W20.882

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HHATL-0.253
FUT9-0.249
PCDH9-0.238
OMG-0.222
NTSR2-0.217
C1orf53-0.214
PLA2G6-0.214
SLC1A4-0.213
GABRG1-0.213
ACSL6-0.211

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of SERPINA9 mRNA"22698814
D000082AcetaminophenAcetaminophen affects the expression of SERPINA9 mRNA17562736
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of SERPINA9 mRNA21298039
D000638AmiodaroneAmiodarone results in decreased expression of SERPINA9 mRNA24535564
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SERPINA9 mRNA16483693
C006780bisphenol Abisphenol A results in decreased methylation of SERPINA9 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of SERPINA9 mRNA25181051
C037123cadmium sulfatecadmium sulfate results in increased expression of SERPINA9 mRNA16221973
D002737ChloropreneChloroprene results in increased expression of SERPINA9 mRNA23125180
C093628cyproconazolecyproconazole results in decreased expression of SERPINA9 mRNA22334560
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SERPINA9 mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of SERPINA9 mRNA28962523
C109476epoxiconazoleepoxiconazole results in decreased expression of SERPINA9 mRNA22334560
C024565ethylene dichlorideethylene dichloride results in decreased expression of SERPINA9 mRNA28189721
C039281furanfuran results in increased expression of SERPINA9 mRNA24183702
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SERPINA9 mRNA25613284
D007840LatexLatex analog results in increased expression of SERPINA9 mRNA24768652
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of SERPINA9 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SERPINA9 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SERPINA9 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SERPINA9 mRNA"25620056
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of SERPINA9 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of SERPINA9 mRNA19270015|1948288
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of SERPINA9 mRNA28903501
C045950propiconazolepropiconazole results in decreased expression of SERPINA9 mRNA22334560|2397080
C009250sevofluranesevoflurane results in decreased expression of SERPINA9 mRNA26206149
D012822Silicon DioxideSilicon Dioxide results in decreased expression of SERPINA9 mRNA23221170
D053260SootSoot results in increased expression of SERPINA9 mRNA26551751
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SERPINA9 mRNA25613284
C009495titanium dioxidetitanium dioxide affects the expression of SERPINA9 mRNA23557971
C032910triadimefontriadimefon results in decreased expression of SERPINA9 mRNA23970803
D014241TrichloroethyleneTrichloroethylene results in decreased expression of SERPINA9 mRNA25549359
C057693troglitazonetroglitazone results in decreased expression of SERPINA9 mRNA28973697
D014635Valproic AcidValproic Acid results in decreased expression of SERPINA9 mRNA24535564

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004867serine-type endopeptidase inhibitor activity-IBA21873635  
GO:0004867serine-type endopeptidase inhibitor activity-IDA15489334  
GO ID GO Term Qualifier Evidence PubMed
GO:0010951negative regulation of endopeptidase activity-IBA21873635  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0005737cytoplasm-IEA-  
GO:0016020membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal