Gene info: ID 328

Gene: APEX1

GENE ID: 328

Synonyms: APE|APE1|APEN|APEX|APX|HAP1|REF1

Description: apurinic/apyrimidinic endodeoxyribonuclease 1

Gene type: protein-coding

Location: 14q11.2

dbXrefs: Ensembl:ENSG00000100823 MIM:107748 Vega:OTTHUMG00000029544 UniprotKB:P27695

RefSeq: NG_008718.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 14

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.878e-1 (AD) 3.765e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
XRCC6	0.964
POLDIP2	0.96
MAGED2	0.958
SLC25A3	0.957
CAPZB	0.955
PHB2	0.953
EMC4	0.952
ARFGAP2	0.952
CDC123	0.95
EIF2AK1	0.95

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.812
OR4F29	-0.763
MTRNR2L6	-0.323
MTRNR2L9	-0.313
MTRNR2L10	-0.274
PPBP	-0.241
VNN3	-0.222
HMHB1	-0.219
TRPV5	-0.216
TTLL10	-0.216

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB04967	Lucanthone	Small Molecule	479-50-5	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C478160	(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane	"[Sodium Selenite co-treated with (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] results in decreased expression of and affects the localization of APEX1 protein"	28757135
C478160	(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane	"[Sodium Selenite co-treated with (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] results in decreased expression of APEX1 mRNA"	28757135
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of APEX1 mRNA"	19162173
C038983	1,3-dimethylthiourea	"1,3-dimethylthiourea inhibits the reaction [Puromycin Aminonucleoside results in increased expression of APEX1 protein]"	17035936
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of APEX1 mRNA"	21346803
C019499	2-nitrofluorene	2-nitrofluorene results in increased expression of APEX1 mRNA	15890375
C016617	2-nitropropane	2-nitropropane results in increased expression of APEX1 mRNA	19268524
C016617	2-nitropropane	2-nitropropane results in increased expression of APEX1 protein	19268524
C016617	2-nitropropane	APEX1 protein affects the susceptibility to 2-nitropropane	19268524
C016617	2-nitropropane	APEX1 protein inhibits the reaction [2-nitropropane results in increased activity of CASP3 protein]	19268524
C016617	2-nitropropane	APEX1 protein inhibits the reaction [2-nitropropane results in increased expression of GADD45G mRNA]	19268524
C016617	2-nitropropane	APEX1 protein inhibits the reaction [2-nitropropane results in increased expression of TRP53 protein]	19268524
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased expression of APEX1 mRNA	19191707
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of APEX1 mRNA	15890375
C067134	8-oxo-7-hydrodeoxyguanosine	APEX1 gene SNP affects the abundance of 8-oxo-7-hydrodeoxyguanosine	19896490
D000082	Acetaminophen	Acetaminophen results in increased expression of APEX1 mRNA	16751229
D000108	Acetylcarnitine	Acetylcarnitine results in increased expression of APEX1 mRNA	14654561
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of APEX1 protein]	12231548
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of APEX1 mRNA]	17938202
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of APEX1 mRNA	15890375
D000393	Air Pollutants	Air Pollutants results in increased expression of APEX1 mRNA	24792328
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of APEX1 mRNA	16483693
C023650	aniline	aniline results in increased expression of and results in increased activity of APEX1 protein	23352893
C023650	aniline	aniline results in increased expression of APEX1 mRNA	23352893
D001115	Arecoline	Arecoline results in decreased expression of APEX1 mRNA	17682004
D001151	Arsenic	APEX1 gene polymorphism affects the susceptibility to Arsenic	17374727
D001151	Arsenic	APEX1 protein affects the susceptibility to Arsenic	18053222
C015001	arsenite	arsenite affects the expression of APEX1 mRNA	18252256
C015001	arsenite	arsenite results in increased expression of APEX1 mRNA	15996700
C015001	arsenite	arsenite results in increased expression of APEX1 protein	18252256
D017636	Asbestos, Amphibole	"Asbestos, Amphibole affects the expression of APEX1 protein"	24598051
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite affects the localization of APEX1 protein"	12023366
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite affects the localization of APEX1 protein"	12023366
D017638	Asbestos, Crocidolite	"diphenyleneiodonium inhibits the reaction [Asbestos, Crocidolite affects the localization of APEX1 protein]"	12023366
D001280	Atrazine	Atrazine results in increased expression of APEX1 protein	27957240
D001554	Benzene	APEX1 gene polymorphism affects the susceptibility to Benzene	22245109
D001554	Benzene	Benzene affects the expression of APEX1 mRNA	16188086
D001564	Benzo(a)pyrene	AHR protein affects the reaction [Benzo(a)pyrene affects the expression of APEX1 mRNA]	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of APEX1 mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of APEX1 mRNA	22228805
D016227	Benzoquinones	APEX1 protein results in increased reduction of and results in increased susceptibility to Benzoquinones	10190555
C032776	beryllium chloride	beryllium chloride affects the expression of APEX1 mRNA	23793613
D004958	Estradiol	Estradiol results in increased expression of APEX1 mRNA	17522070
D001622	Betaine	Betaine results in decreased expression of APEX1 mRNA	26391144
D001629	Bezafibrate	Bezafibrate results in increased expression of APEX1 mRNA	15447978
C006780	bisphenol A	bisphenol A affects the expression of APEX1 mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of APEX1 mRNA	21932408
C006780	bisphenol A	bisphenol A results in increased expression of APEX1 mRNA	25181051
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of APEX1 mRNA	17553608
D002066	Busulfan	APEX1 protein mutant form results in increased susceptibility to Busulfan	19470598
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in increased expression of APEX1 protein	23736079
D002087	Butyrates	Butyrates results in decreased expression of APEX1 mRNA	14674679
D002104	Cadmium	Cadmium affects the activity of APEX1 protein	21605570
D002104	Cadmium	Cadmium affects the expression of APEX1 mRNA	21605570
D002104	Cadmium	TP53 protein affects the reaction [Cadmium affects the activity of APEX1 protein]	21605570
D002104	Cadmium	TP53 protein affects the reaction [Cadmium affects the expression of APEX1 mRNA]	21605570
D002104	Cadmium	Cadmium results in decreased activity of APEX1 protein	16677676
C028031	cadmium acetate	cadmium acetate affects the expression of APEX1 mRNA	16249259
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of APEX1 mRNA	18804290
D002110	Caffeine	"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of APEX1 mRNA"	20230807
D002110	Caffeine	"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of APEX1 mRNA]"	20230807
D002244	Carbon	Carbon analog results in increased expression of APEX1 mRNA	24792328
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of APEX1 mRNA	27339419
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of APEX1 mRNA	17522070
D002330	Carmustine	APEX1 protein mutant form results in increased susceptibility to Carmustine	17259346\|1947059
D002330	Carmustine	APEX1 protein results in decreased susceptibility to Carmustine	12231548\|1624381
D002713	Chlorine	[Ozone co-treated with Chlorine] results in decreased expression of APEX1 mRNA	18636392
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of APEX1 mRNA	25113976
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of APEX1 mRNA	18804290
D002725	Chloroform	Chloroform results in increased expression of APEX1 mRNA	17522070
D002994	Clofibrate	Clofibrate results in increased expression of APEX1 mRNA	16081524
D002994	Clofibrate	Clofibrate results in decreased expression of APEX1 mRNA	17522070
D002995	Clofibric Acid	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of APEX1 mRNA	17602206
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of APEX1 mRNA	19320972
C018021	cobaltous chloride	[cobaltous chloride results in increased activity of SRC protein] promotes the reaction [[[HIF1A protein binds to STAT3 protein modified form] which binds to VEGFA promoter] binds to [APEX1 protein binds to CREBBP promoter]]	15735682
D003300	Copper	Copper results in increased expression of APEX1	25109342
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of APEX1 mRNA	19549813
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of APEX1 mRNA	17654400
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of APEX1 mRNA	11599041
C093628	cyproconazole	[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of APEX1 mRNA	29038839
C093628	cyproconazole	[cyproconazole co-treated with epoxiconazole] results in increased expression of APEX1 mRNA	29038839
C093628	cyproconazole	cyproconazole results in increased expression of APEX1 mRNA	29038839
D003606	Dacarbazine	APEX1 protein mutant form results in increased susceptibility to Dacarbazine	19470598
D003606	Dacarbazine	APEX1 protein results in decreased susceptibility to Dacarbazine	16373707
D003630	Daunorubicin	APEX1 protein results in increased reduction of and results in increased susceptibility to Daunorubicin	10190555
D016047	Zalcitabine	APEX1 protein mutant form results in increased susceptibility to Zalcitabine	17259346
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of APEX1 mRNA	17361019\|2126653
D002945	Cisplatin	APEX1 protein results in decreased susceptibility to Cisplatin	16373707\|2085619
D002945	Cisplatin	Cisplatin promotes the reaction [APEX1 protein modified form binds to [YBX1 protein binds to EP300 protein]]	20856196
D002945	Cisplatin	Cisplatin promotes the reaction [[APEX1 protein modified form promotes the reaction [YBX1 protein binds to EP300 protein]] which binds to ABCB1 promoter]	20856196
D002945	Cisplatin	Cisplatin results in decreased expression of APEX1 mRNA	27594783
D002945	Cisplatin	Cisplatin results in increased acetylation of APEX1 protein	20856196
D002945	Cisplatin	[Cisplatin results in increased acetylation of APEX1 protein] promotes the reaction [APEX1 protein modified form binds to ABCB1 promoter]	20856196
D002945	Cisplatin	[Cisplatin results in increased acetylation of APEX1 protein] promotes the reaction [[APEX1 protein modified form binds to ABCB1 promoter] which results in increased expression of ABCB1 mRNA]	20856196
D002945	Cisplatin	EP300 protein promotes the reaction [Cisplatin results in increased acetylation of APEX1 protein]	20856196
D002945	Cisplatin	Cisplatin results in decreased expression of APEX1 mRNA	21151649
D002945	Cisplatin	[methoxyamine results in decreased activity of APEX1 protein] which results in decreased susceptibility to Cisplatin	21357694
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of APEX1 mRNA	17602206
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of APEX1 mRNA	11323195
D004052	Diethylnitrosamine	[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of APEX1 mRNA	18253720\|1877588
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of APEX1 mRNA	15890375
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of APEX1 mRNA"	25697376
D015127	9,10-Dimethyl-1,2-benzanthracene	"Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of APEX1 mRNA]"	25697376
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of APEX1 mRNA	15890375
D004147	Dioxins	Dioxins affects the expression of APEX1 mRNA	20463971
C007517	diphenyleneiodonium	"diphenyleneiodonium inhibits the reaction [Asbestos, Crocidolite affects the localization of APEX1 protein]"	12023366
D004229	Dithiothreitol	Dithiothreitol promotes the reaction [MAPK1 protein binds to APEX1 protein]	23370007
C075569	E 3330	E 3330 inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]]	23370007
D004785	Environmental Pollutants	APEX1 gene SNP affects the susceptibility to Environmental Pollutants	24036326
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of APEX1 protein	23301498
C109476	epoxiconazole	[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of APEX1 mRNA	29038839
C109476	epoxiconazole	[cyproconazole co-treated with epoxiconazole] results in increased expression of APEX1 mRNA	29038839
D004918	Erythromycin Estolate	Erythromycin Estolate results in decreased expression of APEX1 mRNA	17522070
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of APEX1 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of APEX1 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of APEX1 mRNA	17942748
C036216	ethylene	ethylene results in increased expression of APEX1 protein	16051529
D005027	Ethylene Oxide	Ethylene Oxide results in increased expression of APEX1 protein	16051529
D005033	Ethylmaleimide	Ethylmaleimide inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]]	23370007
D005047	Etoposide	APEX1 protein results in decreased susceptibility to Etoposide	20856196
D011345	Fenofibrate	[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of APEX1 mRNA	18253720\|1877588
D011345	Fenofibrate	Fenofibrate results in increased expression of APEX1 mRNA	17264098\|1877588
C024555	ferric chloride	ferric chloride affects the localization of APEX1 protein	12023366
C024555	ferric chloride	[ferric chloride co-treated with Tetradecanoylphorbol Acetate] affects the localization of APEX1 protein	12023366
D005467	Floxuridine	APEX1 protein mutant form results in increased susceptibility to Floxuridine	19470598
D005467	Floxuridine	APEX1 protein results in decreased susceptibility to Floxuridine	22194930
C007738	fluoranthene	fluoranthene results in increased expression of APEX1 mRNA	18522720
D005472	Fluorouracil	APEX1 protein mutant form results in increased susceptibility to Fluorouracil	19470598
D005485	Flutamide	Flutamide results in increased expression of APEX1 mRNA	24136188
C039281	furan	furan results in increased expression of APEX1 mRNA	22079235\|2553966
D005839	Gentamicins	Gentamicins results in increased expression of APEX1 mRNA	22061828
D005897	Glafenine	Glafenine results in increased expression of APEX1 mRNA	24136188
D006861	Hydrogen Peroxide	APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]	23370007
D006861	Hydrogen Peroxide	APEX1 protein mutant form results in increased susceptibility to Hydrogen Peroxide	17259346
D006861	Hydrogen Peroxide	E 3330 inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]]	23370007
D006861	Hydrogen Peroxide	Ethylmaleimide inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]]	23370007
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of APEX1 mRNA	22539617
D006861	Hydrogen Peroxide	APEX1 protein promotes the reaction [Hydrogen Peroxide results in increased expression of IL4 mRNA]	12884291
D006861	Hydrogen Peroxide	APEX1 protein promotes the reaction [Hydrogen Peroxide results in increased expression of IL6 mRNA]	12884291
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the localization of APEX1 protein	12884291
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of APEX1 mRNA	17938202
D006997	Hypochlorous Acid	Acetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of APEX1 protein]	12231548
D006997	Hypochlorous Acid	Hypochlorous Acid results in increased activity of APEX1 protein	12231548
D006997	Hypochlorous Acid	Hypochlorous Acid results in increased expression of APEX1 protein	12231548
C492448	ICG 001	ICG 001 results in decreased expression of APEX1 mRNA	26191083
C492448	ICG 001	ICG 001 results in increased expression of APEX1 mRNA	26191083
C056493	imiquimod	imiquimod results in decreased expression of APEX1 mRNA	21878529
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of APEX1 mRNA	25613284
D007545	Isoproterenol	Isoproterenol results in increased expression of APEX1 mRNA	21335049
C561695	(+)-JQ1 compound	(+)-JQ1 compound affects the expression of APEX1	24394663
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of APEX1 mRNA	25982114
D007608	Kainic Acid	[Raloxifene Hydrochloride co-treated with Kainic Acid] results in increased expression of APEX1 mRNA	16120186
D007854	Lead	Lead results in decreased activity of APEX1 protein	17013835
D007854	Lead	APEX1 gene polymorphism affects the susceptibility to Lead	22466227
D007854	Lead	APEX1 protein inhibits the reaction [Lead results in decreased activity of APEX1 protein]	17013835
D007854	Lead	Lead affects the expression of APEX1 mRNA	28903495
C008261	lead acetate	APEX1 protein promotes the reaction [lead acetate results in increased expression of CCND1 protein]	23370007
C008261	lead acetate	APEX1 protein promotes the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]	23370007
C008261	lead acetate	APEX1 protein promotes the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]	23370007
C008261	lead acetate	APEX1 protein results in decreased susceptibility to lead acetate	23370007
C008261	lead acetate	lead acetate promotes the reaction [APEX1 protein results in increased phosphorylation of MAPK1 protein]	23370007
C008261	lead acetate	lead acetate promotes the reaction [APEX1 protein results in increased phosphorylation of MAPK3 protein]	23370007
C008261	lead acetate	lead acetate promotes the reaction [MAPK1 protein modified form binds to APEX1 protein]	23370007
C008261	lead acetate	lead acetate results in increased expression of APEX1 protein	23370007
C008261	lead acetate	[lead acetate results in increased expression of APEX1 protein] which results in increased abundance of Reactive Oxygen Species	23370007
C482199	lipopolysaccharide, E coli O55-B5	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of APEX1 mRNA"	18930950
D058955	Metalloids	APEX1 gene SNP affects the susceptibility to Metalloids	24036326
D008670	Metals	APEX1 gene SNP affects the susceptibility to Metals	24036326
D008687	Metformin	"Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of APEX1 mRNA]"	25697376
D008701	Methapyrilene	Methapyrilene results in increased expression of APEX1 mRNA	15890375\|2893558
C005214	methoxyamine	methoxyamine results in decreased activity of APEX1 protein	21357694
C005214	methoxyamine	[methoxyamine results in decreased activity of APEX1 protein] which results in decreased susceptibility to Cisplatin	21357694
C005214	methoxyamine	[methoxyamine results in decreased activity of APEX1 protein] which results in increased susceptibility to Mitomycin	21357694
C005214	methoxyamine	[methoxyamine results in decreased activity of APEX1 protein] which results in increased susceptibility to transplatin	21357694
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of APEX1 mRNA	18804290
D008741	Methyl Methanesulfonate	APEX1 protein mutant form results in increased susceptibility to Methyl Methanesulfonate	17259346
D008741	Methyl Methanesulfonate	APEX1 protein results in decreased susceptibility to Methyl Methanesulfonate	12231548
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of APEX1 mRNA	23649840
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of APEX1 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of APEX1 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of APEX1 mRNA]"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of APEX1 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of APEX1 mRNA]"	20230807
D008825	Miconazole	Miconazole results in decreased expression of APEX1 mRNA	22262564
D008825	Miconazole	APEX1 protein inhibits the reaction [Miconazole results in increased abundance of Superoxides]	22262564
D008825	Miconazole	APEX1 protein results in decreased susceptibility to Miconazole	22262564
C059539	midostaurin	midostaurin results in decreased expression of APEX1 mRNA	20980353
D016685	Mitomycin	APEX1 protein results in increased reduction of and results in increased susceptibility to Mitomycin	10190555
D016685	Mitomycin	[methoxyamine results in decreased activity of APEX1 protein] which results in increased susceptibility to Mitomycin	21357694
D009270	Naloxone	Naloxone results in decreased expression of APEX1 mRNA	17522070
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of APEX1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of APEX1 mRNA"	25554681
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of APEX1 mRNA	17522070
C051752	nefazodone	nefazodone results in increased expression of APEX1 mRNA	24136188
D009538	Nicotine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of APEX1 mRNA"	20230807
D009538	Nicotine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of APEX1 mRNA]"	20230807
C012655	nimesulide	nimesulide results in increased expression of APEX1 mRNA	24136188
D005996	Nitroglycerin	Nitroglycerin results in increased expression of APEX1 mRNA	12102619
C025589	ochratoxin A	ochratoxin A results in decreased expression of APEX1 mRNA	23358140
D010100	Oxygen	APEX1 protein inhibits the reaction [RAC1 protein inhibits the reaction [Oxygen deficiency results in increased expression of SERPINE1 mRNA]]	12719791
D010100	Oxygen	APEX1 protein promotes the reaction [Oxygen deficiency results in increased expression of SERPINE1 mRNA]	12719791
D010100	Oxygen	Oxygen deficiency results in decreased expression of APEX1 protein	25030372
D010126	Ozone	[Ozone co-treated with Chlorine] results in decreased expression of APEX1 mRNA	18636392
D010126	Ozone	Ozone results in increased expression of APEX1 mRNA	16330353
D010269	Paraquat	APEX1 gene mutant form results in increased susceptibility to Paraquat	11454706
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of APEX1 mRNA	19162173
C011272	perfosfamide	perfosfamide results in decreased expression of APEX1 mRNA	11754170
D010634	Phenobarbital	Phenobarbital results in decreased expression of APEX1 mRNA	24090815
D010634	Phenobarbital	Phenobarbital results in increased expression of APEX1 mRNA	19162173
D010862	Pilocarpine	Pilocarpine affects the localization of APEX1 mRNA	20206232
D010862	Pilocarpine	Pilocarpine results in decreased expression of APEX1 protein	20446108
D010862	Pilocarpine	Pilocarpine results in increased expression of APEX1 mRNA	17971868
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of APEX1 mRNA	15890375
C006253	pirinixic acid	pirinixic acid results in increased expression of APEX1 mRNA	18301758\|2381119
C006253	pirinixic acid	pirinixic acid results in increased expression of APEX1 mRNA	15890375\|1916217
D011160	Porfiromycin	APEX1 protein results in increased reduction of and results in increased susceptibility to Porfiromycin	10190555
C019536	potassium bromate	potassium bromate results in increased expression of APEX1 mRNA	22539617
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of APEX1 mRNA	28903501
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of APEX1 mRNA	19162173
C045362	prochloraz	[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of APEX1 mRNA	29038839
C045362	prochloraz	prochloraz results in increased expression of APEX1 mRNA	29038839
C035988	procymidone	procymidone results in increased expression of APEX1 mRNA	15686871
D011374	Progesterone	Progesterone results in decreased expression of APEX1 mRNA	18037150
C045950	propiconazole	propiconazole results in increased expression of APEX1 mRNA	21278054
C010313	pseudocumene	pseudocumene results in decreased expression of APEX1 protein	17337753
D011692	Puromycin Aminonucleoside	"1,3-dimethylthiourea inhibits the reaction [Puromycin Aminonucleoside results in increased expression of APEX1 protein]"	17035936
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in increased expression of APEX1 protein	17035936
C031280	pyrazole	pyrazole results in increased expression of APEX1 mRNA	17945193
D020849	Raloxifene Hydrochloride	[Raloxifene Hydrochloride co-treated with Kainic Acid] results in increased expression of APEX1 mRNA	16120186
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in increased expression of APEX1 mRNA	16120186
D017382	Reactive Oxygen Species	[lead acetate results in increased expression of APEX1 protein] which results in increased abundance of Reactive Oxygen Species	23370007
C059514	resveratrol	resveratrol results in decreased activity of APEX1 protein	16373707
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of APEX1 mRNA	25351596
C440975	silybin	[silybin binds to PDIA3 protein] promotes the reaction [PDIA3 protein binds to APEX1 protein]	24530445
C009277	sodium arsenate	sodium arsenate results in increased expression of APEX1 mRNA	16882884
C017947	sodium arsenite	APEX1 affects the susceptibility to sodium arsenite	17938202
C017947	sodium arsenite	APEX1 inhibits the reaction [[ATF4 mutant form results in increased susceptibility to sodium arsenite] which results in increased mutagenesis of HPRT1 gene]	17938202
C017947	sodium arsenite	APEX1 inhibits the reaction [[ATF4 mutant form results in increased susceptibility to sodium arsenite] which results in increased mutagenesis of TK1 gene]	17938202
C017947	sodium arsenite	ATF4 mutant form inhibits the reaction [sodium arsenite results in increased expression of APEX1 protein]	17938202
C017947	sodium arsenite	sodium arsenite results in decreased expression of APEX1 mRNA	12076508\|1237797
C017947	sodium arsenite	sodium arsenite results in decreased expression of APEX1 protein	12076508
C017947	sodium arsenite	sodium arsenite results in increased expression of APEX1 mRNA	12076508\|1793820
C017947	sodium arsenite	sodium arsenite results in increased expression of APEX1 protein	12076508\|1793820
C017947	sodium arsenite	Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of APEX1 mRNA]	17938202
C017947	sodium arsenite	APEX1 affects the susceptibility to sodium arsenite	17938202
C017947	sodium arsenite	ATF4 mutant form inhibits the reaction [sodium arsenite results in increased expression of APEX1 protein]	17938202
C017947	sodium arsenite	[sodium arsenite promotes the reaction [JUN protein binds to ATF4 protein]] which binds to APEX1 promoter	17938202
C017947	sodium arsenite	[[sodium arsenite promotes the reaction [JUN protein binds to ATF4 protein]] which binds to APEX1 promoter] which results in increased expression of APEX1 mRNA	17938202\|1793820
C017947	sodium arsenite	[sodium arsenite promotes the reaction [JUN protein binds to ATF4 protein]] which results in increased expression of APEX1 mRNA	17938202
C017947	sodium arsenite	sodium arsenite results in decreased expression of APEX1 mRNA	25787150
C017947	sodium arsenite	sodium arsenite results in increased expression of and results in increased activity of APEX1 protein	17938202
C017947	sodium arsenite	sodium arsenite results in increased expression of APEX1 mRNA	17451858\|1793820
C016104	sodium bichromate	sodium bichromate results in increased expression of APEX1 mRNA	22155349
C016104	sodium bichromate	sodium bichromate results in increased expression of APEX1 mRNA	12325037\|2256133
D018038	Sodium Selenite	"[Sodium Selenite co-treated with (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] results in decreased expression of and affects the localization of APEX1 protein"	28757135
D018038	Sodium Selenite	"[Sodium Selenite co-treated with (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] results in decreased expression of APEX1 mRNA"	28757135
D018038	Sodium Selenite	Sodium Selenite results in increased expression of APEX1 mRNA	18175754
D013311	Streptozocin	APEX1 protein mutant form results in increased susceptibility to Streptozocin	19470598
D013481	Superoxides	APEX1 protein inhibits the reaction [Miconazole results in increased abundance of Superoxides]	22262564
D013629	Tamoxifen	Tamoxifen affects the expression of APEX1 mRNA	17555576
D013629	Tamoxifen	Tamoxifen results in increased expression of APEX1 mRNA	12841865
C047246	temozolomide	APEX1 protein mutant form results in increased susceptibility to temozolomide	19470598
C047246	temozolomide	APEX1 protein results in decreased susceptibility to temozolomide	12231548\|1624381
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of APEX1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of APEX1 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to APEX1 promoter]	19654925
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of APEX1 mRNA	17942748
D013752	Tetracycline	Tetracycline results in increased expression of APEX1 mRNA	17522070
D013755	Tetradecanoylphorbol Acetate	[ferric chloride co-treated with Tetradecanoylphorbol Acetate] affects the localization of APEX1 protein	12023366
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of APEX1 mRNA	25613284
D013806	Theophylline	Theophylline results in decreased expression of APEX1 mRNA	17522070
D013853	Thioacetamide	Thioacetamide results in increased expression of APEX1 mRNA	23411599
C523062	thio-dimethylarsinate	thio-dimethylarsinate results in increased expression of APEX1 mRNA	27320638
D013852	Thiotepa	APEX1 protein mutant form results in increased susceptibility to Thiotepa	19470598
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of APEX1 mRNA	22363418
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of APEX1 protein	21778470
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of APEX1 mRNA	15289447
C034697	transplatin	[methoxyamine results in decreased activity of APEX1 protein] which results in increased susceptibility to transplatin	21357694
C012589	trichostatin A	trichostatin A promotes the reaction [EP300 protein binds to APEX1 protein]	20856196
C012589	trichostatin A	trichostatin A results in increased acetylation of APEX1 protein	20856196
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of APEX1 mRNA	19042947
D014303	Trinitrotoluene	Trinitrotoluene affects the expression of APEX1 mRNA	21346803
C080163	trovafloxacin	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of APEX1 mRNA"	18930950
C074908	troxacitabine	APEX1 protein mutant form results in increased susceptibility to troxacitabine	19470598
D014502	Uranyl Nitrate	Uranyl Nitrate results in increased expression of APEX1 mRNA	26362510
D014635	Valproic Acid	Valproic Acid affects the expression of APEX1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of APEX1 mRNA	23179753\|2915479
D014635	Valproic Acid	Valproic Acid results in decreased expression of APEX1 mRNA	20546886
D014640	Vancomycin	Vancomycin results in decreased expression of APEX1 mRNA	18930951
D014810	Vitamin E	Vitamin E results in increased expression of APEX1 mRNA	19244175
D024483	Vitamin K 3	APEX1 gene mutant form results in increased susceptibility to Vitamin K 3	11454706
D015032	Zinc	Zinc deficiency results in decreased expression of APEX1 mRNA	12672911

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003677	DNA binding	-	IDA	11286553
GO:0003684	damaged DNA binding	-	IDA	12524539 14706345 24703901
GO:0003691	double-stranded telomeric DNA binding	-	IDA	24703901
GO:0003713	transcription coactivator activity	-	IDA	9119221
GO:0003714	transcription corepressor activity	-	TAS	7961715
GO:0003723	RNA binding	-	HDA	22681889
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	-	IBA	21873635
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	-	IDA	8932386 15707971 18973764 19188445 24703901
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	-	TAS	9119221
GO:0004519	endonuclease activity	-	IDA	11478795
GO:0004520	endodeoxyribonuclease activity	-	TAS	-
GO:0004523	RNA-DNA hybrid ribonuclease activity	-	TAS	11286553
GO:0004528	phosphodiesterase I activity	-	IBA	21873635
GO:0004528	phosphodiesterase I activity	-	TAS	9119221
GO:0004844	uracil DNA N-glycosylase activity	-	TAS	10805771
GO:0005515	protein binding	-	IPI	8621488 9207062 11118054 11809897 12524539 15518571 15942031 18809583 19188445 19465398 19505873 19934257 20231292 20696907 20808282 20856196
GO:0008081	phosphoric diester hydrolase activity	-	IDA	11478795 18973764
GO:0008309	double-stranded DNA exodeoxyribonuclease activity	-	IDA	24703901
GO:0008311	double-stranded DNA 3'-5' exodeoxyribonuclease activity	-	IBA	21873635
GO:0008408	3'-5' exonuclease activity	-	IDA	11832948
GO:0008408	3'-5' exonuclease activity	-	TAS	11286553
GO:0016491	oxidoreductase activity	-	IDA	9119221 12524539
GO:0016890	site-specific endodeoxyribonuclease activity, specific for altered base	-	IDA	19188445 24703901
GO:0031490	chromatin DNA binding	-	IDA	11809897
GO:0044877	protein-containing complex binding	-	IEA	-
GO:0046872	metal ion binding	-	IDA	11286553
GO:0051059	NF-kappaB binding	-	IEA	-
GO:0140078	class I DNA-(apurinic or apyrimidinic site) endonuclease activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000723	telomere maintenance	-	IDA	24703901
GO:0006281	DNA repair	-	IDA	9560228
GO:0006284	base-excision repair	-	IBA	21873635
GO:0006284	base-excision repair	-	IDA	8932386
GO:0006284	base-excision repair	-	TAS	-
GO:0006286	base-excision repair, base-free sugar-phosphate removal	-	TAS	-
GO:0006310	DNA recombination	-	IEA	-
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0006355	regulation of transcription, DNA-templated	-	IEA	-
GO:0007568	aging	-	IEA	-
GO:0014912	negative regulation of smooth muscle cell migration	-	IEA	-
GO:0042981	regulation of apoptotic process	-	IDA	19934257
GO:0043488	regulation of mRNA stability	-	IMP	19401441
GO:0045454	cell redox homeostasis	-	IEA	-
GO:0055114	oxidation-reduction process	-	IEA	-
GO:0070301	cellular response to hydrogen peroxide	-	IEA	-
GO:0071320	cellular response to cAMP	-	IEA	-
GO:0071375	cellular response to peptide hormone stimulus	-	IEA	-
GO:0080111	DNA demethylation	-	IDA	21496894
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	-	IEA	-
GO:0097698	telomere maintenance via base-excision repair	-	IDA	24703901
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	-	IEA	-
GO:1903507	negative regulation of nucleic acid-templated transcription	-	IEA	-
GO:1903508	positive regulation of nucleic acid-templated transcription	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000784	nuclear chromosome, telomeric region	-	IC	24703901
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IDA	9119221 15942031 19934257
GO:0005654	nucleoplasm	-	IDA	17148573
GO:0005654	nucleoplasm	-	TAS	-
GO:0005667	transcription factor complex	-	IEA	-
GO:0005730	nucleolus	-	IDA	17148573 19188445
GO:0005737	cytoplasm	-	IDA	9560228
GO:0005739	mitochondrion	-	IDA	20231292
GO:0005783	endoplasmic reticulum	-	TAS	12524539
GO:0005813	centrosome	-	IDA	-
GO:0005840	ribosome	-	TAS	12524539
GO:0016607	nuclear speck	-	IDA	17148573
GO:0048471	perinuclear region of cytoplasm	-	IDA	12524539

KEGG ID	KEGG Term
hsa03410	Base excision repair

Reactome ID	Reactome Term	Evidence
R-HSA-110357	Displacement of DNA glycosylase by APEX1	TAS
R-HSA-110362	POLB-Dependent Long Patch Base Excision Repair	TAS
R-HSA-110373	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	TAS
R-HSA-110381	Resolution of AP sites via the single-nucleotide replacement pathway	TAS
R-HSA-5651801	PCNA-Dependent Long Patch Base Excision Repair	TAS
R-HSA-73884	Base Excision Repair	TAS
R-HSA-73894	DNA Repair	TAS
R-HSA-73930	Abasic sugar-phosphate removal via the single-nucleotide replacement pathway	TAS
R-HSA-73933	Resolution of Abasic Sites (AP sites)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
17034901	Polymorphisms in the DNA repair genes XRCC1, APEX1, XRCC3 and NBS1, and the risk for lung cancer in never- and ever-smokers. (2006 Dec)	Ryk C	Lung Cancer
22792228	Correlation between base-excision repair gene polymorphisms and levels of in-vitro BPDE-induced DNA adducts in cultured peripheral blood lymphocytes. (2012)	Yu H	PLoS One
17922186	Polymorphisms in three base excision repair genes and breast cancer risk in Thai women. (2008 Sep)	Sangrajrang S	Breast Cancer Res Treat
17220334	High-order interactions among genetic variants in DNA base excision repair pathway genes and smoking in bladder cancer susceptibility. (2007 Jan)	Huang M	Cancer Epidemiol Biomarkers Prev
28464393	Association of the rs1760944 polymorphism in the APEX1 base excision repair gene with risk of nasopharyngeal carcinoma in a population from an endemic area in South China. (2018 Feb)	Lu Z	J Clin Lab Anal
23749940	The contribution of DNA apurinic/apyrimidinic endonuclease genotype and smoking habit to Taiwan lung cancer risk. (2013 Jun)	Chen WC	Anticancer Res
19902366	Genetic variation in DNA repair genes and prostate cancer risk: results from a population-based study. (2010 Feb)	Agalliu I	Cancer Causes Control
21198260	APEX1 Asp148Glu gene polymorphism is a risk factor for lung cancer in relation to smoking in Japanese. (2010)	Osawa K	Asian Pac J Cancer Prev
25156607	The interaction of APEX1 variant with polycyclic aromatic hydrocarbons on increasing chromosome damage and lung cancer risk among male Chinese. (2015 Jun)	Li X	Mol Carcinog
27754415	Effect of Genetic Polymorphisms and Long-Term Tobacco Exposure on the Risk of Breast Cancer. (2016 Oct 14)	Verde Z	Int J Mol Sci
25422360	The role of apurinic/apyrimidinic endonuclease DNA repair gene in endometriosis. (2014 Nov-Dec)	Hsu CM	Cancer Genomics Proteomics
23951112	Genetic variation in the base excision repair pathway, environmental risk factors, and colorectal adenoma risk. (2013)	Corral R	PLoS One
17203305	Genetic variation in the base excision repair pathway and bladder cancer risk. (2007 Apr)	Figueroa JD	Hum Genet
22541966	Incorporating single-nucleotide polymorphisms into the Lyman model to improve prediction of radiation pneumonitis. (2013 Jan 1)	Tucker SL	Int J Radiat Oncol Biol Phys