Gene: APEX1

328
APE|APE1|APEN|APEX|APX|HAP1|REF1
apurinic/apyrimidinic endodeoxyribonuclease 1
protein-coding
14q11.2
Ensembl:ENSG00000100823 MIM:107748 Vega:OTTHUMG00000029544 UniprotKB:P27695
NG_008718.1
PubMed
ND
14   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.878e-1 (AD)  3.765e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
XRCC60.964
POLDIP20.96
MAGED20.958
SLC25A30.957
CAPZB0.955
PHB20.953
EMC40.952
ARFGAP20.952
CDC1230.95
EIF2AK10.95

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.812
OR4F29-0.763
MTRNR2L6-0.323
MTRNR2L9-0.313
MTRNR2L10-0.274
PPBP-0.241
VNN3-0.222
HMHB1-0.219
TRPV5-0.216
TTLL10-0.216

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04967LucanthoneSmall Molecule479-50-5Approved|InvestigationalTarget
ID Drug Name Action PubMed
C478160(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane"[Sodium Selenite co-treated with (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] results in decreased expression of and affects the localization of APEX1 protein"28757135
C478160(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane"[Sodium Selenite co-treated with (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] results in decreased expression of APEX1 mRNA"28757135
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of APEX1 mRNA"19162173
C0389831,3-dimethylthiourea"1,3-dimethylthiourea inhibits the reaction [Puromycin Aminonucleoside results in increased expression of APEX1 protein]"17035936
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of APEX1 mRNA"21346803
C0194992-nitrofluorene2-nitrofluorene results in increased expression of APEX1 mRNA15890375
C0166172-nitropropane2-nitropropane results in increased expression of APEX1 mRNA19268524
C0166172-nitropropane2-nitropropane results in increased expression of APEX1 protein19268524
C0166172-nitropropaneAPEX1 protein affects the susceptibility to 2-nitropropane19268524
C0166172-nitropropaneAPEX1 protein inhibits the reaction [2-nitropropane results in increased activity of CASP3 protein]19268524
C0166172-nitropropaneAPEX1 protein inhibits the reaction [2-nitropropane results in increased expression of GADD45G mRNA]19268524
C0166172-nitropropaneAPEX1 protein inhibits the reaction [2-nitropropane results in increased expression of TRP53 protein]19268524
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of APEX1 mRNA19191707
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of APEX1 mRNA15890375
C0671348-oxo-7-hydrodeoxyguanosineAPEX1 gene SNP affects the abundance of 8-oxo-7-hydrodeoxyguanosine19896490
D000082AcetaminophenAcetaminophen results in increased expression of APEX1 mRNA16751229
D000108AcetylcarnitineAcetylcarnitine results in increased expression of APEX1 mRNA14654561
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of APEX1 protein]12231548
D000111AcetylcysteineAcetylcysteine inhibits the reaction [sodium arsenite results in increased expression of APEX1 mRNA]17938202
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of APEX1 mRNA15890375
D000393Air PollutantsAir Pollutants results in increased expression of APEX1 mRNA24792328
D000643Ammonium ChlorideAmmonium Chloride affects the expression of APEX1 mRNA16483693
C023650anilineaniline results in increased expression of and results in increased activity of APEX1 protein23352893
C023650anilineaniline results in increased expression of APEX1 mRNA23352893
D001115ArecolineArecoline results in decreased expression of APEX1 mRNA17682004
D001151ArsenicAPEX1 gene polymorphism affects the susceptibility to Arsenic17374727
D001151ArsenicAPEX1 protein affects the susceptibility to Arsenic18053222
C015001arsenitearsenite affects the expression of APEX1 mRNA18252256
C015001arsenitearsenite results in increased expression of APEX1 mRNA15996700
C015001arsenitearsenite results in increased expression of APEX1 protein18252256
D017636Asbestos, Amphibole"Asbestos, Amphibole affects the expression of APEX1 protein"24598051
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the localization of APEX1 protein"12023366
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the localization of APEX1 protein"12023366
D017638Asbestos, Crocidolite"diphenyleneiodonium inhibits the reaction [Asbestos, Crocidolite affects the localization of APEX1 protein]"12023366
D001280AtrazineAtrazine results in increased expression of APEX1 protein27957240
D001554BenzeneAPEX1 gene polymorphism affects the susceptibility to Benzene22245109
D001554BenzeneBenzene affects the expression of APEX1 mRNA16188086
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of APEX1 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of APEX1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of APEX1 mRNA22228805
D016227BenzoquinonesAPEX1 protein results in increased reduction of and results in increased susceptibility to Benzoquinones10190555
C032776beryllium chlorideberyllium chloride affects the expression of APEX1 mRNA23793613
D004958EstradiolEstradiol results in increased expression of APEX1 mRNA17522070
D001622BetaineBetaine results in decreased expression of APEX1 mRNA26391144
D001629BezafibrateBezafibrate results in increased expression of APEX1 mRNA15447978
C006780bisphenol Abisphenol A affects the expression of APEX1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of APEX1 mRNA21932408
C006780bisphenol Abisphenol A results in increased expression of APEX1 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of APEX1 mRNA17553608
D002066BusulfanAPEX1 protein mutant form results in increased susceptibility to Busulfan19470598
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased expression of APEX1 protein23736079
D002087ButyratesButyrates results in decreased expression of APEX1 mRNA14674679
D002104CadmiumCadmium affects the activity of APEX1 protein21605570
D002104CadmiumCadmium affects the expression of APEX1 mRNA21605570
D002104CadmiumTP53 protein affects the reaction [Cadmium affects the activity of APEX1 protein]21605570
D002104CadmiumTP53 protein affects the reaction [Cadmium affects the expression of APEX1 mRNA]21605570
D002104CadmiumCadmium results in decreased activity of APEX1 protein16677676
C028031cadmium acetatecadmium acetate affects the expression of APEX1 mRNA16249259
D019256Cadmium ChlorideCadmium Chloride results in increased expression of APEX1 mRNA18804290
D002110Caffeine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of APEX1 mRNA"20230807
D002110Caffeine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of APEX1 mRNA]"20230807
D002244CarbonCarbon analog results in increased expression of APEX1 mRNA24792328
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of APEX1 mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of APEX1 mRNA17522070
D002330CarmustineAPEX1 protein mutant form results in increased susceptibility to Carmustine17259346|1947059
D002330CarmustineAPEX1 protein results in decreased susceptibility to Carmustine12231548|1624381
D002713Chlorine[Ozone co-treated with Chlorine] results in decreased expression of APEX1 mRNA18636392
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of APEX1 mRNA25113976
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of APEX1 mRNA18804290
D002725ChloroformChloroform results in increased expression of APEX1 mRNA17522070
D002994ClofibrateClofibrate results in increased expression of APEX1 mRNA16081524
D002994ClofibrateClofibrate results in decreased expression of APEX1 mRNA17522070
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of APEX1 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of APEX1 mRNA19320972
C018021cobaltous chloride[cobaltous chloride results in increased activity of SRC protein] promotes the reaction [[[HIF1A protein binds to STAT3 protein modified form] which binds to VEGFA promoter] binds to [APEX1 protein binds to CREBBP promoter]]15735682
D003300CopperCopper results in increased expression of APEX125109342
D019327Copper SulfateCopper Sulfate results in decreased expression of APEX1 mRNA19549813
C057862cyanoginosin LRcyanoginosin LR results in increased expression of APEX1 mRNA17654400
D003520CyclophosphamideCyclophosphamide results in increased expression of APEX1 mRNA11599041
C093628cyproconazole[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of APEX1 mRNA29038839
C093628cyproconazole[cyproconazole co-treated with epoxiconazole] results in increased expression of APEX1 mRNA29038839
C093628cyproconazolecyproconazole results in increased expression of APEX1 mRNA29038839
D003606DacarbazineAPEX1 protein mutant form results in increased susceptibility to Dacarbazine19470598
D003606DacarbazineAPEX1 protein results in decreased susceptibility to Dacarbazine16373707
D003630DaunorubicinAPEX1 protein results in increased reduction of and results in increased susceptibility to Daunorubicin10190555
D016047ZalcitabineAPEX1 protein mutant form results in increased susceptibility to Zalcitabine17259346
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of APEX1 mRNA17361019|2126653
D002945CisplatinAPEX1 protein results in decreased susceptibility to Cisplatin16373707|2085619
D002945CisplatinCisplatin promotes the reaction [APEX1 protein modified form binds to [YBX1 protein binds to EP300 protein]]20856196
D002945CisplatinCisplatin promotes the reaction [[APEX1 protein modified form promotes the reaction [YBX1 protein binds to EP300 protein]] which binds to ABCB1 promoter]20856196
D002945CisplatinCisplatin results in decreased expression of APEX1 mRNA27594783
D002945CisplatinCisplatin results in increased acetylation of APEX1 protein20856196
D002945Cisplatin[Cisplatin results in increased acetylation of APEX1 protein] promotes the reaction [APEX1 protein modified form binds to ABCB1 promoter]20856196
D002945Cisplatin[Cisplatin results in increased acetylation of APEX1 protein] promotes the reaction [[APEX1 protein modified form binds to ABCB1 promoter] which results in increased expression of ABCB1 mRNA]20856196
D002945CisplatinEP300 protein promotes the reaction [Cisplatin results in increased acetylation of APEX1 protein]20856196
D002945CisplatinCisplatin results in decreased expression of APEX1 mRNA21151649
D002945Cisplatin[methoxyamine results in decreased activity of APEX1 protein] which results in decreased susceptibility to Cisplatin21357694
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of APEX1 mRNA17602206
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of APEX1 mRNA11323195
D004052Diethylnitrosamine[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of APEX1 mRNA18253720|1877588
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of APEX1 mRNA15890375
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of APEX1 mRNA"25697376
D0151279,10-Dimethyl-1,2-benzanthracene"Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of APEX1 mRNA]"25697376
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of APEX1 mRNA15890375
D004147DioxinsDioxins affects the expression of APEX1 mRNA20463971
C007517diphenyleneiodonium"diphenyleneiodonium inhibits the reaction [Asbestos, Crocidolite affects the localization of APEX1 protein]"12023366
D004229DithiothreitolDithiothreitol promotes the reaction [MAPK1 protein binds to APEX1 protein]23370007
C075569E 3330E 3330 inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]]23370007
D004785Environmental PollutantsAPEX1 gene SNP affects the susceptibility to Environmental Pollutants24036326
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of APEX1 protein23301498
C109476epoxiconazole[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of APEX1 mRNA29038839
C109476epoxiconazole[cyproconazole co-treated with epoxiconazole] results in increased expression of APEX1 mRNA29038839
D004918Erythromycin EstolateErythromycin Estolate results in decreased expression of APEX1 mRNA17522070
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of APEX1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of APEX1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of APEX1 mRNA17942748
C036216ethyleneethylene results in increased expression of APEX1 protein16051529
D005027Ethylene OxideEthylene Oxide results in increased expression of APEX1 protein16051529
D005033EthylmaleimideEthylmaleimide inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]]23370007
D005047EtoposideAPEX1 protein results in decreased susceptibility to Etoposide20856196
D011345Fenofibrate[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of APEX1 mRNA18253720|1877588
D011345FenofibrateFenofibrate results in increased expression of APEX1 mRNA17264098|1877588
C024555ferric chlorideferric chloride affects the localization of APEX1 protein12023366
C024555ferric chloride[ferric chloride co-treated with Tetradecanoylphorbol Acetate] affects the localization of APEX1 protein12023366
D005467FloxuridineAPEX1 protein mutant form results in increased susceptibility to Floxuridine19470598
D005467FloxuridineAPEX1 protein results in decreased susceptibility to Floxuridine22194930
C007738fluoranthenefluoranthene results in increased expression of APEX1 mRNA18522720
D005472FluorouracilAPEX1 protein mutant form results in increased susceptibility to Fluorouracil19470598
D005485FlutamideFlutamide results in increased expression of APEX1 mRNA24136188
C039281furanfuran results in increased expression of APEX1 mRNA22079235|2553966
D005839GentamicinsGentamicins results in increased expression of APEX1 mRNA22061828
D005897GlafenineGlafenine results in increased expression of APEX1 mRNA24136188
D006861Hydrogen PeroxideAPEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]23370007
D006861Hydrogen PeroxideAPEX1 protein mutant form results in increased susceptibility to Hydrogen Peroxide17259346
D006861Hydrogen PeroxideE 3330 inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]]23370007
D006861Hydrogen PeroxideEthylmaleimide inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]]23370007
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of APEX1 mRNA22539617
D006861Hydrogen PeroxideAPEX1 protein promotes the reaction [Hydrogen Peroxide results in increased expression of IL4 mRNA]12884291
D006861Hydrogen PeroxideAPEX1 protein promotes the reaction [Hydrogen Peroxide results in increased expression of IL6 mRNA]12884291
D006861Hydrogen PeroxideHydrogen Peroxide affects the localization of APEX1 protein12884291
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of APEX1 mRNA17938202
D006997Hypochlorous AcidAcetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of APEX1 protein]12231548
D006997Hypochlorous AcidHypochlorous Acid results in increased activity of APEX1 protein12231548
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of APEX1 protein12231548
C492448ICG 001ICG 001 results in decreased expression of APEX1 mRNA26191083
C492448ICG 001ICG 001 results in increased expression of APEX1 mRNA26191083
C056493imiquimodimiquimod results in decreased expression of APEX1 mRNA21878529
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of APEX1 mRNA25613284
D007545IsoproterenolIsoproterenol results in increased expression of APEX1 mRNA21335049
C561695(+)-JQ1 compound(+)-JQ1 compound affects the expression of APEX124394663
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of APEX1 mRNA25982114
D007608Kainic Acid[Raloxifene Hydrochloride co-treated with Kainic Acid] results in increased expression of APEX1 mRNA16120186
D007854LeadLead results in decreased activity of APEX1 protein17013835
D007854LeadAPEX1 gene polymorphism affects the susceptibility to Lead22466227
D007854LeadAPEX1 protein inhibits the reaction [Lead results in decreased activity of APEX1 protein]17013835
D007854LeadLead affects the expression of APEX1 mRNA28903495
C008261lead acetateAPEX1 protein promotes the reaction [lead acetate results in increased expression of CCND1 protein]23370007
C008261lead acetateAPEX1 protein promotes the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]23370007
C008261lead acetateAPEX1 protein promotes the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]23370007
C008261lead acetateAPEX1 protein results in decreased susceptibility to lead acetate23370007
C008261lead acetatelead acetate promotes the reaction [APEX1 protein results in increased phosphorylation of MAPK1 protein]23370007
C008261lead acetatelead acetate promotes the reaction [APEX1 protein results in increased phosphorylation of MAPK3 protein]23370007
C008261lead acetatelead acetate promotes the reaction [MAPK1 protein modified form binds to APEX1 protein]23370007
C008261lead acetatelead acetate results in increased expression of APEX1 protein23370007
C008261lead acetate[lead acetate results in increased expression of APEX1 protein] which results in increased abundance of Reactive Oxygen Species23370007
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of APEX1 mRNA"18930950
D058955MetalloidsAPEX1 gene SNP affects the susceptibility to Metalloids24036326
D008670MetalsAPEX1 gene SNP affects the susceptibility to Metals24036326
D008687Metformin"Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of APEX1 mRNA]"25697376
D008701MethapyrileneMethapyrilene results in increased expression of APEX1 mRNA15890375|2893558
C005214methoxyaminemethoxyamine results in decreased activity of APEX1 protein21357694
C005214methoxyamine[methoxyamine results in decreased activity of APEX1 protein] which results in decreased susceptibility to Cisplatin21357694
C005214methoxyamine[methoxyamine results in decreased activity of APEX1 protein] which results in increased susceptibility to Mitomycin21357694
C005214methoxyamine[methoxyamine results in decreased activity of APEX1 protein] which results in increased susceptibility to transplatin21357694
D008748MethylcholanthreneMethylcholanthrene results in increased expression of APEX1 mRNA18804290
D008741Methyl MethanesulfonateAPEX1 protein mutant form results in increased susceptibility to Methyl Methanesulfonate17259346
D008741Methyl MethanesulfonateAPEX1 protein results in decreased susceptibility to Methyl Methanesulfonate12231548
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of APEX1 mRNA23649840
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of APEX1 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of APEX1 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of APEX1 mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of APEX1 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of APEX1 mRNA]"20230807
D008825MiconazoleMiconazole results in decreased expression of APEX1 mRNA22262564
D008825MiconazoleAPEX1 protein inhibits the reaction [Miconazole results in increased abundance of Superoxides]22262564
D008825MiconazoleAPEX1 protein results in decreased susceptibility to Miconazole22262564
C059539midostaurinmidostaurin results in decreased expression of APEX1 mRNA20980353
D016685MitomycinAPEX1 protein results in increased reduction of and results in increased susceptibility to Mitomycin10190555
D016685Mitomycin[methoxyamine results in decreased activity of APEX1 protein] which results in increased susceptibility to Mitomycin21357694
D009270NaloxoneNaloxone results in decreased expression of APEX1 mRNA17522070
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of APEX1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of APEX1 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of APEX1 mRNA17522070
C051752nefazodonenefazodone results in increased expression of APEX1 mRNA24136188
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of APEX1 mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of APEX1 mRNA]"20230807
C012655nimesulidenimesulide results in increased expression of APEX1 mRNA24136188
D005996NitroglycerinNitroglycerin results in increased expression of APEX1 mRNA12102619
C025589ochratoxin Aochratoxin A results in decreased expression of APEX1 mRNA23358140
D010100OxygenAPEX1 protein inhibits the reaction [RAC1 protein inhibits the reaction [Oxygen deficiency results in increased expression of SERPINE1 mRNA]]12719791
D010100OxygenAPEX1 protein promotes the reaction [Oxygen deficiency results in increased expression of SERPINE1 mRNA]12719791
D010100OxygenOxygen deficiency results in decreased expression of APEX1 protein25030372
D010126Ozone[Ozone co-treated with Chlorine] results in decreased expression of APEX1 mRNA18636392
D010126OzoneOzone results in increased expression of APEX1 mRNA16330353
D010269ParaquatAPEX1 gene mutant form results in increased susceptibility to Paraquat11454706
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of APEX1 mRNA19162173
C011272perfosfamideperfosfamide results in decreased expression of APEX1 mRNA11754170
D010634PhenobarbitalPhenobarbital results in decreased expression of APEX1 mRNA24090815
D010634PhenobarbitalPhenobarbital results in increased expression of APEX1 mRNA19162173
D010862PilocarpinePilocarpine affects the localization of APEX1 mRNA20206232
D010862PilocarpinePilocarpine results in decreased expression of APEX1 protein20446108
D010862PilocarpinePilocarpine results in increased expression of APEX1 mRNA17971868
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of APEX1 mRNA15890375
C006253pirinixic acidpirinixic acid results in increased expression of APEX1 mRNA18301758|2381119
C006253pirinixic acidpirinixic acid results in increased expression of APEX1 mRNA15890375|1916217
D011160PorfiromycinAPEX1 protein results in increased reduction of and results in increased susceptibility to Porfiromycin10190555
C019536potassium bromatepotassium bromate results in increased expression of APEX1 mRNA22539617
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of APEX1 mRNA28903501
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of APEX1 mRNA19162173
C045362prochloraz[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of APEX1 mRNA29038839
C045362prochlorazprochloraz results in increased expression of APEX1 mRNA29038839
C035988procymidoneprocymidone results in increased expression of APEX1 mRNA15686871
D011374ProgesteroneProgesterone results in decreased expression of APEX1 mRNA18037150
C045950propiconazolepropiconazole results in increased expression of APEX1 mRNA21278054
C010313pseudocumenepseudocumene results in decreased expression of APEX1 protein17337753
D011692Puromycin Aminonucleoside"1,3-dimethylthiourea inhibits the reaction [Puromycin Aminonucleoside results in increased expression of APEX1 protein]"17035936
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of APEX1 protein17035936
C031280pyrazolepyrazole results in increased expression of APEX1 mRNA17945193
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with Kainic Acid] results in increased expression of APEX1 mRNA16120186
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of APEX1 mRNA16120186
D017382Reactive Oxygen Species[lead acetate results in increased expression of APEX1 protein] which results in increased abundance of Reactive Oxygen Species23370007
C059514resveratrolresveratrol results in decreased activity of APEX1 protein16373707
D012822Silicon DioxideSilicon Dioxide results in decreased expression of APEX1 mRNA25351596
C440975silybin[silybin binds to PDIA3 protein] promotes the reaction [PDIA3 protein binds to APEX1 protein]24530445
C009277sodium arsenatesodium arsenate results in increased expression of APEX1 mRNA16882884
C017947sodium arseniteAPEX1 affects the susceptibility to sodium arsenite17938202
C017947sodium arseniteAPEX1 inhibits the reaction [[ATF4 mutant form results in increased susceptibility to sodium arsenite] which results in increased mutagenesis of HPRT1 gene]17938202
C017947sodium arseniteAPEX1 inhibits the reaction [[ATF4 mutant form results in increased susceptibility to sodium arsenite] which results in increased mutagenesis of TK1 gene]17938202
C017947sodium arseniteATF4 mutant form inhibits the reaction [sodium arsenite results in increased expression of APEX1 protein]17938202
C017947sodium arsenitesodium arsenite results in decreased expression of APEX1 mRNA12076508|1237797
C017947sodium arsenitesodium arsenite results in decreased expression of APEX1 protein12076508
C017947sodium arsenitesodium arsenite results in increased expression of APEX1 mRNA12076508|1793820
C017947sodium arsenitesodium arsenite results in increased expression of APEX1 protein12076508|1793820
C017947sodium arseniteAcetylcysteine inhibits the reaction [sodium arsenite results in increased expression of APEX1 mRNA]17938202
C017947sodium arseniteAPEX1 affects the susceptibility to sodium arsenite17938202
C017947sodium arseniteATF4 mutant form inhibits the reaction [sodium arsenite results in increased expression of APEX1 protein]17938202
C017947sodium arsenite[sodium arsenite promotes the reaction [JUN protein binds to ATF4 protein]] which binds to APEX1 promoter17938202
C017947sodium arsenite[[sodium arsenite promotes the reaction [JUN protein binds to ATF4 protein]] which binds to APEX1 promoter] which results in increased expression of APEX1 mRNA17938202|1793820
C017947sodium arsenite[sodium arsenite promotes the reaction [JUN protein binds to ATF4 protein]] which results in increased expression of APEX1 mRNA17938202
C017947sodium arsenitesodium arsenite results in decreased expression of APEX1 mRNA25787150
C017947sodium arsenitesodium arsenite results in increased expression of and results in increased activity of APEX1 protein17938202
C017947sodium arsenitesodium arsenite results in increased expression of APEX1 mRNA17451858|1793820
C016104sodium bichromatesodium bichromate results in increased expression of APEX1 mRNA22155349
C016104sodium bichromatesodium bichromate results in increased expression of APEX1 mRNA12325037|2256133
D018038Sodium Selenite"[Sodium Selenite co-treated with (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] results in decreased expression of and affects the localization of APEX1 protein"28757135
D018038Sodium Selenite"[Sodium Selenite co-treated with (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] results in decreased expression of APEX1 mRNA"28757135
D018038Sodium SeleniteSodium Selenite results in increased expression of APEX1 mRNA18175754
D013311StreptozocinAPEX1 protein mutant form results in increased susceptibility to Streptozocin19470598
D013481SuperoxidesAPEX1 protein inhibits the reaction [Miconazole results in increased abundance of Superoxides]22262564
D013629TamoxifenTamoxifen affects the expression of APEX1 mRNA17555576
D013629TamoxifenTamoxifen results in increased expression of APEX1 mRNA12841865
C047246temozolomideAPEX1 protein mutant form results in increased susceptibility to temozolomide19470598
C047246temozolomideAPEX1 protein results in decreased susceptibility to temozolomide12231548|1624381
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of APEX1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of APEX1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to APEX1 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of APEX1 mRNA17942748
D013752TetracyclineTetracycline results in increased expression of APEX1 mRNA17522070
D013755Tetradecanoylphorbol Acetate[ferric chloride co-treated with Tetradecanoylphorbol Acetate] affects the localization of APEX1 protein12023366
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of APEX1 mRNA25613284
D013806TheophyllineTheophylline results in decreased expression of APEX1 mRNA17522070
D013853ThioacetamideThioacetamide results in increased expression of APEX1 mRNA23411599
C523062thio-dimethylarsinatethio-dimethylarsinate results in increased expression of APEX1 mRNA27320638
D013852ThiotepaAPEX1 protein mutant form results in increased susceptibility to Thiotepa19470598
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of APEX1 mRNA22363418
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of APEX1 protein21778470
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of APEX1 mRNA15289447
C034697transplatin[methoxyamine results in decreased activity of APEX1 protein] which results in increased susceptibility to transplatin21357694
C012589trichostatin Atrichostatin A promotes the reaction [EP300 protein binds to APEX1 protein]20856196
C012589trichostatin Atrichostatin A results in increased acetylation of APEX1 protein20856196
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of APEX1 mRNA19042947
D014303TrinitrotolueneTrinitrotoluene affects the expression of APEX1 mRNA21346803
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of APEX1 mRNA"18930950
C074908troxacitabineAPEX1 protein mutant form results in increased susceptibility to troxacitabine19470598
D014502Uranyl NitrateUranyl Nitrate results in increased expression of APEX1 mRNA26362510
D014635Valproic AcidValproic Acid affects the expression of APEX1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of APEX1 mRNA23179753|2915479
D014635Valproic AcidValproic Acid results in decreased expression of APEX1 mRNA20546886
D014640VancomycinVancomycin results in decreased expression of APEX1 mRNA18930951
D014810Vitamin EVitamin E results in increased expression of APEX1 mRNA19244175
D024483Vitamin K 3APEX1 gene mutant form results in increased susceptibility to Vitamin K 311454706
D015032ZincZinc deficiency results in decreased expression of APEX1 mRNA12672911

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IDA11286553  
GO:0003684damaged DNA binding-IDA12524539  14706345  24703901  
GO:0003691double-stranded telomeric DNA binding-IDA24703901  
GO:0003713transcription coactivator activity-IDA9119221  
GO:0003714transcription corepressor activity-TAS7961715  
GO:0003723RNA binding-HDA22681889  
GO:0003906DNA-(apurinic or apyrimidinic site) endonuclease activity-IBA21873635  
GO:0003906DNA-(apurinic or apyrimidinic site) endonuclease activity-IDA8932386  15707971  18973764  19188445  24703901  
GO:0003906DNA-(apurinic or apyrimidinic site) endonuclease activity-TAS9119221  
GO:0004519endonuclease activity-IDA11478795  
GO:0004520endodeoxyribonuclease activity-TAS-  
GO:0004523RNA-DNA hybrid ribonuclease activity-TAS11286553  
GO:0004528phosphodiesterase I activity-IBA21873635  
GO:0004528phosphodiesterase I activity-TAS9119221  
GO:0004844uracil DNA N-glycosylase activity-TAS10805771  
GO:0005515protein binding-IPI8621488  9207062  11118054  11809897  12524539  15518571  
15942031  18809583  19188445  19465398  19505873  19934257  
20231292  20696907  20808282  20856196  
GO:0008081phosphoric diester hydrolase activity-IDA11478795  18973764  
GO:0008309double-stranded DNA exodeoxyribonuclease activity-IDA24703901  
GO:0008311double-stranded DNA 3'-5' exodeoxyribonuclease activity-IBA21873635  
GO:00084083'-5' exonuclease activity-IDA11832948  
GO:00084083'-5' exonuclease activity-TAS11286553  
GO:0016491oxidoreductase activity-IDA9119221  12524539  
GO:0016890site-specific endodeoxyribonuclease activity, specific for altered base-IDA19188445  24703901  
GO:0031490chromatin DNA binding-IDA11809897  
GO:0044877protein-containing complex binding-IEA-  
GO:0046872metal ion binding-IDA11286553  
GO:0051059NF-kappaB binding-IEA-  
GO:0140078class I DNA-(apurinic or apyrimidinic site) endonuclease activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000723telomere maintenance-IDA24703901  
GO:0006281DNA repair-IDA9560228  
GO:0006284base-excision repair-IBA21873635  
GO:0006284base-excision repair-IDA8932386  
GO:0006284base-excision repair-TAS-  
GO:0006286base-excision repair, base-free sugar-phosphate removal-TAS-  
GO:0006310DNA recombination-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0007568aging-IEA-  
GO:0014912negative regulation of smooth muscle cell migration-IEA-  
GO:0042981regulation of apoptotic process-IDA19934257  
GO:0043488regulation of mRNA stability-IMP19401441  
GO:0045454cell redox homeostasis-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO:0070301cellular response to hydrogen peroxide-IEA-  
GO:0071320cellular response to cAMP-IEA-  
GO:0071375cellular response to peptide hormone stimulus-IEA-  
GO:0080111DNA demethylation-IDA21496894  
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic-IEA-  
GO:0097698telomere maintenance via base-excision repair-IDA24703901  
GO:1900087positive regulation of G1/S transition of mitotic cell cycle-IEA-  
GO:1903507negative regulation of nucleic acid-templated transcription-IEA-  
GO:1903508positive regulation of nucleic acid-templated transcription-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000784nuclear chromosome, telomeric region-IC24703901  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA9119221  15942031  19934257  
GO:0005654nucleoplasm-IDA17148573  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IEA-  
GO:0005730nucleolus-IDA17148573  19188445  
GO:0005737cytoplasm-IDA9560228  
GO:0005739mitochondrion-IDA20231292  
GO:0005783endoplasmic reticulum-TAS12524539  
GO:0005813centrosome-IDA-  
GO:0005840ribosome-TAS12524539  
GO:0016607nuclear speck-IDA17148573  
GO:0048471perinuclear region of cytoplasm-IDA12524539  
KEGG ID KEGG Term
hsa03410Base excision repair
Reactome ID Reactome Term Evidence
R-HSA-110357Displacement of DNA glycosylase by APEX1TAS
R-HSA-110362POLB-Dependent Long Patch Base Excision RepairTAS
R-HSA-110373Resolution of AP sites via the multiple-nucleotide patch replacement pathwayTAS
R-HSA-110381Resolution of AP sites via the single-nucleotide replacement pathwayTAS
R-HSA-5651801PCNA-Dependent Long Patch Base Excision RepairTAS
R-HSA-73884Base Excision RepairTAS
R-HSA-73894DNA RepairTAS
R-HSA-73930Abasic sugar-phosphate removal via the single-nucleotide replacement pathwayTAS
R-HSA-73933Resolution of Abasic Sites (AP sites)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17034901Polymorphisms in the DNA repair genes XRCC1, APEX1, XRCC3 and NBS1, and the risk for lung cancer in never- and ever-smokers. (2006 Dec)Ryk CLung Cancer
22792228Correlation between base-excision repair gene polymorphisms and levels of in-vitro BPDE-induced DNA adducts in cultured peripheral blood lymphocytes. (2012)Yu HPLoS One
17922186Polymorphisms in three base excision repair genes and breast cancer risk in Thai women. (2008 Sep)Sangrajrang SBreast Cancer Res Treat
17220334High-order interactions among genetic variants in DNA base excision repair pathway genes and smoking in bladder cancer susceptibility. (2007 Jan)Huang MCancer Epidemiol Biomarkers Prev
28464393Association of the rs1760944 polymorphism in the APEX1 base excision repair gene with risk of nasopharyngeal carcinoma in a population from an endemic area in South China. (2018 Feb)Lu ZJ Clin Lab Anal
23749940The contribution of DNA apurinic/apyrimidinic endonuclease genotype and smoking habit to Taiwan lung cancer risk. (2013 Jun)Chen WCAnticancer Res
19902366Genetic variation in DNA repair genes and prostate cancer risk: results from a population-based study. (2010 Feb)Agalliu ICancer Causes Control
21198260APEX1 Asp148Glu gene polymorphism is a risk factor for lung cancer in relation to smoking in Japanese. (2010)Osawa KAsian Pac J Cancer Prev
25156607The interaction of APEX1 variant with polycyclic aromatic hydrocarbons on increasing chromosome damage and lung cancer risk among male Chinese. (2015 Jun)Li XMol Carcinog
27754415Effect of Genetic Polymorphisms and Long-Term Tobacco Exposure on the Risk of Breast Cancer. (2016 Oct 14)Verde ZInt J Mol Sci
25422360The role of apurinic/apyrimidinic endonuclease DNA repair gene in endometriosis. (2014 Nov-Dec)Hsu CMCancer Genomics Proteomics
23951112Genetic variation in the base excision repair pathway, environmental risk factors, and colorectal adenoma risk. (2013)Corral RPLoS One
17203305Genetic variation in the base excision repair pathway and bladder cancer risk. (2007 Apr)Figueroa JDHum Genet
22541966Incorporating single-nucleotide polymorphisms into the Lyman model to improve prediction of radiation pneumonitis. (2013 Jan 1)Tucker SLInt J Radiat Oncol Biol Phys