Gene: HSBP1

3281
NPC-A-13
heat shock factor binding protein 1
protein-coding
16q23.3
Ensembl:ENSG00000230989 MIM:604553 Vega:OTTHUMG00000176653 UniprotKB:O75506
NC_000016.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.476e-1 (AD)  5.436e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VBP10.946
YWHAQ0.925
VTI1B0.916
C1orf430.916
ENOPH10.916
UBE2D20.915
NDUFB60.914
SKP10.907
DNAJC80.907
NDUFS40.906

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.736
OR4F29-0.723
ANPEP-0.273
P2RY14-0.269
MTRNR2L10-0.248
MTRNR2L6-0.246
KCNK5-0.245
MAGEA12-0.243
MTRNR2L3-0.236
C8orf74-0.233

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of HSBP1 mRNA28329830
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of HSBP1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HSBP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HSBP1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of HSBP1 mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Thioacetamide results in increased expression of HSBP1 protein]17103249
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HSBP1 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of HSBP1 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HSBP1 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HSBP1 mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of HSBP1 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of HSBP1 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of HSBP1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of HSBP1 mRNA15336504
C018021cobaltous chloridecobaltous chloride results in decreased expression of HSBP1 mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of HSBP1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of HSBP1 mRNA25562108
C000944dicrotophosdicrotophos results in decreased expression of HSBP1 mRNA28302478
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of HSBP1 protein18691550
D004052DiethylnitrosamineHSBP1 protein inhibits the reaction [Diethylnitrosamine results in increased abundance of Reactive Oxygen Species]18691550
D004052DiethylnitrosamineMAPK14 protein promotes the reaction [Diethylnitrosamine results in increased expression of HSBP1 mRNA]18691550
D004052DiethylnitrosamineMAPK14 protein promotes the reaction [Diethylnitrosamine results in increased expression of HSBP1 protein]18691550
D000431EthanolEthanol affects the expression of HSBP1 mRNA24355176
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of HSBP1 mRNA28329830
D004397FonofosFonofos results in increased methylation of HSBP1 promoter22847954
D006046GoldGold results in decreased expression of HSBP1 mRNA25523186
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of HSBP1 mRNA17183730
C027185indirubinindirubin results in decreased expression of HSBP1 mRNA15056799
D007213IndomethacinIndomethacin inhibits the reaction [Thioacetamide results in increased expression of HSBP1 protein]17103249
C410337K 7174K 7174 results in decreased expression of HSBP1 mRNA24086573
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to HSBP1 promoter]20348232
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of HSBP1 mRNA28001369
D010278ParathionParathion results in increased methylation of HSBP1 promoter22847954
D010862PilocarpinePilocarpine results in decreased expression of HSBP1 mRNA17971868
D010894PiroxicamPiroxicam results in decreased expression of HSBP1 mRNA21858171
D010936Plant ExtractsPlant Extracts results in increased expression of HSBP1 mRNA23557933
D017382Reactive Oxygen SpeciesHSBP1 protein inhibits the reaction [Diethylnitrosamine results in increased abundance of Reactive Oxygen Species]18691550
C064116S-(1,1,2,2-tetrafluoroethyl)cysteine"S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of HSBP1 mRNA"16678137
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of HSBP1 mRNA21427059
C012568terbufosterbufos results in increased methylation of HSBP1 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HSBP1 mRNA15056799
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HSBP1 mRNA21570461
D013853ThioacetamideAcetylcysteine inhibits the reaction [Thioacetamide results in increased expression of HSBP1 protein]17103249
D013853ThioacetamideIndomethacin inhibits the reaction [Thioacetamide results in increased expression of HSBP1 protein]17103249
D013853ThioacetamideThioacetamide results in increased expression of HSBP1 protein17103249
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HSBP1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of HSBP1 mRNA26272509
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of HSBP1 mRNA"26179874
D014415TunicamycinTunicamycin results in decreased expression of HSBP1 mRNA17127020
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of HSBP1 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of HSBP1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of HSBP1 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of HSBP1 mRNA20546886|2142705
D024483Vitamin K 3Vitamin K 3 affects the expression of HSBP1 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003714transcription corepressor activity-IEA-  
GO:0005515protein binding-IPI16189514  25416956  27107014  
GO:0042802identical protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-TAS9649501  
GO:0006936muscle contraction-IEA-  
GO:0035987endodermal cell differentiation-IEA-  
GO:0070370cellular heat acclimation-IBA21873635  
GO:1900034regulation of cellular response to heat-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-TAS9649501  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IBA21873635  
GO:0005856cytoskeleton-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2262752Cellular responses to stressTAS
R-HSA-3371511HSF1 activationTAS
R-HSA-3371556Cellular response to heat stressTAS
R-HSA-3371568Attenuation phaseTAS
R-HSA-3371571HSF1-dependent transactivationTAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25803269Maternal Smoking Dysregulates Protein Expression in Second Trimester Human Fetal Livers in a Sex-Specific Manner. (2015 Jun)Filis PJ Clin Endocrinol Metab