Gene info: ID 3283

Gene: HSD3B1

GENE ID: 3283

Description: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

Gene type: protein-coding

Location: 1p12

dbXrefs: Ensembl:ENSG00000203857 MIM:109715 Vega:OTTHUMG00000012525 UniprotKB:P14060

RefSeq: NG_050909.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.802e-2 (AD) 2.225e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PDC	0.506
NR6A1	0.445
ZACN	0.431
TNRC6B	0.429
RGL4	0.424
ZIM2	0.423
CCSER1	0.415
TTLL2	0.412
ERVW-1	0.411
ERVH48-1	0.41

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NMB	-0.333
HOMER3	-0.301
MCM7	-0.285
KIF1C	-0.279
ANP32B	-0.278
SGMS2	-0.277
BCAS1	-0.277
LPAR1	-0.275
AIF1L	-0.274
AAMDC	-0.271

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00157	NADH	Small Molecule	58-68-4	Approved\|Nutraceutical	Target
DB00741	Hydrocortisone	Small Molecule	50-23-7	Approved	Target
DB01108	Trilostane	Small Molecule	13647-35-3	Approved\|Investigational\|Withdrawn	Target
DB01536	Androstenedione	Small Molecule	63-05-8	Experimental\|Illicit	Target
DB09070	Tibolone	Small Molecule	5630-53-5	Approved\|Investigational	Enzyme

ID	Drug Name	Action	PubMed
C576882	1-(2-trifluoromethoxyphenyl)-2-nitroethanone	1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in decreased expression of HSD3B1 protein	22527513
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of HSD3B1 mRNA"	22698814
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of HSD3B1 mRNA]"	22698814
C120129	2,2',3,4',5',6-hexachlorobiphenyl	"2,2',3,4',5',6-hexachlorobiphenyl metabolite inhibits the reaction [2,2',3,4',5',6-hexachlorobiphenyl results in increased expression of HSD3B1 mRNA]"	16216300
C120129	2,2',3,4',5',6-hexachlorobiphenyl	"2,2',3,4',5',6-hexachlorobiphenyl results in increased expression of HSD3B1 mRNA"	16216300
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of HSD3B1 mRNA"	26794138
C035476	2,2',4,4'-tetrahydroxybenzophenone	"2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]]"	21726595
C035476	2,2',4,4'-tetrahydroxybenzophenone	"2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]]"	21726595
C035476	2,2',4,4'-tetrahydroxybenzophenone	"2,2',4,4'-tetrahydroxybenzophenone promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of HSD3B1 mRNA]"	21726595
C035476	2,2',4,4'-tetrahydroxybenzophenone	"2,2',4,4'-tetrahydroxybenzophenone promotes the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]"	21726595
C035476	2,2',4,4'-tetrahydroxybenzophenone	"2,2',4,4'-tetrahydroxybenzophenone results in increased expression of HSD3B1 mRNA"	21726595
C035476	2,2',4,4'-tetrahydroxybenzophenone	"2,2',4,4'-tetrahydroxybenzophenone results in increased expression of HSD3B1 protein"	21726595
C035476	2,2',4,4'-tetrahydroxybenzophenone	"THRA mutant form inhibits the reaction [2,2',4,4'-tetrahydroxybenzophenone promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of HSD3B1 mRNA]]"	21726595
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of HSD3B1 mRNA]"	19414516
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [FSHB protein results in increased expression of HSD3B1 mRNA]"	16737795
C547124	2,3-dibromopropyl-2,4,6-tribromophenyl ether	"2,3-dibromopropyl-2,4,6-tribromophenyl ether analog results in decreased expression of HSD3B1 mRNA"	25818047
C547124	2,3-dibromopropyl-2,4,6-tribromophenyl ether	"2,3-dibromopropyl-2,4,6-tribromophenyl ether results in decreased expression of HSD3B1 mRNA"	25818047
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of HSD3B1 mRNA"	27832956
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [LHB protein results in increased expression of HSD3B1 mRNA]"	27832956
C009828	2,4,5,2',5'-pentachlorobiphenyl	"2,4,5,2',5'-pentachlorobiphenyl metabolite results in increased expression of HSD3B1 mRNA"	16216300
C009828	2,4,5,2',5'-pentachlorobiphenyl	"2,4,5,2',5'-pentachlorobiphenyl results in increased expression of HSD3B1 mRNA"	16216300
C004554	2,4,6-tribromophenol	"2,4,6-tribromophenol affects the expression of HSD3B1 mRNA"	19931292
C024564	2,4,6-trichlorophenol	"2,4,6-trichlorophenol results in decreased expression of HSD3B1 mRNA"	21296122
C104450	25-hydroxyvitamin D	25-hydroxyvitamin D deficiency results in decreased expression of HSD3B1 mRNA	28655646
C018535	2-ethylhexyldiphenylphosphate	2-ethylhexyldiphenylphosphate results in increased expression of HSD3B1 mRNA	28282128
C018535	2-ethylhexyldiphenylphosphate	PPARG protein affects the reaction [2-ethylhexyldiphenylphosphate results in increased expression of HSD3B1 mRNA]	28282128
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl affects the reaction [LHB protein results in increased expression of HSD3B1 mRNA]"	27832956
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of HSD3B1 mRNA"	27832956
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of HSD3B1 mRNA"	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of HSD3B1 mRNA"	25670856
C041594	4-nonylphenol	4-nonylphenol results in decreased expression of HSD3B1 mRNA	29029336
C105260	4-tert-octylphenol	4-tert-octylphenol results in decreased expression of HSD3B1 mRNA	29029336
D000079	Acetaldehyde	[CGA protein results in increased abundance of Acetaldehyde] which results in increased expression of HSD3B1 mRNA	22285649
D000242	Cyclic AMP	Cyclic AMP results in increased expression of HSD3B1 mRNA	25576683
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of HSD3B1 mRNA	22100608
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of HSD3B1 mRNA	21641981\|2340293
D016604	Aflatoxin B1	finrozole inhibits the reaction [Aflatoxin B1 results in increased expression of HSD3B1 mRNA]	23402939
C031143	AICA ribonucleotide	AICA ribonucleotide results in decreased expression of HSD3B1 mRNA	16020477
C031143	AICA ribonucleotide	AICA ribonucleotide results in decreased expression of HSD3B1 protein	16020477
D013196	Dihydrotestosterone	Dihydrotestosterone results in decreased expression of HSD3B1 mRNA	22948218
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in increased expression of HSD3B1 mRNA	21298039
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of HSD3B1 mRNA	16483693
D015114	Androstenediol	HSD3B1 protein affects the metabolism of Androstenediol	16054388
D000735	Androstenedione	HSD3B1 protein results in increased chemical synthesis of Androstenedione	16054388
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of HSD3B1 mRNA	24449571
D001104	Arbutin	Arbutin results in decreased expression of HSD3B1 mRNA	17103032
D001205	Ascorbic Acid	Ascorbic Acid results in increased expression of HSD3B1 mRNA	17901237
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of HSD3B1 mRNA]	17280759
D001280	Atrazine	Atrazine results in decreased expression of HSD3B1 mRNA	23591565
D001280	Atrazine	Atrazine results in decreased expression of HSD3B1 protein	20045047
D001374	Azacitidine	Azacitidine affects the expression of HSD3B1 mRNA	18033690
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased mutagenesis of HSD3B1 gene	25435355
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of HSD3B1 mRNA	22342234
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of HSD3B1 mRNA	21737371
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of HSD3B1 protein	21737371
D004958	Estradiol	Estradiol results in increased expression of HSD3B1 mRNA	12858341
D004958	Estradiol	[Dieldrin co-treated with Estradiol] results in increased expression of HSD3B1 mRNA	23041725
D004958	Estradiol	Estradiol results in decreased expression of HSD3B1 mRNA	16311018
D001688	Biological Products	Biological Products results in decreased expression of HSD3B1 mRNA	26055946
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in decreased expression of HSD3B1 mRNA	25470364
C006780	bisphenol A	bisphenol A affects the expression of HSD3B1 mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of HSD3B1	26584595
C006780	bisphenol A	bisphenol A results in decreased expression of HSD3B1 mRNA	20956811\|2897013
C006780	bisphenol A	bisphenol A results in increased expression of HSD3B1 mRNA	12021184
C006780	bisphenol A	bisphenol A results in increased expression of HSD3B1 mRNA	18180321\|2665842
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of HSD3B1 mRNA	18815356\|2207961
D015124	8-Bromo Cyclic Adenosine Monophosphate	"2,2',4,4'-tetrahydroxybenzophenone promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of HSD3B1 mRNA]"	21726595
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of HSD3B1 mRNA	21726595
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of HSD3B1 protein	21726595
D015124	8-Bromo Cyclic Adenosine Monophosphate	"THRA mutant form inhibits the reaction [2,2',4,4'-tetrahydroxybenzophenone promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of HSD3B1 mRNA]]"	21726595
D015124	8-Bromo Cyclic Adenosine Monophosphate	Triiodothyronine inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of HSD3B1 mRNA]	21726595
C027561	butylbenzyl phthalate	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of HSD3B1 mRNA	28013214
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of HSD3B1 mRNA	12080015
D002110	Caffeine	Caffeine results in increased expression of HSD3B1 mRNA	25868845
D002229	Carbenoxolone	[Carbenoxolone co-treated with NADP] binds to HSD3B1 protein	25526675
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of HSD3B1 mRNA	16239168
D002509	Cephaloridine	Cephaloridine results in increased expression of HSD3B1 mRNA	18500788
D002713	Chlorine	Chlorine results in decreased expression of HSD3B1 mRNA	18636392
D002713	Chlorine	[Ozone co-treated with Chlorine] affects the expression of HSD3B1 mRNA	18636392
D020111	Chlorodiphenyl (54% Chlorine)	Ascorbic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of HSD3B1 mRNA]	17280759
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased activity of HSD3B1 protein	19071209
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of HSD3B1 mRNA	17280759\|2920848
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of HSD3B1 protein	29208485
D020111	Chlorodiphenyl (54% Chlorine)	lycopene inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of HSD3B1 protein]	19071209
D020111	Chlorodiphenyl (54% Chlorine)	Vitamin E inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of HSD3B1 mRNA]	17280759
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of HSD3B1 mRNA	20938992
D002922	Ciguatoxins	Ciguatoxins affects the expression of HSD3B1 mRNA	18353800
D002953	Citrinin	Citrinin results in decreased expression of HSD3B1 protein	22564900
D003008	Cloprostenol	Cloprostenol results in increased expression of HSD3B1 mRNA	15713365
D009243	NAD	NAD binds to and results in increased activity of HSD3B1 protein	25526675
D009249	NADP	[Carbenoxolone co-treated with NADP] binds to HSD3B1 protein	25526675
D009249	NADP	[Glycyrrhetinic Acid co-treated with NADP] binds to HSD3B1 protein	25526675
D009249	NADP	[Vitamin K 3 co-treated with NADP] binds to HSD3B1 protein	25526675
D009249	NADP	HSD3B1 protein results in increased chemical synthesis of NADP	16079965
D005576	Colforsin	BMP6 protein inhibits the reaction [Colforsin results in increased expression of HSD3B1 mRNA]	18936084
C029892	cupric chloride	HSD3B1 protein binds to cupric chloride	22699969
C017160	cypermethrin	cypermethrin results in decreased expression of HSD3B1 mRNA	24810582
C017160	cypermethrin	cypermethrin results in decreased expression of HSD3B1 protein	24810582
C004742	daidzein	[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of HSD3B1 mRNA	28964809
C013908	daidzin	[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of HSD3B1 mRNA	28964809
D003634	DDT	DDT results in increased expression of HSD3B1 mRNA	27894940
D003634	DDT	DDT results in increased expression of HSD3B1 mRNA	12858341
C010902	decabromobiphenyl ether	decabromobiphenyl ether analog results in increased expression of HSD3B1 mRNA	25222814
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of HSD3B1 mRNA	26602377
D003671	DEET	DEET results in decreased expression of HSD3B1 mRNA	27091632
D003671	DEET	[fipronil co-treated with DEET] results in decreased expression of HSD3B1 mRNA	27091632
D003687	Dehydroepiandrosterone	HSD3B1 protein affects the metabolism of Dehydroepiandrosterone	16054388
D003687	Dehydroepiandrosterone	HSD3B1 protein affects the metabolism of Dehydroepiandrosterone	15261307
C086916	delta-hexachlorocyclohexane	delta-hexachlorocyclohexane results in decreased expression of HSD3B1 mRNA	10993823
C526766	diaminochlorotriazine	diaminochlorotriazine results in increased expression of HSD3B1 mRNA	24632104
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of HSD3B1 mRNA	29029336
D003993	Dibutyl Phthalate	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of HSD3B1 mRNA	28013214
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of HSD3B1 mRNA	15141095\|2126653
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of HSD3B1 protein	15141095
D003994	Bucladesine	Bucladesine results in increased expression of HSD3B1 mRNA	21458522
D004026	Dieldrin	[Dieldrin co-treated with Estradiol] results in increased expression of HSD3B1 mRNA	23041725
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased activity of HSD3B1 protein	17009524
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of HSD3B1 mRNA	28123099
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of HSD3B1 protein	17009524
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of HSD3B1 mRNA	25701202
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of HSD3B1 protein	17009524
D004051	Diethylhexyl Phthalate	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of HSD3B1 mRNA	28013214
D004051	Diethylhexyl Phthalate	[Diethylhexyl Phthalate co-treated with ethylene dimethanesulfonate] results in decreased expression of HSD3B1 mRNA	23064086
D004051	Diethylhexyl Phthalate	[Diethylhexyl Phthalate co-treated with Genistein] results in decreased expression of HSD3B1 mRNA	25031359
D004051	Diethylhexyl Phthalate	[Diethylhexyl Phthalate co-treated with Genistein] results in decreased expression of HSD3B1 protein	25031359
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of HSD3B1 mRNA	17229994\|2503135
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of HSD3B1 protein	25031359
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of HSD3B1 mRNA	28943392
C007379	diethyl phthalate	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of HSD3B1 mRNA	28013214
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of HSD3B1 mRNA	12858341
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of HSD3B1 mRNA	17229994
D002117	Calcitriol	Calcitriol results in increased expression of HSD3B1 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in increased expression of HSD3B1 mRNA	21592394
C025605	diisobutyl phthalate	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of HSD3B1 mRNA	28013214
C012125	diisononyl phthalate	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of HSD3B1 mRNA	28013214
C012125	diisononyl phthalate	diisononyl phthalate results in decreased expression of HSD3B1 mRNA	25445723
C012125	diisononyl phthalate	diisononyl phthalate results in decreased expression of HSD3B1 protein	25445723
C027387	di-n-hexyl phthalate	di-n-hexyl phthalate results in decreased expression of HSD3B1 mRNA	26934186
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of HSD3B1 mRNA"	21899001
D004726	Endosulfan	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HSD3B1 mRNA	26159488
D004726	Endosulfan	Endosulfan results in decreased activity of HSD3B1 protein	11225895
C118739	entinostat	entinostat results in increased expression of HSD3B1 mRNA	27188386
D004785	Environmental Pollutants	Environmental Pollutants results in increased expression of HSD3B1 mRNA	20064776
D000431	Ethanol	Ethanol affects the expression of HSD3B1 mRNA	26188107
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of HSD3B1 mRNA	16872691
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of HSD3B1 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of HSD3B1 mRNA	23550701
C024565	ethylene dichloride	ethylene dichloride affects the expression of HSD3B1 mRNA	28973639
C002994	ethylene dimethanesulfonate	[Diethylhexyl Phthalate co-treated with ethylene dimethanesulfonate] results in decreased expression of HSD3B1 mRNA	23064086
D015025	Zearalenone	Zearalenone results in decreased expression of HSD3B1 mRNA	24512812
C033789	fenarimol	fenarimol results in increased expression of HSD3B1 mRNA	21722721
C111409	finrozole	finrozole inhibits the reaction [Aflatoxin B1 results in increased expression of HSD3B1 mRNA]	23402939
C082360	fipronil	[fipronil co-treated with DEET] results in decreased expression of HSD3B1 mRNA	27091632
C082360	fipronil	fipronil results in decreased expression of HSD3B1 mRNA	27091632
D005485	Flutamide	Flutamide results in increased expression of HSD3B1 mRNA	14967917\|1722999
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of HSD3B1 mRNA	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of HSD3B1 mRNA	28937961
D019833	Genistein	Genistein results in decreased expression of HSD3B1 mRNA	24967385\|2679261
D019833	Genistein	[Diethylhexyl Phthalate co-treated with Genistein] results in decreased expression of HSD3B1 mRNA	25031359
D019833	Genistein	[Diethylhexyl Phthalate co-treated with Genistein] results in decreased expression of HSD3B1 protein	25031359
D019833	Genistein	[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of HSD3B1 mRNA	28964809
D019833	Genistein	Genistein results in decreased expression of HSD3B1 mRNA	25031359
D019833	Genistein	Genistein results in decreased expression of HSD3B1 protein	25031359
C040641	genistin	[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of HSD3B1 mRNA	28964809
D005938	Glucocorticoids	HSD3B1 protein results in increased oxidation of and results in decreased activity of Glucocorticoids	16079965
D005947	Glucose	[INS protein co-treated with Glucose] results in increased expression of HSD3B1 mRNA	22634610
D005978	Glutathione	Glutathione inhibits the reaction [sodium arsenite results in decreased activity of HSD3B1 protein]	20580664
C086566	glycitein	[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of HSD3B1 mRNA	28964809
C433283	glycitin	[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of HSD3B1 mRNA	28964809
D006034	Glycyrrhetinic Acid	[Glycyrrhetinic Acid co-treated with NADP] binds to HSD3B1 protein	25526675
C010974	glyphosate	glyphosate results in decreased expression of HSD3B1 mRNA	10964798
C081021	Go 6976	CRH protein inhibits the reaction [Go 6976 results in increased expression of HSD3B1 mRNA]	17170093
C081021	Go 6976	Go 6976 results in increased expression of HSD3B1 mRNA	17170093
D006064	Gonadotropins, Equine	"Gonadotropins, Equine inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of HSD3B1 mRNA]"	19276399
D006063	Chorionic Gonadotropin	Chorionic Gonadotropin results in increased expression of HSD3B1 mRNA	15930178
D006854	Hydrocortisone	Hydrocortisone binds to HSD3B1 protein	25526675
D007220	Industrial Waste	Industrial Waste results in decreased expression of HSD3B1 mRNA	26055946
D007529	Isoflavones	Isoflavones results in increased activity of HSD3B1 protein	15698548
D007545	Isoproterenol	Isoproterenol results in decreased expression of HSD3B1 mRNA	21335049
D007654	Ketoconazole	Ketoconazole results in decreased expression of HSD3B1 mRNA	17229994
D001556	Lindane	Lindane results in decreased activity of HSD3B1 protein	11404799
D044243	Linoleic Acids, Conjugated	"Linoleic Acids, Conjugated results in decreased expression of HSD3B1 mRNA"	21480431
C015329	lycopene	lycopene inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of HSD3B1 protein]	19071209
C545385	Mequindox	Mequindox results in increased expression of HSD3B1 mRNA	19733641\|2137748
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of HSD3B1 mRNA	20938992
D008727	Methotrexate	Methotrexate affects the expression of HSD3B1 mRNA	18502557
D008731	Methoxychlor	Methoxychlor results in increased expression of HSD3B1 mRNA	12858341
D008731	Methoxychlor	Methoxychlor results in decreased expression of HSD3B1 mRNA	21514315
D008731	Methoxychlor	Methoxychlor metabolite inhibits the reaction [FSHB protein results in increased expression of HSD3B1 mRNA]	16737795
C005219	methyl cellosolve	methyl cellosolve results in decreased expression of HSD3B1 mRNA	21061450
D015735	Mifepristone	Mifepristone results in increased expression of HSD3B1 mRNA	19439560
C500085	muraglitazar	muraglitazar results in decreased expression of HSD3B1 mRNA	21515302
D009538	Nicotine	Nicotine results in decreased activity of HSD3B1 protein	28986172
D009538	Nicotine	Nicotine results in decreased expression of HSD3B1 mRNA	28986172
D009538	Nicotine	Nicotine results in decreased expression of HSD3B1 protein	28986172
D026423	S-Nitroso-N-Acetylpenicillamine	S-Nitroso-N-Acetylpenicillamine results in decreased expression of HSD3B1 mRNA	16303614
D026423	S-Nitroso-N-Acetylpenicillamine	S-Nitroso-N-Acetylpenicillamine results in decreased expression of HSD3B1 protein	16303614
C025256	nonylphenol	nonylphenol results in decreased expression of HSD3B1 mRNA	17229994
C025589	ochratoxin A	ochratoxin A results in increased expression of HSD3B1 mRNA	23466516
C025589	ochratoxin A	ochratoxin A results in increased expression of HSD3B1 protein	23466516
C474055	octylphenol	octylphenol results in decreased expression of HSD3B1 mRNA	17229994
C108709	oleoyl-estrone	oleoyl-estrone results in increased expression of HSD3B1 mRNA	19793540
D008939	Mitotane	Mitotane results in decreased expression of HSD3B1 mRNA	22966885
C005290	oxybenzone	oxybenzone results in decreased expression of HSD3B1 mRNA	22721600
D010126	Ozone	[Ozone co-treated with Chlorine] affects the expression of HSD3B1 mRNA	18636392
D010416	Pentachlorophenol	Pentachlorophenol results in decreased expression of HSD3B1 mRNA	21296122
C522391	perfluorododecanoic acid	perfluorododecanoic acid results in decreased expression of HSD3B1 mRNA	17400581
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of HSD3B1 mRNA	23427857
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of HSD3B1 mRNA	21712084
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of HSD3B1 mRNA	17681415\|2821976
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of HSD3B1 protein	22414604
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of HSD3B1 protein	20118188
C023036	perfluorooctanoic acid	PPARA affects the reaction [perfluorooctanoic acid affects the expression of HSD3B1 mRNA]	21712084
C023036	perfluorooctanoic acid	PPARA gene mutant form inhibits the reaction [perfluorooctanoic acid results in decreased expression of HSD3B1 protein]	22414604
C023036	perfluorooctanoic acid	PPARA promotes the reaction [perfluorooctanoic acid results in increased expression of HSD3B1 protein]	20118188
D026023	Permethrin	Permethrin analog results in decreased expression of HSD3B1 mRNA	21745691
D010634	Phenobarbital	Phenobarbital affects the expression of HSD3B1 mRNA	19159669
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of HSD3B1 mRNA	15728792\|2106145
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of HSD3B1 mRNA	19710929
D010936	Plant Extracts	Plant Extracts results in decreased activity of HSD3B1 protein	16254570
D059808	Polyphenols	Polyphenols results in decreased expression of HSD3B1 mRNA	16293270
D011284	Pregnenolone	HSD3B1 protein affects the metabolism of Pregnenolone	16054388
C045362	prochloraz	prochloraz results in increased expression of HSD3B1 mRNA	21158436
D011374	Progesterone	Progesterone results in increased expression of HSD3B1 mRNA	16303614\|2063139
D011374	Progesterone	Progesterone results in increased expression of HSD3B1 protein	16303614
D011374	Progesterone	HSD3B1 protein results in increased chemical synthesis of Progesterone	16054388
D011374	Progesterone	Progesterone results in increased expression of HSD3B1 mRNA	19690047
D011374	Progesterone	HSD3B1 protein affects the metabolism of Progesterone	15261307
D011441	Propylthiouracil	Propylthiouracil results in increased expression of HSD3B1 mRNA	21158436
D015237	Dinoprost	Dinoprost results in decreased expression of HSD3B1 mRNA	20484870
D011794	Quercetin	Quercetin inhibits the reaction [sodium arsenite results in increased expression of HSD3B1 mRNA]	28414027
C502851	quinocetone	quinocetone affects the expression of HSD3B1 mRNA	26296292
C059514	resveratrol	resveratrol results in decreased expression of HSD3B1 mRNA	24524197
C059514	resveratrol	[Simvastatin co-treated with resveratrol] results in decreased expression of HSD3B1 mRNA	24524197
D015474	Isotretinoin	Isotretinoin results in decreased expression of HSD3B1 mRNA	20436886
C089730	rosiglitazone	rosiglitazone results in decreased expression of HSD3B1 mRNA	21515302
C106263	rostafuroxin	[LSS gene polymorphism co-treated with HSD3B1 gene polymorphism co-treated with ABCB1 gene polymorphism co-treated with ADD1 gene polymorphism co-treated with ADD3 gene polymorphism] affects the susceptibility to rostafuroxin	21106941
D012645	Selenomethionine	Selenomethionine results in increased expression of HSD3B1 mRNA	21762653
D012834	Silver	Silver analog results in increased expression of HSD3B1 mRNA	24447867
D019821	Simvastatin	[Simvastatin co-treated with resveratrol] results in decreased expression of HSD3B1 mRNA	24524197
C017947	sodium arsenite	Quercetin inhibits the reaction [sodium arsenite results in increased expression of HSD3B1 mRNA]	28414027
C017947	sodium arsenite	sodium arsenite results in increased expression of HSD3B1 mRNA	28414027
C017947	sodium arsenite	Glutathione inhibits the reaction [sodium arsenite results in decreased activity of HSD3B1 protein]	20580664
C017947	sodium arsenite	sodium arsenite results in decreased activity of HSD3B1 protein	20580664
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of HSD3B1 mRNA	27862939
D012460	Sulfasalazine	Sulfasalazine results in decreased expression of HSD3B1 mRNA	29197623
C025462	sulindac sulfide	sulindac sulfide results in decreased expression of HSD3B1 mRNA	16184548
D014284	Triiodothyronine	"2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]]"	21726595
D014284	Triiodothyronine	"2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]]"	21726595
D014284	Triiodothyronine	Triiodothyronine inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of HSD3B1 mRNA]	21726595
D014284	Triiodothyronine	Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]	21726595
D014284	Triiodothyronine	Triiodothyronine promotes the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]	21726595
D013629	Tamoxifen	Tamoxifen results in increased expression of HSD3B1	26584595
C037565	terbutylazine	terbutylazine results in decreased expression of HSD3B1 mRNA	23591565
C501413	tesaglitazar	tesaglitazar results in decreased expression of HSD3B1 mRNA	21515302
D013739	Testosterone	[FSHB protein co-treated with Testosterone] results in increased expression of HSD3B1 mRNA	18535249
D013739	Testosterone	HSD3B1 protein results in increased chemical synthesis of Testosterone	16054388
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in increased expression of HSD3B1 mRNA	21592394
D013739	Testosterone	Testosterone results in decreased expression of HSD3B1 mRNA	21592394
D013739	Testosterone	HSD3B1 protein affects the chemical synthesis of Testosterone	15932923
D013739	Testosterone	Testosterone results in decreased expression of HSD3B1 mRNA	17229994
D013739	Testosterone	Testosterone results in increased expression of HSD3B1 mRNA	17229994
D013739	Testosterone	HSD3B1 protein affects the chemical synthesis of Testosterone	22564900
D013739	Testosterone	[PRKACA protein mutant form co-treated with Testosterone] results in increased expression of HSD3B1 mRNA	18535249
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of HSD3B1 mRNA	25470364
D013749	Tetrachlorodibenzodioxin	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HSD3B1 mRNA	26159488
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HSD3B1 mRNA	21998131
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HSD3B1 gene]	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HSD3B1 mRNA	21354282
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of HSD3B1 mRNA	22889882\|2821309
D013749	Tetrachlorodibenzodioxin	"Gonadotropins, Equine inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of HSD3B1 mRNA]"	19276399
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of HSD3B1 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HSD3B1 mRNA	18637154\|1927639
D013750	Tetrachloroethylene	Tetrachloroethylene results in decreased expression of HSD3B1 mRNA	28973375
C582340	tetradecabromodiphenoxybenzene	tetradecabromodiphenoxybenzene analog results in increased expression of HSD3B1 mRNA	25222814
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of HSD3B1 mRNA	28943392
D013853	Thioacetamide	Thioacetamide results in increased expression of HSD3B1 mRNA	26222700
D014050	Toluene	Toluene results in decreased expression of HSD3B1 mRNA	19110042
D014050	Toluene	Toluene results in decreased expression of HSD3B1 protein	19110042
D014212	Tretinoin	Tretinoin results in increased expression of HSD3B1 mRNA	19744992
C025541	tri-o-cresyl phosphate	[tri-o-cresyl phosphate co-treated with LHB protein] results in decreased expression of HSD3B1 mRNA	26794138
C025541	tri-o-cresyl phosphate	tri-o-cresyl phosphate results in decreased expression of HSD3B1 mRNA	26794138
C005445	triphenyl phosphate	PPARG protein affects the reaction [triphenyl phosphate results in increased expression of HSD3B1 mRNA]	28282128
C005445	triphenyl phosphate	triphenyl phosphate results in increased expression of HSD3B1 mRNA	28282128
C005445	triphenyl phosphate	triphenyl phosphate results in decreased expression of HSD3B1 mRNA	26049154
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of HSD3B1 mRNA"	25242413
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSD3B1 mRNA"	25242413
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate results in increased expression of HSD3B1 mRNA	27912163
C031324	tris(chloroethyl)phosphate	[tris(chloroethyl)phosphate co-treated with CGB3 protein] results in decreased expression of HSD3B1 mRNA	26049154
C031324	tris(chloroethyl)phosphate	tris(chloroethyl)phosphate results in decreased expression of HSD3B1 mRNA	26049154\|2618380
C057693	troglitazone	troglitazone results in decreased expression of HSD3B1 mRNA	21515302
D014501	Uranium	Uranium analog results in decreased expression of HSD3B1 mRNA	27544493
D014635	Valproic Acid	Valproic Acid results in decreased expression of HSD3B1 mRNA	23152920
D014635	Valproic Acid	Valproic Acid results in increased expression of HSD3B1 mRNA	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of HSD3B1 mRNA	17292431
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of HSD3B1 mRNA	26682919
D014810	Vitamin E	Vitamin E inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of HSD3B1 mRNA]	17280759
D024483	Vitamin K 3	Vitamin K 3 affects the expression of HSD3B1 mRNA	20044591
D024483	Vitamin K 3	[Vitamin K 3 co-treated with NADP] binds to HSD3B1 protein	25526675
D015039	Ziram	Ziram results in decreased activity of HSD3B1 protein	28973382
D015039	Ziram	Ziram results in decreased expression of HSD3B1 mRNA	28973382
D015039	Ziram	Ziram results in decreased expression of HSD3B1 protein	28973382

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity	-	IBA	21873635
GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity	-	ISS	1944309
GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity	-	TAS	-
GO:0004769	steroid delta-isomerase activity	-	ISS	1944309
GO:0004769	steroid delta-isomerase activity	-	TAS	-
GO:0016491	oxidoreductase activity	-	IBA	21873635
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	-	IBA	21873635
GO:0102294	cholesterol dehydrogenase activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006694	steroid biosynthetic process	-	IBA	21873635
GO:0006694	steroid biosynthetic process	-	ISS	1944309
GO:0006702	androgen biosynthetic process	-	TAS	1944309
GO:0006703	estrogen biosynthetic process	-	TAS	1944309
GO:0006704	glucocorticoid biosynthetic process	-	TAS	-
GO:0006705	mineralocorticoid biosynthetic process	-	TAS	-
GO:0008207	C21-steroid hormone metabolic process	-	IBA	21873635
GO:0021766	hippocampus development	-	IBA	21873635
GO:0051412	response to corticosterone	-	IBA	21873635
GO:0055114	oxidation-reduction process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005743	mitochondrial inner membrane	-	IDA	8274411
GO:0005758	mitochondrial intermembrane space	-	IDA	8274411
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0016020	membrane	-	IBA	21873635
GO:0016021	integral component of membrane	-	IEA	-
GO:0030868	smooth endoplasmic reticulum membrane	-	ISS	-
GO:0043231	intracellular membrane-bounded organelle	-	IBA	21873635

KEGG ID	KEGG Term
hsa00140	Steroid hormone biosynthesis
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-193048	Androgen biosynthesis	TAS
R-HSA-193993	Mineralocorticoid biosynthesis	TAS
R-HSA-194002	Glucocorticoid biosynthesis	TAS
R-HSA-196071	Metabolism of steroid hormones	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-8957322	Metabolism of steroids	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22449891	Prediction of susceptibility to major depression by a model of interactions of multiple functional genetic variants and environmental factors. (2012 Jun)	Wong ML	Mol Psychiatry