Gene info: ID 3290

Gene: HSD11B1

GENE ID: 3290

Description: hydroxysteroid 11-beta dehydrogenase 1

Gene type: protein-coding

Location: 1q32.2

dbXrefs: Ensembl:ENSG00000117594 MIM:600713 Vega:OTTHUMG00000036481 UniprotKB:P28845

RefSeq: NG_012081.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.792e-1 (AD) 7.852e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CNDP1	0.783
UGT8	0.75
GPR37	0.743
ENPP2	0.741
KLK6	0.741
TF	0.713
THBS2	0.712
GJB1	0.709
FA2H	0.704
CNTN2	0.685

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TECTB	-0.297
DRAXIN	-0.289
NAT16	-0.285
MTRNR2L8	-0.282
RGS22	-0.267
MFSD6L	-0.261
SPTA1	-0.254
FBXO43	-0.25
HKDC1	-0.247
MS4A3	-0.246

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00157	NADH	Small Molecule	58-68-4	Approved\|Nutraceutical	Target
DB00635	Prednisone	Small Molecule	53-03-2	Approved	Target
DB02329	Carbenoxolone	Small Molecule	5697-56-3	Experimental	Target
DB03461	2'-Monophosphoadenosine 5'-Diphosphoribose	Small Molecule		Experimental	Target
DB03814	2-(N-Morpholino)-Ethanesulfonic Acid	Small Molecule		Experimental	Target
DB04652	Corticosterone	Small Molecule	50-22-6	Experimental	Target
DB05064	INCB13739	Small Molecule	-	Investigational	Target
DB06992	(3,3-dimethylpiperidin-1-yl)(6-(3-fluoro-4-methylphenyl)pyridin-2-yl)methanone	Small Molecule		Experimental	Target
DB07017	(5S)-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-5-(1-hydroxy-1-methylethyl)-5-methyl-1,3-thiazol-4(5H)-one	Small Molecule		Experimental	Target
DB07049	(2R)-1-[(4-tert-butylphenyl)sulfonyl]-2-methyl-4-(4-nitrophenyl)piperazine	Small Molecule		Experimental	Target
DB07056	2-(6-{[(3-chloro-2-methylphenyl)sulfonyl]amino}pyridin-2-yl)-N,N-diethylacetamide	Small Molecule		Experimental	Target
DB07310	(5S)-2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-methyl-5-(trifluoromethyl)-1,3-thiazol-4(5H)-one	Small Molecule		Experimental	Target
DB07316	N-{1-[(1-carbamoylcyclopropyl)methyl]piperidin-4-yl}-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide	Small Molecule		Experimental	Target
DB07619	N-cyclopropyl-N-(trans-4-pyridin-3-ylcyclohexyl)-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide	Small Molecule		Experimental	Target
DB07624	1-{[(3R)-3-methyl-4-({4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]phenyl}sulfonyl)piperazin-1-yl]methyl}cyclopropanecarboxamide	Small Molecule		Experimental	Target
DB07866	(5S)-2-(cyclooctylamino)-5-methyl-5-propyl-1,3-thiazol-4(5H)-one	Small Molecule		Experimental	Target
DB08277	2-(2-CHLORO-4-FLUOROPHENOXY)-2-METHYL-N-[(1R,2S,3S,5S,7S)-5-(METHYLSULFONYL)-2-ADAMANTYL]PROPANAMIDE	Small Molecule		Experimental	Target
DB08280	(1S,3R,4S,5S,7S)-4-{[2-(4-METHOXYPHENOXY)-2-METHYLPROPANOYL]AMINO}ADAMANTANE-1-CARBOXAMIDE	Small Molecule		Experimental	Target
DB08771	(5R)-2-[(2-fluorophenyl)amino]-5-(1-methylethyl)-1,3-thiazol-4(5H)-one	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C003552	11-dehydrocorticosterone	HSD11B1 gene affects the susceptibility to 11-dehydrocorticosterone	16751407
C003552	11-dehydrocorticosterone	HSD11B1 gene mutant form affects the abundance of 11-dehydrocorticosterone	25061560
C003552	11-dehydrocorticosterone	HSD11B1 protein results in increased metabolism of 11-dehydrocorticosterone	16751407
C003552	11-dehydrocorticosterone	HSD11B1 protein results in increased metabolism of 11-dehydrocorticosterone	23814014
C003552	11-dehydrocorticosterone	[HSD11B1 protein results in increased oxidation of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone	26859423
C003552	11-dehydrocorticosterone	HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone	26859423
C003552	11-dehydrocorticosterone	[HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone] which results in increased chemical synthesis of Corticosterone	26859423
C003552	11-dehydrocorticosterone	resveratrol inhibits the reaction [HSD11B1 protein results in increased metabolism of 11-dehydrocorticosterone]	23814014
C003552	11-dehydrocorticosterone	Ziram inhibits the reaction [HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone]	26859423
C003552	11-dehydrocorticosterone	Ziram inhibits the reaction [[HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone] which results in increased chemical synthesis of Corticosterone]	26859423
C026486	1,2,5,6-dibenzanthracene	"[1,2,5,6-dibenzanthracene co-treated with dibenzo(a,l)pyrene] affects the expression of HSD11B1 mRNA"	18711122
C026486	1,2,5,6-dibenzanthracene	"[1,2,5,6-dibenzanthracene co-treated with fluoranthene] affects the expression of HSD11B1 mRNA"	18711122
C026486	1,2,5,6-dibenzanthracene	"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of HSD11B1 mRNA"	18711122
C119129	18alpha-glycyrrhetinic acid	18alpha-glycyrrhetinic acid results in decreased activity of HSD11B1 protein	24135201
C119129	18alpha-glycyrrhetinic acid	18alpha-glycyrrhetinic acid results in decreased activity of HSD11B1 protein	24135201
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased activity of HSD11B1 protein"	23333641
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of HSD11B1 mRNA]"	19414516
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased activity of HSD11B1 protein"	23333641
C558395	2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone	"2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone results in decreased activity of HSD11B1 protein"	21315688
C558395	2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone	"[2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone co-treated with Lipopolysaccharides] results in decreased activity of HSD11B1 protein"	27523796
C558395	2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone	"2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Cortisone results in increased expression of and results in increased activity of HSD11B1 protein]"	21315688
C558395	2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone	"2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased expression of HSD11B1 mRNA]"	27523796
C558395	2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone	"2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone results in decreased activity of HSD11B1 protein"	21315688
C558395	2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone	"zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased expression of HSD11B1 mRNA]]"	27523796
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of HSD11B1 mRNA"	21346803
C028451	3,4,3',4'-tetrachlorobiphenyl	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of HSD11B1 mRNA]"	19467301
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of HSD11B1 mRNA"	23196670
C552826	4-(2-adamantan-1-yl-2-oxoethoxymethyl)-N,N-dimethylbenzamide	"4-(2-adamantan-1-yl-2-oxoethoxymethyl)-N,N-dimethylbenzamide results in decreased activity of HSD11B1 protein"	20486152
C525872	4'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide	4'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide inhibits the reaction [[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of HSD11B1 mRNA]	23275455
C525872	4'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide	4'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide results in decreased activity of HSD11B1 protein	23275455
C525872	4'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide	4'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide results in decreased activity of HSD11B1 protein	23264615
C525872	4'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide	4'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide results in decreased expression of HSD11B1 mRNA	23264615
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	drospirenone inhibits the reaction [HSD11B1 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]	28257955
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	Ethinyl Estradiol inhibits the reaction [HSD11B1 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]	28257955
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	HSD11B1 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	28257955
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	Progesterone inhibits the reaction [HSD11B1 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]	28257955
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	Testosterone inhibits the reaction [HSD11B1 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]	28257955
C041594	4-nonylphenol	4-nonylphenol results in decreased activity of HSD11B1 protein	16184081
C105260	4-tert-octylphenol	4-tert-octylphenol results in decreased expression of HSD11B1 mRNA	17011747
C105260	4-tert-octylphenol	4-tert-octylphenol results in increased expression of HSD11B1 mRNA	17011747
C029370	4-toluidine	4-toluidine results in increased expression of HSD11B1 mRNA	27638505
C108492	5-androstene-3,7,17-triol	"HSD11B1 protein results in increased chemical synthesis of 5-androstene-3,7,17-triol"	22384159
C053876	6-isopropoxy-9-oxoxanthene-2-carboxylic acid	6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [butaprost results in increased activity of HSD11B1 protein]	17761898
C053876	6-isopropoxy-9-oxoxanthene-2-carboxylic acid	6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [Dinoprostone results in increased activity of HSD11B1 protein]	17761898
C023867	7-ketodeoxycholic acid	HSD11B1 gene mutant form results in increased abundance of 7-ketodeoxycholic acid	25061560
C023020	7-ketolithocholic acid	HSD11B1 protein results in increased reduction of 7-ketolithocholic acid	21453287
C023020	7-ketolithocholic acid	[HSD11B1 protein results in increased reduction of 7-ketolithocholic acid] which results in increased chemical synthesis of Chenodeoxycholic Acid	21453287
C023020	7-ketolithocholic acid	[HSD11B1 protein results in increased reduction of 7-ketolithocholic acid] which results in increased chemical synthesis of Ursodeoxycholic Acid	21453287
D000082	Acetaminophen	Acetaminophen results in decreased expression of HSD11B1 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of HSD11B1 mRNA	17562736
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of HSD11B1 mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of HSD11B1 mRNA]	17585979
D000214	Acyl Coenzyme A	Acyl Coenzyme A binds to HSD11B1 protein	25526675
C006418	adrenocorticotropin zinc	adrenocorticotropin zinc results in decreased expression of HSD11B1 mRNA	19920212
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of HSD11B1 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of HSD11B1 mRNA	22100608\|2715375
C103303	alitretinoin	alitretinoin results in decreased expression of HSD11B1 mRNA	15982314
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of HSD11B1 mRNA	16483693
D000728	Androgens	Androgens results in increased expression of and results in increased activity of HSD11B1 protein	17628001
D015113	Androstane-3,17-diol	"Androstane-3,17-diol binds to HSD11B1 protein"	25526675
D015113	Androstane-3,17-diol	"[Androstane-3,17-diol co-treated with NAD] binds to HSD11B1 protein"	25526675
C025657	arsenic acid	arsenic acid affects the methylation of HSD11B1 gene	26855884
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of HSD11B1 mRNA"	25351596
D001379	Azathioprine	Azathioprine results in decreased expression of HSD11B1 mRNA	19192274
C547126	AZM551248	AZM551248 results in increased expression of HSD11B1 mRNA	22323515
C037689	benzamide	benzamide analog results in decreased activity of HSD11B1 protein	18553955\|1921777
C037689	benzamide	benzamide analog results in decreased activity of HSD11B1 protein	18553955
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of HSD11B1 mRNA	18711122
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of HSD11B1 mRNA	20106945
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of HSD11B1 mRNA	22342234
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of HSD11B1 mRNA	23735875
D001564	Benzo(a)pyrene	"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of HSD11B1 mRNA"	18711122
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of HSD11B1 mRNA	18711122
D001564	Benzo(a)pyrene	"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of HSD11B1 mRNA"	18711122
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of HSD11B1 mRNA	21839799
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of HSD11B1 mRNA"	20382639
D004958	Estradiol	[Estradiol co-treated with NAD] binds to HSD11B1 protein	25526675
D004958	Estradiol	[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Estradiol] results in increased expression of HSD11B1 protein	23275455
D004958	Estradiol	Estradiol results in decreased expression of HSD11B1 mRNA	19484750
D004958	Estradiol	Estradiol results in decreased activity of HSD11B1 protein	23814014
D001629	Bezafibrate	Bezafibrate results in decreased activity of HSD11B1 protein	17190905
D001629	Bezafibrate	Bezafibrate results in decreased expression of HSD11B1 mRNA	17190905
D001647	Bile Acids and Salts	HSD11B1 gene mutant form affects the metabolism of and results in increased abundance of Bile Acids and Salts	25061560
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of HSD11B1 mRNA	27685785
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of HSD11B1 mRNA	28628672
C006780	bisphenol A	bisphenol A results in decreased activity of HSD11B1 protein	23069880
C006780	bisphenol A	bisphenol A results in decreased expression of HSD11B1 mRNA	22576693
C006780	bisphenol A	bisphenol A results in increased activity of HSD11B1 protein	23090578
C006780	bisphenol A	bisphenol A results in increased expression of HSD11B1 mRNA	23090578\|2768578
C006780	bisphenol A	bisphenol A results in increased methylation of HSD11B1 gene	22576693
C006780	bisphenol A	Mifepristone inhibits the reaction [bisphenol A results in increased expression of HSD11B1 mRNA]	23090578
C006780	bisphenol A	bisphenol A results in increased expression of HSD11B1 mRNA	26063408
C006780	bisphenol A	bisphenol A results in increased methylation of HSD11B1 promoter	27312807
C006780	bisphenol A	bisphenol A affects the expression of HSD11B1 mRNA	25181051
C006780	bisphenol A	bisphenol A results in decreased activity of HSD11B1 protein	23069880
C006780	bisphenol A	bisphenol A results in increased methylation of HSD11B1 gene	28505145
C006780	bisphenol A	bisphenol A results in decreased expression of HSD11B1 mRNA	26794494
D015124	8-Bromo Cyclic Adenosine Monophosphate	4'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide inhibits the reaction [[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of HSD11B1 mRNA]	23275455
D015124	8-Bromo Cyclic Adenosine Monophosphate	Hydrocortisone promotes the reaction [[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of HSD11B1 mRNA]	23275455
D015124	8-Bromo Cyclic Adenosine Monophosphate	[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of and results in increased activity of HSD11B1 protein	23275455
D015124	8-Bromo Cyclic Adenosine Monophosphate	[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of HSD11B1 mRNA	23275455
D015124	8-Bromo Cyclic Adenosine Monophosphate	[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Estradiol] results in increased expression of HSD11B1 protein	23275455
D015124	8-Bromo Cyclic Adenosine Monophosphate	[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of HSD11B1 mRNA	23275455
C048491	butaprost	6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [butaprost results in increased activity of HSD11B1 protein]	17761898
C048491	butaprost	butaprost results in increased activity of HSD11B1 protein	17761898
C048491	butaprost	"Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide promotes the reaction [butaprost results in increased activity of HSD11B1 protein]"	17761898
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of HSD11B1 mRNA	23741332
D002110	Caffeine	Caffeine results in increased expression of HSD11B1 mRNA	22583948
D002136	Calcium, Dietary	"Calcium, Dietary results in decreased expression of HSD11B1 protein"	19918113
D002229	Carbenoxolone	Carbenoxolone results in decreased activity of HSD11B1 protein	24135201
D002229	Carbenoxolone	Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased expression of HSD11B1 mRNA]	27523796
D002229	Carbenoxolone	Carbenoxolone results in decreased activity of HSD11B1 protein	24135201
D002229	Carbenoxolone	Carbenoxolone results in decreased activity of HSD11B1 protein	23814014
D002229	Carbenoxolone	Carbenoxolone results in decreased activity of HSD11B1 protein	21786805
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of HSD11B1 mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of HSD11B1 mRNA	27339419
D002395	Catecholamines	Catecholamines results in increased expression of HSD11B1 mRNA	15855228
D002635	Chenodeoxycholic Acid	Chenodeoxycholic Acid results in decreased activity of HSD11B1 protein	10664531
D002635	Chenodeoxycholic Acid	[HSD11B1 protein results in increased reduction of 7-ketolithocholic acid] which results in increased chemical synthesis of Chenodeoxycholic Acid	21453287
D002635	Chenodeoxycholic Acid	HSD11B1 gene mutant form results in increased abundance of Chenodeoxycholic Acid	25061560
D019826	Cholic Acid	HSD11B1 gene mutant form results in increased abundance of Cholic Acid	25061560
D002857	Chromium	Chromium deficiency results in increased expression of HSD11B1 mRNA	19846803
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of HSD11B1 mRNA	17585979
D002994	Clofibrate	Clofibrate results in decreased expression of HSD11B1 mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of HSD11B1 mRNA]	17585979
D002994	Clofibrate	Clofibrate results in decreased expression of HSD11B1 mRNA	12851107
D002995	Clofibric Acid	[Clofibric Acid co-treated with Diethylnitrosamine] results in decreased expression of HSD11B1 mRNA	15833021
D002995	Clofibric Acid	Clofibric Acid results in decreased expression of HSD11B1 mRNA	15833021
D009243	NAD	"[Androstane-3,17-diol co-treated with NAD] binds to HSD11B1 protein"	25526675
D009243	NAD	[Disulfiram co-treated with NAD] binds to HSD11B1 protein	25526675
D009243	NAD	[Estradiol co-treated with NAD] binds to HSD11B1 protein	25526675
D009243	NAD	[Quercetin co-treated with NAD] binds to HSD11B1 protein	25526675
D009243	NAD	[Testosterone co-treated with NAD] binds to HSD11B1 protein	25526675
D009249	NADP	HSD11B1 protein results in increased oxidation of NADP	26859423
D009249	NADP	HSD11B1 protein results in increased reduction of NADP	26859423
D009249	NADP	NADP binds to and results in increased activity of HSD11B1 protein	25526675
D009249	NADP	HSD11B1 protein results in increased oxidation of NADP	26859423
D009249	NADP	HSD11B1 protein results in increased reduction of NADP	26859423
D009249	NADP	Ziram inhibits the reaction [HSD11B1 protein results in increased oxidation of NADP]	26859423
D003345	Corticosterone	HSD11B1 gene mutant form results in decreased abundance of Corticosterone	25061560
D003345	Corticosterone	HSD11B1 protein results in increased chemical synthesis of Corticosterone	16751407
D003345	Corticosterone	Corticosterone results in increased expression of HSD11B1 mRNA	15755911
D003345	Corticosterone	HSD11B1 protein results in increased chemical synthesis of Corticosterone	23814014
D003345	Corticosterone	HSD11B1 protein results in increased oxidation of Corticosterone	26859423
D003345	Corticosterone	[HSD11B1 protein results in increased oxidation of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone	26859423
D003345	Corticosterone	[HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone] which results in increased chemical synthesis of Corticosterone	26859423
D003345	Corticosterone	resveratrol inhibits the reaction [HSD11B1 protein results in increased chemical synthesis of Corticosterone]	23814014
D003345	Corticosterone	Ziram inhibits the reaction [[HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone] which results in increased chemical synthesis of Corticosterone]	26859423
D003345	Corticosterone	HSD11B1 protein results in increased chemical synthesis of Corticosterone	22178014
D003345	Corticosterone	[HSD11B1 protein results in increased metabolism of Ketosteroids] which results in increased chemical synthesis of Corticosterone	22178014
D003348	Cortisone	[Calcitriol co-treated with Cortisone] results in increased expression of HSD11B1 mRNA	19918113
D003348	Cortisone	HSD11B1 protein affects the metabolism of Cortisone	16054388
D003348	Cortisone	[HSD11B1 protein results in increased activity of Cortisone] inhibits the reaction [sulforafan results in increased activity of NFE2L2 protein]	22606287
D003348	Cortisone	HSD11B1 protein results in increased metabolism of Cortisone	16751407
D003348	Cortisone	[HSD11B1 protein results in increased oxidation of Hydrocortisone] which results in increased chemical synthesis of Cortisone	26859423
D003348	Cortisone	HSD11B1 protein results in increased reduction of Cortisone	26859423
D003348	Cortisone	[HSD11B1 protein results in increased reduction of Cortisone] which results in increased chemical synthesis of Hydrocortisone	26859423
D003348	Cortisone	[Mifepristone binds to and results in decreased activity of NR3C1 protein] inhibits the reaction [[HSD11B1 protein results in increased activity of Cortisone] inhibits the reaction [sulforafan results in increased activity of NFE2L2 protein]]	22606287
D003348	Cortisone	"2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Cortisone results in increased expression of and results in increased activity of HSD11B1 protein]"	21315688
D003348	Cortisone	Cortisone results in increased expression of and results in increased activity of HSD11B1 protein	21315688
D003348	Cortisone	Cortisone results in increased expression of HSD11B1 mRNA	24135201
D003348	Cortisone	HSD11B1 protein affects the susceptibility to Cortisone	22606287
D003348	Cortisone	[HSD11B1 protein affects the susceptibility to Cortisone] which results in decreased activity of NFE2L2 protein	22606287
D003348	Cortisone	[HSD11B1 protein co-treated with Cortisone] results in decreased expression of NQO1 mRNA	22606287
D003348	Cortisone	HSD11B1 protein affects the metabolism of Cortisone	15877012
D003348	Cortisone	[HSD11B1 protein co-treated with Cortisone] results in decreased expression of GSTA2 mRNA	22606287
D003348	Cortisone	[HSD11B1 protein co-treated with Cortisone] results in decreased expression of HMOX1	22606287
D003348	Cortisone	HSD11B1 protein results in increased activity of Cortisone	22606287
D003348	Cortisone	HSD11B1 protein results in increased metabolism of Cortisone	19696010
D003348	Cortisone	[HSD11B1 protein results in increased metabolism of Cortisone] which results in increased chemical synthesis of Hydrocortisone	19696010
D003471	Cuprizone	Cuprizone results in decreased expression of HSD11B1 mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in decreased expression of HSD11B1 mRNA	20106945
D003671	DEET	[fipronil co-treated with DEET] results in decreased expression of HSD11B1 mRNA	27091632
D013759	Dronabinol	Dronabinol results in increased expression of HSD11B1 mRNA	21955143
D003840	Deoxycholic Acid	HSD11B1 gene mutant form results in increased abundance of Deoxycholic Acid	25061560
D003907	Dexamethasone	Dexamethasone results in increased expression of HSD11B1 mRNA	21798686
D003907	Dexamethasone	[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of HSD11B1 mRNA	19186324
D003907	Dexamethasone	Dexamethasone results in increased expression of and results in increased activity of HSD11B1 protein	20922465
D003907	Dexamethasone	Dexamethasone results in increased expression of HSD11B1 mRNA	19853017
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of HSD11B1 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of HSD11B1 mRNA	28628672
D003907	Dexamethasone	NR3C1 protein affects the reaction [Dexamethasone results in increased expression of and results in increased activity of HSD11B1 protein]	20922465
D003907	Dexamethasone	rosiglitazone inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of HSD11B1 mRNA]	19186324
D003907	Dexamethasone	Dexamethasone results in increased expression of HSD11B1 mRNA	19344079\|2273378
D003907	Dexamethasone	Dexamethasone affects the expression of HSD11B1 mRNA	15102944
C041517	dibenzo(a,l)pyrene	"[1,2,5,6-dibenzanthracene co-treated with dibenzo(a,l)pyrene] affects the expression of HSD11B1 mRNA"	18711122
C041517	dibenzo(a,l)pyrene	"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of HSD11B1 mRNA"	18711122
D012531	Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide	"Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide promotes the reaction [butaprost results in increased activity of HSD11B1 protein]"	17761898
D012531	Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide	"Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide promotes the reaction [Dinoprostone results in increased activity of HSD11B1 protein]"	17761898
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of HSD11B1 mRNA	28528174
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of HSD11B1 protein	19815848
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in decreased expression of HSD11B1 mRNA	28962523
D002945	Cisplatin	Cisplatin results in increased expression of HSD11B1 protein	22023808
D004041	Dietary Fats	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of HSD11B1 mRNA]"	19467301
D004041	Dietary Fats	Dietary Fats results in decreased expression of HSD11B1 mRNA	18042831\|1849283
D004041	Dietary Fats	Dietary Fats results in increased expression of HSD11B1 mRNA	19467301
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of HSD11B1 mRNA	19245819
D004052	Diethylnitrosamine	[Clofibric Acid co-treated with Diethylnitrosamine] results in decreased expression of HSD11B1 mRNA	15833021
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of HSD11B1 mRNA	17011747
D002117	Calcitriol	Calcitriol affects the expression of HSD11B1 protein	19918113
D002117	Calcitriol	[Calcitriol co-treated with Cortisone] results in increased expression of HSD11B1 mRNA	19918113
C013966	dioctyl adipate	dioctyl adipate results in decreased activity of HSD11B1 protein	16184081
D004221	Disulfiram	[Disulfiram co-treated with NAD] binds to HSD11B1 protein	25526675
D004237	Diuron	Diuron results in increased expression of HSD11B1 mRNA	21551480
C035144	drospirenone	drospirenone inhibits the reaction [HSD11B1 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]	28257955
D004785	Environmental Pollutants	"[perfluorononanoic acid co-treated with [Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides]] results in decreased expression of HSD11B1 mRNA"	25588985
D000431	Ethanol	Ethanol results in decreased expression of HSD11B1 mRNA	21955143
D000431	Ethanol	Ethanol results in increased expression of HSD11B1 mRNA	26188107
D004997	Ethinyl Estradiol	Ethinyl Estradiol inhibits the reaction [HSD11B1 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]	28257955
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HSD11B1 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of HSD11B1 mRNA	29097150
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of HSD11B1 mRNA	12655037\|1583489
D011345	Fenofibrate	Fenofibrate results in increased expression of HSD11B1 mRNA	25572481
C082360	fipronil	[fipronil co-treated with DEET] results in decreased expression of HSD11B1 mRNA	27091632
C007738	fluoranthene	"[1,2,5,6-dibenzanthracene co-treated with fluoranthene] affects the expression of HSD11B1 mRNA"	18711122
D005485	Flutamide	Flutamide results in increased expression of HSD11B1 mRNA	17222921
D005520	Food Preservatives	"[perfluorononanoic acid co-treated with [Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides]] results in decreased expression of HSD11B1 mRNA"	25588985
C056933	fumonisin B1	fumonisin B1 results in decreased expression of HSD11B1 mRNA	16221962
D005659	Fungicides, Industrial	"[perfluorononanoic acid co-treated with [Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides]] results in decreased expression of HSD11B1 mRNA"	25588985
C039281	furan	furan results in increased expression of HSD11B1 mRNA	26194646
D005665	Furosemide	Furosemide results in decreased activity of HSD11B1 protein	11749789
D019833	Genistein	Genistein results in decreased expression of HSD11B1 mRNA	21782745
D005938	Glucocorticoids	HSD11B1 protein results in increased activity of Glucocorticoids	22606287
D005938	Glucocorticoids	[HSD11B1 protein results in increased activity of Glucocorticoids] which results in increased activity of NR3C1 protein	22606287
D005938	Glucocorticoids	HSD11B1 protein results in increased metabolism of Glucocorticoids	17628001
D005938	Glucocorticoids	HSD11B1 results in increased abundance of Glucocorticoids	20410225
D005999	Glycochenodeoxycholic Acid	HSD11B1 gene mutant form results in decreased abundance of Glycochenodeoxycholic Acid	25061560
C027746	glycolithocholic acid	HSD11B1 gene mutant form results in decreased abundance of glycolithocholic acid	25061560
D006052	Gold Sodium Thiomalate	Gold Sodium Thiomalate results in decreased expression of HSD11B1 mRNA	19192274
D006540	Herbicides	"[perfluorononanoic acid co-treated with [Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides]] results in decreased expression of HSD11B1 mRNA"	25588985
D017313	Fenretinide	Fenretinide results in decreased expression of HSD11B1 mRNA	28973697
D006854	Hydrocortisone	Dinoprostone promotes the reaction [HSD11B1 protein affects the oxidation of Hydrocortisone]	17761898
D006854	Hydrocortisone	HSD11B1 protein affects the oxidation of Hydrocortisone	17761898
D006854	Hydrocortisone	HSD11B1 protein results in increased chemical synthesis of Hydrocortisone	16054388\|1675140
D006854	Hydrocortisone	[HSD11B1 protein results in increased metabolism of Ketosteroids] which results in increased chemical synthesis of Hydrocortisone	22178014
D006854	Hydrocortisone	HSD11B1 protein results in increased oxidation of Hydrocortisone	26859423
D006854	Hydrocortisone	[HSD11B1 protein results in increased oxidation of Hydrocortisone] which results in increased chemical synthesis of Cortisone	26859423
D006854	Hydrocortisone	[HSD11B1 protein results in increased reduction of Cortisone] which results in increased chemical synthesis of Hydrocortisone	26859423
D006854	Hydrocortisone	Hydrocortisone promotes the reaction [[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of HSD11B1 mRNA]	23275455
D006854	Hydrocortisone	Hydrocortisone results in increased activity of HSD11B1 protein	20410225
D006854	Hydrocortisone	Hydrocortisone results in increased expression of HSD11B1	16054388\|2728809
D006854	Hydrocortisone	Hydrocortisone results in increased expression of HSD11B1 mRNA	20410225
D006854	Hydrocortisone	perfluorooctane sulfonic acid inhibits the reaction [Hydrocortisone results in increased expression of HSD11B1]	27288094
D006854	Hydrocortisone	HSD11B1 protein results in increased chemical synthesis of Hydrocortisone	23264615
D006854	Hydrocortisone	Hydrocortisone results in decreased expression of HSD11B1 mRNA	15961419
D006854	Hydrocortisone	Hydrocortisone results in increased activity of HSD11B1 protein	23264615
D006854	Hydrocortisone	Hydrocortisone results in increased expression of HSD11B1 mRNA	15855228\|2326461
D006854	Hydrocortisone	meloxicam inhibits the reaction [Hydrocortisone results in increased activity of HSD11B1 protein]	23264615
D006854	Hydrocortisone	meloxicam inhibits the reaction [Hydrocortisone results in increased expression of HSD11B1 mRNA]	23264615
D006854	Hydrocortisone	HSD11B1 protein affects the susceptibility to Hydrocortisone	22606287
D006854	Hydrocortisone	[HSD11B1 protein affects the susceptibility to Hydrocortisone] which results in decreased activity of NFE2L2 protein	22606287
D006854	Hydrocortisone	HSD11B1 protein results in increased chemical synthesis of Hydrocortisone	15877012
D006854	Hydrocortisone	[HSD11B1 protein results in increased metabolism of Cortisone] which results in increased chemical synthesis of Hydrocortisone	19696010
D006854	Hydrocortisone	HSD11B1 results in increased abundance of Hydrocortisone	15199296
D006854	Hydrocortisone	HSD11B1 results in increased metabolism of Hydrocortisone	9683905
D006854	Hydrocortisone	Hydrocortisone results in increased activity of HSD11B1 protein	19696010
C010471	hyodeoxycholic acid	HSD11B1 gene mutant form results in increased abundance of hyodeoxycholic acid	25061560
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of HSD11B1 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of HSD11B1 mRNA	28628672
D007306	Insecticides	"[perfluorononanoic acid co-treated with [Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides]] results in decreased expression of HSD11B1 mRNA"	25588985
C541917	INT 131	INT 131 results in increased expression of HSD11B1 mRNA	19452630
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of HSD11B1 mRNA	19186324
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of HSD11B1 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of HSD11B1 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	rosiglitazone inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of HSD11B1 mRNA]	19186324
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of HSD11B1 mRNA	25982114\|2664458
D007608	Kainic Acid	Kainic Acid results in decreased expression of HSD11B1 mRNA	17997037
D007649	Ketamine	Ketamine results in increased expression of HSD11B1 mRNA	20080153
D007664	Ketosteroids	[HSD11B1 protein results in increased metabolism of Ketosteroids] which results in increased chemical synthesis of Hydrocortisone	22178014
D007664	Ketosteroids	[HSD11B1 protein results in increased metabolism of Ketosteroids] which results in increased chemical synthesis of Corticosterone	22178014
C099406	L 742694	L 742694 affects the expression of HSD11B1 mRNA	15102944
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of HSD11B1 mRNA	21798686
D008070	Lipopolysaccharides	"[2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone co-treated with Lipopolysaccharides] results in decreased activity of HSD11B1 protein"	27523796
D008070	Lipopolysaccharides	"2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased expression of HSD11B1 mRNA]"	27523796
D008070	Lipopolysaccharides	Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased expression of HSD11B1 mRNA]	27523796
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of HSD11B1 mRNA	16847310\|2752379
D008070	Lipopolysaccharides	"zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased expression of HSD11B1 mRNA]]"	27523796
D017258	Medroxyprogesterone Acetate	[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of and results in increased activity of HSD11B1 protein	23275455
D017258	Medroxyprogesterone Acetate	[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of HSD11B1 mRNA	23275455
C065757	meloxicam	meloxicam inhibits the reaction [Hydrocortisone results in increased activity of HSD11B1 protein]	23264615
C065757	meloxicam	meloxicam inhibits the reaction [Hydrocortisone results in increased expression of HSD11B1 mRNA]	23264615
C065757	meloxicam	meloxicam inhibits the reaction [IFNE protein results in increased activity of HSD11B1 protein]	22205698
C065757	meloxicam	meloxicam inhibits the reaction [IFNE protein results in increased expression of HSD11B1 mRNA]	22205698
C065757	meloxicam	meloxicam results in decreased activity of HSD11B1 protein	22205698\|2326461
C065757	meloxicam	meloxicam results in decreased expression of HSD11B1 mRNA	21270428\|2220569
D015122	Mercaptopurine	Mercaptopurine results in increased expression of HSD11B1 mRNA	23358152
D008727	Methotrexate	Methotrexate results in decreased expression of HSD11B1 mRNA	19192274
D008727	Methotrexate	Methotrexate results in increased expression of HSD11B1 mRNA	17400583
D008731	Methoxychlor	Methoxychlor results in decreased activity of HSD11B1 protein	23333641
D008775	Methylprednisolone	Methylprednisolone results in decreased expression of HSD11B1 mRNA	19192274
D008797	Metyrapone	Metyrapone results in decreased activity of HSD11B1 protein	10664531
D015735	Mifepristone	[Mifepristone binds to and results in decreased activity of NR3C1 protein] inhibits the reaction [[HSD11B1 protein results in increased activity of Cortisone] inhibits the reaction [sulforafan results in increased activity of NFE2L2 protein]]	22606287
D015735	Mifepristone	Mifepristone inhibits the reaction [bisphenol A results in increased expression of HSD11B1 mRNA]	23090578
D015735	Mifepristone	Mifepristone inhibits the reaction [Progesterone results in increased expression of HSD11B1 mRNA]	19696010
D015735	Mifepristone	[Mifepristone binds to and results in decreased activity of NR3C1 protein] inhibits the reaction [HSD11B1 protein results in decreased activity of NFE2L2 protein]	22606287
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of HSD11B1 mRNA	20024957
D009020	Morphine	Morphine results in decreased expression of HSD11B1 mRNA	21955143
C004821	muricholic acid	HSD11B1 gene mutant form results in decreased abundance of muricholic acid	25061560
C004821	muricholic acid	HSD11B1 gene mutant form results in increased abundance of muricholic acid	25061560
D009151	Mustard Gas	Mustard Gas results in increased expression of HSD11B1 mRNA	25102026
D009532	Nickel	Nickel results in decreased expression of HSD11B1 mRNA	24768652
D009538	Nicotine	Nicotine results in increased expression of HSD11B1 mRNA	21955143
D009538	Nicotine	Nicotine results in increased expression of HSD11B1 mRNA	22265867\|2680384
D009538	Nicotine	tauroursodeoxycholic acid inhibits the reaction [Nicotine results in increased expression of HSD11B1 mRNA]	26803847
C025256	nonylphenol	nonylphenol results in increased expression of and results in increased activity of HSD11B1 protein	22765982
C108709	oleoyl-estrone	oleoyl-estrone results in decreased expression of HSD11B1 mRNA	19793540
C053238	onapristone	[LHB protein co-treated with onapristone] results in increased expression of and results in increased activity of HSD11B1 protein	23325624
C053238	onapristone	[LHB protein co-treated with onapristone] results in increased expression of HSD11B1 mRNA	23325624
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of HSD11B1 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of HSD11B1 mRNA	25729387
D010098	Oxycodone	Oxycodone results in decreased expression of HSD11B1 mRNA	23439660
D000073878	Palm Oil	Palm Oil results in decreased expression of HSD11B1 mRNA	18042831
C016030	pantogab	pantogab results in decreased expression of HSD11B1 mRNA	17379144
D010269	Paraquat	Paraquat results in increased expression of HSD11B1 mRNA	18198484
C584865	perfluorononanoic acid	"[perfluorononanoic acid co-treated with [Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides]] results in decreased expression of HSD11B1 mRNA"	25588985
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid inhibits the reaction [Hydrocortisone results in increased expression of HSD11B1]	27288094
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased activity of HSD11B1 protein	22178014
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of HSD11B1	27288094
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased activity of HSD11B1 protein	22178014
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased activity of HSD11B1 protein	22178014
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of HSD11B1 mRNA	17681415
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased activity of HSD11B1 protein	22178014
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of HSD11B1 mRNA	16221955\|1916217
D015232	Dinoprostone	6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [Dinoprostone results in increased activity of HSD11B1 protein]	17761898
D015232	Dinoprostone	"Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide promotes the reaction [Dinoprostone results in increased activity of HSD11B1 protein]"	17761898
D015232	Dinoprostone	Dinoprostone promotes the reaction [HSD11B1 protein affects the oxidation of Hydrocortisone]	17761898
D015232	Dinoprostone	Dinoprostone results in increased activity of HSD11B1 protein	17761898
D015232	Dinoprostone	PTGER2 protein promotes the reaction [Dinoprostone results in increased activity of HSD11B1 protein]	17761898
D015232	Dinoprostone	Dinoprostone results in increased expression of and results in increased activity of HSD11B1 protein	22205698
D015232	Dinoprostone	Dinoprostone results in increased expression of HSD11B1 mRNA	22205698
D010634	Phenobarbital	Phenobarbital results in increased expression of HSD11B1 mRNA	19162173
D064209	Phytochemicals	"[perfluorononanoic acid co-treated with [Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides]] results in decreased expression of HSD11B1 mRNA"	25588985
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in decreased expression of HSD11B1 mRNA	22484513
C006253	pirinixic acid	[pirinixic acid co-treated with PPARA] results in decreased expression of HSD11B1 mRNA	20813756
C006253	pirinixic acid	pirinixic acid results in decreased expression of HSD11B1 mRNA	11798191\|1622196
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in decreased expression of HSD11B1 mRNA]	20059764
C006253	pirinixic acid	pirinixic acid results in decreased expression of HSD11B1 mRNA	19162173\|2248451
D010894	Piroxicam	Piroxicam results in decreased expression of HSD11B1 mRNA	19192274
D010968	Plasticizers	"[perfluorononanoic acid co-treated with [Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides]] results in decreased expression of HSD11B1 mRNA"	25588985
D011239	Prednisolone	Prednisolone results in decreased expression of HSD11B1 mRNA	19192274
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of HSD11B1 mRNA	19162173
D011374	Progesterone	Progesterone results in increased expression of HSD11B1	22205698
D011374	Progesterone	4'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide inhibits the reaction [[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of HSD11B1 mRNA]	23275455
D011374	Progesterone	Hydrocortisone promotes the reaction [[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of HSD11B1 mRNA]	23275455
D011374	Progesterone	[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Estradiol] results in increased expression of HSD11B1 protein	23275455
D011374	Progesterone	[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of HSD11B1 mRNA	23275455
D011374	Progesterone	Progesterone inhibits the reaction [HSD11B1 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]	28257955
D011374	Progesterone	Progesterone results in increased expression of HSD11B1 mRNA	21795739
D011374	Progesterone	Mifepristone inhibits the reaction [Progesterone results in increased expression of HSD11B1 mRNA]	19696010
D011374	Progesterone	Progesterone results in increased expression of HSD11B1 mRNA	19690047\|1969601
D011374	Progesterone	Progesterone affects the expression of HSD11B1 mRNA	19208548
D011374	Progesterone	Progesterone affects the expression of HSD11B1 protein	19208548
D011374	Progesterone	Progesterone results in increased expression of HSD11B1 mRNA	20726854
D011374	Progesterone	Progesterone results in increased activity of HSD11B1 protein	19696010
D011372	Progestins	Progestins results in decreased expression of HSD11B1 mRNA	19609016
C015586	propiverine	propiverine binds to HSD11B1 protein	29273565
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of HSD11B1 mRNA	24780913
D015237	Dinoprost	Dinoprost results in increased expression of and results in increased activity of HSD11B1 protein	22205698
D015237	Dinoprost	Dinoprost results in increased expression of HSD11B1 mRNA	22205698
D011464	Epoprostenol	Epoprostenol results in increased expression of and results in increased activity of HSD11B1 protein	22205698
D011464	Epoprostenol	Epoprostenol results in increased expression of HSD11B1 mRNA	22205698
D011453	Prostaglandins	Prostaglandins results in increased activity of HSD11B1 protein	19696010
D054328	Proton Pump Inhibitors	Proton Pump Inhibitors results in decreased expression of HSD11B1 mRNA	25626140
D011794	Quercetin	[Quercetin co-treated with NAD] binds to HSD11B1 protein	25526675
C059514	resveratrol	resveratrol results in decreased activity of HSD11B1 protein	23814014
C059514	resveratrol	resveratrol inhibits the reaction [HSD11B1 protein results in increased chemical synthesis of Corticosterone]	23814014
C059514	resveratrol	resveratrol inhibits the reaction [HSD11B1 protein results in increased metabolism of 11-dehydrocorticosterone]	23814014
C059514	resveratrol	resveratrol results in decreased activity of HSD11B1 protein	23814014
D015474	Isotretinoin	Isotretinoin results in decreased expression of HSD11B1 mRNA	15982314\|2043688
C089730	rosiglitazone	rosiglitazone results in increased expression of HSD11B1 mRNA	21798686
C089730	rosiglitazone	rosiglitazone inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of HSD11B1 mRNA]	19186324
C089730	rosiglitazone	rosiglitazone results in decreased expression of HSD11B1 mRNA	17148569\|1755549
C089730	rosiglitazone	rosiglitazone results in increased activity of HSD11B1 protein	17555498
C089730	rosiglitazone	rosiglitazone affects the expression of HSD11B1 mRNA	17245590
C089730	rosiglitazone	rosiglitazone results in increased expression of HSD11B1 mRNA	19452630
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of HSD11B1 mRNA"	24160326
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in decreased expression of HSD11B1 mRNA"	16251409
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of HSD11B1 mRNA	25351596
C009277	sodium arsenate	sodium arsenate results in decreased glycosylation of HSD11B1 protein	22960421
C017947	sodium arsenite	sodium arsenite results in decreased expression of HSD11B1 mRNA	17350061
C016766	sulforafan	[HSD11B1 protein results in increased activity of Cortisone] inhibits the reaction [sulforafan results in increased activity of NFE2L2 protein]	22606287
C016766	sulforafan	[Mifepristone binds to and results in decreased activity of NR3C1 protein] inhibits the reaction [[HSD11B1 protein results in increased activity of Cortisone] inhibits the reaction [sulforafan results in increased activity of NFE2L2 protein]]	22606287
D013473	Sunscreening Agents	"[perfluorononanoic acid co-treated with [Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides]] results in decreased expression of HSD11B1 mRNA"	25588985
C446685	systhane	systhane results in increased expression of HSD11B1 mRNA	16643972
D014284	Triiodothyronine	Triiodothyronine results in decreased expression of HSD11B1 mRNA	15961419
D013658	Taurolithocholic Acid	HSD11B1 gene mutant form results in increased abundance of Taurolithocholic Acid	25061560
C031655	tauroursodeoxycholic acid	HSD11B1 gene mutant form results in decreased abundance of tauroursodeoxycholic acid	25061560
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid inhibits the reaction [Nicotine results in increased expression of HSD11B1 mRNA]	26803847
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid results in decreased expression of HSD11B1 mRNA	15885361
D000068698	Tenofovir	Tenofovir affects the expression of HSD11B1 mRNA	20032539
D013739	Testosterone	[Testosterone co-treated with NAD] binds to HSD11B1 protein	25526675
D013739	Testosterone	Testosterone inhibits the reaction [HSD11B1 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]	28257955
D013739	Testosterone	Testosterone results in increased activity of HSD11B1 protein	20410225
D013739	Testosterone	Testosterone results in increased expression of HSD11B1 mRNA	20410225
D013739	Testosterone	Testosterone results in increased expression of HSD11B1 mRNA	19693291
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HSD11B1 mRNA	21998131\|2366920
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of HSD11B1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HSD11B1 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HSD11B1 promoter]	19654925
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HSD11B1 mRNA	16960034
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of HSD11B1 mRNA	17035482
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of HSD11B1 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HSD11B1 mRNA	16960034\|2121527
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased activity of HSD11B1 protein	16533503
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of HSD11B1 mRNA	16533503
D013864	Thioglycolates	Thioglycolates results in increased activity of HSD11B1 protein	16751407
C009495	titanium dioxide	titanium dioxide results in decreased expression of HSD11B1 mRNA	23557971
D014028	Tobacco Smoke Pollution	[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of HSD11B1 mRNA	24096154
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of HSD11B1 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of HSD11B1 mRNA	25729387
C032910	triadimefon	HSD11B1 protein results in increased reduction of triadimefon	18763812
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of HSD11B1 mRNA	21513799
C057693	troglitazone	troglitazone results in increased expression of HSD11B1 mRNA	25572481
C057693	troglitazone	troglitazone results in decreased expression of HSD11B1 mRNA	14697232
D014425	Turpentine	Turpentine results in decreased expression of HSD11B1 mRNA	16044259
D014580	Ursodeoxycholic Acid	[HSD11B1 protein results in increased reduction of 7-ketolithocholic acid] which results in increased chemical synthesis of Ursodeoxycholic Acid	21453287
D014580	Ursodeoxycholic Acid	HSD11B1 gene mutant form results in increased abundance of Ursodeoxycholic Acid	25061560
D014635	Valproic Acid	Valproic Acid results in increased expression of HSD11B1 mRNA	28001369
C025643	vinclozolin	vinclozolin results in increased expression of HSD11B1 mRNA	18348629
C025643	vinclozolin	vinclozolin affects the expression of HSD11B1 mRNA	19015723
D014810	Vitamin E	Vitamin E results in increased expression of HSD11B1 mRNA	19244175
D015215	Zidovudine	Zidovudine affects the expression of HSD11B1 mRNA	20032539
C017803	zinc protoporphyrin	"zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased expression of HSD11B1 mRNA]]"	27523796
D019287	Zinc Sulfate	Zinc Sulfate results in decreased expression of HSD11B1 mRNA	12756304
D015039	Ziram	Ziram inhibits the reaction [HSD11B1 protein results in increased oxidation of NADP]	26859423
D015039	Ziram	Ziram inhibits the reaction [HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone]	26859423
D015039	Ziram	Ziram inhibits the reaction [[HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone] which results in increased chemical synthesis of Corticosterone]	26859423
D015039	Ziram	Ziram results in decreased activity of HSD11B1 protein	26859423
D015039	Ziram	Ziram results in decreased expression of HSD11B1 mRNA	28973382
D015039	Ziram	Ziram results in decreased expression of HSD11B1 protein	28973382
C088658	zoledronic acid	zoledronic acid results in increased expression of HSD11B1 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003845	11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity	-	IBA	21873635
GO:0003845	11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity	-	TAS	-
GO:0005496	steroid binding	-	IBA	21873635
GO:0070524	11-beta-hydroxysteroid dehydrogenase (NADP+) activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006704	glucocorticoid biosynthetic process	-	TAS	-
GO:0006706	steroid catabolic process	-	IBA	21873635
GO:0030324	lung development	-	IEA	-
GO:0055114	oxidation-reduction process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0016020	membrane	-	HDA	19946888
GO:0016021	integral component of membrane	-	IEA	-

KEGG ID	KEGG Term
hsa00140	Steroid hormone biosynthesis
hsa01100	Metabolic pathways
hsa04960	Aldosterone-regulated sodium reabsorption

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-194002	Glucocorticoid biosynthesis	TAS
R-HSA-196071	Metabolism of steroid hormones	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-8957322	Metabolism of steroids	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27088373	Tandem mass spectrometry determined maternal cortisone to cortisol ratio and psychiatric morbidity during pregnancy-interaction with birth weight. (2016 Jul)	Hellgren C	Psychoneuroendocrinology
15769990	Genomewide linkage analysis of weight change in the Framingham Heart Study. (2005 Jun)	Fox CS	J Clin Endocrinol Metab