Gene: HSD11B2

3291
AME|AME1|HSD11K|HSD2|SDR9C3
hydroxysteroid 11-beta dehydrogenase 2
protein-coding
16q22.1
Ensembl:ENSG00000176387 MIM:614232 Vega:OTTHUMG00000137507 UniprotKB:P80365
NG_016549.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.363e-1 (AD)  8.043e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AOC20.701
ELK10.649
ADAMTS20.645
PLK10.63
RAD54L0.621
MROH60.619
GPR550.612
ESYT30.61
MTRF10.608
DNA20.608

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DIO2-0.408
CRH-0.407
RERGL-0.379
HES5-0.376
NODAL-0.371
FGFBP3-0.369
CLDN1-0.366
ADAMTS5-0.356
HPDL-0.352
MYLK2-0.35

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00741HydrocortisoneSmall Molecule50-23-7ApprovedTarget
DB01185FluoxymesteroneSmall Molecule76-43-7Approved|IllicitTarget
DB01569FormeboloneSmall Molecule2454-11-7Experimental|IllicitTarget
ID Drug Name Action PubMed
C00355211-dehydrocorticosterone[HSD11B2 protein results in increased oxidation of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone26859423
C00355211-dehydrocorticosteroneZiram inhibits the reaction [[HSD11B2 protein results in increased oxidation of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone]26859423
C03791411-hydroxytestosteroneHSD11B2 protein results in increased metabolism of 11-hydroxytestosterone22796344
C00360011-ketotestosteroneHSD11B2 protein results in increased chemical synthesis of 11-ketotestosterone22796344
C00360011-ketotestosteroneHSD11B2 protein results in increased chemical synthesis of 11-ketotestosterone22796344
C00360011-ketotestosteroneHSD11B2 protein results in increased chemical synthesis of 11-ketotestosterone22796344
C02017516 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione"[16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione co-treated with PGR protein] results in increased expression of HSD11B2 mRNA"21130152
C0211831,7-dimethylxanthine"1,7-dimethylxanthine results in decreased expression of and results in decreased activity of HSD11B2 protein"22701600
C0211831,7-dimethylxanthine"1,7-dimethylxanthine results in decreased expression of HSD11B2 mRNA"22701600
C0211831,7-dimethylxanthine"ADORA2B mutant form inhibits the reaction [1,7-dimethylxanthine results in decreased expression of and results in decreased activity of HSD11B2 protein]"22701600
C0211831,7-dimethylxanthine"ADORA2B mutant form inhibits the reaction [1,7-dimethylxanthine results in decreased expression of HSD11B2 mRNA]"22701600
C0211831,7-dimethylxanthine"Colforsin inhibits the reaction [1,7-dimethylxanthine results in decreased expression of and results in decreased activity of HSD11B2 protein]"22701600
C0211831,7-dimethylxanthine"Colforsin inhibits the reaction [1,7-dimethylxanthine results in decreased expression of HSD11B2 mRNA]"22701600
C11912918alpha-glycyrrhetinic acid18alpha-glycyrrhetinic acid results in decreased activity of HSD11B2 protein24135201
C11912918alpha-glycyrrhetinic acid18alpha-glycyrrhetinic acid results in decreased activity of HSD11B2 protein24135201
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HSD11B2 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of HSD11B2 mRNA"25614096
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of HSD11B2 mRNA"23146750
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased activity of HSD11B2 protein"23333641
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased activity of HSD11B2 protein"23333641
C0368372,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone"[2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone co-treated with Leukotriene B4] results in decreased expression of HSD11B2 protein"18032417
C0368372,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone"2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in increased activity of HSD11B2 protein"18032417
C0368372,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone"Leukotriene B4 inhibits the reaction [2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in increased activity of HSD11B2 protein]"18032417
C5471242,3-dibromopropyl-2,4,6-tribromophenyl ether"2,3-dibromopropyl-2,4,6-tribromophenyl ether analog results in decreased expression of HSD11B2 mRNA"25818047
C5471242,3-dibromopropyl-2,4,6-tribromophenyl ether"2,3-dibromopropyl-2,4,6-tribromophenyl ether results in decreased expression of HSD11B2 mRNA"25818047
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HSD11B2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of HSD11B2 mRNA"23146750
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HSD11B2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HSD11B2 mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of HSD11B2 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HSD11B2 mRNA"25510870
C5850042-monochloropropanediol2-monochloropropanediol results in increased expression of HSD11B2 mRNA28522335
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HSD11B2 mRNA"28973690
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HSD11B2 mRNA"23146750
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSD11B2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSD11B2 mRNA"27188386
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone[Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of HSD11B2 mRNA20146248
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneGrape Seed Proanthocyanidins inhibits the reaction [[Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of HSD11B2 mRNA]20146248
C0415944-nonylphenol4-nonylphenol results in decreased activity of HSD11B2 protein16184081
C0804174-octylphenol4-octylphenol results in decreased activity of HSD11B2 protein16184081
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSD11B2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSD11B2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of HSD11B2 mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of HSD11B2 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of HSD11B2 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of HSD11B2 mRNA17585979
D000111AcetylcysteineAcetylcysteine inhibits the reaction [SOD2 protein affects the expression of HSD11B2 mRNA]18829485
D003366CosyntropinCosyntropin results in decreased expression of HSD11B2 protein11082157
D000305Adrenal Cortex HormonesHSD11B2 protein affects the susceptibility to Adrenal Cortex Hormones11934730
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of HSD11B2 mRNA23630614
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HSD11B2 mRNA16483693
C025657arsenic acidarsenic acid results in increased expression of HSD11B2 mRNA26855884
D001280AtrazineAtrazine results in decreased expression of HSD11B2 mRNA27413107
D001280AtrazineAtrazine results in increased expression of HSD11B2 mRNA18461179
D001280AtrazineNR5A1 protein promotes the reaction [Atrazine results in increased expression of HSD11B2 mRNA]18461179
D001280AtrazineSGK1 protein affects the reaction [Atrazine results in increased expression of HSD11B2 mRNA]18461179
D001379AzathioprineAzathioprine results in decreased expression of HSD11B2 mRNA22623647
C006680baicalein"12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [baicalein results in increased activity of HSD11B2 protein]"18032417
C006680baicaleinbaicalein results in increased activity of HSD11B2 protein18032417
D001507BeclomethasoneBeclomethasone results in increased expression of HSD11B2 mRNA23656298
D001507BeclomethasoneHSD11B2 protein results in increased metabolism of Beclomethasone16549198
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of HSD11B2 mRNA20146248
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HSD11B2 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HSD11B2 mRNA24361490
D001564Benzo(a)pyreneGrape Seed Proanthocyanidins inhibits the reaction [[Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of HSD11B2 mRNA]20146248
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Progesterone results in increased expression of HSD11B2 mRNA]15857753
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of HSD11B2 mRNA20404318
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of HSD11B2 mRNA20660070
D004958EstradiolEstradiol results in decreased expression of HSD11B2 protein17515840
D004958EstradiolEstradiol results in increased expression of HSD11B2 mRNA23019147
D004958Estradiol[bisphenol A results in increased susceptibility to Estradiol] which results in decreased expression of HSD11B2 mRNA27312807
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of HSD11B2 mRNA26496021
D001623BetamethasoneHSD11B2 protein results in increased metabolism of Betamethasone16549198
D001623BetamethasoneBetamethasone inhibits the reaction [HSD11B2 protein affects the metabolism of Corticosterone]19490994
C006780bisphenol Abisphenol A results in increased expression of HSD11B2 mRNA25048937
C006780bisphenol Abisphenol A results in decreased activity of HSD11B2 protein23069880
C006780bisphenol Abisphenol A results in decreased expression of HSD11B2 mRNA23146750
C006780bisphenol Abisphenol A results in increased expression of and results in increased activity of HSD11B2 protein25784278
C006780bisphenol Abisphenol A results in increased expression of HSD11B2 mRNA25784278
C006780bisphenol Abisphenol A results in decreased expression of HSD11B2 mRNA26063408
C006780bisphenol Abisphenol A results in increased methylation of HSD11B2 promoter27312807
C006780bisphenol A[bisphenol A results in increased susceptibility to Estradiol] which results in decreased expression of HSD11B2 mRNA27312807
C006780bisphenol A[bisphenol A co-treated with Ethinyl Estradiol co-treated with Genistein] results in increased expression of HSD11B2 mRNA21721901
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of HSD11B2 mRNA26496021
C006780bisphenol Abisphenol A results in decreased activity of HSD11B2 protein23069880
C006780bisphenol Abisphenol A results in increased expression of HSD11B2 mRNA12075121|2518105
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of HSD11B2 mRNA22079614
D0151248-Bromo Cyclic Adenosine Monophosphate[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of HSD11B2 protein23275455
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide affects the expression of HSD11B2 mRNA23410634
D002104CadmiumCadmium results in decreased activity of HSD11B2 protein22796344|2388031
D002104CadmiumCadmium results in decreased expression of and results in decreased activity of HSD11B2 protein16144812|2396631
D002104CadmiumCadmium results in decreased expression of HSD11B2 mRNA16144812|2396631
D002104CadmiumCadmium results in decreased methylation of HSD11B2 promoter20624455
D002104CadmiumCadmium results in increased activity of HSD11B2 protein20624455
D002104CadmiumCadmium results in increased expression of HSD11B2 mRNA20624455
D002104CadmiumU 0126 inhibits the reaction [Cadmium results in decreased expression of and results in decreased activity of HSD11B2 protein]23966319
D002104CadmiumU 0126 inhibits the reaction [Cadmium results in decreased expression of HSD11B2 mRNA]23966319
D019256Cadmium ChlorideCadmium Chloride results in increased expression of HSD11B2 mRNA17961207
D002110CaffeineADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein]22701600
D002110CaffeineADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of HSD11B2 mRNA]22701600
D002110CaffeineCaffeine results in decreased expression of and results in decreased activity of HSD11B2 protein22701600
D002110CaffeineCaffeine results in decreased expression of HSD11B2 mRNA22701600
D002110CaffeineColforsin inhibits the reaction [Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein]22701600
D002110CaffeineColforsin inhibits the reaction [Caffeine results in decreased expression of HSD11B2 mRNA]22701600
D002110CaffeineCaffeine results in decreased expression of HSD11B2 mRNA22583948
D002229CarbenoxoloneCarbenoxolone results in decreased activity of HSD11B2 protein16857225|2413520
D002229CarbenoxoloneCarbenoxolone results in decreased activity of HSD11B2 protein24135201
D002229CarbenoxoloneCarbenoxolone results in decreased activity of HSD11B2 protein23814014
D002229CarbenoxoloneCarbenoxolone results in decreased activity of HSD11B2 protein15743993|2178680
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of HSD11B2 protein16192424
D002395CatecholaminesCatecholamines results in increased expression of HSD11B2 mRNA15855228
D002737ChloropreneChloroprene results in decreased expression of HSD11B2 mRNA23125180
D009243NADHSD11B2 protein results in increased reduction of NAD26859423
D009243NADZiram inhibits the reaction [HSD11B2 protein results in increased reduction of NAD]26859423
D009243NADHSD11B2 protein results in increased reduction of NAD26859423
D009243NADZiram inhibits the reaction [HSD11B2 protein results in increased reduction of NAD]26859423
D009249NADPNADP binds to and results in increased activity of HSD11B2 protein25526675
D005576Colforsin"Colforsin inhibits the reaction [1,7-dimethylxanthine results in decreased expression of and results in decreased activity of HSD11B2 protein]"22701600
D005576Colforsin"Colforsin inhibits the reaction [1,7-dimethylxanthine results in decreased expression of HSD11B2 mRNA]"22701600
D005576ColforsinColforsin inhibits the reaction [Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein]22701600
D005576ColforsinColforsin inhibits the reaction [Caffeine results in decreased expression of HSD11B2 mRNA]22701600
D005576ColforsinColforsin results in increased expression of HSD11B2 mRNA24361490
D019327Copper SulfateCopper Sulfate results in decreased expression of HSD11B2 mRNA19789285
D019327Copper SulfateCopper Sulfate results in decreased expression of HSD11B2 mRNA19549813
D003345CorticosteroneHSD11B2 protein results in increased metabolism of Corticosterone22796344
D003345CorticosteroneBetamethasone inhibits the reaction [HSD11B2 protein affects the metabolism of Corticosterone]19490994
D003345CorticosteroneDexamethasone inhibits the reaction [HSD11B2 protein affects the metabolism of Corticosterone]19490994
D003345CorticosteroneHSD11B2 protein affects the metabolism of Corticosterone19490994
D003345CorticosteroneHSD11B2 protein results in increased oxidation of Corticosterone26859423
D003345Corticosterone[HSD11B2 protein results in increased oxidation of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone26859423
D003345CorticosteroneZiram inhibits the reaction [HSD11B2 protein results in increased oxidation of Corticosterone]26859423
D003345CorticosteroneZiram inhibits the reaction [[HSD11B2 protein results in increased oxidation of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone]26859423
D003348CortisoneHSD11B2 protein results in increased chemical synthesis of Cortisone22796344
D003348Cortisone[HSD11B2 protein results in increased oxidation of Hydrocortisone] which results in increased chemical synthesis of Cortisone26859423
D003348CortisoneZiram inhibits the reaction [[HSD11B2 protein results in increased oxidation of Hydrocortisone] which results in increased chemical synthesis of Cortisone]26859423
D003348CortisoneHSD11B2 protein affects the metabolism of Cortisone15743993
D003348CortisoneHSD11B2 protein results in increased chemical synthesis of Cortisone17515840
D003348Cortisone[HSD11B2 protein results in increased metabolism of Hydrocortisone] which results in increased chemical synthesis of Cortisone19696010
D016572CyclosporineCyclosporine results in decreased expression of HSD11B2 mRNA25562108
D003613DanazolDanazol inhibits the reaction [HSD11B2 protein results in decreased activity of Glucocorticoids]22273746
D003613DanazolDanazol results in decreased activity of HSD11B2 protein22273746
C014347decitabinedecitabine results in increased expression of HSD11B2 mRNA15489962
C014347decitabinedecitabine results in increased expression of HSD11B2 mRNA15489962
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of HSD11B2 mRNA]27941970
D003907DexamethasoneDexamethasone results in increased expression of HSD11B2 mRNA15679045
D003907DexamethasoneDexamethasone results in increased expression of HSD11B2 protein15679045
D003907DexamethasoneHSD11B2 protein results in increased metabolism of Dexamethasone16549198
D003907DexamethasoneHSD11B2 protein results in increased oxidation of Dexamethasone16857225
D003907DexamethasoneThiram inhibits the reaction [HSD11B2 protein results in increased oxidation of Dexamethasone]16857225
D003907DexamethasoneDexamethasone inhibits the reaction [HSD11B2 protein affects the metabolism of Corticosterone]19490994
D003907DexamethasoneDexamethasone results in increased expression of HSD11B2 mRNA19490994
D003907DexamethasoneHSD11B2 protein results in increased oxidation of Dexamethasone16857225
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased activity of HSD11B2 protein19786001
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HSD11B2 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased activity of HSD11B2 protein19786001
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HSD11B2 mRNA19560483|2126653
C000944dicrotophosdicrotophos results in increased expression of HSD11B2 mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in decreased activity of HSD11B2 protein16184081
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in decreased activity of HSD11B2 protein19786001
D004041Dietary FatsDietary Fats results in decreased expression of HSD11B2 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of HSD11B2 mRNA25016146
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of HSD11B2 mRNA19560483
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of HSD11B2 mRNA21658437
D002117CalcitriolCalcitriol results in increased expression of HSD11B2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of HSD11B2 mRNA21592394
C056189di-n-butyltindi-n-butyltin results in decreased activity of HSD11B2 protein22796344
C034171di-n-pentyl phthalatedi-n-pentyl phthalate results in decreased expression of HSD11B2 mRNA19560483
C106479di-n-propylphthalatedi-n-propylphthalate results in decreased activity of HSD11B2 protein19786001
C106479di-n-propylphthalatedi-n-propylphthalate results in decreased activity of HSD11B2 protein19786001
C063612diphenyltindiphenyltin results in decreased activity of HSD11B2 protein22796344
D004221DisulfiramDisulfiram results in decreased activity of HSD11B2 protein22796344
D004229DithiothreitolDithiothreitol inhibits the reaction [Thiram results in decreased activity of HSD11B2 protein]12901862
D004229DithiothreitolDithiothreitol inhibits the reaction [Ziram results in decreased activity of HSD11B2 protein]26859423
D004229DithiothreitolDithiothreitol inhibits the reaction [Ziram results in decreased activity of HSD11B2 protein]26859423
D004050DitiocarbDitiocarb results in decreased activity of HSD11B2 protein22796344
C012301domoic aciddomoic acid results in increased expression of HSD11B2 mRNA18936300
D004317DoxorubicinDoxorubicin results in decreased activity of HSD11B2 protein11981059
D004726EndosulfanEndosulfan results in decreased expression of HSD11B2 mRNA22307005
D004726Endosulfan[Flutamide co-treated with Endosulfan] results in decreased expression of HSD11B2 mRNA22307005
C118739entinostatentinostat results in increased expression of HSD11B2 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSD11B2 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of HSD11B2 mRNA16872691
D004997Ethinyl Estradiol[bisphenol A co-treated with Ethinyl Estradiol co-treated with Genistein] results in increased expression of HSD11B2 mRNA21721901
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of HSD11B2 mRNA12075121|1265503
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of HSD11B2 mRNA23550701
D005033EthylmaleimideEthylmaleimide promotes the reaction [Thiram results in decreased activity of HSD11B2 protein]22796344
D005474FluoxymesteroneFluoxymesterone inhibits the reaction [HSD11B2 protein results in decreased activity of Glucocorticoids]22273746
D005474FluoxymesteroneFluoxymesterone results in decreased activity of HSD11B2 protein22273746
D005474FluoxymesteroneHSD11B2 protein binds to and results in increased metabolism of Fluoxymesterone22273746
D005480FlurbiprofenFlurbiprofen results in increased expression of HSD11B2 mRNA16949054
D005485Flutamide[Flutamide co-treated with Endosulfan] results in decreased expression of HSD11B2 mRNA22307005
D005485FlutamideFlutamide results in decreased expression of HSD11B2 mRNA22307005
D005485FlutamideFlutamide results in decreased expression of HSD11B2 mRNA21126777
C069837fullerene C60fullerene C60 results in decreased expression of HSD11B2 mRNA19167457
D019833GenisteinGenistein results in increased expression of HSD11B2 mRNA23019147
D019833Genistein[bisphenol A co-treated with Ethinyl Estradiol co-treated with Genistein] results in increased expression of HSD11B2 mRNA21721901
D019833GenisteinGenistein results in increased expression of HSD11B2 mRNA12075121
D005839GentamicinsGentamicins results in decreased expression of HSD11B2 mRNA22061828
D005938GlucocorticoidsDanazol inhibits the reaction [HSD11B2 protein results in decreased activity of Glucocorticoids]22273746
D005938GlucocorticoidsFluoxymesterone inhibits the reaction [HSD11B2 protein results in decreased activity of Glucocorticoids]22273746
D005938GlucocorticoidsGlucocorticoids affects the expression of HSD11B2 protein11932298
D005938GlucocorticoidsGlucocorticoids results in increased activity of HSD11B2 protein11932298
D005938GlucocorticoidsHSD11B2 protein results in decreased activity of Glucocorticoids22273746
D005938GlucocorticoidsOxymetholone inhibits the reaction [HSD11B2 protein results in decreased activity of Glucocorticoids]22273746
D005938GlucocorticoidsTestosterone inhibits the reaction [HSD11B2 protein results in decreased activity of Glucocorticoids]22273746
D005938GlucocorticoidsHSD11B2 protein affects the metabolism of and results in decreased activity of Glucocorticoids15974890
D005938GlucocorticoidsHSD11B2 protein affects the metabolism of Glucocorticoids12943734
D005938GlucocorticoidsHSD11B2 protein affects the susceptibility to Glucocorticoids9683905
D005947GlucoseGlucose results in decreased expression of HSD11B2 mRNA15017115
D006034Glycyrrhetinic AcidGlycyrrhetinic Acid results in decreased activity of HSD11B2 protein16061069
D006034Glycyrrhetinic AcidGlycyrrhetinic Acid results in decreased activity of HSD11B2 protein9683905
D019695Glycyrrhizic AcidGlycyrrhizic Acid results in decreased expression of HSD11B2 mRNA10474021|1179865
C511402Grape Seed ProanthocyanidinsGrape Seed Proanthocyanidins inhibits the reaction [[Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of HSD11B2 mRNA]20146248
D007975Leukotriene B4"[2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone co-treated with Leukotriene B4] results in decreased expression of HSD11B2 protein"18032417
D007975Leukotriene B4"Leukotriene B4 inhibits the reaction [2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in increased activity of HSD11B2 protein]"18032417
D007975Leukotriene B4Leukotriene B4 inhibits the reaction [Masoprocol results in increased activity of HSD11B2 protein]18032417
D007975Leukotriene B4Leukotriene B4 results in decreased activity of HSD11B2 protein10377029|1803241
D007975Leukotriene B4Leukotriene B4 results in decreased expression of HSD11B2 mRNA18032417
D007975Leukotriene B4[Masoprocol co-treated with Leukotriene B4] results in decreased expression of HSD11B2 protein18032417
D01937712-Hydroxy-5,8,10,14-eicosatetraenoic Acid"12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [baicalein results in increased activity of HSD11B2 protein]"18032417
D01937712-Hydroxy-5,8,10,14-eicosatetraenoic Acid"12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [Masoprocol results in increased activity of HSD11B2 protein]"18032417
D01937712-Hydroxy-5,8,10,14-eicosatetraenoic Acid"12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [Masoprocol results in increased expression of HSD11B2 mRNA]"18032417
D01937712-Hydroxy-5,8,10,14-eicosatetraenoic Acid"12-Hydroxy-5,8,10,14-eicosatetraenoic Acid results in decreased activity of HSD11B2 protein"18032417
D01937712-Hydroxy-5,8,10,14-eicosatetraenoic Acid"12-Hydroxy-5,8,10,14-eicosatetraenoic Acid results in decreased expression of HSD11B2 mRNA"18032417
D01937712-Hydroxy-5,8,10,14-eicosatetraenoic Acid"[Masoprocol co-treated with 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid] results in decreased expression of HSD11B2 protein"18032417
D01937712-Hydroxy-5,8,10,14-eicosatetraenoic Acid"Mifepristone inhibits the reaction [12-Hydroxy-5,8,10,14-eicosatetraenoic Acid results in decreased activity of HSD11B2 protein]"18032417
D006854HydrocortisoneHSD11B2 protein binds to Hydrocortisone22273746
D006854HydrocortisoneHSD11B2 protein results in increased metabolism of Hydrocortisone22796344
D006854HydrocortisoneHSD11B2 protein results in increased oxidation of Hydrocortisone26859423
D006854Hydrocortisone[HSD11B2 protein results in increased oxidation of Hydrocortisone] which results in increased chemical synthesis of Cortisone26859423
D006854HydrocortisoneZiram inhibits the reaction [HSD11B2 protein results in increased oxidation of Hydrocortisone]26859423
D006854HydrocortisoneZiram inhibits the reaction [[HSD11B2 protein results in increased oxidation of Hydrocortisone] which results in increased chemical synthesis of Cortisone]26859423
D006854HydrocortisoneHydrocortisone results in increased expression of HSD11B2 mRNA15855228|1596141
D006854HydrocortisoneHSD11B2 protein affects the metabolism of Hydrocortisone15743993
D006854HydrocortisoneHSD11B2 protein results in increased metabolism of Hydrocortisone19696010
D006854Hydrocortisone[HSD11B2 protein results in increased metabolism of Hydrocortisone] which results in increased chemical synthesis of Cortisone19696010
D006854HydrocortisoneHSD11B2 protein results in increased oxidation of Hydrocortisone17515840
D006854HydrocortisoneHSD11B2 results in increased metabolism of Hydrocortisone9683905
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of HSD11B2 mRNA23410634
D007213IndomethacinIndomethacin results in decreased activity of HSD11B2 protein10377029
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HSD11B2 mRNA26752646
D007654KetoconazoleKetoconazole results in decreased activity of HSD11B2 protein10664531
C045463leflunomideleflunomide results in decreased expression of HSD11B2 mRNA24136188
D008094LithiumLithium results in increased expression of HSD11B2 mRNA15687245
D008094LithiumLithium results in increased expression of HSD11B2 protein15687245
D008344ManebManeb results in decreased activity of HSD11B2 protein22796344
D009637Masoprocol"12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [Masoprocol results in increased activity of HSD11B2 protein]"18032417
D009637Masoprocol"12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [Masoprocol results in increased expression of HSD11B2 mRNA]"18032417
D009637MasoprocolLeukotriene B4 inhibits the reaction [Masoprocol results in increased activity of HSD11B2 protein]18032417
D009637Masoprocol"[Masoprocol co-treated with 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid] results in decreased expression of HSD11B2 protein"18032417
D009637Masoprocol[Masoprocol co-treated with Leukotriene B4] results in decreased expression of HSD11B2 protein18032417
D009637MasoprocolMasoprocol inhibits the reaction [Progesterone results in decreased activity of HSD11B2 protein]18032417
D009637MasoprocolMasoprocol promotes the reaction [Mifepristone results in increased activity of HSD11B2 protein]18032417
D009637MasoprocolMasoprocol results in increased activity of HSD11B2 protein10377029|1803241
D009637MasoprocolMasoprocol results in increased expression of HSD11B2 mRNA18032417
D017258Medroxyprogesterone Acetate[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of HSD11B2 protein23275455
C065757meloxicam[IFNE protein co-treated with meloxicam] results in increased expression of HSD11B2 mRNA22205698
C065757meloxicammeloxicam results in increased expression of HSD11B2 mRNA22205698
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of HSD11B2 protein16189294
D008797MetyraponeMetyrapone results in decreased activity of HSD11B2 protein10664531
D008797MetyraponeMetyrapone results in increased expression of HSD11B2 mRNA15265784
D015735MifepristoneMasoprocol promotes the reaction [Mifepristone results in increased activity of HSD11B2 protein]18032417
D015735Mifepristone"Mifepristone inhibits the reaction [12-Hydroxy-5,8,10,14-eicosatetraenoic Acid results in decreased activity of HSD11B2 protein]"18032417
D015735MifepristoneMifepristone inhibits the reaction [Progesterone results in decreased activity of HSD11B2 protein]18032417
D015735MifepristoneMifepristone inhibits the reaction [Progesterone results in decreased expression of HSD11B2 mRNA]18032417
D015735MifepristoneMifepristone inhibits the reaction [Progesterone results in decreased expression of HSD11B2 protein]18032417
D015735MifepristoneMifepristone results in increased expression of HSD11B2 mRNA18032417
D015735MifepristoneMifepristone results in increased expression of HSD11B2 protein18032417
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased activity of HSD11B2 protein19786001
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate affects the expression of HSD11B2 mRNA21195148
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased activity of HSD11B2 protein19786001
C028577monobutyl phthalatemonobutyl phthalate affects the expression of HSD11B2 mRNA21195148
D009532NickelNickel results in decreased expression of HSD11B2 mRNA24768652|2558310
C022838nickel chloridenickel chloride results in decreased expression of HSD11B2 mRNA24612858
D009538NicotineNicotine results in decreased expression of HSD11B2 mRNA22265867
D009538NicotineNicotine results in decreased expression of HSD11B2 protein22265867
C005290oxybenzoneoxybenzone results in decreased expression of HSD11B2 mRNA22721600
D010100OxygenOxygen deficiency results in decreased expression of HSD11B215199296
D010110OxymetholoneOxymetholone inhibits the reaction [HSD11B2 protein results in decreased activity of Glucocorticoids]22273746
D010110OxymetholoneOxymetholone results in decreased activity of HSD11B2 protein22273746
D000073878Palm OilPalm Oil results in decreased expression of HSD11B2 mRNA18042831
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HSD11B2 mRNA"25510870
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of HSD11B2 mRNA23427857
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of HSD11B2 mRNA23146750
D015232DinoprostoneDinoprostone results in decreased activity of HSD11B2 protein10377029
D010936Plant ExtractsPlant Extracts results in decreased expression of HSD11B2 mRNA23557933
D011239PrednisoloneHSD11B2 protein results in increased metabolism of Prednisolone16549198
D011239PrednisoloneHSD11B2 protein affects the metabolism of Prednisolone18300859
D011241PrednisoneHSD11B2 protein affects the metabolism of Prednisone18300859
D011342ProcainamideProcainamide results in increased expression of HSD11B2 mRNA15489962
D011342ProcainamideProcainamide results in increased expression of HSD11B2 mRNA15489962
D011374Progesteronebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Progesterone results in increased expression of HSD11B2 mRNA]15857753
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of HSD11B2 mRNA20660070
D011374ProgesteroneMasoprocol inhibits the reaction [Progesterone results in decreased activity of HSD11B2 protein]18032417
D011374ProgesteroneMifepristone inhibits the reaction [Progesterone results in decreased activity of HSD11B2 protein]18032417
D011374ProgesteroneMifepristone inhibits the reaction [Progesterone results in decreased expression of HSD11B2 mRNA]18032417
D011374ProgesteroneMifepristone inhibits the reaction [Progesterone results in decreased expression of HSD11B2 protein]18032417
D011374ProgesteroneProgesterone results in decreased activity of HSD11B2 protein18032417
D011374ProgesteroneProgesterone results in decreased expression of HSD11B2 mRNA18032417|1807036
D011374ProgesteroneProgesterone results in decreased expression of HSD11B2 protein18032417
D011374ProgesteroneProgesterone results in increased expression of HSD11B2 mRNA15857753
D011441PropylthiouracilPropylthiouracil results in increased expression of HSD11B2 mRNA24780913
D015237DinoprostDinoprost results in decreased activity of HSD11B2 protein10377029
D015237DinoprostDinoprost results in decreased expression of HSD11B2 mRNA11517196
D011464EpoprostenolEpoprostenol results in decreased expression of HSD11B2 mRNA22205698
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in decreased activity of HSD11B2 protein11981059
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid results in decreased activity of HSD11B2 protein22796344
D011794QuercetinQuercetin results in decreased expression of HSD11B2 protein18095365
C502851quinocetonequinocetone results in increased expression of HSD11B2 mRNA27046791
D012643Selenium[Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of HSD11B2 mRNA11444866
D012822Silicon DioxideSilicon Dioxide results in decreased expression of HSD11B2 mRNA25351596
D012964SodiumHSD11B2 protein affects the abundance of Sodium15199296
C009277sodium arsenatesodium arsenate results in decreased expression of HSD11B2 mRNA16882884|2392266
C009277sodium arsenatesodium arsenate results in decreased expression of HSD11B2 mRNA12727804
C017947sodium arsenitesodium arsenite results in decreased expression of HSD11B2 mRNA12727804
C016104sodium bichromatesodium bichromate results in decreased expression of HSD11B2 mRNA24612858
D012965Sodium ChlorideSodium Chloride results in decreased activity of HSD11B2 protein12943734
D012965Sodium ChlorideSodium Chloride results in decreased expression of HSD11B2 mRNA12943734
D013148SpironolactoneSpironolactone results in decreased expression of HSD11B2 mRNA17587755
D014284TriiodothyronineTriiodothyronine results in increased expression of HSD11B2 mRNA15961419
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of HSD11B2 mRNA21592394
D013739TestosteroneTestosterone inhibits the reaction [HSD11B2 protein results in decreased activity of Glucocorticoids]22273746
D013739TestosteroneTestosterone results in decreased activity of HSD11B2 protein22273746
D013739TestosteroneTestosterone results in increased expression of HSD11B2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HSD11B2 mRNA16443690
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HSD11B2 mRNA22298810
D013792ThalidomideThalidomide results in decreased expression of HSD11B2 mRNA26217789
D013893ThiramThiram results in decreased activity of HSD11B2 protein mutant form22796344
D013893ThiramDithiothreitol inhibits the reaction [Thiram results in decreased activity of HSD11B2 protein]12901862
D013893ThiramEthylmaleimide promotes the reaction [Thiram results in decreased activity of HSD11B2 protein]22796344
D013893ThiramThiram inhibits the reaction [HSD11B2 protein results in increased oxidation of Dexamethasone]16857225
D013893ThiramThiram results in decreased activity of HSD11B2 protein12901862|1685722
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of HSD11B2 mRNA20133372
C011559tributyltintributyltin results in decreased activity of HSD11B2 protein16184081|2279634
D014241TrichloroethyleneTrichloroethylene results in increased methylation of HSD11B2 gene27618143
C012589trichostatin Atrichostatin A results in increased expression of HSD11B2 mRNA24935251
D014303TrinitrotolueneTrinitrotoluene affects the expression of HSD11B2 mRNA21346803
C030665triphenyltintriphenyltin results in decreased activity of HSD11B2 protein16184081|2279634
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of HSD11B2 mRNA"26179874
C113580U 0126U 0126 inhibits the reaction [Cadmium results in decreased expression of and results in decreased activity of HSD11B2 protein]23966319
C113580U 0126U 0126 inhibits the reaction [Cadmium results in decreased expression of HSD11B2 mRNA]23966319
C113580U 0126U 0126 results in increased expression of and results in increased activity of HSD11B2 protein23966319
C113580U 0126U 0126 results in increased expression of HSD11B2 mRNA23966319
D014520UrethaneUrethane results in decreased expression of HSD11B2 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSD11B2 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of HSD11B2 mRNA23179753|2627250
C025643vinclozolinvinclozolin results in decreased expression of HSD11B2 mRNA21126777
C029297vinylidene chloridevinylidene chloride results in decreased expression of HSD11B2 mRNA26682919
D014810Vitamin E[Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of HSD11B2 mRNA11444866
D024483Vitamin K 3Vitamin K 3 affects the expression of HSD11B2 mRNA23410634
C063449zileutonzileuton results in increased activity of HSD11B2 protein10377029
D015032ZincZinc deficiency results in decreased expression of HSD11B2 mRNA15671213
D015034Zinc OxideZinc Oxide analog results in decreased expression of HSD11B2 mRNA27215404
D015038ZinebZineb results in decreased activity of HSD11B2 protein22796344
D015039ZiramDithiothreitol inhibits the reaction [Ziram results in decreased activity of HSD11B2 protein]26859423
D015039ZiramZiram inhibits the reaction [HSD11B2 protein results in increased oxidation of Hydrocortisone]26859423
D015039ZiramZiram inhibits the reaction [[HSD11B2 protein results in increased oxidation of Hydrocortisone] which results in increased chemical synthesis of Cortisone]26859423
D015039ZiramZiram inhibits the reaction [HSD11B2 protein results in increased reduction of NAD]26859423
D015039ZiramZiram results in decreased activity of HSD11B2 protein26859423
D015039ZiramDithiothreitol inhibits the reaction [Ziram results in decreased activity of HSD11B2 protein]26859423
D015039ZiramZiram inhibits the reaction [HSD11B2 protein results in increased oxidation of Corticosterone]26859423
D015039ZiramZiram inhibits the reaction [[HSD11B2 protein results in increased oxidation of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone]26859423
D015039ZiramZiram inhibits the reaction [HSD11B2 protein results in increased reduction of NAD]26859423
D015039ZiramZiram results in decreased activity of HSD11B2 protein26859423
C088658zoledronic acidzoledronic acid results in decreased expression of HSD11B2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:000384511-beta-hydroxysteroid dehydrogenase [NAD(P)] activity-TAS-  
GO:0005496steroid binding-IEA-  
GO:0051287NAD binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001666response to hypoxia-IEA-  
GO:0002017regulation of blood volume by renal aldosterone-IEA-  
GO:0006704glucocorticoid biosynthetic process-TAS-  
GO:0007565female pregnancy-IEA-  
GO:0032094response to food-IEA-  
GO:0032868response to insulin-IEA-  
GO:0042493response to drug-IEA-  
GO:0051384response to glucocorticoid-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-TAS-  
KEGG ID KEGG Term
hsa00140Steroid hormone biosynthesis
hsa01100Metabolic pathways
hsa04960Aldosterone-regulated sodium reabsorption
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-194002Glucocorticoid biosynthesisTAS
R-HSA-196071Metabolism of steroid hormonesTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26203295Altered placental DNA methylation patterns associated with maternal smoking: current perspectives. (2015 May 7)Maccani JZAdv Genomics Genet
16144812Cadmium reduces 11 beta-hydroxysteroid dehydrogenase type 2 activity and expression in human placental trophoblast cells. (2006 Jan)Yang KAm J Physiol Endocrinol Metab