Gene: HSD17B1

3292
17-beta-HSD|20-alpha-HSD|E2DH|EDH17B2|EDHB17|HSD17|SDR28C1
hydroxysteroid 17-beta dehydrogenase 1
protein-coding
17q21.2
Ensembl:ENSG00000108786 MIM:109684 Vega:OTTHUMG00000180243 UniprotKB:P14061
NC_000017.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.791e-1 (AD)  8.422e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
P2RX70.761
ZNF6090.735
ZNF37A0.713
CEP1040.706
SLC22A230.701
DNASE10.697
POGK0.691
HDAC40.684
RNF1300.68
MPDZ0.675

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ENDOU-0.369
PRSS27-0.335
RPE65-0.335
PRRX2-0.334
CCT6B-0.322
HORMAD2-0.315
RGS22-0.315
PON3-0.312
C9orf50-0.31
OR4F29-0.309

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB01536AndrostenedioneSmall Molecule63-05-8Experimental|IllicitTarget
DB01561AndrostanedioneSmall Molecule846-46-8Experimental|IllicitTarget
DB01708PrasteroneSmall Molecule53-43-0Approved|Investigational|NutraceuticalTarget
DB02187EquilinSmall Molecule474-86-2ApprovedTarget
DB02323EM-1745Small MoleculeExperimentalTarget
DB02901StanoloneSmall Molecule521-18-6Illicit|InvestigationalTarget
DB034612'-Monophosphoadenosine 5'-DiphosphoriboseSmall MoleculeExperimentalTarget
DB13951Stanolone acetateSmall Molecule1164-91-6ExperimentalTarget
ID Drug Name Action PubMed
C03455416 alpha-bromo-17 beta-estradiol16 alpha-bromo-17 beta-estradiol results in decreased activity of HSD17B1 protein15806153
C0552381-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene"1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene results in increased expression of HSD17B1 mRNA"23333615
C1201292,2',3,4',5',6-hexachlorobiphenyl"2,2',3,4',5',6-hexachlorobiphenyl metabolite inhibits the reaction [2,2',3,4',5',6-hexachlorobiphenyl results in increased expression of HSD17B1 mRNA]"16216300
C1201292,2',3,4',5',6-hexachlorobiphenyl"2,2',3,4',5',6-hexachlorobiphenyl results in increased expression of HSD17B1 mRNA"16216300
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of HSD17B1 mRNA"25614096
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether metabolite results in increased expression of HSD17B1 mRNA"18248924
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of HSD17B1 protein"21871953
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"2,3-bis(3'-hydroxybenzyl)butyrolactone results in decreased activity of HSD17B1 protein"15876411
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Androstenedione] results in increased activity of HSD17B1 protein"16151981
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of HSD17B1 protein"16151981
C0098282,4,5,2',5'-pentachlorobiphenyl"2,4,5,2',5'-pentachlorobiphenyl metabolite results in decreased expression of HSD17B1 mRNA"16216300
C0045542,4,6-tribromophenol"2,4,6-tribromophenol affects the expression of HSD17B1 mRNA"19931292
C0139302,4-dibromophenol"2,4-dibromophenol results in increased expression of HSD17B1 mRNA"17447562
C0389642,6-dibromophenol"2,6-dibromophenol results in decreased expression of HSD17B1 mRNA"17447562
C0320382-bromophenol2-bromophenol results in increased expression of HSD17B1 mRNA17447562
C0327903,3',4,4',5,5'-hexabromobiphenyl"3,3',4,4',5,5'-hexabromobiphenyl results in increased expression of HSD17B1 mRNA"17447562
C0366853,3',4,4'-tetrabromobiphenyl"3,3',4,4'-tetrabromobiphenyl results in increased expression of HSD17B1 mRNA"17447562
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HSD17B1 mRNA"25433332
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased activity of HSD17B1 protein"16151981
C5622433-acetyl-7-(4-hydroxyphenyl)-2H-chromen-2-one3-acetyl-7-(4-hydroxyphenyl)-2H-chromen-2-one results in decreased activity of HSD17B1 protein21138273
C5794853-acetyl-7-methoxycoumarin3-acetyl-7-methoxycoumarin affects the activity of HSD17B1 protein21138273
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of HSD17B1 mRNA"18648102
D000079Acetaldehyde[CGA protein results in increased abundance of Acetaldehyde] which results in increased expression of HSD17B1 mRNA22285649
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of HSD17B1 mRNA23402939
D016604Aflatoxin B1finrozole inhibits the reaction [Aflatoxin B1 results in increased expression of HSD17B1 mRNA]23402939
C103303alitretinoinalitretinoin results in increased activity of HSD17B1 protein16513093
C103303alitretinoinalitretinoin results in increased expression of HSD17B1 mRNA16513093
D013196DihydrotestosteroneDihydrotestosterone results in decreased expression of HSD17B1 mRNA22948218
D000616Aminoglutethimide[Colforsin co-treated with Aminoglutethimide] results in decreased expression of HSD17B1 mRNA16935330
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HSD17B1 mRNA16483693
D015114AndrostenediolHSD17B1 protein affects the metabolism of Androstenediol16054388
D015114AndrostenediolHSD17B1 protein results in increased chemical synthesis of Androstenediol16054388
D000735Androstenedione"[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Androstenedione] results in increased activity of HSD17B1 protein"16151981
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of HSD17B1 mRNA24449571
D047310ApigeninApigenin results in decreased activity of HSD17B1 protein16023337
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [chromium hexavalent ion results in decreased expression of HSD17B1 mRNA]18602937
D001280AtrazineAtrazine results in increased expression of HSD17B1 mRNA23326527
D001572BenzofuransBenzofurans results in increased expression of HSD17B1 mRNA17447562
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of HSD17B1 mRNA"20382639
D004958EstradiolEstradiol results in increased expression of HSD17B1 mRNA12858341
D004958EstradiolHSD17B1 protein affects the metabolism of Estradiol16054388
D004958EstradiolHSD17B1 protein results in increased chemical synthesis of Estradiol16054388
D004958EstradiolHSD17B1 protein results in increased abundance of Estradiol25617485
D004958EstradiolHSD17B1 protein results in increased chemical synthesis of Estradiol18855374
D004958Estradiol[HSD17B1 protein results in increased reduction of Estrone] which results in increased chemical synthesis of Estradiol18855374
C099952bifenthrinbifenthrin results in decreased expression of HSD17B1 mRNA24938463
C004541biochanin Abiochanin A results in decreased activity of HSD17B1 protein16023337
C006780bisphenol A8-Bromo Cyclic Adenosine Monophosphate promotes the reaction [bisphenol A results in decreased expression of HSD17B1 mRNA]21273127
C006780bisphenol Abisphenol A results in decreased expression of HSD17B1 mRNA21273127
C006780bisphenol Abisphenol A results in increased expression of HSD17B1 mRNA26746108
C006780bisphenol A[bisphenol A co-treated with Ethinyl Estradiol co-treated with Genistein] results in increased expression of HSD17B1 mRNA21721901
C006780bisphenol Abisphenol A results in decreased expression of HSD17B1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of HSD17B1 gene28505145
C000611646bisphenol Fbisphenol F results in decreased expression of HSD17B1 mRNA28741210
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate promotes the reaction [bisphenol A results in decreased expression of HSD17B1 mRNA]21273127
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of HSD17B1 mRNA18815356
C026405bromotriethylstannanebromotriethylstannane results in increased activity of HSD17B1 protein16513093
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased activity of HSD17B1 protein15808795|1728323
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of HSD17B1 mRNA17283232
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of HSD17B1 protein29208485
C074702chromium hexavalent ionAscorbic Acid inhibits the reaction [chromium hexavalent ion results in decreased expression of HSD17B1 mRNA]18602937
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of HSD17B1 mRNA18602937
D003060Cod Liver OilCod Liver Oil results in increased expression of HSD17B1 mRNA26055946
D009249NADPcoumarin analog inhibits the reaction [[HSD17B1 protein co-treated with NADP] results in increased reduction of Estrone]21232530
D009249NADP[HSD17B1 protein co-treated with NADP] results in increased reduction of Estrone21232530
D009249NADPNADP binds to and results in increased activity of HSD17B1 protein25526675
D005576ColforsinColforsin affects the expression of HSD17B1 mRNA20726872
D005576Colforsin[Colforsin co-treated with Aminoglutethimide] results in decreased expression of HSD17B1 mRNA16935330
D005576Colforsin[Colforsin co-treated with Metyrapone] results in decreased expression of HSD17B1 mRNA16935330
D005576ColforsinColforsin results in increased expression of HSD17B1 mRNA16935330|2244682
D005576ColforsinValproic Acid affects the reaction [Colforsin affects the expression of HSD17B1 mRNA]20726872
D019327Copper SulfateCopper Sulfate results in increased expression of HSD17B1 mRNA19789285
C030123coumarincoumarin analog inhibits the reaction [[HSD17B1 protein co-treated with NADP] results in increased reduction of Estrone]21232530
D003471CuprizoneCuprizone results in increased expression of HSD17B1 mRNA27523638
C001765cyhexatincyhexatin results in increased activity of HSD17B1 protein16513093
C001765cyhexatincyhexatin results in increased expression of HSD17B1 mRNA16513093
C004742daidzeindaidzein results in decreased activity of HSD17B1 protein16023337
D003634DDTDDT results in decreased expression of HSD17B1 mRNA12858341
D003634DDTMT2A protein inhibits the reaction [DDT results in decreased expression of HSD17B1 mRNA]12858341
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of HSD17B1 mRNA23640034
D003687DehydroepiandrosteroneHSD17B1 protein affects the metabolism of Dehydroepiandrosterone16054388
D003687DehydroepiandrosteroneHSD17B1 protein results in increased chemical synthesis of Dehydroepiandrosterone16054388
D003907DexamethasoneDexamethasone affects the expression of HSD17B1 mRNA15102944
C020735dibutyldichlorotindibutyldichlorotin results in increased activity of HSD17B1 protein16513093
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HSD17B1 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of HSD17B1 mRNA25765776
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HSD17B1 mRNA26706031
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HSD17B1 protein26706031
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of HSD17B1 mRNA26924002
D004042Dietary Fats, Unsaturated"[perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in decreased expression of HSD17B1 mRNA"23626681
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate affects the expression of HSD17B1 mRNA25701202
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of HSD17B1 mRNA12858341
C024629dimethyl phthalatedimethyl phthalate results in increased expression of HSD17B1 mRNA26924002
D000068538DutasterideDutasteride results in increased expression of HSD17B1 mRNA17636412
D004857EquilinEquilin results in decreased activity of HSD17B1 protein21138273
D004970Estronecoumarin analog inhibits the reaction [[HSD17B1 protein co-treated with NADP] results in increased reduction of Estrone]21232530
D004970EstroneHSD17B1 protein affects the metabolism of Estrone16054388
D004970Estrone[HSD17B1 protein co-treated with NADP] results in increased reduction of Estrone21232530
D004970EstroneHSD17B1 protein results in increased chemical synthesis of Estrone16054388
D004970EstroneHSD17B1 protein results in increased metabolism of Estrone25617485
D004970EstroneHSD17B1 protein results in increased reduction of Estrone18855374
D004970Estrone[HSD17B1 protein results in increased reduction of Estrone] which results in increased chemical synthesis of Estradiol18855374
D000431EthanolEthanol results in increased expression of HSD17B1 mRNA28069986
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of HSD17B1 mRNA17215170
D004997Ethinyl Estradiol[bisphenol A co-treated with Ethinyl Estradiol co-treated with Genistein] results in increased expression of HSD17B1 mRNA21721901
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of HSD17B1 mRNA17222921
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of HSD17B1 mRNA12655037
C024565ethylene dichlorideethylene dichloride affects the expression of HSD17B1 mRNA28973639
C017690fenvaleratefenvalerate affects the expression of HSD17B1 protein21232584
C017690fenvaleratefenvalerate results in decreased expression of HSD17B1 mRNA16001830
C111409finrozolefinrozole inhibits the reaction [Aflatoxin B1 results in increased expression of HSD17B1 mRNA]23402939
D005411Flame RetardantsFlame Retardants metabolite results in decreased expression of HSD17B1 mRNA18248924
D005411Flame RetardantsFlame Retardants metabolite results in increased expression of HSD17B1 mRNA18248924
D005411Flame RetardantsFlame Retardants results in decreased expression of HSD17B1 mRNA17447562
D005411Flame RetardantsFlame Retardants results in increased expression of HSD17B1 mRNA17447562
D005485FlutamideFlutamide affects the expression of HSD17B1 mRNA17222921
D005485FlutamideFlutamide results in increased expression of HSD17B1 mRNA26485406
D005557FormaldehydeFormaldehyde results in decreased expression of HSD17B1 mRNA20655997
C014594formestaneformestane results in decreased activity of HSD17B1 protein15876411
D019833GenisteinGenistein results in decreased activity of HSD17B1 protein15876411
D019833Genistein[bisphenol A co-treated with Ethinyl Estradiol co-treated with Genistein] results in increased expression of HSD17B1 mRNA21721901
D019833GenisteinGenistein results in decreased activity of HSD17B1 protein16023337
D005978GlutathioneGlutathione inhibits the reaction [sodium arsenite results in decreased activity of HSD17B1 protein]20580664
C010176halofuginonehalofuginone results in decreased expression of HSD17B1 mRNA17180598
D055768Halogenated Diphenyl EthersHalogenated Diphenyl Ethers metabolite results in increased expression of HSD17B1 mRNA18248924|1831309
C571106halowax 1051halowax 1051 results in decreased activity of HSD17B1 protein22001251
C571106halowax 1051halowax 1051 results in decreased expression of HSD17B1 protein22001251
C571106halowax 1051halowax 1051 results in increased activity of HSD17B1 protein22001251
C571106halowax 1051halowax 1051 results in increased expression of HSD17B1 protein22001251
D006581HexachlorobenzeneHexachlorobenzene results in decreased expression of HSD17B1 protein21296658
C012351HT-2 toxinHT-2 toxin results in increased expression of HSD17B1 mRNA22982764
C040920isoliquiritigeninisoliquiritigenin results in decreased expression of HSD17B1 mRNA27773742
C099406L 742694L 742694 affects the expression of HSD17B1 mRNA15102944
C095104LG 100268LG 100268 results in increased activity of HSD17B1 protein16513093
C095104LG 100268LG 100268 results in increased expression of HSD17B1 mRNA16513093
D001556LindaneLindane results in decreased activity of HSD17B1 protein11404799
D008731MethoxychlorMethoxychlor results in decreased expression of HSD17B1 mRNA12858341
D008731MethoxychlorMT2A protein inhibits the reaction [Methoxychlor results in decreased expression of HSD17B1 mRNA]12858341
D008731MethoxychlorMethoxychlor results in decreased expression of HSD17B1 mRNA21514315
D008731MethoxychlorMethoxychlor results in increased expression of HSD17B1 mRNA22285353
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of HSD17B1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of HSD17B1 mRNA26011545
D008797Metyrapone[Colforsin co-treated with Metyrapone] results in decreased expression of HSD17B1 mRNA16935330
D008797MetyraponeMetyrapone results in decreased expression of HSD17B1 mRNA16935330
C517284monomethyl phthalatemonomethyl phthalate affects the expression of HSD17B1 mRNA26924002
C048581monotributyltin trichloridemonotributyltin trichloride results in increased activity of HSD17B1 protein16513093
D009281NaphthalenesNaphthalenes analog results in decreased activity of HSD17B1 protein18950679
D009538NicotineNicotine results in decreased expression of HSD17B1 protein20498001
D009538NicotineTaurine inhibits the reaction [Nicotine results in decreased expression of HSD17B1 protein]20498001
C025589ochratoxin Aochratoxin A results in decreased expression of HSD17B1 mRNA18417182
D052638Particulate MatterParticulate Matter results in decreased expression of HSD17B1 mRNA29165613
C098189pentabromophenolpentabromophenol results in increased expression of HSD17B1 mRNA17447562
C003072perflubronperflubron results in increased expression of HSD17B1 mRNA25871633
C522391perfluorododecanoic acidperfluorododecanoic acid results in decreased expression of HSD17B1 mRNA19429406
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of HSD17B1 mRNA23074026
C023036perfluorooctanoic acid"[perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in decreased expression of HSD17B1 mRNA"23626681
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of HSD17B1 mRNA20118188
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of HSD17B1 protein22414604
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of HSD17B1 protein20118188
C023036perfluorooctanoic acidPPARA gene mutant form inhibits the reaction [perfluorooctanoic acid results in decreased expression of HSD17B1 protein]22414604
C023036perfluorooctanoic acidPPARA promotes the reaction [perfluorooctanoic acid results in increased expression of HSD17B1 mRNA]20118188
D010936Plant ExtractsPlant Extracts results in decreased expression of HSD17B1 mRNA23557933
D011284PregnenolonePregnenolone results in increased expression of HSD17B1 mRNA20956811
C045362prochlorazprochloraz results in increased expression of HSD17B1 mRNA21158436
D011441PropylthiouracilPropylthiouracil results in increased expression of HSD17B1 mRNA21158436
D011794QuercetinQuercetin results in decreased activity of HSD17B1 protein16023337
C406527R 115866R 115866 results in decreased expression of HSD17B1 mRNA20580668
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of HSD17B1 mRNA25895662
C017947sodium arsenitesodium arsenite results in increased expression of HSD17B1 mRNA17350061
C017947sodium arseniteGlutathione inhibits the reaction [sodium arsenite results in decreased activity of HSD17B1 protein]20580664
C017947sodium arsenitesodium arsenite results in decreased activity of HSD17B1 protein20580664
D013654TaurineTaurine inhibits the reaction [Nicotine results in decreased expression of HSD17B1 protein]20498001
D013739TestosteroneHSD17B1 protein affects the chemical synthesis of Testosterone15932923
C102881tetrabutyltintetrabutyltin results in increased activity of HSD17B1 protein16513093
C102881tetrabutyltintetrabutyltin results in increased expression of HSD17B1 mRNA16513093
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HSD17B1 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HSD17B1 mRNA22889882|2821309
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HSD17B1 mRNA19276399
D013752TetracyclineTetracycline results in increased expression of HSD17B1 mRNA16917069
D014212TretinoinTretinoin results in decreased expression of HSD17B1 mRNA23724009
D014212TretinoinTretinoin results in increased activity of HSD17B1 protein11245337|1651309
D014212TretinoinTretinoin results in increased expression of HSD17B1 mRNA16249480|1651309
C533760tribromodiphenyl ether 28tribromodiphenyl ether 28 metabolite results in increased expression of HSD17B1 mRNA18248924
C011559tributyltintributyltin results in increased activity of HSD17B1 protein16513093
C011559tributyltintributyltin results in increased expression of HSD17B1 mRNA16513093
C012589trichostatin Atrichostatin A results in decreased expression of HSD17B1 mRNA24935251
C005445triphenyl phosphatetriphenyl phosphate results in increased expression of HSD17B1 mRNA26865342
C030665triphenyltintriphenyltin results in decreased expression of HSD17B1 mRNA19031914
C030665triphenyltintriphenyltin results in increased expression of HSD17B1 mRNA19031914
C012594triphenyltin chloridetriphenyltin chloride results in increased activity of HSD17B1 protein16513093
C012594triphenyltin chloridetriphenyltin chloride results in increased expression of HSD17B1 mRNA16513093
C007567triphenyltin hydroxidetriphenyltin hydroxide results in increased activity of HSD17B1 protein16513093
C007567triphenyltin hydroxidetriphenyltin hydroxide results in increased expression of HSD17B1 mRNA16513093
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of HSD17B1 mRNA"25637911
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate results in increased expression of HSD17B1 mRNA26547027|2713181
D014520UrethaneUrethane results in decreased expression of HSD17B1 mRNA28818685
D014635Valproic AcidValproic Acid inhibits the reaction [FSHB protein results in increased expression of HSD17B1 mRNA]23152920
D014635Valproic AcidValproic Acid affects the expression of HSD17B1 mRNA25979313
D014635Valproic AcidValproic Acid affects the reaction [Colforsin affects the expression of HSD17B1 mRNA]20726872
D014635Valproic AcidValproic Acid results in decreased expression of HSD17B1 mRNA19566492|2438349
D014635Valproic AcidValproic Acid results in increased methylation of HSD17B1 gene29154799
C025643vinclozolinvinclozolin metabolite results in increased expression of HSD17B1 mRNA23326527

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003824catalytic activity-TAS8547176  
GO:0004303estradiol 17-beta-dehydrogenase activity-IDA4396689  9525918  10625652  
GO:0004303estradiol 17-beta-dehydrogenase activity-TAS-  
GO:0005496steroid binding-IDA4396689  
GO:0070401NADP+ binding-IMP9525918  
GO:1903924estradiol binding-IDA10625652  
GO ID GO Term Qualifier Evidence PubMed
GO:0006694steroid biosynthetic process-TAS8547176  
GO:0006703estrogen biosynthetic process-IEA-  
GO:0006703estrogen biosynthetic process-TAS-  
GO:0008210estrogen metabolic process-TAS2584224  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-TAS8547176  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00140Steroid hormone biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-162582Signal TransductionIEA
R-HSA-193144Estrogen biosynthesisTAS
R-HSA-196071Metabolism of steroid hormonesTAS
R-HSA-2187338Visual phototransductionIEA
R-HSA-2453902The canonical retinoid cycle in rods (twilight vision)IEA
R-HSA-372790Signaling by GPCRIEA
R-HSA-388396GPCR downstream signallingIEA
R-HSA-418594G alpha (i) signalling eventsIEA
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23197595Steroidogenic enzyme expression in the human fetal liver and potential role in the endocrinology of pregnancy. (2013 Mar)O'Shaughnessy PJMol Hum Reprod