Gene: HSD17B3

3293
EDH17B3|SDR12C2
hydroxysteroid 17-beta dehydrogenase 3
protein-coding
9q22.32
Ensembl:ENSG00000130948 MIM:605573 Vega:OTTHUMG00000020292 UniprotKB:P37058
NG_008157.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.520e-1 (AD)  9.670e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNH80.874
CD220.829
COL4A50.827
C10orf900.826
ERBB30.824
PLEKHH10.823
SLC45A30.818
SH3TC20.816
TMEM63A0.814
MYRF0.809

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CALB2-0.407
SP8-0.392
CHRNA2-0.377
HCN4-0.374
NPBWR1-0.372
EPHA6-0.372
KCNG1-0.365
NDNF-0.362
CNGB1-0.357
PCDH8-0.352

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of HSD17B3 mRNA"25614096
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased activity of HSD17B3 protein"20522127
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"NADP analog inhibits the reaction [2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased activity of HSD17B3 protein]"20522127
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased activity of HSD17B3 protein"20522127
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"NADP analog inhibits the reaction [2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased activity of HSD17B3 protein]"20522127
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of HSD17B3 mRNA"19114083
C5471242,3-dibromopropyl-2,4,6-tribromophenyl ether"2,3-dibromopropyl-2,4,6-tribromophenyl ether analog results in decreased expression of HSD17B3 mRNA"25818047
C5471242,3-dibromopropyl-2,4,6-tribromophenyl ether"2,3-dibromopropyl-2,4,6-tribromophenyl ether results in decreased expression of HSD17B3 mRNA"25818047
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in decreased expression of HSD17B3 mRNA"22504055
D000082AcetaminophenAcetaminophen results in decreased expression of HSD17B3 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of HSD17B3 mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Dimethoate results in decreased expression of HSD17B3 mRNA]26769589
D016604Aflatoxin B1Aflatoxin B1 affects the expression of HSD17B3 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of HSD17B3 protein24373827
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HSD17B3 mRNA16483693
D000735AndrostenedioneHSD17B3 protein results in increased metabolism of Androstenedione17071532
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of HSD17B3 mRNA]17280759
D001280AtrazineAtrazine results in increased expression of HSD17B3 mRNA23591565
D001507BeclomethasoneBeclomethasone results in increased expression of HSD17B3 mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of HSD17B3 mRNA20106945
D004958EstradiolEstradiol affects the expression of HSD17B3 mRNA14699072
D004958EstradiolEstradiol results in decreased expression of HSD17B3 mRNA20144698|2480634
C099952bifenthrinbifenthrin results in decreased expression of HSD17B3 mRNA26071804
C006780bisphenol Abisphenol A results in decreased activity of HSD17B3 protein21925253
C006780bisphenol Abisphenol A results in decreased expression of HSD17B3 mRNA25434310
C006780bisphenol Abisphenol A results in decreased expression of HSD17B3 protein25434310
C006780bisphenol Abisphenol A inhibits the reaction [Dietary Fats results in increased expression of HSD17B3 protein]24472609
C006780bisphenol Abisphenol A results in decreased activity of HSD17B3 protein21925253
C006780bisphenol Abisphenol A results in decreased expression of HSD17B3 mRNA20144698|2518105
C006780bisphenol Abisphenol A results in decreased expression of HSD17B3 protein22302688|2447260
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of HSD17B3 mRNA22079614
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of HSD17B3 mRNA19897027
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of HSD17B3 protein19897027
C010059carbamylhydrazinecarbamylhydrazine analog results in decreased expression of HSD17B3 mRNA28834696
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of HSD17B3 mRNA16239168
D020111Chlorodiphenyl (54% Chlorine)Ascorbic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of HSD17B3 mRNA]17280759
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of HSD17B3 mRNA17280759|2920848
D020111Chlorodiphenyl (54% Chlorine)Vitamin E inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of HSD17B3 mRNA]17280759
D002994ClofibrateClofibrate results in increased expression of HSD17B3 mRNA15033592
D009249NADP"NADP analog inhibits the reaction [2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased activity of HSD17B3 protein]"20522127
D009249NADPNADP binds to and results in increased activity of HSD17B3 protein25526675
D009249NADP"NADP analog inhibits the reaction [2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased activity of HSD17B3 protein]"20522127
D009249NADPHSD17B3 protein affects the metabolism of NADP16079965
D005576ColforsinColforsin results in increased expression of HSD17B3 mRNA22461451
D016572CyclosporineCyclosporine results in decreased expression of HSD17B3 mRNA20106945
C017160cypermethrincypermethrin results in decreased expression of HSD17B3 mRNA24810582
C017160cypermethrincypermethrin results in decreased expression of HSD17B3 protein24810582
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of HSD17B3 mRNA26602377
D003671DEET[fipronil co-treated with DEET] results in decreased expression of HSD17B3 mRNA27091632
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HSD17B3 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HSD17B3 protein25434310
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HSD17B3 mRNA28528174
D004041Dietary Fatsbisphenol A inhibits the reaction [Dietary Fats results in increased expression of HSD17B3 protein]24472609
D004041Dietary FatsDietary Fats results in increased expression of HSD17B3 protein24472609
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of HSD17B3 mRNA28123099
C025605diisobutyl phthalatediisobutyl phthalate results in increased expression of HSD17B3 mRNA28655647
C012125diisononyl phthalatediisononyl phthalate results in decreased expression of HSD17B3 mRNA25445723
D004117DimethoateAcetylcysteine inhibits the reaction [Dimethoate results in decreased expression of HSD17B3 mRNA]26769589
D004117DimethoateDimethoate results in decreased expression of HSD17B3 mRNA26769589
C027387di-n-hexyl phthalatedi-n-hexyl phthalate results in increased expression of HSD17B3 mRNA26934186
D004237DiuronDiuron results in increased expression of HSD17B3 mRNA25152437
D004317DoxorubicinDoxorubicin results in decreased activity of HSD17B3 protein24593989
D004317DoxorubicinDoxorubicin results in decreased expression of HSD17B3 mRNA24593989
D004317DoxorubicinPropolis inhibits the reaction [Doxorubicin results in decreased activity of HSD17B3 protein]24593989
D004317DoxorubicinPropolis inhibits the reaction [Doxorubicin results in decreased expression of HSD17B3 mRNA]24593989
D000068538DutasterideDutasteride results in increased expression of HSD17B3 mRNA17636412
D052244Endocrine DisruptorsEndocrine Disruptors results in increased expression of HSD17B3 mRNA25198161
D004785Environmental Pollutants"[perfluorononanoic acid co-treated with [Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides]] results in decreased expression of HSD17B3 mRNA"25588985
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of HSD17B3 mRNA22721600
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of HSD17B3 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of HSD17B3 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HSD17B3 mRNA17942748
D015025ZearalenoneZearalenone results in decreased expression of HSD17B3 mRNA24512812
D005278FenitrothionFenitrothion results in decreased expression of HSD17B3 mRNA26264430
D005278FenitrothionQuercetin inhibits the reaction [Fenitrothion results in decreased expression of HSD17B3 mRNA]26264430
C082360fipronil[fipronil co-treated with DEET] results in decreased expression of HSD17B3 mRNA27091632
C082360fipronilfipronil results in decreased expression of HSD17B3 mRNA27091632
D005419FlavonoidsFlavonoids results in increased expression of HSD17B3 mRNA18035473
D005485FlutamideFlutamide results in decreased expression of HSD17B3 mRNA21126777
D004397FonofosFonofos results in increased methylation of HSD17B3 promoter22847954
D005520Food Preservatives"[perfluorononanoic acid co-treated with [Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides]] results in decreased expression of HSD17B3 mRNA"25588985
D005659Fungicides, Industrial"[perfluorononanoic acid co-treated with [Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides]] results in decreased expression of HSD17B3 mRNA"25588985
D006540Herbicides"[perfluorononanoic acid co-treated with [Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides]] results in decreased expression of HSD17B3 mRNA"25588985
C089796hexabromocyclododecane[hexabromocyclododecane co-treated with CGA protein] results in decreased expression of HSD17B3 mRNA25447410
C089796hexabromocyclododecanehexabromocyclododecane results in decreased expression of HSD17B3 mRNA25447410
D007306Insecticides"[perfluorononanoic acid co-treated with [Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides]] results in decreased expression of HSD17B3 mRNA"25588985
D008044LinuronLinuron results in decreased expression of HSD17B3 mRNA28007637
C545385MequindoxMequindox results in decreased expression of HSD17B3 mRNA21377486
D008731MethoxychlorMethoxychlor results in decreased expression of HSD17B3 mRNA22285353|2480634
D015735MifepristoneMifepristone results in increased expression of HSD17B3 mRNA22475373
D009538NicotineNicotine results in decreased activity of HSD17B3 protein28986172
D009538NicotineNicotine results in decreased expression of HSD17B3 mRNA28986172
D009538NicotineNicotine results in decreased expression of HSD17B3 protein28986172
D016912LevonorgestrelLevonorgestrel affects the expression of HSD17B3 mRNA22475373
C005290oxybenzoneoxybenzone results in decreased expression of HSD17B3 mRNA22721600
D010278ParathionParathion results in increased methylation of HSD17B3 promoter22847954
D052638Particulate MatterParticulate Matter results in increased expression of HSD17B3 mRNA18449530
C522391perfluorododecanoic acidperfluorododecanoic acid results in decreased expression of HSD17B3 mRNA17400581
C584865perfluorononanoic acid"[perfluorononanoic acid co-treated with [Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides]] results in decreased expression of HSD17B3 mRNA"25588985
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased activity of HSD17B3 protein20619251
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased activity of HSD17B3 protein20619251
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased activity of HSD17B3 protein20619251
C023036perfluorooctanoic acid[perfluorooctanoic acid co-treated with PPARA] results in increased expression of HSD17B3 mRNA20118188
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased activity of HSD17B3 protein20619251
D010795Phthalic AcidsPhthalic Acids results in increased expression of HSD17B3 mRNA15728792
D064209Phytochemicals"[perfluorononanoic acid co-treated with [Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides]] results in decreased expression of HSD17B3 mRNA"25588985
D010968Plasticizers"[perfluorononanoic acid co-treated with [Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides]] results in decreased expression of HSD17B3 mRNA"25588985
D011374ProgesteroneProgesterone results in increased expression of HSD17B3 mRNA22475373
C005556propionaldehydepropionaldehyde results in increased expression of HSD17B3 mRNA26079696
D011429PropolisPropolis inhibits the reaction [Doxorubicin results in decreased activity of HSD17B3 protein]24593989
D011429PropolisPropolis inhibits the reaction [Doxorubicin results in decreased expression of HSD17B3 mRNA]24593989
D011441PropylthiouracilPropylthiouracil results in decreased expression of HSD17B3 mRNA24780913
C013226pyralenepyralene results in decreased expression of HSD17B3 mRNA16439096
D011794QuercetinQuercetin inhibits the reaction [Fenitrothion results in decreased expression of HSD17B3 mRNA]26264430
D011794QuercetinQuercetin inhibits the reaction [Zinc Oxide analog results in decreased expression of HSD17B3 mRNA]27111109
D011794QuercetinQuercetin results in increased expression of HSD17B3 mRNA27111109
C541923sandostatinLARsandostatinLAR results in decreased expression of HSD17B3 mRNA17210224
C009277sodium arsenatesodium arsenate results in decreased expression of HSD17B3 mRNA23922661
C017947sodium arsenitesodium arsenite results in decreased expression of HSD17B3 mRNA28414027
C016104sodium bichromatesodium bichromate results in decreased expression of HSD17B3 mRNA24612858
D012460SulfasalazineSulfasalazine results in decreased expression of HSD17B3 mRNA29197623
C009361sulisobenzonesulisobenzone results in increased expression of HSD17B3 mRNA20937294
D013473Sunscreening Agents"[perfluorononanoic acid co-treated with [Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides]] results in decreased expression of HSD17B3 mRNA"25588985
C446685systhanesysthane results in decreased expression of HSD17B3 mRNA16730040
D013629TamoxifenTamoxifen affects the expression of HSD17B3 mRNA17555576
C012568terbufosterbufos results in increased methylation of HSD17B3 promoter22847954
C037565terbutylazineterbutylazine results in increased expression of HSD17B3 mRNA23591565
D013739TestosteroneHSD17B3 protein results in increased chemical synthesis of Testosterone17071532
D013739TestosteroneHSD17B3 protein affects the chemical synthesis of Testosterone15932923
D013739TestosteroneHSD17B3 protein results in increased chemical synthesis of Testosterone17158782
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HSD17B3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HSD17B3 mRNA17942748
D013853ThioacetamideThioacetamide results in increased expression of HSD17B3 mRNA23411599
D013893ThiramThiram results in increased expression of HSD17B3 mRNA20530235
C024746tobacco tartobacco tar results in decreased expression of HSD17B3 mRNA19559774
D014260TriclosanTriclosan results in decreased activity of HSD17B3 protein19118620
D014260TriclosanTriclosan results in decreased expression of HSD17B3 mRNA19118620
D001335Vehicle EmissionsVehicle Emissions results in increased expression of HSD17B3 mRNA18449530
D014810Vitamin EVitamin E inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of HSD17B3 mRNA]17280759
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of HSD17B3 mRNA"25198161
D015034Zinc OxideQuercetin inhibits the reaction [Zinc Oxide analog results in decreased expression of HSD17B3 mRNA]27111109
D015034Zinc OxideZinc Oxide analog results in decreased expression of HSD17B3 mRNA27111109
D015039ZiramZiram results in decreased activity of HSD17B3 protein28973382
D015039ZiramZiram results in decreased expression of HSD17B3 mRNA28973382
D015039ZiramZiram results in decreased expression of HSD17B3 protein28973382

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0047035testosterone dehydrogenase (NAD+) activity-TAS-  
GO:0047045testosterone 17-beta-dehydrogenase (NADP+) activity-IBA21873635  
GO:0047045testosterone 17-beta-dehydrogenase (NADP+) activity-IDA26545797  
GO ID GO Term Qualifier Evidence PubMed
GO:0006694steroid biosynthetic process-IBA21873635  
GO:0006702androgen biosynthetic process-TAS-  
GO:0030539male genitalia development-IEA-  
GO:0042445hormone metabolic process-IBA21873635  
GO:0055114oxidation-reduction process-IEA-  
GO:0061370testosterone biosynthetic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005783endoplasmic reticulum-IDA26545797  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0043231intracellular membrane-bounded organelle-TAS8075637  
KEGG ID KEGG Term
hsa00140Steroid hormone biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-193048Androgen biosynthesisTAS
R-HSA-196071Metabolism of steroid hormonesTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-75105Fatty acyl-CoA biosynthesisTAS
R-HSA-75876Synthesis of very long-chain fatty acyl-CoAsTAS
R-HSA-8957322Metabolism of steroidsTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23197595Steroidogenic enzyme expression in the human fetal liver and potential role in the endocrinology of pregnancy. (2013 Mar)O'Shaughnessy PJMol Hum Reprod
15654505Association of habitual smoking and drinking with single nucleotide polymorphism (SNP) in 40 candidate genes: data from random population-based Japanese samples. (2005)Liu YJ Hum Genet