Gene info: ID 3294

Gene: HSD17B2

GENE ID: 3294

Synonyms: EDH17B2|HSD17|SDR9C2

Description: hydroxysteroid 17-beta dehydrogenase 2

Gene type: protein-coding

Location: 16q23.3

dbXrefs: Ensembl:ENSG00000086696 MIM:109685 Vega:OTTHUMG00000137631 UniprotKB:P37059

RefSeq: NC_000016.10

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.684e-2 (AD) 8.293e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SPAG11B	0.753
OR10K2	0.743
ADAM30	0.738
OR6C2	0.734
DAOA	0.732
OR4C5	0.729
PRAMEF18	0.728
SPATA31D1	0.725
BAGE2	0.723
OR51S1	0.722

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HHATL	-0.283
SLC13A3	-0.281
C9orf24	-0.266
MARC1	-0.255
PLA2G6	-0.251
C16orf95	-0.249
ACSL6	-0.247
DNAI1	-0.246
LGI1	-0.243
B3GALT1	-0.243

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00157	NADH	Small Molecule	58-68-4	Approved\|Nutraceutical	Target
DB00783	Estradiol	Small Molecule	50-28-2	Approved\|Investigational	Target
DB13952	Estradiol acetate	Small Molecule	4245-41-4	Approved\|Investigational	Target
DB13953	Estradiol benzoate	Small Molecule	50-50-0	Approved\|Investigational	Target
DB13954	Estradiol cypionate	Small Molecule	313-06-4	Approved\|Investigational	Target
DB13955	Estradiol dienanthate	Small Molecule	7732-97-0	Approved\|Investigational	Target
DB13956	Estradiol valerate	Small Molecule	979-32-8	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of HSD17B2 mRNA"	28903501
C014037	1'-hydroxyestragole	HSD17B2 protein results in increased oxidation of 1'-hydroxyestragole	19920071
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of HSD17B2 mRNA"	27291303
C014211	2,3,7,8-tetrachlorodibenzofuran	"2,3,7,8-tetrachlorodibenzofuran affects the expression of HSD17B2 mRNA"	20702594
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of HSD17B2 mRNA"	20005886
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of HSD17B2 mRNA"	21346803
C035208	2-amino-4,6-dinitrotoluene	"2-amino-4,6-dinitrotoluene affects the expression of HSD17B2 mRNA"	21346803
C022830	2-methoxyestradiol	HSD17B2 protein results in decreased susceptibility to 2-methoxyestradiol	16397246
C022830	2-methoxyestradiol	[HSD17B2 protein results in increased metabolism of and results in decreased activity of 2-methoxyestradiol] which results in increased chemical synthesis of 2-methoxyestrone	16397246
C003655	2-methoxyestrone	[HSD17B2 protein results in increased metabolism of and results in decreased activity of 2-methoxyestradiol] which results in increased chemical synthesis of 2-methoxyestrone	16397246
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of HSD17B2 mRNA"	19692669
C014464	3,4-dichloroaniline	"3,4-dichloroaniline results in increased expression of HSD17B2 mRNA"	24172598
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of HSD17B2 mRNA"	25380136
C569669	6-(4-hydroxy-3-(trifluoromethyl)phenyl)-1-naphthol	6-(4-hydroxy-3-(trifluoromethyl)phenyl)-1-naphthol inhibits the reaction [Estradiol binds to HSD17B2 protein]	21972996
C569669	6-(4-hydroxy-3-(trifluoromethyl)phenyl)-1-naphthol	6-(4-hydroxy-3-(trifluoromethyl)phenyl)-1-naphthol results in decreased activity of HSD17B2 protein	21972996
C569669	6-(4-hydroxy-3-(trifluoromethyl)phenyl)-1-naphthol	6-(4-hydroxy-3-(trifluoromethyl)phenyl)-1-naphthol results in decreased activity of HSD17B2 protein	21972996
C569669	6-(4-hydroxy-3-(trifluoromethyl)phenyl)-1-naphthol	6-(4-hydroxy-3-(trifluoromethyl)phenyl)-1-naphthol results in decreased activity of HSD17B2 protein	21972996
D000082	Acetaminophen	Acetaminophen affects the expression of HSD17B2 mRNA	25064622
D000082	Acetaminophen	Acetaminophen results in decreased expression of HSD17B2 mRNA	21420995\|2906747
D000082	Acetaminophen	Acetaminophen results in increased expression of HSD17B2 mRNA	22230336
D000082	Acetaminophen	Acetaminophen affects the expression of HSD17B2 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in decreased expression of HSD17B2 mRNA	15120968
C010667	acetoacetyl CoA	acetoacetyl CoA binds to HSD17B2 protein	25526675
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of HSD17B2 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of HSD17B2 gene	27153756
D000452	Aldrin	Aldrin results in increased expression of HSD17B2 mRNA	18579281
D000638	Amiodarone	Amiodarone affects the expression of HSD17B2 mRNA	25064622
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of HSD17B2 mRNA	16483693
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in decreased expression of HSD17B2 mRNA"	22863853
D015114	Androstenediol	HSD17B2 protein affects the metabolism of Androstenediol	16054388
D015114	Androstenediol	HSD17B2 protein results in increased chemical synthesis of Androstenediol	16054388
D000735	Androstenedione	HSD17B2 protein results in increased chemical synthesis of Androstenedione	16054388
D000965	Antimony	Antimony results in decreased expression of HSD17B2 mRNA	17547211
D000966	Antimony Potassium Tartrate	Antimony Potassium Tartrate results in decreased expression of HSD17B2 mRNA	17547211
D001151	Arsenic	Arsenic affects the methylation of HSD17B2 gene	25304211
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of HSD17B2 mRNA	17547211
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of HSD17B2 mRNA"	25351596
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [chromium hexavalent ion results in decreased expression of HSD17B2 mRNA]	18602937
D001280	Atrazine	Atrazine results in decreased expression of HSD17B2 mRNA	22285353
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of HSD17B2 mRNA	18164116
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in decreased expression of HSD17B2 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of HSD17B2 mRNA	20106945
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of HSD17B2 mRNA"	20382639
D004958	Estradiol	6-(4-hydroxy-3-(trifluoromethyl)phenyl)-1-naphthol inhibits the reaction [Estradiol binds to HSD17B2 protein]	21972996
D004958	Estradiol	Estradiol binds to HSD17B2 protein	21972996
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of HSD17B2 mRNA	20660070
D004958	Estradiol	Estradiol results in decreased expression of HSD17B2 mRNA	20106945\|2163298
D004958	Estradiol	HSD17B2 protein affects the metabolism of Estradiol	16054388
D004958	Estradiol	HSD17B2 protein results in increased chemical synthesis of Estradiol	16054388
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in increased expression of HSD17B2 mRNA	17404688
D004958	Estradiol	HSD17B2 protein results in increased metabolism of Estradiol	18855374\|2197299
D004958	Estradiol	[HSD17B2 protein results in increased metabolism of Estradiol] which results in increased chemical synthesis of Estrone	18855374
C095105	bexarotene	bexarotene results in decreased expression of HSD17B2 mRNA	16648578
C095105	bexarotene	bexarotene analog results in increased expression of HSD17B2 mRNA	28689802
C006780	bisphenol A	bisphenol A inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of HSD17B2 mRNA]	21273127
C006780	bisphenol A	bisphenol A results in decreased expression of HSD17B2 mRNA	22285353\|2518105
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of HSD17B2 mRNA	21273127
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of HSD17B2 protein	18815356
D015124	8-Bromo Cyclic Adenosine Monophosphate	bisphenol A inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of HSD17B2 mRNA]	21273127
D015124	8-Bromo Cyclic Adenosine Monophosphate	[NR5A1 protein co-treated with 8-Bromo Cyclic Adenosine Monophosphate] affects the expression of HSD17B2 mRNA	21610156
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of HSD17B2 mRNA	15003993
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of HSD17B2 mRNA	26472689
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of HSD17B2 mRNA	25993096
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of HSD17B2 mRNA	27339419
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of HSD17B2 mRNA	16239168
D002509	Cephaloridine	Cephaloridine results in decreased expression of HSD17B2 mRNA	18500788
D002746	Chlorpromazine	Chlorpromazine affects the expression of HSD17B2 mRNA	25064622
D002793	Cholic Acids	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of HSD17B2 mRNA	27344345
C074702	chromium hexavalent ion	Ascorbic Acid inhibits the reaction [chromium hexavalent ion results in decreased expression of HSD17B2 mRNA]	18602937
C074702	chromium hexavalent ion	chromium hexavalent ion results in decreased expression of HSD17B2 mRNA	18602937
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of HSD17B2 mRNA	22816610
D009243	NAD	NAD binds to and results in increased activity of HSD17B2 protein	25526675
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of HSD17B2 mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of HSD17B2 mRNA	19549813
D016572	Cyclosporine	Cyclosporine affects the expression of HSD17B2 mRNA	25064622
D016572	Cyclosporine	Cyclosporine results in decreased expression of HSD17B2 mRNA	20106945\|2163298
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of HSD17B2 mRNA	23640034
D003687	Dehydroepiandrosterone	HSD17B2 protein affects the metabolism of Dehydroepiandrosterone	16054388
D003687	Dehydroepiandrosterone	HSD17B2 protein results in increased chemical synthesis of Dehydroepiandrosterone	16054388
D003907	Dexamethasone	Dexamethasone results in decreased expression of HSD17B2 mRNA	20607812
D002945	Cisplatin	Cisplatin results in decreased expression of HSD17B2 mRNA	22023808
C023635	dienogest	dienogest results in decreased expression of HSD17B2 mRNA	23183084
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of HSD17B2 mRNA	27405655
C014476	diethyl maleate	diethyl maleate results in decreased expression of HSD17B2 mRNA	21161181
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of HSD17B2 mRNA	18164116
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of HSD17B2 mRNA	19638242
D002117	Calcitriol	Calcitriol results in increased expression of HSD17B2 mRNA	12040012\|1600243
D002117	Calcitriol	Ketoconazole promotes the reaction [Calcitriol results in increased expression of HSD17B2 mRNA]	12040012
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in increased expression of HSD17B2 mRNA	21592394
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in decreased expression of HSD17B2 mRNA	17547211
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in decreased expression of HSD17B2 mRNA	17072980
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of HSD17B2 mRNA	25380136
D011397	Promegestone	mithramycin A inhibits the reaction [Promegestone promotes the reaction [SP1 protein binds to HSD17B2 promoter]]	16807381
D011397	Promegestone	mithramycin A inhibits the reaction [Promegestone promotes the reaction [SP3 protein binds to HSD17B2 promoter]]	16807381
D011397	Promegestone	Promegestone promotes the reaction [SP1 protein binds to HSD17B2 promoter]	16807381
D011397	Promegestone	Promegestone promotes the reaction [SP3 protein binds to HSD17B2 promoter]	16807381
D004237	Diuron	Diuron metabolite results in increased expression of HSD17B2 mRNA	24172598
D004237	Diuron	Diuron results in increased expression of HSD17B2 mRNA	21551480
D004394	Dydrogesterone	Dydrogesterone results in decreased expression of HSD17B2 mRNA	23183084
D004394	Dydrogesterone	Dydrogesterone results in increased expression of HSD17B2 protein	23183084
C109476	epoxiconazole	epoxiconazole results in increased expression of HSD17B2 mRNA	25182419
D004970	Estrone	HSD17B2 protein affects the metabolism of Estrone	16054388
D004970	Estrone	HSD17B2 protein results in increased chemical synthesis of Estrone	16054388
D004970	Estrone	HSD17B2 protein results in increased chemical synthesis of Estrone	18855374
D004970	Estrone	[HSD17B2 protein results in increased metabolism of Estradiol] which results in increased chemical synthesis of Estrone	18855374
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of HSD17B2 mRNA	25064622
D015025	Zearalenone	Zearalenone results in increased expression of HSD17B2 mRNA	20607812
C082360	fipronil	fipronil results in decreased expression of HSD17B2 mRNA	23962444
D005472	Fluorouracil	Fluorouracil affects the expression of HSD17B2 mRNA	16584549
C039281	furan	furan results in increased expression of HSD17B2 mRNA	15120968
C039281	furan	furan results in increased methylation of HSD17B2 gene	22079235
D005897	Glafenine	Glafenine results in decreased expression of HSD17B2 mRNA	24136188
D006581	Hexachlorobenzene	Hexachlorobenzene results in decreased expression of HSD17B2 mRNA	15159207
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of HSD17B2 mRNA	20044591
C561695	(+)-JQ1 compound	[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of HSD17B2 mRNA	25119042
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of HSD17B2 mRNA	24796395\|2511904
D007654	Ketoconazole	Ketoconazole promotes the reaction [Calcitriol results in increased expression of HSD17B2 mRNA]	12040012
C045463	leflunomide	leflunomide results in increased expression of HSD17B2 mRNA	28988120
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate results in decreased expression of HSD17B2 mRNA	23183084
D008627	Mercuric Chloride	Mercuric Chloride results in decreased expression of HSD17B2 mRNA	16507785
D008731	Methoxychlor	Methoxychlor results in decreased expression of HSD17B2 mRNA	22285353
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of HSD17B2 mRNA	26011545
C066851	mithramycin A	mithramycin A inhibits the reaction [Promegestone promotes the reaction [SP1 protein binds to HSD17B2 promoter]]	16807381
C066851	mithramycin A	mithramycin A inhibits the reaction [Promegestone promotes the reaction [SP3 protein binds to HSD17B2 promoter]]	16807381
C066851	mithramycin A	mithramycin A inhibits the reaction [SP1 protein binds to HSD17B2 promoter]	16807381
C066851	mithramycin A	mithramycin A inhibits the reaction [SP3 protein binds to HSD17B2 promoter]	16807381
C066851	mithramycin A	mithramycin A results in decreased expression of HSD17B2 mRNA	16807381
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased expression of HSD17B2 mRNA	20024957
C500085	muraglitazar	muraglitazar results in increased expression of HSD17B2 mRNA	21515302
C554954	N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride	N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride results in increased expression of HSD17B2 mRNA	28174063
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of HSD17B2 mRNA"	25620056
D015058	1-Naphthylisothiocyanate	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of HSD17B2 mRNA	27344345
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in decreased expression of HSD17B2 mRNA	25380136
D019829	Nevirapine	Nevirapine metabolite results in decreased expression of HSD17B2 mRNA	23947594
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of HSD17B2 mRNA	20971185
D010100	Oxygen	Oxygen deficiency results in increased expression of HSD17B2 mRNA	26516004
D010269	Paraquat	Paraquat affects the expression of HSD17B2 mRNA	25064622
D052638	Particulate Matter	Particulate Matter results in increased expression of HSD17B2 mRNA	28341207
C506614	PD 0325901	[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of HSD17B2 mRNA	25119042
C506614	PD 0325901	PD 0325901 results in decreased expression of HSD17B2 mRNA	25119042
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of HSD17B2 mRNA	20118188
C023036	perfluorooctanoic acid	PPARA promotes the reaction [perfluorooctanoic acid results in increased expression of HSD17B2 mRNA]	20118188
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of HSD17B2 mRNA	19162173
D010634	Phenobarbital	Phenobarbital affects the expression of HSD17B2 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in decreased expression of HSD17B2 mRNA	19162173
C006253	pirinixic acid	pirinixic acid results in decreased expression of HSD17B2 mRNA	18445702\|2381119
C006253	pirinixic acid	pirinixic acid results in increased expression of HSD17B2 mRNA	19162173
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of HSD17B2 mRNA	19162173
C045362	prochloraz	prochloraz results in increased expression of HSD17B2 mRNA	25182419
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of HSD17B2 mRNA	20660070
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in increased expression of HSD17B2 mRNA	17404688
D011374	Progesterone	Progesterone results in decreased expression of HSD17B2 mRNA	23183084
D011374	Progesterone	Progesterone results in decreased expression of HSD17B2 protein	23183084
D011794	Quercetin	Quercetin results in decreased expression of HSD17B2 mRNA	21632981
C059514	resveratrol	[resveratrol co-treated with Streptozocin] results in decreased expression of HSD17B2 mRNA	25905778
C059514	resveratrol	resveratrol results in increased expression of HSD17B2 mRNA	19228061
D012176	Retinoids	HSD17B2 protein affects the metabolism of Retinoids	17510238
C078903	seocalcitol	seocalcitol results in increased expression of HSD17B2 mRNA	12040012
C009250	sevoflurane	sevoflurane affects the expression of HSD17B2 mRNA	15967596
C017947	sodium arsenite	sodium arsenite affects the methylation of HSD17B2 gene	28589171
D013311	Streptozocin	[resveratrol co-treated with Streptozocin] results in decreased expression of HSD17B2 mRNA	25905778
D013629	Tamoxifen	Tamoxifen affects the expression of HSD17B2 mRNA	20937368
D013739	Testosterone	HSD17B2 protein affects the metabolism of Testosterone	16054388
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in increased expression of HSD17B2 mRNA	21592394
D013739	Testosterone	Testosterone results in increased expression of HSD17B2 mRNA	21592394
D013739	Testosterone	HSD17B2 protein results in increased metabolism of Testosterone	21972996
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of HSD17B2 mRNA	26988606
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of HSD17B2 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of HSD17B2 mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of HSD17B2 mRNA	20702594\|2637764
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of HSD17B2 mRNA	16214954
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of HSD17B2 mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HSD17B2 gene]	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HSD17B2 mRNA	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of HSD17B2 mRNA	17949056\|1879615
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of HSD17B2 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HSD17B2 mRNA	20959002\|2121527
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of HSD17B2 mRNA	16054898\|1969266
D013752	Tetracycline	Tetracycline affects the expression of HSD17B2 mRNA	25064622
D013752	Tetracycline	Tetracycline results in increased expression of HSD17B2 mRNA	16917069
D013853	Thioacetamide	Thioacetamide affects the expression of HSD17B2 mRNA	25064622
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of HSD17B2 mRNA	27189315
D014212	Tretinoin	Tretinoin results in increased expression of HSD17B2 mRNA	16249480
C032910	triadimefon	triadimefon results in decreased expression of HSD17B2 mRNA	16730040
C057693	troglitazone	troglitazone results in decreased expression of HSD17B2 mRNA	21515302
D014635	Valproic Acid	Valproic Acid affects the expression of HSD17B2 mRNA	25064622
D015032	Zinc	Zinc deficiency results in decreased expression of HSD17B2 mRNA	15671213
C088658	zoledronic acid	zoledronic acid results in increased expression of HSD17B2 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004303	estradiol 17-beta-dehydrogenase activity	-	IDA	8099587 17538076
GO:0004303	estradiol 17-beta-dehydrogenase activity	-	TAS	-
GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	-	TAS	17538076
GO:0047035	testosterone dehydrogenase (NAD+) activity	-	IDA	8099587

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001701	in utero embryonic development	-	IEA	-
GO:0001890	placenta development	-	IEA	-
GO:0006703	estrogen biosynthetic process	-	TAS	-
GO:0032526	response to retinoic acid	-	IDA	17538076
GO:0055114	oxidation-reduction process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0016021	integral component of membrane	-	IEA	-

KEGG ID	KEGG Term
hsa00140	Steroid hormone biosynthesis
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-193144	Estrogen biosynthesis	TAS
R-HSA-196071	Metabolism of steroid hormones	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-8957322	Metabolism of steroids	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27189315	The human placental proteome is affected by maternal smoking. (2016 Aug)	Huuskonen P	Reprod Toxicol
23197595	Steroidogenic enzyme expression in the human fetal liver and potential role in the endocrinology of pregnancy. (2013 Mar)	O'Shaughnessy PJ	Mol Hum Reprod