Gene: HSF1

3297
HSTF1
heat shock transcription factor 1
protein-coding
8q24.3
Ensembl:ENSG00000185122 MIM:140580 Vega:OTTHUMG00000174604 UniprotKB:Q00613
NC_000008.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.214e-2 (AD)  2.869e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TKT0.914
TRIM280.908
LMAN20.904
KHSRP0.9
UPF10.899
NUCB10.896
SNRPA0.895
TPD52L20.892
SDF40.888
YIPF30.883

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.757
OR4F29-0.722
CETP-0.297
CPA3-0.263
KLRB1-0.255
MXRA5-0.247
KLRF1-0.241
CEACAM3-0.236
XCL2-0.236
OR6C74-0.235

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB06258BimoclomolSmall Molecule130493-03-7InvestigationalTarget
ID Drug Name Action PubMed
C09724015-deoxy-delta(12,14)-prostaglandin J2"HSF1 protein inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA]"15618017
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether affects the expression of HSF1 mRNA"24680724
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of HSF1 protein]9822662
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of HSF1 mRNA"21346803
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of HSF1 mRNA]11424089
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [squamosamide results in increased expression of HSF1 protein modified form]21295016
C0194992-nitrofluorene2-nitrofluorene results in increased expression of HSF1 mRNA15890375
C5457472-phenylacetylenesulfonamide2-phenylacetylenesulfonamide inhibits the reaction [solanesol promotes the reaction [HSF1 protein binds to STUB1 protein]]25645596
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of HSF1 mRNA15890375
D000082AcetaminophenAcetaminophen results in increased expression of HSF1 mRNA22230336
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cadmium Chloride results in decreased activity of HSF1 protein]10403520
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Particulate Matter affects the localization of HSF1 protein]17922515
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Vehicle Emissions affects the localization of HSF1 protein]17922515
D020106AcrylamideAcrylamide results in increased phosphorylation of HSF1 protein16129430
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of HSF1 mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of HSF1 mRNA15890375
D000535AluminumAluminum results in increased activity of HSF1 protein9551088
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HSF1 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased phosphorylation of HSF1 protein15978632
C006632arsenic trioxideHSF1 protein affects the susceptibility to arsenic trioxide20724260
C006632arsenic trioxideMAP2K4 protein promotes the reaction [arsenic trioxide results in increased phosphorylation of HSF1 protein]15978632
C006632arsenic trioxidepyrazolanthrone inhibits the reaction [arsenic trioxide results in increased phosphorylation of HSF1 protein]15978632
C015001arsenitearsenite affects the localization of HSF1 protein20835880
C015001arsenitearsenite results in increased activity of HSF1 protein20835880
C015001arsenitearsenite results in increased expression of HSF1 protein20835880
C015001arseniteHSF1 protein affects the reaction [arsenite results in increased expression of HSPA1B mRNA]20835880
C015001arseniteHSF1 protein affects the reaction [arsenite results in increased expression of HSPA1B protein]20835880
C015001arsenitePIK3R1 gene mutant form inhibits the reaction [arsenite affects the localization of HSF1 protein]20835880
C015001arsenitePIK3R1 gene mutant form inhibits the reaction [arsenite results in increased expression of HSF1 protein]20835880
C015001arsenite[arsenite co-treated with Curcumin] results in increased phosphorylation of HSF1 protein9764755
C015001arsenitearsenite results in increased phosphorylation of HSF1 protein9764755
C015001arsenitearsenite results in increased activity of HSF1 protein9551088
D017636Asbestos, Amphibole"Asbestos, Amphibole results in increased expression of HSF1 protein"20855422
D001241AspirinAspirin results in increased activity of HSF1 protein10328874
C017037aurinaurin affects the localization of HSF1 protein25477506
D001554BenzeneBenzene results in increased expression of HSF1 mRNA15050406
D001564Benzo(a)pyreneBenzo(a)pyrene affects the activity of HSF1 protein20624995
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HSF1 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HSF1 protein21467743
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of HSF1 protein11893605
D004958EstradiolEstradiol results in increased expression of HSF1 mRNA12927369
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in increased expression of HSF1 mRNA]12927369
C116174bisindolylmaleimide IIbisindolylmaleimide II inhibits the reaction [Oxygen deficiency results in increased expression of HSF1 mRNA]11424089
C006780bisphenol Abisphenol A results in increased expression of HSF1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of HSF1 gene28505145
D000069286BortezomibBortezomib promotes the reaction [HSF1 protein binds to HSPA1A promoter]23874968
D000069286BortezomibBortezomib results in increased expression of HSF1 mRNA17895889
D002104CadmiumCadmium inhibits the reaction [HSF1 protein binds to HSP90AB1 protein]28115653
D002104CadmiumCadmium results in increased expression of and results in increased phosphorylation of and results in increased localization of and results in increased activity of HSF1 protein28115653
D002104CadmiumHSF1 affects the reaction [Cadmium results in increased expression of HSPA1A protein]28115653
D002104CadmiumHSF1 protein results in decreased susceptibility to Cadmium28115653
D002104CadmiumCadmium promotes the reaction [HSF1 protein binds to HMOX1 promoter]17244614
D002104CadmiumCadmium promotes the reaction [HSF1 protein binds to HSPA1A enhancer]16460681
D002104CadmiumCadmium promotes the reaction [HSF1 protein binds to HSPA1A promoter]17244614
D002104CadmiumCadmium results in increased activity of HSF1 protein16460681|1724461
D002104CadmiumCadmium results in increased activity of HSF1 protein16282982
D002104CadmiumHSF1 protein affects the reaction [Cadmium results in increased expression of HSPA1B protein]16282982
D002104CadmiumCadmium results in increased activity of HSF1 protein9551088
D002104CadmiumCadmium results in increased phosphorylation of HSF1 protein11341981
D019256Cadmium ChlorideAcetylcysteine inhibits the reaction [Cadmium Chloride results in decreased activity of HSF1 protein]10403520
D019256Cadmium ChlorideCadmium Chloride promotes the reaction [HSF1 protein binds to HSF1 protein binds to HSF1 protein]11341981
D019256Cadmium ChlorideCadmium Chloride results in decreased activity of HSF1 protein10403520
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of HSF1 mRNA19426795
D019256Cadmium ChlorideCadmium Chloride results in decreased phosphorylation of HSF1 protein24412756
D019256Cadmium ChlorideCadmium Chloride results in increased expression of HSF1 mRNA12160620
D019256Cadmium Chlorideresveratrol inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of HSF1 protein]24412756
D019256Cadmium ChlorideCadmium Chloride results in increased phosphorylation of HSF1 protein18348256
D019256Cadmium Chloride[MAP2K4 co-treated with MAP2K7] affects the reaction [Cadmium Chloride results in increased phosphorylation of HSF1 protein]18348256
D019256Cadmium ChlorideMAP2K4 mutant form inhibits the reaction [Cadmium Chloride results in increased phosphorylation of HSF1 protein]18348256
D019256Cadmium ChlorideMAP2K7 mutant form promotes the reaction [Cadmium Chloride results in increased phosphorylation of HSF1 protein]18348256
D019256Cadmium Chloride2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of HSF1 protein]9822662
D019256Cadmium ChlorideCadmium Chloride results in increased phosphorylation of HSF1 protein9822662
D019256Cadmium ChlorideSB 203580 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of HSF1 protein]9822662
C037123cadmium sulfatecadmium sulfate promotes the reaction [HSF1 protein binds to HMOX1 promoter]17244614
C037123cadmium sulfatecadmium sulfate promotes the reaction [HSF1 protein binds to HSPA1A enhancer]16460681
C037123cadmium sulfatecadmium sulfate promotes the reaction [HSF1 protein binds to HSPA1A promoter]17244614
C037123cadmium sulfatecadmium sulfate results in increased activity of HSF1 protein16460681|1724461
C080866cagA protein, Helicobacter pylori"cagA protein, Helicobacter pylori results in increased expression of HSF1 protein"26427350
C080866cagA protein, Helicobacter pylori"ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in increased expression of HSF1 protein]"26427350
C080866cagA protein, Helicobacter pylori"N2-(1H-indazole-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine inhibits the reaction [cagA protein, Helicobacter pylori results in increased expression of HSF1 protein]"26427350
D000001CalcimycinCalcimycin affects the phosphorylation of HSF1 protein8663271
D002211CapsaicinCapsaicin results in increased expression of HSF1 mRNA24746025
D002259Carbonyl Cyanide p-TrifluoromethoxyphenylhydrazoneCarbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of HSF1 mRNA16039398
D003035Cobalt[Cobalt co-treated with Organometallic Compounds] results in increased expression of HSF1 mRNA22147119
C018021cobaltous chloridecobaltous chloride results in increased expression of HSF1 mRNA19376846
D003042CocaineCocaine affects the expression of HSF1 mRNA20187946
D003474CurcuminCurcumin promotes the reaction [HSF1 protein binds to HSF1 protein]11322385
D003474Curcumin[arsenite co-treated with Curcumin] results in increased phosphorylation of HSF1 protein9764755
C038459curdlancurdlan results in decreased expression of HSF1 mRNA23543010
C009160cyclonitecyclonite results in increased expression of HSF1 mRNA25559034
D016572CyclosporineCyclosporine results in increased expression of HSF1 mRNA20106945|2556210
C089595cylindrospermopsincylindrospermopsin results in increased expression of HSF1 mRNA24921660
D013759DronabinolDronabinol results in decreased expression of HSF1 mRNA16039398
D003907DexamethasoneDexamethasone results in decreased activity of HSF1 protein14673132
D003907DexamethasoneMifepristone inhibits the reaction [Dexamethasone results in decreased activity of HSF1 protein]14673132
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HSF1 mRNA17361019
C000944dicrotophosdicrotophos results in increased expression of HSF1 mRNA28302478
D004052Diethylnitrosamine[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of HSF1 mRNA18253720
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of HSF1 mRNA15890375
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of HSF1 mRNA15890375
D007980LevodopaEPO protein inhibits the reaction [Levodopa results in decreased expression of HSF1 protein]21683736
D007980LevodopaLevodopa results in decreased expression of HSF1 protein18387727|1978606
D004317DoxorubicinHSF1 protein affects the reaction [Doxorubicin promotes the reaction [TRP53 protein binds to HSPB1 protein modified form]]20363884
D004317DoxorubicinHSF1 protein affects the reaction [Doxorubicin results in increased expression of BAX protein]20363884
D004317DoxorubicinHSF1 protein affects the reaction [Doxorubicin results in increased expression of HSPB1 protein]20363884
D004317DoxorubicinHSF1 protein affects the susceptibility to Doxorubicin20363884
D004837EpinephrineEpinephrine affects the localization of HSF1 protein19135123
D004837EpinephrineEpinephrine promotes the reaction [[Xanthine co-treated with XDH protein] affects the localization of HSF1 protein]19135123
D000431EthanolEthanol results in decreased expression of HSF1 mRNA24355176
D000431EthanolEthanol results in decreased expression of HSF1 protein24355176
D000431EthanolHSF1 protein affects the reaction [Ethanol results in increased expression of HSP90AA1 mRNA]17189318
D000431EthanolHSF1 protein affects the reaction [Ethanol results in increased expression of HSPA1A mRNA]17189318
D000431EthanolHSF1 protein affects the reaction [Ethanol results in increased expression of HSPA1A protein]17189318
D000431EthanolHSF1 protein affects the reaction [Ethanol results in increased expression of HSPB1 mRNA]17189318
D000431EthanolHSF1 protein affects the susceptibility to Ethanol17189318
D000431EthanolEthanol results in increased activity of HSF1 protein9551088
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of HSF1 mRNA16940010
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of HSF1 3' UTR27776689
D011345Fenofibrate[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of HSF1 mRNA18253720
D005419FlavonoidsFlavonoids results in decreased expression of HSF1 mRNA18035473
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in increased expression of HSF1 mRNA]12927369
C001277geldanamycingeldanamycin inhibits the reaction [solanesol promotes the reaction [HSF1 protein binds to STUB1 protein]]25645596
C001277geldanamycingeldanamycin results in increased phosphorylation of and results in increased activity of HSF1 protein10632574
D005839GentamicinsHSF1 protein affects the susceptibility to Gentamicins18512096
D005839GentamicinsGentamicins results in decreased expression of HSF1 protein21081137
C031049geranylgeranylacetonegeranylgeranylacetone promotes the reaction [[HSF1 protein binds to DLG1 promoter] which results in increased expression of DLG1 mRNA]21232033
C031049geranylgeranylacetonegeranylgeranylacetone results in increased expression of HSF1 protein21232033
C031049geranylgeranylacetoneHSF1 protein affects the susceptibility to geranylgeranylacetone17189318
C031049geranylgeranylacetonegeranylgeranylacetone results in increased activity of HSF1 protein21232033
C097367ginsenoside Rg3"ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in increased expression of HSF1 protein]"26427350
C097367ginsenoside Rg3ginsenoside Rg3 results in decreased expression of HSF1 protein26427350
D006046Gold[Polyethyleneimine binds to Gold] which results in decreased expression of HSF1 mRNA28433809
C089796hexabromocyclododecanehexabromocyclododecane affects the expression of HSF1 mRNA24680724
C007956homocysteic acidhomocysteic acid results in decreased expression of HSF1 protein24478344
D006851Hydrochloric AcidHSF1 protein affects the susceptibility to Hydrochloric Acid17189318
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of HSF1 protein19401454
D006861Hydrogen PeroxideHSF1 protein inhibits the reaction [Hydrogen Peroxide affects the localization of HMGB1 protein]22246807
D006861Hydrogen PeroxideHSF1 protein inhibits the reaction [Hydrogen Peroxide results in increased expression of and results in increased secretion of HMGB1 protein]22246807
D007052IbuprofenIbuprofen results in increased activity of HSF1 protein10328874
D000068877Imatinib MesylateImatinib Mesylate results in increased expression of HSF1 mRNA21935477
C082770IMM 125IMM 125 results in decreased expression of HSF1 protein21081137
D007213IndomethacinIndomethacin results in increased activity of HSF1 protein10701834|1206505
D007213IndomethacinIndomethacin results in increased activity of HSF1 protein14706622
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HSF1 mRNA25613284
D007501IronIron results in increased activity of HSF1 protein9551088
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of HSF1 mRNA12832151
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of HSF1 protein16323059
C410027KNK 437KNK 437 results in decreased activity of HSF1 protein23874968
C067713lactacystinlactacystin results in increased activity of HSF1 protein11893605
C008261lead acetatelead acetate results in increased expression of HSF1 mRNA21829687
C052901lemongrass oillemongrass oil affects the expression of HSF1 mRNA25976427
C027820ligustilideligustilide affects the localization of HSF1 protein26212861
C018584linaloollinalool results in increased expression of HSF1 mRNA19922762
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of HSF1 mRNA"21540803
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of HSF1 protein"21540803
D008344Maneb[Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA23963992
D008344ManebMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA]23963992
D008344ManebSilymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA]23963992
D008550MelatoninMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA]23963992
D008627Mercuric ChlorideMercuric Chloride promotes the reaction [HSF1 protein binds to HMOX1 promoter]17244614
D008627Mercuric ChlorideMercuric Chloride promotes the reaction [HSF1 protein binds to HSPA1A promoter]17244614
D008627Mercuric ChlorideMercuric Chloride results in increased activity of HSF1 protein17244614
D008628MercuryMercury promotes the reaction [HSF1 protein binds to HMOX1 promoter]17244614
D008628MercuryMercury promotes the reaction [HSF1 protein binds to HSPA1A promoter]17244614
D008628MercuryMercury results in increased activity of HSF1 protein17244614
D008628MercuryMercury results in increased activity of HSF1 protein9551088
D000432MethanolMethanol results in increased activity of HSF1 protein9551088
D008701MethapyrileneMethapyrilene results in increased expression of HSF1 mRNA15890375
D008767Methylmercury CompoundsHSF1 protein results in decreased susceptibility to Methylmercury Compounds22129751
D015735MifepristoneMifepristone inhibits the reaction [Dexamethasone results in decreased activity of HSF1 protein]14673132
C556094N2-(1H-indazole-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine"N2-(1H-indazole-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine inhibits the reaction [cagA protein, Helicobacter pylori results in increased expression of HSF1 protein]"26427350
C556094N2-(1H-indazole-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine"N2-(1H-indazole-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine inhibits the reaction [solanesol promotes the reaction [HSF1 protein binds to STUB1 protein]]"25645596
C029938nickel sulfatenickel sulfate results in increased expression of HSF1 mRNA18651567
D009942Organometallic Compounds[Cobalt co-treated with Organometallic Compounds] results in increased expression of HSF1 mRNA22147119
D010100Oxygen2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of HSF1 mRNA]11424089
D010100Oxygenbisindolylmaleimide II inhibits the reaction [Oxygen deficiency results in increased expression of HSF1 mRNA]11424089
D010100OxygenOxygen deficiency results in increased expression of HSF1 mRNA11424089
D010100OxygenPRKCD protein promotes the reaction [Oxygen deficiency results in increased expression of HSF1 mRNA]11424089
D010100OxygenQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of HSF1 mRNA]11424089
D010100Oxygenwortmannin inhibits the reaction [Oxygen deficiency results in increased expression of HSF1 mRNA]11424089
D010269Paraquat[Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA23963992
D010269ParaquatMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA]23963992
D010269ParaquatSilymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA]23963992
D052638Particulate MatterAcetylcysteine inhibits the reaction [Particulate Matter affects the localization of HSF1 protein]17922515
D052638Particulate MatterParticulate Matter affects the localization of HSF1 protein17922515
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of HSF1 mRNA15890375
C006253pirinixic acidpirinixic acid results in increased expression of HSF1 mRNA18445702
C006253pirinixic acidpirinixic acid results in increased expression of HSF1 mRNA15890375
D011094Polyethyleneimine[Polyethyleneimine binds to Gold] which results in decreased expression of HSF1 mRNA28433809
D011189Potassium ChloridePotassium Chloride deficiency results in decreased expression of HSF1 mRNA24478344
D011189Potassium ChloridePotassium Chloride deficiency results in decreased expression of HSF1 protein24478344
D011710PyocyaninePyocyanine results in increased activity of HSF1 protein27613716
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [arsenic trioxide results in increased phosphorylation of HSF1 protein]15978632
C010423pyrithione zincpyrithione zinc results in increased expression of HSF1 mRNA21424779
D011794QuercetinHSF1 protein results in increased susceptibility to Quercetin27041924
D011794QuercetinQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of HSF1 mRNA]11424089
D011794QuercetinQuercetin inhibits the reaction [squamosamide results in increased expression of HSF1 protein modified form]21295016
D011794QuercetinQuercetin results in decreased expression of HSF1 protein27041924
D011794QuercetinQuercetin results in decreased expression of HSF116579653
D011794QuercetinQuercetin results in decreased activity of HSF1 protein21295016
C059514resveratrolresveratrol inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of HSF1 protein]24412756
C059514resveratrolresveratrol inhibits the reaction [sodium arsenite results in decreased phosphorylation of HSF1 protein]24412756
C059514resveratrolresveratrol results in decreased localization of and results in decreased activity of HSF1 protein18429957
C059514resveratrol[resveratrol results in decreased phosphorylation of GSK3B protein] which results in decreased expression of HSF1 mRNA20090934
C059514resveratrol[resveratrol results in increased activity of GSK3B protein] which results in decreased expression of HSF1 mRNA20090934
D000068836RivastigmineRivastigmine results in increased activity of HSF1 protein19218096
D012459SalicylatesSalicylates results in increased activity of HSF1 protein9551088
C093642SB 203580SB 203580 affects the localization of and results in decreased activity of HSF1 protein19291423
C093642SB 203580SB 203580 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of HSF1 protein]9822662
D012834SilverSilver promotes the reaction [HSF1 protein binds to HMOX1 promoter]17244614
D012834SilverSilver promotes the reaction [HSF1 protein binds to HSPA1A enhancer]16460681
D012834SilverSilver promotes the reaction [HSF1 protein binds to HSPA1A promoter]17244614
D012834SilverSilver results in increased activity of HSF1 protein16460681|1724461
D012835Silver NitrateSilver Nitrate promotes the reaction [HSF1 protein binds to HMOX1 promoter]17244614
D012835Silver NitrateSilver Nitrate promotes the reaction [HSF1 protein binds to HSPA1A enhancer]16460681
D012835Silver NitrateSilver Nitrate promotes the reaction [HSF1 protein binds to HSPA1A promoter]17244614
D012835Silver NitrateSilver Nitrate results in increased activity of HSF1 protein16460681|1724461
D012838SilymarinSilymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA]23963992
D019821SimvastatinSimvastatin affects the localization of HSF1 protein16375908
C017947sodium arseniteHSF1 protein inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]15618017
C017947sodium arseniteresveratrol inhibits the reaction [sodium arsenite results in decreased phosphorylation of HSF1 protein]24412756
C017947sodium arsenitesodium arsenite promotes the reaction [HSF1 protein binds to HSF1 protein]11322385
C017947sodium arsenitesodium arsenite results in decreased phosphorylation of HSF1 protein24412756
C017947sodium arseniteHSF1 protein affects the reaction [sodium arsenite results in increased expression of HSPA1A protein]20566634
C017947sodium arseniteHSF1 protein affects the reaction [sodium arsenite results in increased expression of HSPB1 protein]20566634
C017947sodium arseniteMAPK9 protein affects the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of HSF1 protein]20566634
C017947sodium arsenitesodium arsenite results in increased activity of HSF1 protein15327774|1644726
C017947sodium arsenitesodium arsenite results in increased expression of HSF1 mRNA16014739
C017947sodium arsenitesodium arsenite results in increased phosphorylation of and results in increased activity of HSF1 protein20566634
D012980Sodium SalicylateSodium Salicylate results in increased activity of HSF1 protein10328874
D018038Sodium SeleniteSodium Selenite results in increased expression of HSF1 mRNA18175754
C017719solanesol2-phenylacetylenesulfonamide inhibits the reaction [solanesol promotes the reaction [HSF1 protein binds to STUB1 protein]]25645596
C017719solanesolgeldanamycin inhibits the reaction [solanesol promotes the reaction [HSF1 protein binds to STUB1 protein]]25645596
C017719solanesol"N2-(1H-indazole-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine inhibits the reaction [solanesol promotes the reaction [HSF1 protein binds to STUB1 protein]]"25645596
C017719solanesolsolanesol affects the localization of HSF1 protein25645596
C017719solanesolsolanesol promotes the reaction [HSF1 protein binds to STUB1 protein]25645596
C084439squamosamide2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [squamosamide results in increased expression of HSF1 protein modified form]21295016
C084439squamosamideQuercetin inhibits the reaction [squamosamide results in increased expression of HSF1 protein modified form]21295016
C084439squamosamidesquamosamide affects the localization of and results in increased expression of HSF1 protein modified form21295016
C084439squamosamidesquamosamide results in increased phosphorylation of and results in increased activity of HSF1 protein21295016
D013467SulindacSulindac results in increased activity of HSF1 protein10328874
C112765tanespimycintanespimycin affects the localization of HSF1 protein20090934
C112765tanespimycin[tanespimycin affects the localization of HSF1 protein] which results in increased expression of HSPA1A protein20090934
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HSF1 mRNA16039398
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HSF1 mRNA21570461|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HSF1 mRNA21215274
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of HSF1 mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HSF1 mRNA25613284
D013792ThalidomideThalidomide results in decreased expression of HSF1 mRNA26006729|2621778
D013853ThioacetamideThioacetamide results in increased expression of HSF1 mRNA23411599
D013874ThiopentalThiopental results in increased activity of HSF1 protein18218830
D013874ThiopentalThiopental results in increased phosphorylation of HSF1 protein18218830
C050414tripterinetripterine results in increased phosphorylation of and affects the localization of HSF1 protein25903958
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSF1 mRNA"26179874
D014635Valproic AcidValproic Acid results in increased methylation of HSF1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of HSF1 mRNA17292431
D014635Valproic AcidValproic Acid results in decreased expression of HSF1 mRNA21427059
D001335Vehicle EmissionsAcetylcysteine inhibits the reaction [Vehicle Emissions affects the localization of HSF1 protein]17922515
D001335Vehicle EmissionsVehicle Emissions affects the localization of HSF1 protein17922515
C009687wortmanninwortmannin affects the localization of HSF1 protein20090934
C009687wortmanninwortmannin inhibits the reaction [Oxygen deficiency results in increased expression of HSF1 mRNA]11424089
D019820XanthineEpinephrine promotes the reaction [[Xanthine co-treated with XDH protein] affects the localization of HSF1 protein]19135123
D019820Xanthine[Xanthine co-treated with XDH protein] affects the localization of HSF1 protein19135123
D015032ZincZinc deficiency results in increased activity of HSF1 protein18356318
D015032ZincZinc promotes the reaction [HSF1 protein binds to HMOX1 promoter]17244614
D015032ZincZinc promotes the reaction [HSF1 protein binds to HSPA1A enhancer]16460681
D015032ZincZinc promotes the reaction [HSF1 protein binds to HSPA1A promoter]17244614
D015032ZincZinc promotes the reaction [MTF1 protein binds to HSF1 protein]16460681
D015032ZincZinc results in increased activity of HSF1 protein16460681|1724461
D019287Zinc SulfateZinc Sulfate promotes the reaction [HSF1 protein binds to HMOX1 promoter]17244614
D019287Zinc SulfateZinc Sulfate promotes the reaction [HSF1 protein binds to HSPA1A enhancer]16460681
D019287Zinc SulfateZinc Sulfate promotes the reaction [HSF1 protein binds to HSPA1A promoter]17244614
D019287Zinc SulfateZinc Sulfate promotes the reaction [MTF1 protein binds to HSF1 protein]16460681
D019287Zinc SulfateZinc Sulfate results in increased activity of HSF1 protein16460681|1724461

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA8926278  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA8926278  
GO:0001162RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding-IDA10561509  
GO:0003677DNA binding-IDA7760831  7935471  8455624  9222587  9341107  9499401  
9727490  10359787  10413683  10747973  11514557  11583998  
12659875  12665592  12917326  16278218  16554823  26754925  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0003700DNA-binding transcription factor activity-TAS1871105  10821850  
GO:0005515protein binding-IPI9222587  9499401  10747973  11005381  11583998  12917326  
14707147  15016915  16278218  17897941  18794143  19684601  
21085490  21597468  23352416  25036637  25816751  26159920  
26359349  26496226  26517842  26727490  26754925  27173435  
GO:0019901protein kinase binding-IPI16278218  
GO:0031072heat shock protein binding-IDA9727490  11583998  16278218  
GO:0031490chromatin DNA binding-IDA21085490  
GO:0042802identical protein binding-IDA7935471  9222587  9727490  11583998  16554823  26754925  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO:0043565sequence-specific DNA binding-IDA25963659  
GO:0043621protein self-association-IDA7935471  
GO:0046982protein heterodimerization activity-IDA9222587  
GO:0051879Hsp90 protein binding-IDA11583998  
GO:0061770translation elongation factor binding-IDA16554823  
GO:0097677STAT family protein binding-IEA-  
GO:0098847sequence-specific single stranded DNA binding-IEA-  
GO:1990841promoter-specific chromatin binding-IDA25963659  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA8926278  9341107  
GO:0000165MAPK cascade-IDA12917326  
GO:0001892embryonic placenta development-IEA-  
GO:0006281DNA repair-IEA-  
GO:0006397mRNA processing-IEA-  
GO:0006952defense response-IEA-  
GO:0007143female meiotic nuclear division-IEA-  
GO:0007283spermatogenesis-IEA-  
GO:0008284positive regulation of cell proliferation-IMP26754925  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0009299mRNA transcription-IDA21597468  
GO:0010667negative regulation of cardiac muscle cell apoptotic process-IEA-  
GO:0014823response to activity-IEA-  
GO:0032720negative regulation of tumor necrosis factor production-IEA-  
GO:0033574response to testosterone-IEA-  
GO:0034605cellular response to heat-IBA21873635  
GO:0034605cellular response to heat-IDA7935471  9222587  9341107  10359787  10413683  10747973  11514557  11583998  12917326  14707147  16554823  17897941  21085490  26159920  
GO:0034605cellular response to heat-IMP8455624  9727490  
GO:0034620cellular response to unfolded protein-IDA15016915  
GO:0034622cellular protein-containing complex assembly-IDA11583998  
GO:0035865cellular response to potassium ion-IEA-  
GO:0040018positive regulation of multicellular organism growth-IEA-  
GO:0042531positive regulation of tyrosine phosphorylation of STAT protein-IEA-  
GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process-IEA-  
GO:0043497regulation of protein heterodimerization activity-IMP26359349  
GO:0043618regulation of transcription from RNA polymerase II promoter in response to stress-IBA21873635  
GO:0045931positive regulation of mitotic cell cycle-IMP18794143  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA9341107  10561509  11514557  12917326  16278218  21085490  
GO:0051028mRNA transport-IEA-  
GO:0051260protein homooligomerization-IDA8455624  
GO:0060136embryonic process involved in female pregnancy-IEA-  
GO:0061408positive regulation of transcription from RNA polymerase II promoter in response to heat stress-IBA21873635  
GO:0061408positive regulation of transcription from RNA polymerase II promoter in response to heat stress-IDA7760831  9499401  10747973  12659875  12665592  15016915  25963659  26754925  
GO:0070207protein homotrimerization-IDA8455624  
GO:0070301cellular response to hydrogen peroxide-IEA-  
GO:0071222cellular response to lipopolysaccharide-IEA-  
GO:0071276cellular response to cadmium ion-IDA10359787  11514557  15016915  25963659  
GO:0071280cellular response to copper ion-IDA15016915  
GO:0071392cellular response to estradiol stimulus-IEA-  
GO:0071480cellular response to gamma radiation-IDA26359349  
GO:0072738cellular response to diamide-IDA15016915  
GO:0090084negative regulation of inclusion body assembly-IEA-  
GO:0090261positive regulation of inclusion body assembly-IEA-  
GO:1900034regulation of cellular response to heat-IDA11583998  
GO:1900034regulation of cellular response to heat-TAS-  
GO:1900365positive regulation of mRNA polyadenylation-IMP14707147  
GO:1901215negative regulation of neuron death-IEA-  
GO:1902512positive regulation of apoptotic DNA fragmentation-IEA-  
GO:1903936cellular response to sodium arsenite-IDA15016915  
GO:1904385cellular response to angiotensin-IEA-  
GO:1904528positive regulation of microtubule binding-IEA-  
GO:1904843cellular response to nitroglycerin-IEA-  
GO:1904845cellular response to L-glutamine-IEA-  
GO:1990910response to hypobaric hypoxia-IEA-  
GO:1990911response to psychosocial stress-IEA-  
GO:2001033negative regulation of double-strand break repair via nonhomologous end joining-IMP26359349  
GO ID GO Term Qualifier Evidence PubMed
GO:0000776kinetochore-IDA18794143  
GO:0000777condensed chromosome kinetochore-IEA-  
GO:0000791euchromatin-IEA-  
GO:0000792heterochromatin-IEA-  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA8455624  9341107  10413683  10747973  12665592  12917326  14707147  21085490  25963659  26159920  
GO:0005634nucleus-IMP26359349  
GO:0005654nucleoplasm-IDA10359787  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA8455624  10413683  10747973  12917326  21085490  26159920  
GO:0005813centrosome-IDA18794143  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0016605PML body-IDA11514557  
GO:0045120pronucleus-IEA-  
GO:0048471perinuclear region of cytoplasm-IDA21085490  
GO:0097165nuclear stress granule-IDA10359787  10747973  11514557  12665592  14707147  25963659  
GO:0097431mitotic spindle pole-IDA18794143  
GO:1990904ribonucleoprotein complex-IDA16554823  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2262752Cellular responses to stressTAS
R-HSA-3371453Regulation of HSF1-mediated heat shock responseTAS
R-HSA-3371511HSF1 activationTAS
R-HSA-3371556Cellular response to heat stressTAS
R-HSA-3371568Attenuation phaseTAS
R-HSA-3371571HSF1-dependent transactivationTAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20426530Reduced heat shock protein 70 in airway smooth muscle in patients with chronic obstructive pulmonary disease. (2010 May)Xie JExp Lung Res