Gene info: ID 331

Gene: XIAP

GENE ID: 331

Description: X-linked inhibitor of apoptosis

Gene type: protein-coding

Location: Xq25

dbXrefs: Ensembl:ENSG00000101966 MIM:300079 Vega:OTTHUMG00000022336 UniprotKB:P98170

RefSeq: NG_007264.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 11

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : NA (AD) NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CAPRIN1	0.936
NUDT21	0.929
AZIN1	0.924
PUM1	0.921
KPNA4	0.921
CRCP	0.921
CNOT7	0.921
USO1	0.92
CLINT1	0.918
YME1L1	0.916

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.685
OR4F29	-0.639
CSAG1	-0.321
MTRNR2L10	-0.241
MTRNR2L6	-0.24
TTLL10	-0.237
SPRR2D	-0.234
MTRNR2L9	-0.229
PPBP	-0.226
VNN3	-0.223

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB02628	1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-Amide	Small Molecule		Experimental	Target
DB04209	Dequalinium	Small Molecule	6707-58-0	Approved\|Investigational	Target
DB04612	N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C554291	10-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one	"10-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one inhibits the reaction [XIAP protein binds to CASP3 protein]"	20833157
C554291	10-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one	"10-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one inhibits the reaction [XIAP protein binds to CASP9 protein]"	20833157
C554291	10-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one	"10-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one promotes the reaction [XIAP protein binds to DIABLO protein]"	20833157
C554291	10-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one	"10-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one results in decreased expression of XIAP protein"	20833157
C025603	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid results in decreased degradation of XIAP protein"	16223472
C517232	1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane	"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane results in increased expression of XIAP mRNA"	23958786
C517232	1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane	"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane results in increased expression of XIAP mRNA"	24375616
C097240	15-deoxy-delta(12,14)-prostaglandin J2	"15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of XIAP protein"	15498850\|1629925
C072581	16-hydroxycleroda-3,13(14)-dien-15,16-olide	"16-hydroxycleroda-3,13(14)-dien-15,16-olide results in decreased expression of XIAP protein"	21530604
C047948	1'-acetoxychavicol acetate	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of XIAP protein]	15905586
C095284	1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one	"XIAP protein results in decreased activity of 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one"	16288207
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of XIAP mRNA"	25614096
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of XIAP mRNA"	27589474
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of XIAP mRNA"	19576244
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased degradation of XIAP protein"	19576244
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased degradation of XIAP protein]"	19576244
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of XIAP mRNA]"	19576244
C446520	2-(2-hydroxyethylsulfanyl)-3-methyl-1,4-naphthoquinone	"2-(2-hydroxyethylsulfanyl)-3-methyl-1,4-naphthoquinone results in decreased expression of XIAP protein"	16096431
C416653	2-(3'-methoxyphenyl)-6-pyrrolidinyl-4-quinazolinone	2-(3'-methoxyphenyl)-6-pyrrolidinyl-4-quinazolinone results in decreased expression of XIAP protein	23523585
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased degradation of XIAP protein]"	19576244
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of XIAP mRNA]"	19576244
C543150	2-(4-((dimethylamino)methyl)benzylidene)-5,6-dimethoxy-2,3-dihydroinden-1-one	"2-(4-((dimethylamino)methyl)benzylidene)-5,6-dimethoxy-2,3-dihydroinden-1-one inhibits the reaction [Hydrogen Peroxide results in decreased expression of XIAP protein]"	19345205
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of XIAP mRNA"	21346803
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Doxorubicin] results in decreased expression of XIAP protein	20856197
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased expression of XIAP mRNA]	15339911
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased expression of XIAP protein]	15339911
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of XIAP protein	18071906
C557882	25-methoxyldammarane-3,12,20-triol	"25-methoxyldammarane-3,12,20-triol results in decreased expression of XIAP protein"	21924252
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of XIAP mRNA"	21346803
C501280	2-amino-6-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-4-piperidin-4-yl nicotinonitrile	2-amino-6-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-4-piperidin-4-yl nicotinonitrile results in decreased expression of XIAP mRNA	15756023
C487689	(2E,4E,6E,10E)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid	"(2E,4E,6E,10E)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid results in decreased expression of XIAP protein"	16546985
C526437	2-methoxy-3-O-sulfamoyl-17-cyanomethylestra-1,3,5(10)-triene	"2-methoxy-3-O-sulfamoyl-17-cyanomethylestra-1,3,5(10)-triene results in decreased expression of XIAP protein"	19846905
C022830	2-methoxyestradiol	2-methoxyestradiol results in decreased expression of XIAP protein	16356831
C526438	2-methoxyestradiol-3,17-O,O-bis(sulfamate)	"2-methoxyestradiol-3,17-O,O-bis(sulfamate) results in decreased expression of XIAP protein"	19846905
C556168	3-(2-(3-(1-adamantyl)-4-hydroxyphenyl)-5-pyrimidinyl)-2-propenoic acid	3-(2-(3-(1-adamantyl)-4-hydroxyphenyl)-5-pyrimidinyl)-2-propenoic acid results in decreased expression of XIAP	21548569
C572491	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of XIAP protein	26194647
C016392	3,3'-diindolylmethane	"3,3'-diindolylmethane results in decreased expression of XIAP protein"	22290291
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	[3-(4-methylphenylsulfonyl)-2-propenenitrile co-treated with entinostat] results in decreased expression of XIAP protein	15964800
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	[3-(4-methylphenylsulfonyl)-2-propenenitrile co-treated with vorinostat] results in decreased expression of XIAP protein	15964800
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	3-(4-methylphenylsulfonyl)-2-propenenitrile promotes the reaction [trimethyltin chloride results in decreased expression of XIAP protein]	23423712
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	3-(4-methylphenylsulfonyl)-2-propenenitrile results in decreased expression of XIAP mRNA	16174796
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	3-(4-methylphenylsulfonyl)-2-propenenitrile results in decreased expression of XIAP protein	15964800\|1617396
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	3-(4-methylphenylsulfonyl)-2-propenenitrile results in increased expression of XIAP protein	19679660
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	XIAP protein results in decreased susceptibility to [entinostat co-treated with 3-(4-methylphenylsulfonyl)-2-propenenitrile]	15964800
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	XIAP protein results in decreased susceptibility to [vorinostat co-treated with 3-(4-methylphenylsulfonyl)-2-propenenitrile]	15964800
C010567	3-deazaguanine	XIAP protein results in increased susceptibility to 3-deazaguanine	10815900
C480030	4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid	4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid results in decreased expression of XIAP protein	15930313
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Mercuric Chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of XIAP mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of XIAP mRNA"	27188386
C568862	4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline	"4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [bisphenol A results in increased expression of XIAP protein]"	25663485
C406734	4-methylene-2-octyl-5-oxofuran-3-carboxylic acid	4-methylene-2-octyl-5-oxofuran-3-carboxylic acid results in decreased expression of XIAP protein	21442130
C480541	5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one	"5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one results in decreased expression of XIAP protein"	20661229
C580598	5-OH-BDE-47	5-OH-BDE-47 results in decreased expression of XIAP mRNA	27589474
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Mercuric Chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of XIAP mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of XIAP mRNA"	27188386
C580599	6-OH-BDE-47	6-OH-BDE-47 results in decreased expression of XIAP mRNA	27589474
C054852	7-hydroxystaurosporine	7-hydroxystaurosporine results in decreased expression of XIAP protein	10887097
D000082	Acetaminophen	Acetaminophen results in decreased expression of XIAP mRNA	21420995\|2776149
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of XIAP mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of XIAP mRNA]	17585979
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [[Bortezomib co-treated with Butyrates] results in decreased expression of XIAP protein]	15173093
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [[Bortezomib co-treated with vorinostat] results in decreased expression of XIAP protein]	15173093
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [cordycepin results in decreased expression of XIAP protein]	21310227
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [diallyl trisulfide results in decreased expression of XIAP protein]	22578287
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of XIAP protein]	19679660
D015250	Aclarubicin	XIAP protein results in increased susceptibility to Aclarubicin	10815900
C498209	AEG 35156	AEG 35156 results in decreased expression of XIAP mRNA	19652057
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of XIAP mRNA	28943387
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of XIAP mRNA	19770486
C048980	ajoene	ajoene analog inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]	27449564
C038491	allyl sulfide	allyl sulfide results in decreased expression of XIAP protein	17647244
C077990	alvocidib	alvocidib results in decreased expression of XIAP mRNA	12517783\|1597244
C077990	alvocidib	alvocidib results in decreased expression of XIAP protein	10887097\|1251778
C077990	alvocidib	Epothilones promotes the reaction [alvocidib results in decreased expression of XIAP mRNA]	12517783
C077990	alvocidib	Epothilones promotes the reaction [alvocidib results in decreased expression of XIAP protein]	12517783
C077990	alvocidib	[irinotecan co-treated with alvocidib] results in increased cleavage of XIAP protein	11751522
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of XIAP mRNA	16483693
C088115	anacardic acid	anacardic acid inhibits the reaction [TNF protein results in increased expression of XIAP protein]	18349320
C030419	andrographolide	andrographolide results in decreased expression of XIAP protein	23845849
D001149	Arsenates	[Atrazine co-treated with Arsenates] results in increased expression of XIAP mRNA	18585445
D001151	Arsenic	[Arsenic co-treated with Fluorides] results in increased expression of XIAP mRNA	19962721
C006632	arsenic trioxide	arsenic trioxide affects the expression of XIAP protein	18359480
C006632	arsenic trioxide	[arsenic trioxide co-treated with Cisplatin] affects the expression of XIAP mRNA	21118639
C006632	arsenic trioxide	[arsenic trioxide co-treated with Curcumin] results in decreased expression of XIAP protein	27430728
C006632	arsenic trioxide	[arsenic trioxide co-treated with Deoxyglucose] results in decreased expression of XIAP protein	23041229
C006632	arsenic trioxide	[arsenic trioxide co-treated with Ethacrynic Acid] results in decreased expression of XIAP protein	23082001
C006632	arsenic trioxide	[arsenic trioxide co-treated with TNF protein] results in decreased expression of XIAP protein	17673311
C006632	arsenic trioxide	arsenic trioxide promotes the reaction [Curcumin results in decreased expression of XIAP protein]	20605902
C006632	arsenic trioxide	arsenic trioxide promotes the reaction [lonidamine results in decreased expression of XIAP protein]	21889928
C006632	arsenic trioxide	arsenic trioxide promotes the reaction [Quercetin results in decreased expression of XIAP protein]	18359480
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of XIAP mRNA	16174796\|1976391
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of XIAP protein	16105982\|1617479
C006632	arsenic trioxide	Fluorouracil promotes the reaction [arsenic trioxide results in decreased expression of XIAP protein]	22963400
C006632	arsenic trioxide	Genistein promotes the reaction [arsenic trioxide results in decreased expression of XIAP protein]	18546268
C006632	arsenic trioxide	lonidamine promotes the reaction [arsenic trioxide results in decreased expression of XIAP protein]	21889928
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of XIAP protein	21565247
C006632	arsenic trioxide	arsenic trioxide results in increased expression of XIAP mRNA	19730151
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of XIAP protein"	21570478
D001241	Aspirin	Aspirin results in decreased expression of XIAP protein	19595669
D001241	Aspirin	Aspirin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of XIAP protein]	25449198
D001280	Atrazine	[Atrazine co-treated with Arsenates] results in increased expression of XIAP mRNA	18585445
D001397	Azoxymethane	Aspirin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of XIAP protein]	25449198
D001397	Azoxymethane	[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of XIAP protein	25449198
D001397	Azoxymethane	Camptothecin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of XIAP protein]	25449198
D001397	Azoxymethane	Plant Extracts inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of XIAP protein]	25449198
C006680	baicalein	baicalein inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased activity of XIAP protein]	20850421
C012765	bakuchiol	bakuchiol results in decreased expression of XIAP protein	27033605
D001507	Beclomethasone	Beclomethasone results in increased expression of XIAP mRNA	23656298
D000069461	Bendamustine Hydrochloride	Bendamustine Hydrochloride affects the localization of XIAP protein	15359644
D000069461	Bendamustine Hydrochloride	Bendamustine Hydrochloride results in decreased expression of XIAP protein	12948851\|1535964
D000069461	Bendamustine Hydrochloride	Cladribine promotes the reaction [Bendamustine Hydrochloride results in decreased expression of XIAP protein]	12948851
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of XIAP mRNA	19770486
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of XIAP mRNA"	19150397\|2001819
C110772	benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone	benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [phenethyl isothiocyanate results in decreased expression of XIAP protein]	16054126
C110772	benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone	benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [resveratrol results in increased expression of XIAP protein]	12689943
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [diallyl trisulfide results in decreased expression of XIAP protein]	21411500
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[pifithrin co-treated with Topotecan] results in increased degradation of XIAP protein]	19812371
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in decreased expression of XIAP protein]	22627131
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [trimethyltin chloride results in decreased expression of XIAP protein]	23423712
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased cleavage of XIAP protein	16287099
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Topotecan results in increased degradation of XIAP protein]	19812371
D004958	Estradiol	Estradiol results in increased expression of XIAP mRNA	19167446
D004958	Estradiol	Estradiol results in increased expression of XIAP mRNA	23144751
C006780	bisphenol A	"4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [bisphenol A results in increased expression of XIAP protein]"	25663485
C006780	bisphenol A	bisphenol A promotes the reaction [XIAP protein binds to CAV1 protein]	25663485
C006780	bisphenol A	bisphenol A results in increased expression of XIAP protein	25663485
C006780	bisphenol A	bisphenol A affects the expression of XIAP mRNA	21786754
C006780	bisphenol A	bisphenol A affects the expression of XIAP mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of XIAP mRNA	29097150
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of XIAP mRNA	17553608
C476029	Boc-D-FMK	Boc-D-FMK inhibits the reaction [[Bortezomib co-treated with Butyrates] results in decreased expression of XIAP protein]	15173093
C476029	Boc-D-FMK	Boc-D-FMK inhibits the reaction [[Bortezomib co-treated with vorinostat] results in decreased expression of XIAP protein]	15173093
D000069286	Bortezomib	Acetylcysteine inhibits the reaction [[Bortezomib co-treated with Butyrates] results in decreased expression of XIAP protein]	15173093
D000069286	Bortezomib	Acetylcysteine inhibits the reaction [[Bortezomib co-treated with vorinostat] results in decreased expression of XIAP protein]	15173093
D000069286	Bortezomib	Boc-D-FMK inhibits the reaction [[Bortezomib co-treated with Butyrates] results in decreased expression of XIAP protein]	15173093
D000069286	Bortezomib	Boc-D-FMK inhibits the reaction [[Bortezomib co-treated with vorinostat] results in decreased expression of XIAP protein]	15173093
D000069286	Bortezomib	Bortezomib affects the expression of XIAP protein	17326159
D000069286	Bortezomib	[Bortezomib co-treated with Butyrates] results in decreased expression of XIAP protein	15173093
D000069286	Bortezomib	[[Bortezomib co-treated with Butyrates] results in increased abundance of Reactive Oxygen Species] which results in decreased expression of XIAP protein	15173093
D000069286	Bortezomib	[Bortezomib co-treated with vorinostat] results in decreased expression of XIAP protein	15173093
D000069286	Bortezomib	[[Bortezomib co-treated with vorinostat] results in increased abundance of Reactive Oxygen Species] which results in decreased expression of XIAP protein	15173093
D000069286	Bortezomib	Bortezomib promotes the reaction [TNFSF10 protein results in increased cleavage of XIAP protein]	19100720
D000069286	Bortezomib	Bortezomib results in decreased expression of XIAP protein	15543232\|1762607
D000069286	Bortezomib	Bortezomib results in increased cleavage of XIAP protein	19100720
D000069286	Bortezomib	Bortezomib results in increased expression of XIAP mRNA	20977926
D000069286	Bortezomib	[romidepsin co-treated with Bortezomib] results in decreased expression of XIAP protein	18223231
D000069286	Bortezomib	TNFSF10 protein promotes the reaction [Bortezomib results in increased cleavage of XIAP protein]	19100720
D000069286	Bortezomib	Bortezomib results in decreased expression of XIAP protein	18451165
D002066	Busulfan	[clofarabine co-treated with fludarabine co-treated with Busulfan] results in decreased expression of XIAP protein	20933509
D002087	Butyrates	Acetylcysteine inhibits the reaction [[Bortezomib co-treated with Butyrates] results in decreased expression of XIAP protein]	15173093
D002087	Butyrates	Boc-D-FMK inhibits the reaction [[Bortezomib co-treated with Butyrates] results in decreased expression of XIAP protein]	15173093
D002087	Butyrates	[Bortezomib co-treated with Butyrates] results in decreased expression of XIAP protein	15173093
D002087	Butyrates	[[Bortezomib co-treated with Butyrates] results in increased abundance of Reactive Oxygen Species] which results in decreased expression of XIAP protein	15173093
D002087	Butyrates	[Butyrates co-treated with Camptothecin] results in decreased expression of XIAP protein	16061681
D002087	Butyrates	Butyrates results in decreased expression of XIAP protein	16007142
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of XIAP mRNA	21262342
D019256	Cadmium Chloride	Quercetin inhibits the reaction [Cadmium Chloride results in decreased expression of XIAP mRNA]	21262342
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of XIAP mRNA	24982889
C055494	caffeic acid phenethyl ester	caffeic acid phenethyl ester results in decreased expression of XIAP protein	15291876
C071482	calpeptin	calpeptin results in decreased degradation of XIAP protein	16223472
D002166	Camptothecin	[Butyrates co-treated with Camptothecin] results in decreased expression of XIAP protein	16061681
D002166	Camptothecin	[Camptothecin co-treated with FAS protein] results in decreased expression of XIAP protein	19633536
D002166	Camptothecin	XIAP protein results in decreased susceptibility to Camptothecin	16211302
D002166	Camptothecin	Camptothecin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of XIAP protein]	25449198
D002193	Cantharidin	Cantharidin results in decreased expression of XIAP protein	27113412
D002220	Carbamazepine	Carbamazepine affects the expression of XIAP mRNA	24752500
D002108	Ceruletide	Ceruletide results in increased degradation of XIAP protein	16339139
D017338	Cladribine	Cladribine promotes the reaction [Bendamustine Hydrochloride results in decreased expression of XIAP protein]	12948851
D002737	Chloroprene	Chloroprene results in increased expression of XIAP mRNA	23125180
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of XIAP mRNA	18668222
C074702	chromium hexavalent ion	chromium hexavalent ion results in decreased expression of XIAP protein	29069462
C043561	chrysin	BCL2 protein inhibits the reaction [chrysin results in decreased expression of XIAP protein]	16215670
C043561	chrysin	chrysin results in decreased expression of XIAP protein	16215670
C039671	ciglitazone	ciglitazone results in decreased expression of XIAP	17940898
C012843	cinnamic aldehyde	cinnamic aldehyde results in decreased expression of XIAP protein	15566391
C012843	cinnamic aldehyde	Vitamin E inhibits the reaction [cinnamic aldehyde results in decreased expression of XIAP protein]	15566391
C002471	cinobufagin	cinobufagin results in decreased expression of XIAP protein	23164673
C068329	clofarabine	[clofarabine co-treated with fludarabine co-treated with Busulfan] results in decreased expression of XIAP protein	20933509
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of XIAP mRNA	17585979
D002994	Clofibrate	Clofibrate results in decreased expression of XIAP mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of XIAP mRNA]	17585979
C463759	codonoposide	codonoposide results in decreased expression of XIAP protein	15863893
D005576	Colforsin	[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of XIAP mRNA	21255191
D005576	Colforsin	[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of XIAP protein	21255191
D005576	Colforsin	[[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of XIAP protein] which results in decreased susceptibility to Cisplatin	21255191
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of XIAP mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate results in increased expression of XIAP mRNA	19549813
C058120	cordycepin	Acetylcysteine inhibits the reaction [cordycepin results in decreased expression of XIAP protein]	21310227
C058120	cordycepin	cordycepin results in decreased expression of XIAP protein	21310227
C494622	CPS 49	CPS 49 results in decreased expression of XIAP protein	15858615
C551994	crizotinib	crizotinib results in decreased expression of XIAP protein	22729845
C551994	crizotinib	MET gene mutant form promotes the reaction [crizotinib results in increased expression of XIAP protein]	22729845
C029892	cupric chloride	cupric chloride results in decreased expression of XIAP mRNA	24650576
D003474	Curcumin	[arsenic trioxide co-treated with Curcumin] results in decreased expression of XIAP protein	27430728
D003474	Curcumin	arsenic trioxide promotes the reaction [Curcumin results in decreased expression of XIAP protein]	20605902
D003474	Curcumin	Curcumin analog results in decreased expression of XIAP mRNA	17671737\|1925021
D003474	Curcumin	[Curcumin co-treated with Doxorubicin] affects the expression of XIAP mRNA	15911101
D003474	Curcumin	Curcumin inhibits the reaction [Nicotine results in increased expression of XIAP protein]	20727180
D003474	Curcumin	Curcumin inhibits the reaction [Paclitaxel results in increased expression of XIAP protein]	16243823
D003474	Curcumin	Curcumin inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]	16219905
D003474	Curcumin	Curcumin promotes the reaction [lonidamine results in decreased expression of XIAP protein]	20605902
D003474	Curcumin	Curcumin results in decreased expression of XIAP mRNA	17596214\|1767173
D003474	Curcumin	Curcumin results in decreased expression of XIAP protein	16023083\|1617396
D003474	Curcumin	lonidamine promotes the reaction [Curcumin results in decreased expression of XIAP protein]	20605902
D016572	Cyclosporine	Cyclosporine results in increased expression of XIAP mRNA	25562108
D016572	Cyclosporine	Cyclosporine results in decreased expression of XIAP mRNA	19770486
C017160	cypermethrin	cypermethrin results in increased expression of XIAP mRNA	27704156
C093628	cyproconazole	cyproconazole results in decreased expression of XIAP mRNA	22334560
D003561	Cytarabine	XIAP protein results in increased susceptibility to Cytarabine	10815900
D003609	Dactinomycin	Dactinomycin results in decreased expression of XIAP protein	12430140
C004315	danthron	danthron results in decreased expression of XIAP protein	21126053
C014347	decitabine	decitabine results in decreased expression of XIAP protein	19732952
C107676	deguelin	deguelin results in decreased expression of XIAP protein	17035597
C464444	dehydroxymethylepoxyquinomicin	dehydroxymethylepoxyquinomicin results in decreased expression of XIAP protein	15501958
D015255	Idarubicin	[Idarubicin co-treated with triptolide] affects the expression of XIAP protein	18922616
D003847	Deoxyglucose	[arsenic trioxide co-treated with Deoxyglucose] results in decreased expression of XIAP protein	23041229
D003907	Dexamethasone	Dexamethasone inhibits the reaction [TNF protein results in decreased expression of XIAP protein]	11399663
D003907	Dexamethasone	Dexamethasone inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]	21420233
D003907	Dexamethasone	Dexamethasone results in decreased expression of XIAP protein	16144937
D016264	Dextran Sulfate	Aspirin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of XIAP protein]	25449198
D016264	Dextran Sulfate	[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of XIAP protein	25449198
D016264	Dextran Sulfate	Camptothecin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of XIAP protein]	25449198
D016264	Dextran Sulfate	Plant Extracts inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of XIAP protein]	25449198
C028009	diallyl disulfide	diallyl disulfide results in decreased expression of XIAP protein	17647244
C042577	diallyl trisulfide	Acetylcysteine inhibits the reaction [diallyl trisulfide results in decreased expression of XIAP protein]	22578287
C042577	diallyl trisulfide	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [diallyl trisulfide results in decreased expression of XIAP protein]	21411500
C042577	diallyl trisulfide	diallyl trisulfide results in decreased expression of XIAP protein	21411500\|2257828
C042577	diallyl trisulfide	diallyl trisulfide results in increased degradation of XIAP protein	21411500
C042577	diallyl trisulfide	XIAP protein results in decreased susceptibility to diallyl trisulfide	21411500
C042577	diallyl trisulfide	diallyl trisulfide results in decreased expression of XIAP protein	21411500
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of XIAP mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of XIAP mRNA	21266533
D002945	Cisplatin	[arsenic trioxide co-treated with Cisplatin] affects the expression of XIAP mRNA	21118639
D002945	Cisplatin	Cisplatin affects the expression of XIAP protein	18071906
D002945	Cisplatin	Cisplatin inhibits the reaction [GNAS protein results in increased expression of XIAP mRNA]	21255191
D002945	Cisplatin	[Cisplatin promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP3 protein]] which results in increased cleavage of XIAP protein	20856198
D002945	Cisplatin	Cisplatin results in decreased expression of XIAP mRNA	16391810
D002945	Cisplatin	Cisplatin results in decreased expression of XIAP protein	15863139\|1639181
D002945	Cisplatin	[[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of XIAP protein] which results in decreased susceptibility to Cisplatin	21255191
D002945	Cisplatin	[CXCL8 results in increased expression of XIAP mRNA] which results in decreased susceptibility to Cisplatin	21742513
D002945	Cisplatin	[CXCL8 results in increased expression of XIAP protein] which results in decreased susceptibility to Cisplatin	21742513
D002945	Cisplatin	[GNAS protein results in increased expression of XIAP protein] which results in decreased susceptibility to Cisplatin	21255191
D002945	Cisplatin	Sirolimus promotes the reaction [Cisplatin results in decreased expression of XIAP protein]	18058806
D002945	Cisplatin	XIAP protein affects the susceptibility to Cisplatin	18071906
D002945	Cisplatin	XIAP protein results in decreased susceptibility to Cisplatin	11911975\|1465491
D004008	Diclofenac	Diclofenac affects the expression of XIAP mRNA	24752500
D004008	Diclofenac	Diclofenac results in increased expression of XIAP mRNA	26934552
D002117	Calcitriol	Calcitriol results in decreased expression of XIAP protein	12479363
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of XIAP mRNA"	22044346
D015127	9,10-Dimethyl-1,2-benzanthracene	"Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of XIAP mRNA]"	22044346
D004147	Dioxins	Dioxins affects the expression of XIAP mRNA	20463971
C067311	docetaxel	docetaxel results in decreased expression of XIAP protein	15688368\|1730807
C067311	docetaxel	XIAP protein results in decreased susceptibility to docetaxel	19102932
C076946	donepezil	donepezil inhibits the reaction [Hydrogen Peroxide results in decreased expression of XIAP protein]	19345205
D004317	Doxorubicin	XIAP affects the susceptibility to Doxorubicin	16953886
D004317	Doxorubicin	[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Doxorubicin] results in decreased expression of XIAP protein	20856197
D004317	Doxorubicin	[Curcumin co-treated with Doxorubicin] affects the expression of XIAP mRNA	15911101
D004317	Doxorubicin	Doxorubicin affects the expression of XIAP protein	18071906
D004317	Doxorubicin	Doxorubicin affects the localization of XIAP protein	15359644
D004317	Doxorubicin	Doxorubicin results in decreased expression of XIAP mRNA	11911975\|1974615
D004317	Doxorubicin	Doxorubicin results in decreased expression of XIAP protein	15359644
D004317	Doxorubicin	Doxorubicin results in increased expression of XIAP mRNA	17521628
D004317	Doxorubicin	[GNAS protein results in increased expression of XIAP protein] which results in decreased susceptibility to Doxorubicin	21255191
D004317	Doxorubicin	[PI103 co-treated with Doxorubicin] results in decreased expression of XIAP protein	20856197
D004317	Doxorubicin	XIAP protein affects the susceptibility to Doxorubicin	18071906
D004317	Doxorubicin	XIAP protein results in decreased susceptibility to Doxorubicin	11911975\|1621130
D004317	Doxorubicin	Doxorubicin results in decreased expression of XIAP protein	17223244
C022999	echinocystic acid	echinocystic acid analog results in decreased expression of XIAP protein	15863893
C034192	ellipticine	ellipticine results in decreased expression of XIAP protein	16027529\|2184358
C010945	embelin	embelin results in decreased activity of XIAP protein	16339139
C010945	embelin	embelin results in decreased activity of XIAP protein	20144727
C561944	EMD 534085	EMD 534085 results in decreased expression of XIAP protein	18451153
C530049	ent-1,3,6,11-tetrahydroxykaur-16-ene-15-one 3,11-diacetate	"ent-1,3,6,11-tetrahydroxykaur-16-ene-15-one 3,11-diacetate results in decreased expression of XIAP protein"	19509257
C118739	entinostat	[3-(4-methylphenylsulfonyl)-2-propenenitrile co-treated with entinostat] results in decreased expression of XIAP protein	15964800
C118739	entinostat	[fludarabine co-treated with entinostat] results in increased expression of XIAP protein	15059916
C118739	entinostat	XIAP protein results in decreased susceptibility to [entinostat co-treated with 3-(4-methylphenylsulfonyl)-2-propenenitrile]	15964800
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of XIAP protein	23301498
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of XIAP	15705601
D034261	Epothilones	Epothilones promotes the reaction [alvocidib results in decreased expression of XIAP mRNA]	12517783
D034261	Epothilones	Epothilones promotes the reaction [alvocidib results in decreased expression of XIAP protein]	12517783
C109476	epoxiconazole	epoxiconazole results in decreased expression of XIAP mRNA	22334560
D004970	Estrone	Estrone results in increased expression of XIAP mRNA	21767602
D004970	Estrone	Estrone results in increased expression of XIAP protein	21767602
D004976	Ethacrynic Acid	[arsenic trioxide co-treated with Ethacrynic Acid] results in decreased expression of XIAP protein	23082001
D000431	Ethanol	ALDH2 protein inhibits the reaction [Ethanol results in increased expression of XIAP protein]	19429258
D000431	Ethanol	Ethanol results in decreased expression of XIAP mRNA	22535522
D000431	Ethanol	Ethanol results in increased expression of XIAP protein	19429258
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of XIAP mRNA	29097150
C049639	evodiamine	evodiamine inhibits the reaction [TNF protein results in increased expression of XIAP protein]	15710601
C411675	F 12509A	F 12509A results in decreased expression of XIAP protein	16281067
C049328	flavone acetic acid	XIAP protein results in increased susceptibility to flavone acetic acid	10815900
C024352	fludarabine	[clofarabine co-treated with fludarabine co-treated with Busulfan] results in decreased expression of XIAP protein	20933509
C024352	fludarabine	[fludarabine co-treated with entinostat] results in increased expression of XIAP protein	15059916
D005459	Fluorides	[Arsenic co-treated with Fluorides] results in increased expression of XIAP mRNA	19962721
D005472	Fluorouracil	Fluorouracil promotes the reaction [arsenic trioxide results in decreased expression of XIAP protein]	22963400
D005472	Fluorouracil	Fluorouracil results in decreased expression of XIAP mRNA	28599477
D005472	Fluorouracil	Fluorouracil results in increased expression of XIAP mRNA	16628085
D005472	Fluorouracil	Fluorouracil results in increased expression of XIAP protein	16628085
D005472	Fluorouracil	[SM-1 compound co-treated with Fluorouracil] results in decreased expression of XIAP mRNA	28599477
D005472	Fluorouracil	SM-1 compound promotes the reaction [Fluorouracil results in decreased expression of XIAP mRNA]	28599477
D005472	Fluorouracil	XIAP affects the susceptibility to Fluorouracil	16628085
D005472	Fluorouracil	XIAP protein inhibits the reaction [Fluorouracil results in increased susceptibility to TNFSF10 protein]	20876774
D005473	Fluoxetine	Fluoxetine results in increased expression of XIAP mRNA	17033635
D005485	Flutamide	Flutamide results in increased expression of XIAP mRNA	24136188
C039281	furan	furan results in decreased expression of XIAP mRNA	26194646
D005665	Furosemide	Furosemide affects the expression of XIAP mRNA	17497460
C002469	fusarenon-X	fusarenon-X results in decreased expression of XIAP mRNA	24983900
C064925	gadodiamide	gadodiamide results in increased expression of XIAP mRNA	20959327
D005688	Galactosamine	baicalein inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased activity of XIAP protein]	20850421
D005688	Galactosamine	[Galactosamine co-treated with Lipopolysaccharides] results in decreased activity of XIAP protein	20850421
D005688	Galactosamine	Silymarin inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased activity of XIAP protein]	20850421
D005707	Gallic Acid	Gallic Acid inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]	21420233
C056507	gemcitabine	XIAP affects the susceptibility to gemcitabine	16628085
D019833	Genistein	[Genistein co-treated with TNFSF10 protein] results in decreased expression of XIAP protein	19497411
D019833	Genistein	Genistein promotes the reaction [arsenic trioxide results in decreased expression of XIAP protein]	18546268
D019833	Genistein	Genistein results in decreased expression of XIAP protein	18546268
C007845	gingerol	gingerol results in decreased expression of XIAP protein	25034532
D005978	Glutathione	Glutathione inhibits the reaction [Thimerosal results in decreased expression of XIAP protein]	12140745
C037258	gusperimus	XIAP protein results in increased susceptibility to gusperimus	10815900
C500810	GW8510	GW8510 results in decreased activity of XIAP protein	16322690
C500810	GW8510	GW8510 results in decreased expression of XIAP mRNA	16322690
C500810	GW8510	GW8510 results in decreased expression of XIAP protein	16322690
C529376	GYY 4137	GYY 4137 results in decreased expression of XIAP protein	25205294
D018738	Hexamethonium	Hexamethonium affects the reaction [Nicotine results in increased expression of XIAP protein]	16601104
C501367	hispanolone	hispanolone analog results in decreased expression of XIAP protein	25930665
D017313	Fenretinide	Fenretinide results in decreased expression of XIAP protein	17159502
C029424	hydrazine	XIAP protein results in increased susceptibility to hydrazine	10815900
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of XIAP mRNA	26846883
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of XIAP mRNA	18951874
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of XIAP mRNA	21347231
D006861	Hydrogen Peroxide	[Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of XIAP mRNA	20606027
D006861	Hydrogen Peroxide	[Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of XIAP protein	20606027
D006861	Hydrogen Peroxide	RELA protein promotes the reaction [Hydrogen Peroxide results in decreased expression of XIAP mRNA]	21347231
D006861	Hydrogen Peroxide	"2-(4-((dimethylamino)methyl)benzylidene)-5,6-dimethoxy-2,3-dihydroinden-1-one inhibits the reaction [Hydrogen Peroxide results in decreased expression of XIAP protein]"	19345205
D006861	Hydrogen Peroxide	donepezil inhibits the reaction [Hydrogen Peroxide results in decreased expression of XIAP protein]	19345205
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of XIAP protein	19345205
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of XIAP protein	16157298
C016517	indole-3-carbinol	indole-3-carbinol inhibits the reaction [TNF protein results in increased expression of XIAP protein]	15811958
C016517	indole-3-carbinol	indole-3-carbinol results in decreased expression of XIAP	16082211
D007213	Indomethacin	Indomethacin inhibits the reaction [LTA protein results in increased expression of XIAP protein]	17873517
C051890	irinotecan	[irinotecan co-treated with alvocidib] results in increased cleavage of XIAP protein	11751522
D015056	1-Methyl-3-isobutylxanthine	[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of XIAP mRNA	21255191
D015056	1-Methyl-3-isobutylxanthine	[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of XIAP protein	21255191
D015056	1-Methyl-3-isobutylxanthine	[[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of XIAP protein] which results in decreased susceptibility to Cisplatin	21255191
D007530	Isoflurane	Isoflurane results in decreased expression of XIAP mRNA	16978161
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of XIAP mRNA	26254443
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of XIAP protein	26254443
D007608	Kainic Acid	XIAP protein results in decreased susceptibility to Kainic Acid	16336964
C477361	LAQ824	[LAQ824 co-treated with roscovitine] results in decreased expression of XIAP mRNA	16275999
C477361	LAQ824	[LAQ824 co-treated with roscovitine] results in decreased expression of XIAP protein	16275999
C477361	LAQ824	LAQ824 results in decreased expression of XIAP protein	16189296
C477361	LAQ824	XIAP protein results in decreased susceptibility to LAQ824	16189296
C482199	lipopolysaccharide, E coli O55-B5	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of XIAP mRNA"	18930950
D008070	Lipopolysaccharides	baicalein inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased activity of XIAP protein]	20850421
D008070	Lipopolysaccharides	[Galactosamine co-treated with Lipopolysaccharides] results in decreased activity of XIAP protein	20850421
D008070	Lipopolysaccharides	Silymarin inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased activity of XIAP protein]	20850421
C115354	lonafarnib	lonafarnib inhibits the reaction [TNF protein results in increased expression of XIAP protein]	15090542
C016371	lonidamine	arsenic trioxide promotes the reaction [lonidamine results in decreased expression of XIAP protein]	21889928
C016371	lonidamine	Curcumin promotes the reaction [lonidamine results in decreased expression of XIAP protein]	20605902
C016371	lonidamine	lonidamine promotes the reaction [arsenic trioxide results in decreased expression of XIAP protein]	21889928
C016371	lonidamine	lonidamine promotes the reaction [Curcumin results in decreased expression of XIAP protein]	20605902
C016371	lonidamine	lonidamine results in decreased expression of XIAP protein	20605902\|2188992
D008148	Lovastatin	Lovastatin results in increased expression of XIAP mRNA	26739623
D047311	Luteolin	Luteolin promotes the reaction [TNFSF10 protein results in increased ubiquitination of and results in increased degradation of and results in decreased expression of XIAP protein]	16140950
C094099	LY 293111	LY 293111 results in increased cleavage of XIAP protein	16151469
C501277	Mangifera indica extract	Mangifera indica extract inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]	21420233
C013592	mangiferin	mangiferin inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]	21420233
C013592	mangiferin	mangiferin results in decreased expression of XIAP protein	21547680\|2699654
D008555	Melitten	Melitten results in decreased expression of XIAP protein	21456063
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of XIAP mRNA	20353558
D008627	Mercuric Chloride	"[NOG protein co-treated with Mercuric Chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of XIAP mRNA"	27188386
C555027	methyl 5-chloro-4,5-didehydrojasmonate	"methyl 5-chloro-4,5-didehydrojasmonate results in decreased expression of XIAP protein"	20696234
C072239	methyl jasmonate	methyl jasmonate metabolite promotes the reaction [TNFSF10 protein results in decreased expression of XIAP protein]	22079975
D008770	Methylnitrosourea	XIAP protein results in decreased susceptibility to Methylnitrosourea	12766084
D008911	Minocycline	[Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of XIAP mRNA	20606027
D008911	Minocycline	[Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of XIAP protein	20606027
D008911	Minocycline	Minocycline results in increased expression of XIAP protein	14998631
D016685	Mitomycin	XIAP protein affects the susceptibility to Mitomycin	17641843
D008942	Mitoxantrone	Mitoxantrone affects the localization of XIAP protein	15359644
D008942	Mitoxantrone	Mitoxantrone results in decreased expression of XIAP protein	15359644
C455139	myrtucommulone A	myrtucommulone A results in decreased expression of XIAP mRNA	26032814
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of XIAP mRNA"	29244179
C469937	N(2)-(2-aminocyclohexyl)-N(6)-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine	"N(2)-(2-aminocyclohexyl)-N(6)-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine results in decreased expression of XIAP protein"	16140939
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased expression of XIAP mRNA	21255191
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in increased expression of XIAP protein	21255191
C058815	N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide	N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide promotes the reaction [TNFSF10 protein results in increased expression of XIAP protein]	15520213
D053644	Naphthalimides	[Naphthalimides co-treated with Spermidine] results in decreased expression of XIAP protein	21349322
C017557	nickel subsulfide	nickel subsulfide results in decreased expression of XIAP mRNA	24952340
D009534	Niclosamide	Niclosamide results in decreased expression of XIAP protein	20215516
D009538	Nicotine	Curcumin inhibits the reaction [Nicotine results in increased expression of XIAP protein]	20727180
D009538	Nicotine	Hexamethonium affects the reaction [Nicotine results in increased expression of XIAP protein]	16601104
D009538	Nicotine	Nicotine results in increased expression of XIAP mRNA	21267677
D009538	Nicotine	Nicotine results in increased expression of XIAP protein	16601104\|1867677
D009569	Nitric Oxide	Nitric Oxide results in decreased expression of XIAP mRNA	15126337
D009569	Nitric Oxide	Nitric Oxide results in increased expression of XIAP protein	14634119
C064541	NSC 366140	XIAP protein results in increased susceptibility to NSC 366140	10815900
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of XIAP mRNA	20971185
C016340	o,p'-DDT	"o,p'-DDT analog results in decreased expression of XIAP mRNA"	22937105
D008939	Mitotane	Mitotane analog results in increased expression of XIAP mRNA	23485034
C005290	oxybenzone	oxybenzone results in decreased expression of XIAP mRNA	22721600
D017239	Paclitaxel	Curcumin inhibits the reaction [Paclitaxel results in increased expression of XIAP protein]	16243823
D017239	Paclitaxel	[CXCL8 results in increased expression of XIAP mRNA] which results in decreased susceptibility to Paclitaxel	21742513
D017239	Paclitaxel	[CXCL8 results in increased expression of XIAP protein] which results in decreased susceptibility to Paclitaxel	21742513
D017239	Paclitaxel	Paclitaxel affects the expression of XIAP protein	18071906
D017239	Paclitaxel	Paclitaxel results in decreased expression of XIAP protein	16356831\|1845115
D010269	Paraquat	Paraquat results in decreased expression of XIAP mRNA	18836921
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of XIAP mRNA	18593933
D010416	Pentachlorophenol	Pentachlorophenol results in decreased expression of XIAP mRNA	23892564
D010424	Pentobarbital	Pentobarbital results in decreased expression of XIAP mRNA	16978161
D010431	Pentoxifylline	[Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of XIAP protein	20804743
C058305	phenethyl isothiocyanate	benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [phenethyl isothiocyanate results in decreased expression of XIAP protein]	16054126
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in decreased expression of XIAP protein	16054126
C058305	phenethyl isothiocyanate	Vitamin E inhibits the reaction [phenethyl isothiocyanate results in decreased expression of XIAP protein]	16054126
D010634	Phenobarbital	Phenobarbital results in decreased expression of XIAP mRNA	23091169
C471183	phenoxodiol	phenoxodiol results in increased degradation of XIAP protein	16388521
D010695	Phlorhizin	Phlorhizin results in decreased expression of XIAP mRNA	22538082
C522973	PI103	[PI103 co-treated with Doxorubicin] results in decreased expression of XIAP protein	20856197
C121565	pifithrin	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[pifithrin co-treated with Topotecan] results in increased degradation of XIAP protein]	19812371
C121565	pifithrin	[Topotecan co-treated with pifithrin] results in increased degradation of XIAP protein	19812371
C006253	pirinixic acid	pirinixic acid results in decreased expression of XIAP mRNA	18445702
C006253	pirinixic acid	pirinixic acid results in increased expression of XIAP mRNA	17426115
D010936	Plant Extracts	Plant Extracts results in decreased expression of XIAP protein	25449198\|2612252
D010936	Plant Extracts	Plant Extracts results in increased expression of XIAP mRNA	23557933
D010936	Plant Extracts	Plant Extracts inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of XIAP protein]	25449198
D010936	Plant Extracts	Plant Extracts results in increased expression of XIAP protein	16041641
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls affects the expression of XIAP mRNA	21334430
C472086	polyphenon E	polyphenon E results in decreased expression of XIAP protein	23285096
C023617	pregna-4,17-diene-3,16-dione	"pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]"	15322087
C045950	propiconazole	propiconazole results in decreased expression of XIAP mRNA	22334560
C033607	puerarin	puerarin results in increased expression of XIAP protein	16041641
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [trimethyltin chloride results in decreased expression of XIAP protein]	23423712
D011753	Pyrones	Pyrones inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]	21296074
D011794	Quercetin	Quercetin inhibits the reaction [Cadmium Chloride results in decreased expression of XIAP mRNA]	21262342
D011794	Quercetin	arsenic trioxide promotes the reaction [Quercetin results in decreased expression of XIAP protein]	18359480
D011794	Quercetin	Quercetin results in decreased expression of XIAP mRNA	20596804
D011794	Quercetin	Quercetin results in decreased expression of XIAP protein	18359480\|2461213
D011794	Quercetin	"Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of XIAP mRNA]"	22044346
D017382	Reactive Oxygen Species	[[Bortezomib co-treated with Butyrates] results in increased abundance of Reactive Oxygen Species] which results in decreased expression of XIAP protein	15173093
D017382	Reactive Oxygen Species	[[Bortezomib co-treated with vorinostat] results in increased abundance of Reactive Oxygen Species] which results in decreased expression of XIAP protein	15173093
D017382	Reactive Oxygen Species	[sanguinarine results in increased chemical synthesis of Reactive Oxygen Species] which results in decreased expression of XIAP protein	23660334
D017382	Reactive Oxygen Species	[Sulindac results in increased abundance of Reactive Oxygen Species] which results in decreased expression of XIAP protein	17136320
D012116	Resins, Plant	"Resins, Plant results in increased expression of XIAP protein"	27268964
C059514	resveratrol	benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [resveratrol results in increased expression of XIAP protein]	12689943
C059514	resveratrol	resveratrol results in decreased expression of XIAP protein	16490592\|1704912
C059514	resveratrol	resveratrol results in increased expression of XIAP mRNA	17261084
C059514	resveratrol	resveratrol results in increased expression of XIAP protein	12689943
C059514	resveratrol	resveratrol results in increased expression of XIAP protein	21248286
D012293	Rifampin	Rifampin results in increased expression of XIAP protein	12645856
C087123	romidepsin	[romidepsin co-treated with Bortezomib] results in decreased expression of XIAP protein	18223231
C104586	roscovitine	[LAQ824 co-treated with roscovitine] results in decreased expression of XIAP mRNA	16275999
C104586	roscovitine	[LAQ824 co-treated with roscovitine] results in decreased expression of XIAP protein	16275999
C104586	roscovitine	roscovitine results in decreased expression of XIAP protein	16140939\|1623039
C089730	rosiglitazone	rosiglitazone results in decreased expression of XIAP mRNA	19467017\|1973182
C089730	rosiglitazone	Tretinoin promotes the reaction [rosiglitazone results in decreased expression of XIAP mRNA]	19467017\|1973182
C085746	rottlerin	rottlerin results in decreased expression of XIAP protein	22902833
C005705	sanguinarine	[sanguinarine results in increased chemical synthesis of Reactive Oxygen Species] which results in decreased expression of XIAP protein	23660334
C115461	SC 560	SC 560 results in decreased expression of XIAP protein	16391822
C516024	SH-6 compound	SH-6 compound results in decreased expression of XIAP protein	17289836
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of XIAP mRNA	25351596
D012838	Silymarin	Silymarin inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased activity of XIAP protein]	20850421
D019821	Simvastatin	Simvastatin results in decreased expression of XIAP mRNA	19262002
D019821	Simvastatin	Simvastatin results in decreased expression of XIAP protein	19262002
D020123	Sirolimus	Sirolimus promotes the reaction [Cisplatin results in decreased expression of XIAP protein]	18058806
C000619853	SM-1 compound	[SM-1 compound co-treated with Fluorouracil] results in decreased expression of XIAP mRNA	28599477
C000619853	SM-1 compound	SM-1 compound promotes the reaction [Fluorouracil results in decreased expression of XIAP mRNA]	28599477
C009277	sodium arsenate	sodium arsenate results in increased expression of XIAP mRNA	21795629
C017947	sodium arsenite	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in decreased expression of XIAP protein]	22627131
C017947	sodium arsenite	sodium arsenite results in decreased expression of XIAP protein	22627131
C017947	sodium arsenite	sodium arsenite results in increased ubiquitination of and results in increased degradation of XIAP protein	22627131
C017947	sodium arsenite	XIAP protein inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein]	22627131
C017947	sodium arsenite	XIAP results in decreased susceptibility to sodium arsenite	22627131
C471405	sorafenib	[sorafenib co-treated with TNFSF10 protein] results in increased cleavage of XIAP protein	17909059
C471405	sorafenib	sorafenib results in decreased expression of XIAP protein	18200035
C471405	sorafenib	sorafenib results in increased cleavage of XIAP protein	16109713
D013095	Spermidine	[Naphthalimides co-treated with Spermidine] results in decreased expression of XIAP protein	21349322
D013311	Streptozocin	Streptozocin results in increased expression of XIAP protein	15976052
C016766	sulforafan	sulforafan results in decreased expression of XIAP protein	26833863
D013467	Sulindac	[Sulindac results in increased abundance of Reactive Oxygen Species] which results in decreased expression of XIAP protein	17136320
D000952	Antigens, Polyomavirus Transforming	"Antigens, Polyomavirus Transforming results in increased expression of XIAP mRNA"	26680231
C112765	tanespimycin	[tanespimycin co-treated with TNFSF10 protein] results in decreased expression of XIAP protein	15993848
C047246	temozolomide	temozolomide inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]	17638900
C047246	temozolomide	temozolomide results in decreased expression of XIAP mRNA	17638900
C047246	temozolomide	temozolomide results in decreased expression of XIAP protein	28122345
C047246	temozolomide	XAF1 protein promotes the reaction [temozolomide results in decreased expression of XIAP protein]	28122345
C010792	testosterone undecanoate	testosterone undecanoate results in decreased expression of XIAP mRNA	19074003
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of XIAP mRNA	28970181
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of XIAP mRNA	14718646
C117155	tetracycline CMT-3	tetracycline CMT-3 results in decreased expression of XIAP protein	15688368
D013792	Thalidomide	Thalidomide analog results in decreased expression of XIAP protein	15858615
D019284	Thapsigargin	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased expression of XIAP mRNA]	15339911
D019284	Thapsigargin	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased expression of XIAP protein]	15339911
D019284	Thapsigargin	Thapsigargin results in decreased expression of XIAP protein	16382148
D019284	Thapsigargin	Thapsigargin results in increased expression of XIAP mRNA	15339911
D019284	Thapsigargin	Thapsigargin results in increased expression of XIAP protein	15339911
D013806	Theophylline	Theophylline results in increased expression of XIAP mRNA	18951874
D013849	Thimerosal	Glutathione inhibits the reaction [Thimerosal results in decreased expression of XIAP protein]	12140745
D013849	Thimerosal	Thimerosal affects the expression of XIAP protein	16649253
D013849	Thimerosal	Thimerosal results in decreased expression of XIAP protein	12140745
C009495	titanium dioxide	titanium dioxide affects the expression of XIAP mRNA	17656681
D019772	Topotecan	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[pifithrin co-treated with Topotecan] results in increased degradation of XIAP protein]	19812371
D019772	Topotecan	[Topotecan co-treated with pifithrin] results in increased degradation of XIAP protein	19812371
D019772	Topotecan	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Topotecan results in increased degradation of XIAP protein]	19812371
D019772	Topotecan	Topotecan results in increased degradation of XIAP protein	19812371
D019772	Topotecan	TRP53 inhibits the reaction [Topotecan results in increased degradation of XIAP protein]	19812371
D014108	Tosylphenylalanyl Chloromethyl Ketone	Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of XIAP protein]	19679660
D014108	Tosylphenylalanyl Chloromethyl Ketone	Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of XIAP protein	19679660
D014212	Tretinoin	Tretinoin promotes the reaction [rosiglitazone results in decreased expression of XIAP mRNA]	19467017\|1973182
C012589	trichostatin A	trichostatin A results in decreased expression of XIAP mRNA	24935251
C040533	trimethyltin chloride	3-(4-methylphenylsulfonyl)-2-propenenitrile promotes the reaction [trimethyltin chloride results in decreased expression of XIAP protein]	23423712
C040533	trimethyltin chloride	benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [trimethyltin chloride results in decreased expression of XIAP protein]	23423712
C040533	trimethyltin chloride	pyrazolanthrone inhibits the reaction [trimethyltin chloride results in decreased expression of XIAP protein]	23423712
C040533	trimethyltin chloride	trimethyltin chloride results in decreased expression of XIAP protein	23423712
C040533	trimethyltin chloride	U 0126 inhibits the reaction [trimethyltin chloride results in decreased expression of XIAP protein]	23423712
C001899	triptolide	[Idarubicin co-treated with triptolide] affects the expression of XIAP protein	18922616
C080163	trovafloxacin	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of XIAP mRNA"	18930950
C113580	U 0126	U 0126 inhibits the reaction [trimethyltin chloride results in decreased expression of XIAP protein]	23423712
C501517	UCF 101	UCF 101 results in decreased degradation of XIAP protein	15967379
C406224	valdecoxib	valdecoxib results in decreased expression of XIAP mRNA	24136188
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of XIAP mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of XIAP mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of XIAP mRNA	23179753\|2627250
D014635	Valproic Acid	Valproic Acid affects the expression of XIAP mRNA	17292431
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of XIAP gene	25560391
D014757	Viper Venoms	Viper Venoms results in decreased expression of XIAP protein	25417048
D014810	Vitamin E	Vitamin E inhibits the reaction [cinnamic aldehyde results in decreased expression of XIAP protein]	15566391
D014810	Vitamin E	Vitamin E inhibits the reaction [phenethyl isothiocyanate results in decreased expression of XIAP protein]	16054126
C111237	vorinostat	[3-(4-methylphenylsulfonyl)-2-propenenitrile co-treated with vorinostat] results in decreased expression of XIAP protein	15964800
C111237	vorinostat	Acetylcysteine inhibits the reaction [[Bortezomib co-treated with vorinostat] results in decreased expression of XIAP protein]	15173093
C111237	vorinostat	Boc-D-FMK inhibits the reaction [[Bortezomib co-treated with vorinostat] results in decreased expression of XIAP protein]	15173093
C111237	vorinostat	[Bortezomib co-treated with vorinostat] results in decreased expression of XIAP protein	15173093
C111237	vorinostat	[[Bortezomib co-treated with vorinostat] results in increased abundance of Reactive Oxygen Species] which results in decreased expression of XIAP protein	15173093
C111237	vorinostat	TNFSF10 protein promotes the reaction [vorinostat results in decreased expression of XIAP protein]	17410615
C111237	vorinostat	[vorinostat co-treated with TNFSF10 protein] results in decreased expression of XIAP protein	19643600
C111237	vorinostat	vorinostat inhibits the reaction [TNF protein results in increased expression of XIAP protein]	16377638
C111237	vorinostat	vorinostat results in decreased expression of XIAP protein	16144943\|1741061
C111237	vorinostat	XIAP protein results in decreased susceptibility to [vorinostat co-treated with 3-(4-methylphenylsulfonyl)-2-propenenitrile]	15964800
C403304	zerumbone	zerumbone results in decreased expression of XIAP mRNA	16007145
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of XIAP mRNA	18593933
D015032	Zinc	Zinc deficiency results in increased expression of XIAP mRNA	19111725
C088658	zoledronic acid	zoledronic acid results in decreased expression of XIAP mRNA	19036117
C002205	zorubicin	XIAP protein results in increased susceptibility to zorubicin	10815900
D015054	Zymosan	Zymosan analog results in decreased expression of XIAP mRNA	16803582

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004842	ubiquitin-protein transferase activity	-	IDA	19473982 20154138 21931591 22304967
GO:0005515	protein binding	-	IPI	9525868 11140638 11242052 11257230 11257231 11257232 11546791 11583623 11602612 11604410 11801603 12620238 14685266 16189514 16282325 17318174 18022362 19273858 19473982 19549727 19667203 20154138 20171186 21185211 21536684 21849505 21931591 22117219 22304967 22465666 22493164 23251006 24698088 25241761 25260751 25416956 25910212 27107012 27107014 27173435
GO:0042802	identical protein binding	-	IPI	16189514 19273858 27107012
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	-	IBA	21873635
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	-	IDA	9230442
GO:0046872	metal ion binding	-	IEA	-
GO:0061630	ubiquitin protein ligase activity	-	EXP	22304967
GO:0061630	ubiquitin protein ligase activity	-	IBA	21873635
GO:0061630	ubiquitin protein ligase activity	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006915	apoptotic process	-	IEA	-
GO:0006974	cellular response to DNA damage stimulus	-	IEP	18049476
GO:0016055	Wnt signaling pathway	-	IEA	-
GO:0016567	protein ubiquitination	-	IEA	-
GO:0030510	regulation of BMP signaling pathway	-	TAS	18414036
GO:0031398	positive regulation of protein ubiquitination	-	IDA	21931591
GO:0042127	regulation of cell proliferation	-	TAS	18414036
GO:0043066	negative regulation of apoptotic process	-	IMP	18049476 22173242
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	-	IDA	11583623
GO:0045088	regulation of innate immune response	-	TAS	21447281
GO:0050727	regulation of inflammatory response	-	TAS	21447281
GO:0055070	copper ion homeostasis	-	TAS	17382285
GO:0070424	regulation of nucleotide-binding oligomerization domain containing signaling pathway	-	TAS	20888210
GO:0090263	positive regulation of canonical Wnt signaling pathway	-	IBA	21873635
GO:0090263	positive regulation of canonical Wnt signaling pathway	-	IMP	22304967
GO:0090307	mitotic spindle assembly	-	IBA	21873635
GO:1902530	positive regulation of protein linear polyubiquitination	-	IDA	21931591
GO:1990001	inhibition of cysteine-type endopeptidase activity involved in apoptotic process	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IDA	22304967
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005737	cytoplasm	-	IDA	15665297 22304967
GO:0005829	cytosol	-	TAS	-

KEGG ID	KEGG Term
hsa04120	Ubiquitin mediated proteolysis
hsa04210	Apoptosis
hsa04510	Focal adhesion
hsa04621	NOD-like receptor signaling pathway
hsa05145	Toxoplasmosis
hsa05200	Pathways in cancer
hsa05222	Small cell lung cancer

Reactome ID	Reactome Term	Evidence
R-HSA-109581	Apoptosis	IEA
R-HSA-109581	Apoptosis	TAS
R-HSA-109606	Intrinsic Pathway for Apoptosis	IEA
R-HSA-109606	Intrinsic Pathway for Apoptosis	TAS
R-HSA-111463	SMAC binds to IAPs	IEA
R-HSA-111463	SMAC binds to IAPs	TAS
R-HSA-111464	SMAC-mediated dissociation of IAP:caspase complexes	IEA
R-HSA-111464	SMAC-mediated dissociation of IAP:caspase complexes	TAS
R-HSA-111469	SMAC-mediated apoptotic response	IEA
R-HSA-111469	SMAC-mediated apoptotic response	TAS
R-HSA-111471	Apoptotic factor-mediated response	IEA
R-HSA-111471	Apoptotic factor-mediated response	TAS
R-HSA-1257604	PIP3 activates AKT signaling	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-195721	Signaling by WNT	TAS
R-HSA-201681	TCF dependent signaling in response to WNT	TAS
R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	TAS
R-HSA-5213460	RIPK1-mediated regulated necrosis	TAS
R-HSA-5218859	Regulated Necrosis	TAS
R-HSA-5357801	Programmed Cell Death	IEA
R-HSA-5357801	Programmed Cell Death	TAS
R-HSA-5357905	Regulation of TNFR1 signaling	TAS
R-HSA-5357956	TNFR1-induced NFkappaB signaling pathway	TAS
R-HSA-5675482	Regulation of necroptotic cell death	TAS
R-HSA-6807070	PTEN Regulation	TAS
R-HSA-73887	Death Receptor Signalling	TAS
R-HSA-75893	TNF signaling	TAS
R-HSA-8948747	Regulation of PTEN localization	TAS
R-HSA-8948751	Regulation of PTEN stability and activity	TAS
R-HSA-9006925	Intracellular signaling by second messengers	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24852426	Evaluation of urinary XIAP as a diagnostic biomarker of carcinoma of urinary bladder. (2014 Aug)	Srivastava AK	Tumour Biol
29037837	The correlation between XIAP gene polymorphisms and esophageal squamous cell carcinoma susceptibility and prognosis in a Chinese population. (2017 Dec)	Peng H	Pathol Res Pract
18309651	[Expression of inhibitor of apoptosis protein XIAP in laryngeal carcinoma and its clinicopathological significance]. (2007 Nov)	Li X	Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
25421516	Markers of apoptosis induction and proliferation in the orbitofrontal cortex in alcohol dependence. (2014 Nov)	Whittom A	Alcohol Clin Exp Res
18068526	Identification of polymorphisms in the XIAP gene and analysis of association with lung cancer risk in a Korean population. (2008 Jan 1)	Kang HG	Cancer Genet Cytogenet
11566739	Influence of maternal smoking on trophoblast apoptosis throughout development: possible involvement of Xiap regulation. (2001 Oct)	Gruslin A	Biol Reprod
18559983	Fetal growth restriction triggered by polycyclic aromatic hydrocarbons is associated with altered placental vasculature and AhR-dependent changes in cell death. (2008 Aug)	Detmar J	Am J Physiol Endocrinol Metab
27613305	Decreased activation of placental mTOR family members is associated with the induction of intrauterine growth restriction by secondhand smoke in the mouse. (2017 Feb)	Mejia C	Cell Tissue Res
27737349	Morphological and immunohistochemical analysis of apoptosis in the cerebellum of rats subjected to focal cerebral ischemia with or without alcoholism model. (2016 Sep)	Carvalho CA	Acta Cir Bras
19429258	Aldehyde dehydrogenase-2 transgene ameliorates chronic alcohol ingestion-induced apoptosis in cerebral cortex. (2009 Jun 22)	Ren J	Toxicol Lett
16601104	Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and survivin. (2006 Apr 18)	Dasgupta P	Proc Natl Acad Sci U S A