Gene: HSPA6

3310
HSP70B'
heat shock protein family A (Hsp70) member 6
protein-coding
1q23.3
Ensembl:ENSG00000173110 MIM:140555 Vega:OTTHUMG00000034461 UniprotKB:P17066
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.920e-1 (AD)  6.373e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SERPINH10.922
DNAJB10.878
HSPA1A0.861
HSPA1B0.841
ZC3H12A0.812
ATF30.767
G0S20.761
BAG30.751
RRAD0.749
SNAI10.747

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF223-0.455
ENPP6-0.42
MBLAC2-0.42
KNCN-0.403
MAP10-0.402
ASIC2-0.398
STAR-0.397
AMER3-0.396
CASC15-0.394
KBTBD7-0.393

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0394111,2-dibromo-2,4-dicyanobutane"1,2-dibromo-2,4-dicyanobutane results in increased expression of HSPA6 mRNA"23999411
C0152621,6-hexamethylene diisocyanate"1,6-hexamethylene diisocyanate affects the expression of HSPA6 mRNA"19110044
C0038982-anisidine2-anisidine results in increased expression of HSPA6 mRNA28089782
C0127962-butenal[2-butenal co-treated with Tetradecanoylphorbol Acetate] results in increased expression of HSPA6 mRNA24849683
C0127962-butenal2-butenal results in increased expression of HSPA6 mRNA20471460
C0144643,4-dichloroaniline"3,4-dichloroaniline results in increased expression of HSPA6 mRNA"24172598
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPA6 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of HSPA6 mRNA"19561079
C0275634-nitrobenzyl bromide4-nitrobenzyl bromide results in increased expression of HSPA6 mRNA23999411
C0297284-phenylenediamine4-phenylenediamine results in increased expression of HSPA6 mRNA23999411
C4771875-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole"5-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole affects the expression of HSPA6 mRNA"22745752
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPA6 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of HSPA6 mRNA21420995
D000393Air PollutantsAir Pollutants results in increased expression of HSPA6 mRNA23649983
C018453ammonium hexachloroplatinateammonium hexachloroplatinate affects the expression of HSPA6 mRNA19110044
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of HSPA6 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of HSPA6 mRNA15978632|1941714
C006632arsenic trioxidearsenic trioxide results in increased expression of HSPA6 protein15978632|1936412
C006632arsenic trioxideMAP2K4 protein promotes the reaction [arsenic trioxide results in increased expression of HSPA6 mRNA]15978632
C006632arsenic trioxideMAP2K4 protein promotes the reaction [arsenic trioxide results in increased expression of HSPA6 protein]15978632
C006632arsenic trioxidepyrazolanthrone inhibits the reaction [arsenic trioxide results in increased expression of HSPA6 mRNA]15978632
C006632arsenic trioxidepyrazolanthrone inhibits the reaction [arsenic trioxide results in increased expression of HSPA6 protein]15978632
C015001arsenitearsenite results in increased expression of HSPA6 mRNA16132727
D017636Asbestos, Amphibole"Asbestos, Amphibole results in increased expression of HSPA6 protein"20855422
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of HSPA6 mRNA"18687144|2535159
C017037aurinaurin results in increased expression of HSPA6 mRNA25477506
D001374AzacitidineAzacitidine results in increased expression of HSPA6 mRNA19194470
D004958EstradiolEstradiol results in decreased expression of HSPA6 mRNA16029874
D004958EstradiolEstradiol results in increased expression of HSPA6 mRNA20106945
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of HSPA6 mRNA17404688
C006780bisphenol Abisphenol A results in decreased expression of HSPA6 mRNA16029874
D000069286BortezomibBortezomib results in increased expression of HSPA6 mRNA15509775|1789829
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of HSPA6 mRNA12414654
C018475butyraldehydebutyraldehyde results in increased expression of HSPA6 mRNA26079696
D002104CadmiumCadmium results in increased expression of HSPA6 mRNA28115653
D002104CadmiumCadmium results in increased expression of HSPA6 mRNA21120746|2117241
C037123cadmium sulfatecadmium sulfate results in increased expression of HSPA6 mRNA12064557
C117342calfactant"[Nanotubes, Carbon co-treated with calfactant] results in increased expression of HSPA6 protein"23026733
C005563captaxcaptax results in increased expression of HSPA6 mRNA23999411
D012721CarbarylCarbaryl results in decreased expression of HSPA6 mRNA27829164
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPA6 mRNA"27188386
C100187chloropicrinchloropicrin results in increased expression of HSPA6 mRNA26352163
C012843cinnamic aldehydecinnamic aldehyde results in increased expression of HSPA6 mRNA23999411
C020722cinnamyl alcoholcinnamyl alcohol results in increased expression of HSPA6 mRNA23999411
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of HSPA6 mRNA24690739
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of HSPA6 mRNA20971185
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of HSPA6 protein20971185
D003300Copper[Organoselenium Compounds binds to Copper] which results in increased expression of HSPA6 mRNA25167922
D019327Copper SulfateCopper Sulfate results in increased expression of HSPA6 mRNA15287566|1954981
C029892cupric chloridecupric chloride results in increased expression of HSPA6 mRNA17211630
C030973cupric oxidecupric oxide results in increased expression of HSPA6 mRNA22077320|2434327
D016572CyclosporineCyclosporine results in increased expression of HSPA6 mRNA20106945|2556210
D003561CytarabineCytarabine results in increased expression of HSPA6 mRNA19194470
C515055darinaparsindarinaparsin results in increased expression of HSPA6 mRNA19417148
C014347decitabinedecitabine results in increased expression of HSPA6 mRNA19194470
D013759DronabinolDronabinol results in decreased expression of HSPA6 mRNA16039398
D003976DiazinonDiazinon results in increased expression of HSPA6 mRNA24356939
C020735dibutyldichlorotindibutyldichlorotin results in increased expression of HSPA6 mRNA24356939
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of HSPA6 mRNA27392435
D002945CisplatinCisplatin results in increased expression of HSPA6 mRNA19561079|2160359
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of HSPA6 mRNA16314067|2399941
D004139DinitrofluorobenzeneDinitrofluorobenzene results in increased expression of HSPA6 mRNA23999411
D004178DiquatDiquat results in increased expression of HSPA6 mRNA21172416
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of HSPA6 mRNA24690739
D004298DopamineDopamine results in increased expression of HSPA6 protein24675778
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of HSPA6 mRNA"23811387
D004391DustDust results in increased expression of HSPA6 mRNA17805423
C512195elesclomolelesclomol results in increased expression of HSPA6 mRNA18723479
D005054EugenolEugenol results in increased expression of HSPA6 mRNA23999411
D005290Ferric CompoundsFerric Compounds results in decreased expression of HSPA6 mRNA24035972
D005557FormaldehydeFormaldehyde results in increased expression of HSPA6 mRNA17938736|2065599
D005990GlycerolGlycerol results in increased expression of HSPA6 mRNA23999411
D006037GlyoxalGlyoxal results in increased expression of HSPA6 mRNA23999411
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of HSPA6 mRNA12414654
C474021indirubin-3'-monoxime[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of HSPA6 mRNA18958680
C036643isoeugenolisoeugenol results in increased expression of HSPA6 mRNA23999411
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of HSPA6 mRNA27392435
D019344Lactic AcidLactic Acid results in increased expression of HSPA6 mRNA23999411
C045463leflunomideleflunomide results in increased expression of HSPA6 mRNA28988120
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of HSPA6 mRNA22777745
D008627Mercuric ChlorideMercuric Chloride results in increased expression of HSPA6 mRNA15287566
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of HSPA6 mRNA24356939|2800136
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of HSPA6 mRNA22129749
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of HSPA6 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of HSPA6 protein24675778
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of HSPA6 mRNA23876855
D037742Nanotubes, Carbon"[Nanotubes, Carbon co-treated with calfactant] results in increased expression of HSPA6 protein"23026733
D009285NaphthoquinonesNaphthoquinones results in increased expression of HSPA6 mRNA23811387
C498045NCX 4040NCX 4040 results in increased expression of HSPA6 mRNA20188076
D009532NickelNickel results in increased expression of HSPA6 mRNA24768652|2558310
C022838nickel chloridenickel chloride results in increased expression of HSPA6 mRNA15287566
C029938nickel sulfatenickel sulfate results in increased expression of HSPA6 mRNA16314067
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of HSPA6 mRNA20971185
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of HSPA6 protein20971185
C025589ochratoxin Aochratoxin A results in increased acetylation of HSPA6 promoter29098329
C025589ochratoxin A[ochratoxin A results in increased acetylation of HSPA6 promoter] which results in increased expression of HSPA6 mRNA29098329|2909832
C025589ochratoxin Aochratoxin A results in increased expression of HSPA6 mRNA29098329
D016566Organoselenium Compounds[Organoselenium Compounds binds to Copper] which results in increased expression of HSPA6 mRNA25167922
D010081OxazoloneOxazolone results in increased expression of HSPA6 mRNA23999411
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of HSPA6 mRNA18593933
D010396PenicillaminePenicillamine results in increased expression of HSPA6 mRNA22843330
C046012pentanalpentanal results in increased expression of HSPA6 mRNA26079696
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of HSPA6 mRNA25868421
D010938Plant OilsPlant Oils results in increased expression of HSPA6 mRNA23370395
D011137PolystyrenesPolystyrenes results in increased expression of HSPA6 mRNA25102311
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of HSPA6 mRNA17404688
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [arsenic trioxide results in increased expression of HSPA6 mRNA]15978632
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [arsenic trioxide results in increased expression of HSPA6 protein]15978632
C010423pyrithione zincpyrithione zinc results in increased expression of HSPA6 mRNA19809895|2142477
C010423pyrithione zincpyrithione zinc results in increased expression of HSPA6 protein19809895
D011791QuartzQuartz results in increased expression of HSPA6 mRNA27917503
D011794QuercetinQuercetin results in decreased expression of HSPA6 protein19207037
C012526quercitrinquercitrin affects the expression of HSPA6 mRNA25193878
C502851quinocetonequinocetone results in decreased expression of HSPA6 mRNA27046791
D020280SertralineSertraline results in increased expression of HSPA6 mRNA24865413
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of HSPA6 mRNA23806026|2589566
D012822Silicon DioxideSilicon Dioxide results in increased expression of HSPA6 mRNA22300531|2535159
D012834SilverSilver results in increased expression of HSPA6 mRNA26014281|2655175
D012835Silver NitrateSilver Nitrate analog results in increased expression of HSPA6 mRNA22831968
C017947sodium arsenitesodium arsenite results in increased expression of HSPA6 mRNA10544156|1276083
D0150862,6-Dichloroindophenol"[2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA6 mRNA"21034357
D0150862,6-Dichloroindophenol"[2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA6 protein"21034357
D012967Sodium Dodecyl SulfateSodium Dodecyl Sulfate results in increased expression of HSPA6 mRNA23999411
C025462sulindac sulfidesulindac sulfide results in increased expression of HSPA6 mRNA16184548
D013755Tetradecanoylphorbol Acetate[2-butenal co-treated with Tetradecanoylphorbol Acetate] results in increased expression of HSPA6 mRNA24849683
D013755Tetradecanoylphorbol Acetate[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of HSPA6 mRNA18958680
D013849ThimerosalThimerosal results in increased expression of HSPA6 mRNA16870260
D013883ThiostreptonThiostrepton results in increased expression of HSPA6 mRNA22321511
D013883ThiostreptonThiostrepton results in increased expression of HSPA6 protein22321511
D013893ThiramThiram results in increased expression of HSPA6 mRNA23999411
C009495titanium dioxide[Vitallium analog binds to titanium dioxide] which results in decreased expression of HSPA6 mRNA23825117
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of HSPA6 mRNA27404394|2786577
D014212TretinoinTretinoin results in increased expression of HSPA6 mRNA23724009
C015559trimellitic anhydridetrimellitic anhydride affects the expression of HSPA6 mRNA19110044
C050414tripterinetripterine results in increased expression of HSPA6 mRNA25477506
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA6 mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of HSPA6 mRNA19140230|1963173
D014520UrethaneUrethane results in increased expression of HSPA6 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of HSPA6 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of HSPA6 gene29154799
D014800Vitallium[Vitallium analog binds to titanium dioxide] which results in decreased expression of HSPA6 mRNA23825117
D014800VitalliumVitallium analog results in increased expression of HSPA6 mRNA23825117
D024483Vitamin K 3Vitamin K 3 results in increased expression of HSPA6 mRNA12414654
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of HSPA6 mRNA18593933
D015032ZincZinc results in increased expression of HSPA6 mRNA16870260
C016837zinc chloridezinc chloride results in increased expression of HSPA6 mRNA16870260
D017967Zinc CompoundsZinc Compounds results in decreased expression of HSPA6 mRNA24035972
C088658zoledronic acidzoledronic acid results in increased expression of HSPA6 protein28871336

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21044950  
GO:0005524ATP binding-IBA21873635  
GO:0005524ATP binding-IEA-  
GO:0016887ATPase activity-IBA21873635  
GO:0019899enzyme binding-IPI23921388  
GO:0031072heat shock protein binding-IBA21873635  
GO:0031072heat shock protein binding-IPI21231916  
GO:0031625ubiquitin protein ligase binding-IBA21873635  
GO:0042623ATPase activity, coupled-IBA21873635  
GO:0042623ATPase activity, coupled-IDA21231916  
GO:0044183protein binding involved in protein folding-IBA21873635  
GO:0051082unfolded protein binding-IBA21873635  
GO:0051082unfolded protein binding-IDA21231916  
GO:0051787misfolded protein binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006986response to unfolded protein-IBA21873635  
GO:0006986response to unfolded protein-TAS2327978  
GO:0034605cellular response to heat-IBA21873635  
GO:0034605cellular response to heat-IDA24061851  
GO:0034605cellular response to heat-IMP21597468  
GO:0034620cellular response to unfolded protein-IBA21873635  
GO:0042026protein refolding-IBA21873635  
GO:0042026protein refolding-IDA21231916  
GO:0043312neutrophil degranulation-TAS-  
GO:0051085chaperone cofactor-dependent protein refolding-IBA21873635  
GO:0070370cellular heat acclimationNOTIMP21231916  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA24061851  
GO:0005814centriole-IDA24061851  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA21231916  
GO:0008180COP9 signalosomeCOLOCALIZES_WITHIBA21873635  
GO:0008180COP9 signalosomecolocalizes_withIDA18850735  
GO:0034774secretory granule lumen-TAS-  
GO:0070062extracellular exosome-HDA19199708  
GO:0072562blood microparticle-HDA22516433  
GO:1904813ficolin-1-rich granule lumen-TAS-  
KEGG ID KEGG Term
hsa03040Spliceosome
hsa04010MAPK signaling pathway
hsa04141Protein processing in endoplasmic reticulum
hsa04144Endocytosis
hsa04612Antigen processing and presentation
hsa05145Toxoplasmosis
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-3371453Regulation of HSF1-mediated heat shock responseTAS
R-HSA-3371556Cellular response to heat stressTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26826017HSPA6 is an ulcerative colitis susceptibility factor that is induced by cigarette smoke and protects intestinal epithelial cells by stabilizing anti-apoptotic Bcl-XL. (2016 Apr)Regeling ABiochim Biophys Acta