Gene info: ID 3315

Gene: HSPB1

GENE ID: 3315

Synonyms: CMT2F|HEL-S-102|HMN2B|HS.76067|HSP27|HSP28|Hsp25|SRP27

Description: heat shock protein family B (small) member 1

Gene type: protein-coding

Location: 7q11.23

dbXrefs: Ensembl:ENSG00000106211 MIM:602195 Vega:OTTHUMG00000023228 UniprotKB:P04792

RefSeq: NG_008995.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.888e-1 (AD) 4.452e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DNAJB1	0.874
HSPA1A	0.864
MKNK2	0.863
BAG3	0.848
HSPA1B	0.841
SERPINH1	0.838
CDK2AP2	0.804
P4HA1	0.787
CEBPB	0.783
SERTAD1	0.772

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MAP10	-0.491
SLC35G1	-0.461
PPEF1	-0.461
NXPH2	-0.451
ZNF449	-0.446
CASC15	-0.442
ZNF860	-0.44
TUBGCP5	-0.438
PCDHAC1	-0.435
HAPLN1	-0.433

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB06094	Apatorsen	Small Molecule	1002331-21-6	Investigational	Target
DB11638	Artenimol	Small Molecule	71939-50-9	Approved\|Investigational	Target
DB12695	Phenethyl Isothiocyanate	Small Molecule	2257-09-2	Investigational	Target

ID	Drug Name	Action	PubMed
C521487	10-nitro-oleic acid	10-nitro-oleic acid results in increased expression of HSPB1 mRNA	24140437
C521487	10-nitro-oleic acid	10-nitro-oleic acid results in increased expression of HSPB1 protein	24140437
C521487	10-nitro-oleic acid	methyl-beta-cyclodextrin inhibits the reaction [10-nitro-oleic acid results in increased expression of HSPB1 protein]	24140437
C521487	10-nitro-oleic acid	pyrazolanthrone inhibits the reaction [10-nitro-oleic acid results in increased expression of HSPB1 mRNA]	24140437
C521487	10-nitro-oleic acid	pyrazolanthrone inhibits the reaction [10-nitro-oleic acid results in increased expression of HSPB1 protein]	24140437
D014013	1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt	"HSPB1 protein inhibits the reaction [1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Hydrogen Peroxide results in increased activity of MAPK1 protein]]"	14975446
D014013	1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt	"HSPB1 protein inhibits the reaction [1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Hydrogen Peroxide results in increased activity of MAPK3 protein]]"	14975446
D014013	1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt	"HSPB1 protein inhibits the reaction [1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt results in decreased susceptibility to Hydrogen Peroxide]"	14975446
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of HSPB1 mRNA"	21354444
C097240	15-deoxy-delta(12,14)-prostaglandin J2	"15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of HSPB1 protein"	16299251
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of HSPB1 mRNA"	25614096
C029141	2,2,5,7,8-pentamethyl-1-hydroxychroman	"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of HSPB1 mRNA"	21920950
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IL1B protein results in increased phosphorylation of HSPB1 protein]	10903806
C492600	(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate	"(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate affects the expression of HSPB1 mRNA"	19176366
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of HSPB1 mRNA"	21346803
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased phosphorylation of HSPB1 protein]	25373458
C408604	2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole	2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [Fenretinide results in increased phosphorylation of HSPB1 protein]	16407847
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of HSPB1 mRNA"	15059925
C035208	2-amino-4,6-dinitrotoluene	"2-amino-4,6-dinitrotoluene affects the expression of HSPB1 mRNA"	21346803
C031278	2-chloroethyl ethyl sulfide	2-chloroethyl ethyl sulfide results in increased expression of HSPB1 protein	21457723
C031278	2-chloroethyl ethyl sulfide	Filipin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of HSPB1 protein]	21457723
C031278	2-chloroethyl ethyl sulfide	methyl-beta-cyclodextrin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of HSPB1 protein]	21457723
C031278	2-chloroethyl ethyl sulfide	pyrazolanthrone inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of HSPB1 protein]	21457723
C031278	2-chloroethyl ethyl sulfide	SB 203580 inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of HSPB1 protein]	21457723
C030370	2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone	"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of HSPB1 mRNA"	20206263
C019499	2-nitrofluorene	2-nitrofluorene results in increased expression of HSPB1 mRNA	15890375
C016392	3,3'-diindolylmethane	"3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of HSPB1 mRNA]"	11179685
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HSPB1 mRNA"	23196670
C026137	3-hydroxyacetanilide	3-hydroxyacetanilide results in decreased expression of HSPB1 mRNA	18544908
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of HSPB1 mRNA"	21346803
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of HSPB1 mRNA	15890375
C477187	5-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole	"5-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole affects the expression of HSPB1 mRNA"	22745752
C010643	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [cobaltous chloride results in increased phosphorylation of HSPB1 protein]"	17575032
D000082	Acetaminophen	Acetaminophen results in decreased expression of HSPB1 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of HSPB1 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of HSPB1 mRNA	11264010\|1174374
D000082	Acetaminophen	Acetaminophen results in increased expression of HSPB1 protein	12051698\|1501026
D000082	Acetaminophen	PTGS2 protein affects the reaction [Acetaminophen results in increased expression of HSPB1 mRNA]	11743745
D000082	Acetaminophen	S100A9 protein inhibits the reaction [Acetaminophen results in increased expression of HSPB1 protein]	12051698
D000108	Acetylcarnitine	Acetylcarnitine results in decreased expression of HSPB1 mRNA	14654561
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [arsenite results in increased expression of HSPB1 protein]	15175009
D020106	Acrylamide	Acrylamide results in decreased expression of HSPB1 mRNA	28959563
C499366	Active Hexose Correlated Compound	Active Hexose Correlated Compound results in decreased expression of HSPB1 mRNA	24403454
D000255	Adenosine Triphosphate	HSPB1 protein affects the chemical synthesis of Adenosine Triphosphate	21641551
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of HSPB1 mRNA	19770486
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of HSPB1 mRNA	15890375
D000452	Aldrin	Aldrin results in decreased expression of HSPB1 mRNA	18579281
C040534	alpha-hexachlorocyclohexane	alpha-hexachlorocyclohexane results in decreased expression of HSPB1 mRNA	17785943
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of HSPB1 mRNA	16483693
D003913	Dextroamphetamine	Dextroamphetamine results in increased expression of HSPB1 mRNA	12558987\|1919437
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of HSPB1 mRNA"	22863853
D001115	Arecoline	[4-Nitroquinoline-1-oxide co-treated with Arecoline] results in increased expression of HSPB1 protein	19840781
D001127	Arginine Vasopressin	Arginine Vasopressin results in increased expression of HSPB1 mRNA	10839933
D001127	Arginine Vasopressin	Arginine Vasopressin results in increased expression of HSPB1 protein	10839933
D001127	Arginine Vasopressin	Pentobarbital inhibits the reaction [Arginine Vasopressin results in increased expression of HSPB1 mRNA]	10839933
D001127	Arginine Vasopressin	Pentobarbital inhibits the reaction [Arginine Vasopressin results in increased expression of HSPB1 protein]	10839933
C006632	arsenic trioxide	arsenic trioxide results in increased expression of HSPB1 mRNA	28755286
C006632	arsenic trioxide	arsenic trioxide results in increased expression of HSPB1 protein	28755286
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of HSPB1 mRNA	15070760\|1576101
C006632	arsenic trioxide	arsenic trioxide results in increased expression of HSPB1 mRNA	18081892\|1941714
C006632	arsenic trioxide	arsenic trioxide results in increased expression of HSPB1 protein	19364129\|2525818
C015001	arsenite	[arsenite co-treated with Benzo(a)pyrene] results in increased expression of HSPB1 mRNA	15894712
C015001	arsenite	arsenite results in increased expression of HSPB1 mRNA	15894712
C015001	arsenite	Acetylcysteine inhibits the reaction [arsenite results in increased expression of HSPB1 protein]	15175009
C015001	arsenite	arsenite results in increased expression of HSPB1 protein	15175009
C015001	arsenite	Glutathione inhibits the reaction [arsenite results in increased expression of HSPB1 protein]	15175009
D017636	Asbestos, Amphibole	"Asbestos, Amphibole results in decreased expression of HSPB1 protein"	20855422
D001205	Ascorbic Acid	[Quercetin co-treated with Ascorbic Acid] results in increased expression of HSPB1 mRNA	17639512
D001205	Ascorbic Acid	Ascorbic Acid results in increased expression of HSPB1 mRNA	15372504
D001241	Aspirin	Aspirin results in increased expression of HSPB1 mRNA	12800193
D001280	Atrazine	Atrazine results in increased expression of HSPB1 mRNA	25275270
D001280	Atrazine	Atrazine results in increased phosphorylation of HSPB1 protein	25275270
C017037	aurin	aurin results in increased expression of HSPB1 mRNA	25477506
D001383	Azetidinecarboxylic Acid	Azetidinecarboxylic Acid results in increased expression of HSPB1 protein	8113214
C547126	AZM551248	AZM551248 results in decreased expression of HSPB1 mRNA	22323515
D001542	Benomyl	Benomyl results in increased expression of HSPB1 mRNA	15885261
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of HSPB1 protein	18495319
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of HSPB1 mRNA	22316170
D001564	Benzo(a)pyrene	[arsenite co-treated with Benzo(a)pyrene] results in increased expression of HSPB1 mRNA	15894712
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of HSPB1 mRNA	15894712\|2156981
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [bufalin results in decreased expression of HSPB1 protein]	23091618
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HSPB1 mRNA	15914627
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HSPB1 protein	15914627
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	Quercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HSPB1 protein]	15914627
D004958	Estradiol	Estradiol results in decreased expression of HSPB1 mRNA	24349563
D004958	Estradiol	"3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of HSPB1 mRNA]"	11179685
D004958	Estradiol	[Estradiol binds to and results in increased activity of ESR1 protein] which results in increased expression of HSPB1 mRNA	11174852
D004958	Estradiol	Estradiol promotes the reaction [ESR1 protein binds to HSPB1 promoter]	11174852\|1969876
D004958	Estradiol	Estradiol promotes the reaction [[ESR1 protein binds to HSPB1 promoter] which results in increased expression of HSPB1 mRNA]	11174852\|1117485
D004958	Estradiol	Estradiol results in increased expression of HSPB1 mRNA	11174852\|1117968
D004958	Estradiol	fulvestrant inhibits the reaction [Estradiol results in increased expression of HSPB1 mRNA]	11174852
D004958	Estradiol	Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of HSPB1 mRNA]	11174852\|1117968
D004958	Estradiol	[Estradiol co-treated with Testosterone] results in increased expression of HSPB1 mRNA	11375906
C044887	beta-methylcholine	beta-methylcholine affects the expression of HSPB1 mRNA	21179406
C095105	bexarotene	bexarotene results in increased expression of HSPB1 mRNA	16648578
C551172	bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV)	"bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV) results in increased expression of HSPB1 mRNA"	20162321
C006780	bisphenol A	bisphenol A affects the expression of HSPB1 mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of HSPB1 mRNA	15223131\|2927551
C006780	bisphenol A	bisphenol A results in increased expression of HSPB1 protein	15215581
C006780	bisphenol A	bisphenol A affects the expression of HSPB1 mRNA	25181051
D001761	Bleomycin	Bleomycin results in decreased expression of HSPB1 protein	25933445
D001786	Blood Glucose	[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of HSPB1 mRNA	25322861
D001786	Blood Glucose	[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of HSPB1 protein	25322861
D000069286	Bortezomib	HSPB1 protein results in decreased susceptibility to Bortezomib	14559800
D000069286	Bortezomib	Bortezomib results in increased expression of HSPB1 mRNA	20830808
C022777	bufalin	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [bufalin results in decreased expression of HSPB1 protein]	23091618
C022777	bufalin	bufalin inhibits the reaction [HSPB1 protein binds to CYCS protein]	23091618
C022777	bufalin	bufalin results in decreased expression of HSPB1 protein	23091618
C022777	bufalin	HSPB1 protein inhibits the reaction [bufalin affects the localization of RELA protein]	23091618
C022777	bufalin	HSPB1 protein inhibits the reaction [bufalin inhibits the reaction [HSPB1 protein binds to CYCS protein]]	23091618
C022777	bufalin	HSPB1 protein inhibits the reaction [bufalin results in increased cleavage of PARP1 protein]	23091618
C022777	bufalin	HSPB1 protein results in decreased susceptibility to bufalin	23091618
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of HSPB1 mRNA	15336504
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of HSPB1 protein	11295360
D020148	Butyric Acid	Butyric Acid results in increased expression of HSPB1 mRNA	12800193
D002101	Cacodylic Acid	Cacodylic Acid results in decreased expression of HSPB1 mRNA	17441966
D002101	Cacodylic Acid	OGG1 protein inhibits the reaction [Cacodylic Acid results in decreased expression of HSPB1 mRNA]	17441966
D002104	Cadmium	Cadmium results in increased expression of HSPB1 mRNA	26187450
D002104	Cadmium	Cadmium results in increased expression of HSPB1 protein	16729991
C028031	cadmium acetate	cadmium acetate affects the expression of HSPB1 mRNA	16249259
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of HSPB1 mRNA	10379001
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of HSPB1 mRNA	18636176\|1901038
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of HSPB1 protein	16729991
D019256	Cadmium Chloride	HSPB1 protein results in decreased susceptibility to Cadmium Chloride	8917706
C055494	caffeic acid phenethyl ester	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of HSPB1 mRNA	20360939
D002110	Caffeine	Caffeine results in increased expression of HSPB1 mRNA	20864626
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of HSPB1 mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of HSPB1 mRNA	27339419
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of HSPB1 protein	12899939\|1499373
D002251	Carbon Tetrachloride	schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of HSPB1 protein]	12899939
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of HSPB1 mRNA	15963342
D002316	Cardiotonic Agents	[[Niacin binds to Chromium] which co-treated with Cardiotonic Agents] results in increased expression of HSPB1 protein	16840737
D002726	Chlorogenic Acid	Chlorogenic Acid results in increased expression of HSPB1 mRNA	20706672
C100187	chloropicrin	chloropicrin results in increased expression of HSPB1 mRNA	26352163
D002737	Chloroprene	Chloroprene results in increased expression of HSPB1 mRNA	23125180
D002857	Chromium	[[Niacin binds to Chromium] which co-treated with Cardiotonic Agents] results in increased expression of HSPB1 protein	16840737
D002994	Clofibrate	Clofibrate results in increased expression of HSPB1 mRNA	16081524
D002994	Clofibrate	Clofibrate results in increased expression of HSPB1 mRNA	23811191
D002994	Clofibrate	Clofibrate affects the expression of HSPB1 mRNA	12851107
D002994	Clofibrate	Clofibrate results in increased expression of HSPB1 mRNA	21318169
D003033	Coal Tar	Coal Tar results in decreased expression of HSPB1 protein	18495319
C018021	cobaltous chloride	cobaltous chloride results in increased expression of HSPB1 mRNA	19320972\|1937684
C018021	cobaltous chloride	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [cobaltous chloride results in increased phosphorylation of HSPB1 protein]"	17575032
C018021	cobaltous chloride	cobaltous chloride results in increased phosphorylation of HSPB1 protein	17575032
C018021	cobaltous chloride	Thioctic Acid inhibits the reaction [cobaltous chloride results in increased phosphorylation of HSPB1 protein]	17575032
D003042	Cocaine	Cocaine results in increased expression of HSPB1 mRNA	27899881
D003300	Copper	[Disulfiram binds to Copper] which results in decreased expression of HSPB1 mRNA	24690739
D003300	Copper	Copper results in increased expression of HSPB1 mRNA	16629173
D003300	Copper	Copper results in increased expression of HSPB1 mRNA	23825565
D003300	Copper	Copper results in increased expression of HSPB1 mRNA	22465980
D019327	Copper Sulfate	Copper Sulfate results in increased expression of HSPB1 mRNA	19549813
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of HSPB1 mRNA	18579281
D003345	Corticosterone	Corticosterone results in increased expression of HSPB1 mRNA	15755911
D003345	Corticosterone	Corticosterone results in increased expression of HSPB1 protein	15755911
C007164	cumene hydroperoxide	cumene hydroperoxide results in increased expression of HSPB1 protein	11295360
C029892	cupric chloride	cupric chloride results in increased expression of HSPB1 mRNA	17211630
C029892	cupric chloride	cupric chloride results in increased phosphorylation of and results in increased activity of HSPB1 protein	17234613
C029892	cupric chloride	SB 203580 inhibits the reaction [cupric chloride results in increased phosphorylation of and results in increased activity of HSPB1 protein]	17234613
C030973	cupric oxide	cupric oxide results in increased phosphorylation of HSPB1 protein	25470785
D003471	Cuprizone	Cuprizone results in increased expression of HSPB1 mRNA	27523638
D003474	Curcumin	Curcumin inhibits the reaction [Streptozocin results in increased expression of HSPB1 protein]	18204486
D003474	Curcumin	Curcumin promotes the reaction [Isoproterenol results in increased expression of HSPB1 protein]	20125031
C057862	cyanoginosin LR	cyanoginosin LR results in increased phosphorylation of HSPB1 protein	27393157
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of HSPB1 mRNA	17654400
C057862	cyanoginosin LR	cyanoginosin LR results in increased phosphorylation of HSPB1 protein	22000993
C057862	cyanoginosin LR	SB 203580 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of HSPB1 protein]	22000993
C009160	cyclonite	cyclonite results in increased expression of HSPB1 mRNA	25559034
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of HSPB1 mRNA	11906922
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of HSPB1 mRNA	11599041\|1824654
C515055	darinaparsin	darinaparsin results in increased expression of HSPB1 mRNA	19417148
C014347	decitabine	[decitabine co-treated with vorinostat] affects the expression of HSPB1 mRNA	17330099
D003907	Dexamethasone	HSPB1 protein results in decreased susceptibility to Dexamethasone	12855565
D016190	Carboplatin	Carboplatin results in increased expression of HSPB1 mRNA	18172885
D003976	Diazinon	Diazinon results in increased methylation of HSPB1 gene	22964155
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of HSPB1 mRNA	21266533
D003994	Bucladesine	Bucladesine results in increased phosphorylation of HSPB1 protein	7541446
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of HSPB1 mRNA	28962523
D002945	Cisplatin	Cisplatin promotes the reaction [jinfukang results in increased expression of HSPB1 mRNA]	27392435
D002945	Cisplatin	Cisplatin results in increased expression of HSPB1 mRNA	27392435
D002945	Cisplatin	HSPB1 protein affects the susceptibility to Cisplatin	23152886
D002945	Cisplatin	HSPB1 protein affects the susceptibility to [Cisplatin co-treated with Fluorouracil co-treated with Leucovorin]	19088045
D002945	Cisplatin	jinfukang promotes the reaction [Cisplatin results in increased expression of HSPB1 mRNA]	27392435
D002945	Cisplatin	Cisplatin results in increased expression of HSPB1 mRNA	21151649
D002945	Cisplatin	Cisplatin results in increased expression of HSPB1 mRNA	18172885
D002945	Cisplatin	HSPB1 protein results in decreased susceptibility to Cisplatin	8917706
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene results in increased expression of HSPB1 mRNA	15885261
D004008	Diclofenac	Diclofenac results in decreased expression of HSPB1 mRNA	26934552
C005406	dienochlor	dienochlor results in decreased expression of HSPB1 protein	16884889
D004041	Dietary Fats	Dietary Fats results in increased expression of HSPB1 mRNA	22609946
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of HSPB1 mRNA	19850644\|2131816
D004051	Diethylhexyl Phthalate	PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of HSPB1 mRNA]	19850644
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of HSPB1 mRNA	21318169
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of HSPB1 mRNA	18691550
D004052	Diethylnitrosamine	MAPK14 protein inhibits the reaction [Diethylnitrosamine results in decreased expression of HSPB1 mRNA]	18691550
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of HSPB1 mRNA	20360939
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HSPB1 mRNA	18544905
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of HSPB1 mRNA	15890375
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of HSPB1 mRNA	15890375
D004147	Dioxins	Dioxins affects the expression of HSPB1 mRNA	20463971
D004221	Disulfiram	[Disulfiram binds to Copper] which results in decreased expression of HSPB1 mRNA	24690739
D004281	Docosahexaenoic Acids	Docosahexaenoic Acids results in decreased expression of HSPB1 mRNA	16623957
D004317	Doxorubicin	Doxorubicin results in increased expression of HSPB1 mRNA	17680992
D004317	Doxorubicin	HSPB1 protein affects the susceptibility to Doxorubicin	23724044
D004317	Doxorubicin	HSPB1 protein promotes the reaction [ERP29 protein results in decreased susceptibility to Doxorubicin]	20833165
D004317	Doxorubicin	HSPB1 protein results in decreased susceptibility to Doxorubicin	24675091
D004317	Doxorubicin	[resveratrol results in decreased expression of HSPB1 protein] which results in increased susceptibility to Doxorubicin	23724044
D004317	Doxorubicin	Doxorubicin affects the reaction [TRP53 protein binds to HSPB1 protein]	18263706
D004317	Doxorubicin	[Doxorubicin affects the reaction [TRP53 protein binds to HSPB1 protein]] which results in increased expression of CDKN1A protein	18263706
D004317	Doxorubicin	Doxorubicin promotes the reaction [[HSPB1 protein modified form results in increased activity of TRP53 protein] which results in increased expression of BAX protein]	20363884
D004317	Doxorubicin	Doxorubicin promotes the reaction [TRP53 protein binds to HSPB1 protein modified form]	20363884
D004317	Doxorubicin	Doxorubicin results in increased expression of and results in increased phosphorylation of HSPB1 protein	20363884
D004317	Doxorubicin	Doxorubicin results in increased expression of HSPB1 mRNA	20363884
D004317	Doxorubicin	HSF1 protein affects the reaction [Doxorubicin promotes the reaction [TRP53 protein binds to HSPB1 protein modified form]]	20363884
D004317	Doxorubicin	HSF1 protein affects the reaction [Doxorubicin results in increased expression of HSPB1 protein]	20363884
D004317	Doxorubicin	HSPB1 protein affects the reaction [Doxorubicin results in increased abundance of Reactive Oxygen Species]	17481944
D004317	Doxorubicin	HSPB1 protein promotes the reaction [Doxorubicin results in increased expression of HMOX1 protein]	17481944
D004317	Doxorubicin	Doxorubicin affects the reaction [TP53 protein binds to HSPB1 protein]	18263706
D004317	Doxorubicin	[Doxorubicin affects the reaction [TP53 protein binds to HSPB1 protein]] which results in increased expression of CDKN1A protein	18263706
D004317	Doxorubicin	Doxorubicin results in increased expression of HSPB1 protein	16782845
D004317	Doxorubicin	HSPB1 protein affects the susceptibility to Doxorubicin	17873025
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of HSPB1 mRNA"	23811387
C042986	ebselen	ebselen affects the expression of HSPB1 protein	17345791
D004726	Endosulfan	Endosulfan results in decreased expression of HSPB1 protein	16884889
C044101	endotoxin, Escherichia coli	"endotoxin, Escherichia coli results in increased expression of HSPB1 mRNA"	15919760
D000431	Ethanol	Ethanol results in decreased expression of HSPB1 mRNA	15513904
D000431	Ethanol	Ethanol results in increased expression of HSPB1 mRNA	17189318
D000431	Ethanol	HSF1 protein affects the reaction [Ethanol results in increased expression of HSPB1 mRNA]	17189318
D000431	Ethanol	Ethanol results in decreased expression of HSPB1 mRNA	16784954
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of HSPB1 mRNA	15212814\|1614062
C024565	ethylene dichloride	ethylene dichloride results in increased expression of HSPB1 mRNA	28189721
D015025	Zearalenone	Zearalenone results in increased expression of HSPB1 protein	19051279
D011345	Fenofibrate	Fenofibrate results in increased expression of HSPB1 mRNA	21318169
D011345	Fenofibrate	PPARA protein affects the reaction [Fenofibrate results in increased expression of HSPB1 mRNA]	21318169
D011345	Fenofibrate	Fenofibrate affects the expression of HSPB1 mRNA	20801182
D005372	Filipin	Filipin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of HSPB1 protein]	21457723
D018120	Finasteride	Finasteride results in increased expression of HSPB1 mRNA	24136188
D005472	Fluorouracil	HSPB1 protein affects the susceptibility to [Cisplatin co-treated with Fluorouracil co-treated with Leucovorin]	19088045
D005472	Fluorouracil	HSPB1 protein results in decreased susceptibility to Fluorouracil	18949417
D005472	Fluorouracil	HSPB1 mRNA results in decreased susceptibility to Fluorouracil	18949417
D005485	Flutamide	Flutamide results in increased expression of HSPB1 mRNA	15885261
D005557	Formaldehyde	Formaldehyde results in increased expression of HSPB1 mRNA	18499655
D002955	Leucovorin	HSPB1 protein affects the susceptibility to [Cisplatin co-treated with Fluorouracil co-treated with Leucovorin]	19088045
C473894	fujiflavone P40	fujiflavone P40 results in increased expression of HSPB1 mRNA	14656947
C070081	fulvestrant	[fulvestrant binds to and results in increased activity of ESR1 protein] which results in increased expression of HSPB1 mRNA	11174852
C070081	fulvestrant	fulvestrant inhibits the reaction [Estradiol results in increased expression of HSPB1 mRNA]	11174852
C039281	furan	furan results in increased expression of HSPB1 mRNA	20194422\|2418370
C039281	furan	furan results in increased expression of HSPB1 mRNA	25539665\|2619464
C027235	gallium nitrate	gallium nitrate results in decreased expression of HSPB1 mRNA	18586083
C435770	gambierol	gambierol results in increased expression of HSPB1 protein	19397276
C435770	gambierol	[Okadaic Acid co-treated with gambierol] affects the expression of HSPB1 protein modified form	19397276
C435770	gambierol	[Okadaic Acid co-treated with gambierol] results in increased expression of HSPB1 protein	19397276
D019833	Genistein	Genistein results in decreased expression of HSPB1 mRNA	24967385
D005947	Glucose	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased phosphorylation of HSPB1 protein]	25373458
D005947	Glucose	Glucose deficiency results in increased secretion of HSPB1 protein	24802182
D005947	Glucose	Glucose results in increased phosphorylation of HSPB1 protein	25373458
D005947	Glucose	U 0126 inhibits the reaction [Glucose results in increased phosphorylation of HSPB1 protein]	25373458
D005947	Glucose	[Oxygen deficiency co-treated with Glucose deficiency co-treated with Oxygen] results in increased expression of HSPB1 mRNA	23421680
D005947	Glucose	[Oxygen deficiency co-treated with Glucose deficiency co-treated with Oxygen] results in increased expression of HSPB1 protein	23421680
D005947	Glucose	resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency co-treated with Oxygen] results in increased expression of HSPB1 mRNA]	23421680
D005947	Glucose	resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency co-treated with Oxygen] results in increased expression of HSPB1 protein]	23421680
D005978	Glutathione	Glutathione inhibits the reaction [arsenite results in increased expression of HSPB1 protein]	15175009
D006046	Gold	[Polyethyleneimine binds to Gold] which results in decreased expression of HSPB1 mRNA	28433809
D006046	Gold	[Gold co-treated with Polyethylene Glycols] results in decreased expression of HSPB1 mRNA	19695318
D017313	Fenretinide	2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [Fenretinide results in increased phosphorylation of HSPB1 protein]	16407847
D006820	Hyaluronic Acid	Hyaluronic Acid analog results in decreased expression of HSPB1 protein	23178681
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of HSPB1 protein	11295360
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased phosphorylation of HSPB1 protein	11295360
D006861	Hydrogen Peroxide	"HSPB1 protein inhibits the reaction [1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Hydrogen Peroxide results in increased activity of MAPK1 protein]]"	14975446
D006861	Hydrogen Peroxide	"HSPB1 protein inhibits the reaction [1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Hydrogen Peroxide results in increased activity of MAPK3 protein]]"	14975446
D006861	Hydrogen Peroxide	"HSPB1 protein inhibits the reaction [1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt results in decreased susceptibility to Hydrogen Peroxide]"	14975446
D006861	Hydrogen Peroxide	HSPB1 protein inhibits the reaction [[Hydrogen Peroxide affects the activity of PDGFRB protein] which results in increased activity of MAPK1 protein]	14975446
D006861	Hydrogen Peroxide	HSPB1 protein inhibits the reaction [[Hydrogen Peroxide affects the activity of PDGFRB protein] which results in increased activity of MAPK3 protein]	14975446
D006861	Hydrogen Peroxide	HSPB1 protein inhibits the reaction [[Hydrogen Peroxide affects the activity of PRKCD protein] which results in increased activity of MAPK1 protein]	14975446
D006861	Hydrogen Peroxide	HSPB1 protein inhibits the reaction [[Hydrogen Peroxide affects the activity of PRKCD protein] which results in increased activity of MAPK3 protein]	14975446
D006861	Hydrogen Peroxide	HSPB1 protein inhibits the reaction [[Hydrogen Peroxide affects the activity of SRC protein] which results in increased activity of MAPK1 protein]	14975446
D006861	Hydrogen Peroxide	HSPB1 protein inhibits the reaction [[Hydrogen Peroxide affects the activity of SRC protein] which results in increased activity of MAPK3 protein]	14975446
D006861	Hydrogen Peroxide	HSPB1 protein promotes the reaction [Hydrogen Peroxide results in increased activity of SOD2 protein]	14975446
D006861	Hydrogen Peroxide	HSPB1 protein results in decreased susceptibility to Hydrogen Peroxide	14975446
D006861	Hydrogen Peroxide	HSPB1 protein results in decreased susceptibility to [Hydrogen Peroxide results in increased activity of MAPK1 protein]	14975446
D006861	Hydrogen Peroxide	HSPB1 protein results in decreased susceptibility to [Hydrogen Peroxide results in increased activity of MAPK3 protein]	14975446
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of HSPB1 protein	23178681
C475919	hydroxytamoxifen	hydroxytamoxifen results in increased expression of HSPB1 mRNA	11174852
C051781	ICI 164384	[ICI 164384 binds to and results in increased activity of ESR1 protein] which results in increased expression of HSPB1 mRNA	11174852
D000068877	Imatinib Mesylate	Imatinib Mesylate results in increased expression of HSPB1 mRNA	21935477
C082359	imidacloprid	imidacloprid results in decreased expression of HSPB1 protein	16884889
D007213	Indomethacin	Indomethacin results in increased expression of HSPB1 mRNA	18299717
D007501	Iron	[Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of HSPB1 mRNA	22198552
C469852	iroxanadine	iroxanadine promotes the reaction [Oxygen affects the expression of HSPB1 protein]	15583868
C469852	iroxanadine	Quercetin inhibits the reaction [iroxanadine promotes the reaction [Oxygen affects the expression of HSPB1 protein]]	15583868
D007545	Isoproterenol	Curcumin promotes the reaction [Isoproterenol results in increased expression of HSPB1 protein]	20125031
D007545	Isoproterenol	Isoproterenol results in increased expression of HSPB1 protein	20125031
C544151	jinfukang	Cisplatin promotes the reaction [jinfukang results in increased expression of HSPB1 mRNA]	27392435
C544151	jinfukang	jinfukang promotes the reaction [Cisplatin results in increased expression of HSPB1 mRNA]	27392435
C544151	jinfukang	jinfukang results in increased expression of HSPB1 mRNA	27392435
C098607	JP8 aviation fuel	JP8 aviation fuel results in decreased expression of HSPB1 mRNA	15618438
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of HSPB1 mRNA	23086925
C410337	K 7174	K 7174 results in decreased expression of HSPB1 mRNA	24086573
C011890	kojic acid	[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HSPB1 mRNA	18544905
C060282	lariciresinol	lariciresinol results in decreased expression of HSPB1 protein	27417256
C008261	lead acetate	lead acetate affects the expression of HSPB1 mRNA	21864555
C029891	lead chloride	lead chloride results in increased expression of HSPB1 protein	24419708
C045463	leflunomide	leflunomide results in increased expression of HSPB1 mRNA	24136188
C052901	lemongrass oil	lemongrass oil affects the expression of HSPB1 mRNA	25976427
C018584	linalool	linalool results in increased expression of HSPB1 mRNA	20536181
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased phosphorylation of HSPB1 protein	19675143
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of HSPB1 mRNA	15919760
D008095	Lithocholic Acid	Lithocholic Acid results in increased phosphorylation of HSPB1 protein	21224350
C032881	lysophosphatidic acid	lysophosphatidic acid results in increased phosphorylation of HSPB1 protein	20864298
C032881	lysophosphatidic acid	MK2i peptide inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of HSPB1 protein]	20864298
C032881	lysophosphatidic acid	SB 203580 inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of HSPB1 protein]	20864298
D008627	Mercuric Chloride	HSPB1 protein results in decreased susceptibility to Mercuric Chloride	8917706
D008694	Methamphetamine	Methamphetamine results in increased expression of HSPB1 mRNA	26307267
D008694	Methamphetamine	[Methamphetamine co-treated with SCH 23390] results in increased expression of HSPB1 mRNA	19564919
D008694	Methamphetamine	Methamphetamine results in increased expression of HSPB1 mRNA	19564919
D008694	Methamphetamine	Methamphetamine results in increased expression of HSPB1 protein	12684743
D008694	Methamphetamine	SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of HSPB1 mRNA]	19564919
D008701	Methapyrilene	Methapyrilene results in increased expression of HSPB1 mRNA	15890375\|1639366
D008713	Methimazole	Methimazole results in increased expression of HSPB1 mRNA	22504374
D008727	Methotrexate	Methotrexate results in increased expression of HSPB1 mRNA	19100307
D008727	Methotrexate	Methotrexate results in increased expression of HSPB1 protein	19100307
D008727	Methotrexate	SB 203580 inhibits the reaction [Methotrexate results in increased expression of HSPB1 protein]	19100307
D008727	Methotrexate	Methotrexate affects the expression of HSPB1 mRNA	18502557
C013598	methoxyacetic acid	methoxyacetic acid results in increased expression of HSPB1 mRNA	20864626
C108732	methyl-beta-cyclodextrin	methyl-beta-cyclodextrin inhibits the reaction [10-nitro-oleic acid results in increased expression of HSPB1 protein]	24140437
C108732	methyl-beta-cyclodextrin	methyl-beta-cyclodextrin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of HSPB1 protein]	21457723
C108732	methyl-beta-cyclodextrin	methyl-beta-cyclodextrin results in decreased expression of HSPB1 protein	24140437
C002950	methylformamide	methylformamide affects the expression of HSPB1 mRNA	17040096
C002950	methylformamide	methylformamide analog affects the expression of HSPB1 mRNA	17040096
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of HSPB1 mRNA	20864626
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of HSPB1 mRNA	24810058
D015741	Metribolone	Metribolone results in increased expression of HSPB1 protein	17152098
C540575	MK2i peptide	MK2i peptide results in decreased phosphorylation of HSPB1 protein	20864298
C540575	MK2i peptide	[TGFB1 protein co-treated with MK2i peptide] results in decreased expression of HSPB1 protein	20864298
C540575	MK2i peptide	MK2i peptide inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of HSPB1 protein]	20864298
C540575	MK2i peptide	MK2i peptide inhibits the reaction [sodium arsenite results in increased phosphorylation of HSPB1 protein]	20864298
C028577	monobutyl phthalate	monobutyl phthalate results in increased expression of HSPB1 protein	20553848
C028577	monobutyl phthalate	monobutyl phthalate results in increased expression of HSPB1 mRNA	20864626
D016686	Monocrotaline	[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPB1 mRNA	21224054
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of HSPB1 mRNA	20886546
D009020	Morphine	Morphine results in increased expression of HSPB1 mRNA	15497504
D009020	Morphine	Morphine results in increased expression of HSPB1 protein	23056601
C437683	motexafin gadolinium	motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of HSPB1 mRNA]	16357179
C437683	motexafin gadolinium	motexafin gadolinium results in increased expression of HSPB1 mRNA	16357179
C568376	MT19c compound	MT19c compound results in decreased expression of HSPB1 mRNA	21781307
D009151	Mustard Gas	Mustard Gas results in increased phosphorylation of HSPB1 protein	19845377
D009151	Mustard Gas	Mustard Gas results in increased expression of HSPB1 mRNA	15674843
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of HSPB1 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of HSPB1 mRNA"	25554681
C031721	naphthalene	naphthalene results in increased expression of HSPB1 protein	14550745
D009285	Naphthoquinones	Naphthoquinones results in increased expression of HSPB1 mRNA	23811387
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of HSPB1 mRNA	20551477
C066471	NCS 382	NCS 382 results in decreased expression of HSPB1 mRNA	28119166
C051752	nefazodone	nefazodone results in increased expression of HSPB1 mRNA	24136188
D009354	Neodymium	Neodymium results in decreased phosphorylation of HSPB1 protein	20332019
D009354	Neodymium	Neodymium results in increased expression of HSPB1 mRNA	20332019
D009354	Neodymium	Neodymium results in increased expression of HSPB1 protein	20332019
D009525	Niacin	[[Niacin binds to Chromium] which co-treated with Cardiotonic Agents] results in increased expression of HSPB1 protein	16840737
D009532	Nickel	[Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of HSPB1 mRNA	22198552
C012655	nimesulide	nimesulide results in increased expression of HSPB1 mRNA	24136188
D015112	4-Nitroquinoline-1-oxide	[4-Nitroquinoline-1-oxide co-treated with Arecoline] results in increased expression of HSPB1 protein	19840781
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of HSPB1 mRNA	17616710
C047330	N-methylisoindigotin	N-methylisoindigotin results in increased expression of HSPB1 mRNA	26887594
C047330	N-methylisoindigotin	N-methylisoindigotin results in increased phosphorylation of HSPB1 protein	26887594
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in increased expression of HSPB1 mRNA	19716841
C025256	nonylphenol	nonylphenol results in decreased expression of HSPB1 protein	19260726
C025589	ochratoxin A	ochratoxin A results in decreased expression of HSPB1 mRNA	19051279\|1936763
C025589	ochratoxin A	ochratoxin A results in decreased expression of HSPB1 protein	19051279\|1936763
D016627	Oxidopamine	Oxidopamine results in increased expression of HSPB1 mRNA	12486162
D019319	Okadaic Acid	Okadaic Acid affects the expression of HSPB1 protein modified form	19397276
D019319	Okadaic Acid	[Okadaic Acid co-treated with gambierol] affects the expression of HSPB1 protein modified form	19397276
D019319	Okadaic Acid	[Okadaic Acid co-treated with gambierol] results in increased expression of HSPB1 protein	19397276
D019319	Okadaic Acid	Okadaic Acid results in decreased expression of HSPB1 protein	19397276
D019319	Okadaic Acid	Okadaic Acid results in increased expression of HSPB1 protein	19397276
D000069463	Olive Oil	Olive Oil analog affects the expression of HSPB1 mRNA	17349074
C485800	osajin	osajin results in increased expression of HSPB1 mRNA	20706672
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of HSPB1 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of HSPB1 mRNA	25729387
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of HSPB1 mRNA	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of HSPB1 mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of HSPB1 mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	Particulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of HSPB1 mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	Vehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of HSPB1 mRNA]	17655762
D010100	Oxygen	iroxanadine promotes the reaction [Oxygen affects the expression of HSPB1 protein]	15583868
D010100	Oxygen	Oxygen deficiency results in increased expression of HSPB1 mRNA	17914565
D010100	Oxygen	Quercetin inhibits the reaction [iroxanadine promotes the reaction [Oxygen affects the expression of HSPB1 protein]]	15583868
D010100	Oxygen	[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of HSPB1 mRNA	25322861
D010100	Oxygen	[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of HSPB1 protein	25322861
D010100	Oxygen	[Oxygen deficiency co-treated with Glucose deficiency co-treated with Oxygen] results in increased expression of HSPB1 mRNA	23421680
D010100	Oxygen	[Oxygen deficiency co-treated with Glucose deficiency co-treated with Oxygen] results in increased expression of HSPB1 protein	23421680
D010100	Oxygen	resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency co-treated with Oxygen] results in increased expression of HSPB1 mRNA]	23421680
D010100	Oxygen	resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency co-treated with Oxygen] results in increased expression of HSPB1 protein]	23421680
D010126	Ozone	Ozone results in increased expression of HSPB1 protein	12763055
D010126	Ozone	Ozone results in increased expression of HSPB1 mRNA	16330353
C530734	p-aminophenylarsine oxide	p-aminophenylarsine oxide binds to HSPB1 protein	22422341
D010269	Paraquat	Paraquat results in decreased expression of HSPB1 mRNA	20883675
D010269	Paraquat	Paraquat results in decreased expression of HSPB1 mRNA	21371552
D010269	Paraquat	Paraquat affects the expression of HSPB1 mRNA	15206577
D052638	Particulate Matter	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of HSPB1 mRNA]	17655762
D052638	Particulate Matter	Particulate Matter affects the expression of HSPB1 mRNA	17655762
D052638	Particulate Matter	Particulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of HSPB1 mRNA]	17655762
D052638	Particulate Matter	Particulate Matter results in decreased expression of HSPB1 mRNA	24769257
D052638	Particulate Matter	Particulate Matter results in increased phosphorylation of HSPB1 protein	19675143
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of HSPB1 mRNA	18593933
D010424	Pentobarbital	Pentobarbital inhibits the reaction [Arginine Vasopressin results in increased expression of HSPB1 mRNA]	10839933
D010424	Pentobarbital	Pentobarbital inhibits the reaction [Arginine Vasopressin results in increased expression of HSPB1 protein]	10839933
D010424	Pentobarbital	Pentobarbital inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HSPB1 protein]	10839933
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of HSPB1 protein	26178269
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of HSPB1 protein	26879310
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of HSPB1 mRNA	21318169
C023036	perfluorooctanoic acid	PPARA protein affects the reaction [perfluorooctanoic acid results in increased expression of HSPB1 mRNA]	21318169
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of HSPB1 mRNA	19162173\|2131816
D010578	Petroleum	Petroleum analog results in decreased expression of HSPB1 mRNA	23266412
C058305	phenethyl isothiocyanate	HSPB1 protein binds to phenethyl isothiocyanate	21838287
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in increased expression of HSPB1 mRNA	17616710
D010634	Phenobarbital	Phenobarbital affects the expression of HSPB1 mRNA	19162173
D010634	Phenobarbital	Phenobarbital results in decreased expression of HSPB1 mRNA	16510358
D010672	Phenytoin	[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPB1 mRNA	21224054
D010695	Phlorhizin	Phlorhizin results in increased expression of HSPB1 mRNA	22538082
D010862	Pilocarpine	Pilocarpine results in increased expression of HSPB1 mRNA	17971868
D010862	Pilocarpine	Pilocarpine results in increased expression of HSPB1 protein	20971094
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of HSPB1 mRNA	15890375\|2248451
C006253	pirinixic acid	pirinixic acid results in increased expression of HSPB1 mRNA	15375163\|1830175
C006253	pirinixic acid	PPARA protein affects the reaction [pirinixic acid results in increased expression of HSPB1 mRNA]	21318169
C006253	pirinixic acid	pirinixic acid results in increased expression of HSPB1 mRNA	12832660\|1589037
D010936	Plant Extracts	Plant Extracts affects the expression of HSPB1 mRNA	12878215
D010936	Plant Extracts	Plant Extracts results in decreased expression of HSPB1 mRNA	23557933
D011092	Polyethylene Glycols	[Gold co-treated with Polyethylene Glycols] results in decreased expression of HSPB1 mRNA	19695318
D011094	Polyethyleneimine	[Polyethyleneimine binds to Gold] which results in decreased expression of HSPB1 mRNA	28433809
C474837	pomiferin	pomiferin results in increased expression of HSPB1 mRNA	20706672
D011192	Potassium Dichromate	Potassium Dichromate results in decreased phosphorylation of HSPB1 protein	20332019
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of HSPB1 mRNA	20332019
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of HSPB1 protein	20332019
D011374	Progesterone	Progesterone results in increased expression of HSPB1 mRNA	20726854
C045950	propiconazole	propiconazole results in increased expression of HSPB1 mRNA	21278054
D011429	Propolis	Propolis results in increased expression of HSPB1 mRNA	20706672
D011441	Propylthiouracil	Propylthiouracil results in increased expression of HSPB1 mRNA	22504374
C033607	puerarin	puerarin results in increased expression of HSPB1 mRNA	20706672
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [10-nitro-oleic acid results in increased expression of HSPB1 mRNA]	24140437
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [10-nitro-oleic acid results in increased expression of HSPB1 protein]	24140437
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of HSPB1 protein]	21457723
C031280	pyrazole	pyrazole results in increased expression of HSPB1 mRNA	17945193
D011765	Pyruvaldehyde	GLO1 protein affects the reaction [Pyruvaldehyde binds to HSPB1 protein]	20093988
D011765	Pyruvaldehyde	Pyruvaldehyde binds to HSPB1 protein	20093988
D011794	Quercetin	HSPB1 mutant form results in increased susceptibility to Quercetin	24126416
D011794	Quercetin	HSPB1 mutant form results in increased susceptibility to [Quercetin co-treated with temozolomide]	24126416
D011794	Quercetin	[Quercetin co-treated with Ascorbic Acid] results in increased expression of HSPB1 mRNA	17639512
D011794	Quercetin	Quercetin inhibits the reaction [iroxanadine promotes the reaction [Oxygen affects the expression of HSPB1 protein]]	15583868
D011794	Quercetin	Quercetin results in decreased expression of HSPB1 protein	19112469
D011794	Quercetin	Quercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HSPB1 protein]	15914627
D011794	Quercetin	Quercetin results in decreased expression of HSPB1 mRNA	17349211
D011794	Quercetin	Quercetin results in decreased expression of HSPB1 protein	19112469
D017382	Reactive Oxygen Species	HSPB1 protein affects the reaction [Doxorubicin results in increased abundance of Reactive Oxygen Species]	17481944
D017382	Reactive Oxygen Species	HSPB1 protein results in decreased abundance of Reactive Oxygen Species	14975446
C059514	resveratrol	resveratrol results in decreased expression of HSPB1 mRNA	24570423
C059514	resveratrol	resveratrol results in increased expression of HSPB1 mRNA	24570423
C059514	resveratrol	resveratrol results in decreased expression of HSPB1 mRNA	20878097
C059514	resveratrol	resveratrol results in decreased expression of HSPB1 protein	23724044
C059514	resveratrol	[resveratrol results in decreased expression of HSPB1 protein] which results in increased susceptibility to Doxorubicin	23724044
C059514	resveratrol	resveratrol results in increased expression of and results in increased phosphorylation of HSPB1 protein	22349766
C059514	resveratrol	resveratrol results in increased expression of HSPB1 mRNA	20706672
C059514	resveratrol	resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency co-treated with Oxygen] results in increased expression of HSPB1 mRNA]	23421680
C059514	resveratrol	resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency co-treated with Oxygen] results in increased expression of HSPB1 protein]	23421680
C059514	resveratrol	resveratrol results in decreased expression of HSPB1 mRNA	19228061
C059514	resveratrol	resveratrol results in increased expression of HSPB1 mRNA	25905778
D012293	Rifampin	[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPB1 mRNA	21224054
C529148	rosavin	rosavin results in increased expression of HSPB1 mRNA	20706672
C089730	rosiglitazone	rosiglitazone affects the expression of HSPB1 protein	19556978
D012402	Rotenone	Rotenone results in increased expression of HSPB1 mRNA	23186747
C064116	S-(1,1,2,2-tetrafluoroethyl)cysteine	"S-(1,1,2,2-tetrafluoroethyl)cysteine affects the localization of [HSPB1 protein binds to HSPB1 protein]"	16678137
C064116	S-(1,1,2,2-tetrafluoroethyl)cysteine	"S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of HSPB1 mRNA"	16678137
C064116	S-(1,1,2,2-tetrafluoroethyl)cysteine	"S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of [HSPB1 protein binds to HSPB1 protein]"	16678137
C093642	SB 203580	SB 203580 inhibits the reaction [IL1B protein results in increased phosphorylation of HSPB1 protein]	10903806
C093642	SB 203580	SB 203580 inhibits the reaction [Methotrexate results in increased expression of HSPB1 protein]	19100307
C093642	SB 203580	SB 203580 results in decreased phosphorylation of HSPB1 protein	20864298
C093642	SB 203580	SB 203580 inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of HSPB1 protein]	21457723
C093642	SB 203580	SB 203580 inhibits the reaction [cupric chloride results in increased phosphorylation of and results in increased activity of HSPB1 protein]	17234613
C093642	SB 203580	SB 203580 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of HSPB1 protein]	22000993
C093642	SB 203580	SB 203580 inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of HSPB1 protein]	20864298
C093642	SB 203580	SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of HSPB1 protein]	20864298
C534628	SCH 23390	[Methamphetamine co-treated with SCH 23390] results in increased expression of HSPB1 mRNA	19564919
C534628	SCH 23390	SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of HSPB1 mRNA]	19564919
C015499	schizandrin B	schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of HSPB1 protein]	12899939
D012643	Selenium	Selenium results in increased expression of HSPB1 mRNA	19244175
D012822	Silicon Dioxide	Silicon Dioxide analog affects the secretion of HSPB1 protein	25895662
D012834	Silver	Silver results in increased expression of HSPB1 mRNA	26014281\|2895954
C009277	sodium arsenate	sodium arsenate results in decreased expression of HSPB1 mRNA	24349563
C017947	sodium arsenite	sodium arsenite binds to HSPB1 protein	22422341
C017947	sodium arsenite	sodium arsenite results in decreased expression of HSPB1 protein	19294697
C017947	sodium arsenite	sodium arsenite results in increased expression of HSPB1 mRNA	10379001\|1276083
C017947	sodium arsenite	sodium arsenite results in increased expression of HSPB1 protein	15899475\|1672999
C017947	sodium arsenite	sodium arsenite results in increased phosphorylation of HSPB1 protein	7541446
C017947	sodium arsenite	CDKN1B protein inhibits the reaction [sodium arsenite results in increased expression of HSPB1 mRNA]	20566634
C017947	sodium arsenite	CDKN1B protein inhibits the reaction [sodium arsenite results in increased expression of HSPB1 protein]	20566634
C017947	sodium arsenite	HSF1 protein affects the reaction [sodium arsenite results in increased expression of HSPB1 protein]	20566634
C017947	sodium arsenite	JUN protein affects the reaction [sodium arsenite results in increased expression of HSPB1 protein]	20566634
C017947	sodium arsenite	MAPK9 protein affects the reaction [sodium arsenite results in increased expression of HSPB1 protein]	20566634
C017947	sodium arsenite	sodium arsenite results in increased expression of HSPB1 mRNA	16014739
C017947	sodium arsenite	HSPB1 protein results in decreased susceptibility to sodium arsenite	8917706
C017947	sodium arsenite	MK2i peptide inhibits the reaction [sodium arsenite results in increased phosphorylation of HSPB1 protein]	20864298
C017947	sodium arsenite	SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of HSPB1 protein]	20864298
C017947	sodium arsenite	sodium arsenite results in increased expression of HSPB1 protein	16729991
C017947	sodium arsenite	sodium arsenite results in increased phosphorylation of HSPB1 protein	20864298
C016104	sodium bichromate	sodium bichromate results in increased expression of HSPB1 mRNA	25993096
D012967	Sodium Dodecyl Sulfate	Sodium Dodecyl Sulfate results in decreased phosphorylation of HSPB1 protein	20332019
D012967	Sodium Dodecyl Sulfate	Sodium Dodecyl Sulfate results in increased expression of HSPB1 mRNA	20332019
D012967	Sodium Dodecyl Sulfate	Sodium Dodecyl Sulfate results in increased expression of HSPB1 protein	20332019
D012967	Sodium Dodecyl Sulfate	Sodium Dodecyl Sulfate results in decreased expression of HSPB1 mRNA	12815608
D013311	Streptozocin	Curcumin inhibits the reaction [Streptozocin results in increased expression of HSPB1 protein]	18204486
D013481	Superoxides	HSPB1 protein results in decreased abundance of Superoxides	14975446
D013481	Superoxides	[tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in decreased abundance of Superoxides] which results in decreased expression of HSPB1 protein	19193722
D015085	2,4,5-Trichlorophenoxyacetic Acid	"2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HSPB1 mRNA"	18579281
D013629	Tamoxifen	[Tamoxifen binds to and results in increased activity of ESR1 protein] which results in increased expression of HSPB1 mRNA	11174852
D013629	Tamoxifen	Tamoxifen affects the expression of HSPB1 mRNA	20937368
C047246	temozolomide	HSPB1 mutant form results in increased susceptibility to [Quercetin co-treated with temozolomide]	24126416
C047246	temozolomide	HSPB1 mutant form results in increased susceptibility to temozolomide	24126416
D013739	Testosterone	[Estradiol co-treated with Testosterone] results in increased expression of HSPB1 mRNA	11375906
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HSPB1 mRNA	18495758\|2434956
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of HSPB1 mRNA]	11174852\|1117968
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HSPB1 promoter]	11174852
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to HSPB1 promoter] which results in decreased expression of HSPB1 mRNA]	11174852\|1117485
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HSPB1 mRNA	21215274
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased phosphorylation of HSPB1 protein	7541446
D013755	Tetradecanoylphorbol Acetate	Pentobarbital inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HSPB1 protein]	10839933
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of HSPB1 protein	10839933
D015647	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine affects the expression of HSPB1 protein"	25852303
C050950	tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex	[tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in decreased abundance of Superoxides] which results in decreased expression of HSPB1 protein	19193722
D013792	Thalidomide	Thalidomide results in decreased expression of HSPB1 mRNA	26217789
D013849	Thimerosal	Thimerosal results in increased expression of HSPB1 mRNA	16870260
D013853	Thioacetamide	Thioacetamide results in increased expression of HSPB1 mRNA	23411599
D008063	Thioctic Acid	Thioctic Acid inhibits the reaction [cobaltous chloride results in increased phosphorylation of HSPB1 protein]	17575032
C013298	thiodipropionic acid	thiodipropionic acid results in increased expression of HSPB1 mRNA	20332019
C013298	thiodipropionic acid	thiodipropionic acid results in increased expression of HSPB1 protein	20332019
D013874	Thiopental	Thiopental results in increased expression of HSPB1 mRNA	18218830
D013883	Thiostrepton	Thiostrepton results in increased expression of HSPB1 mRNA	22321511
C009495	titanium dioxide	titanium dioxide results in decreased expression of HSPB1 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of HSPB1 mRNA	22363418\|2806579
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of HSPB1 mRNA	15289447
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of HSPB1 protein	22003194
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of HSPB1 mRNA	25729387
D014118	Toxins, Biological	"Toxins, Biological affects the expression of HSPB1 mRNA"	19682533
D014212	Tretinoin	Tretinoin results in decreased expression of HSPB1 mRNA	21934132
D014212	Tretinoin	Tretinoin results in increased expression of HSPB1 mRNA	20117194
D014241	Trichloroethylene	Trichloroethylene results in increased expression of HSPB1 mRNA	25549359
D014241	Trichloroethylene	Trichloroethylene results in increased expression of HSPB1 mRNA	19448997
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of HSPB1 gene	27618143
C057693	troglitazone	troglitazone results in increased expression of HSPB1 mRNA	28973697
D014414	Tungsten	[Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of HSPB1 mRNA	22198552
C113580	U 0126	U 0126 inhibits the reaction [Glucose results in increased phosphorylation of HSPB1 protein]	25373458
C406224	valdecoxib	valdecoxib results in increased expression of HSPB1 mRNA	24136188
D014635	Valproic Acid	Valproic Acid results in increased expression of HSPB1 mRNA	27188386
D014635	Valproic Acid	Valproic Acid results in increased expression of HSPB1 mRNA	24896083
D014635	Valproic Acid	Valproic Acid results in increased expression of HSPB1 mRNA	21318169
D014640	Vancomycin	Vancomycin results in decreased expression of HSPB1 mRNA	18930951
D001335	Vehicle Emissions	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of HSPB1 mRNA]	17655762
D001335	Vehicle Emissions	Vehicle Emissions affects the expression of HSPB1 mRNA	17655762
D001335	Vehicle Emissions	Vehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of HSPB1 mRNA]	17655762
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of HSPB1 gene	25560391
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of HSPB1 mRNA	19465080
C025643	vinclozolin	vinclozolin affects the expression of HSPB1 mRNA	19015723
C029297	vinylidene chloride	vinylidene chloride results in increased expression of HSPB1 mRNA	26682919
D014810	Vitamin E	Vitamin E results in increased expression of HSPB1 mRNA	19244175
D024483	Vitamin K 3	Vitamin K 3 affects the expression of HSPB1 mRNA	20044591
C111237	vorinostat	[decitabine co-treated with vorinostat] affects the expression of HSPB1 mRNA	17330099
C111237	vorinostat	vorinostat results in decreased expression of HSPB1 protein	17593366
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of HSPB1 mRNA	18593933
D019345	Zinc Acetate	motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of HSPB1 mRNA]	16357179
D019345	Zinc Acetate	Zinc Acetate results in increased expression of HSPB1 mRNA	16357179
D019287	Zinc Sulfate	Zinc Sulfate results in decreased expression of HSPB1 mRNA	27215404

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003723	RNA binding	-	HDA	22658674
GO:0005080	protein kinase C binding	-	ISS	-
GO:0005515	protein binding	-	IPI	11003656 11700327 12601044 14594798 15161933 15657067 16169070 17184779 17342744 17353931 18330356 20467437 20618440 21157431 21575178 22365833 23188086 23397142 23948568 24189400 25036637 25241761 25277244 25852190 26496610
GO:0008426	protein kinase C inhibitor activity	-	ISS	-
GO:0019901	protein kinase binding	-	IPI	8774846
GO:0042802	identical protein binding	-	IMP	20178975 23948568
GO:0042802	identical protein binding	-	IPI	11003656 22365833 25036637 25277244
GO:0042803	protein homodimerization activity	-	IDA	28144995
GO:0043130	ubiquitin binding	-	ISS	-
GO:0044183	protein binding involved in protein folding	-	IMP	20178975

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001895	retina homeostasis	-	HEP	23580065
GO:0001932	regulation of protein phosphorylation	-	IMP	23728742
GO:0006446	regulation of translational initiation	-	TAS	10859165
GO:0006469	negative regulation of protein kinase activity	-	ISS	-
GO:0006986	response to unfolded protein	-	NAS	1560006
GO:0009615	response to virus	-	IEP	16548883
GO:0010506	regulation of autophagy	-	NAS	25962073
GO:0032731	positive regulation of interleukin-1 beta production	-	ISS	-
GO:0035556	intracellular signal transduction	-	IMP	18440775
GO:0035924	cellular response to vascular endothelial growth factor stimulus	-	IMP	18440775
GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	-	IMP	18440775
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	-	ISS	-
GO:0043066	negative regulation of apoptotic process	-	TAS	16130169
GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	-	ISS	-
GO:0043488	regulation of mRNA stability	-	TAS	-
GO:0043536	positive regulation of blood vessel endothelial cell migration	-	IMP	18440775
GO:0045766	positive regulation of angiogenesis	-	IMP	18440775
GO:0061077	chaperone-mediated protein folding	-	IMP	20178975 23948568
GO:0070527	platelet aggregation	-	HMP	23382103
GO:0071901	negative regulation of protein serine/threonine kinase activity	-	IEA	-
GO:0099641	anterograde axonal protein transport	-	IMP	23728742
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	-	ISS	-
GO:2001028	positive regulation of endothelial cell chemotaxis	-	IMP	18440775

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000502	proteasome complex	-	ISS	-
GO:0005615	extracellular space	-	HDA	22664934 23580065
GO:0005634	nucleus	-	IDA	19464326
GO:0005737	cytoplasm	-	IDA	19464326 28144995
GO:0005737	cytoplasm	-	TAS	16130169
GO:0005819	spindle	-	IEA	-
GO:0005829	cytosol	-	TAS	-
GO:0005856	cytoskeleton	-	TAS	16130169
GO:0005886	plasma membrane	-	IEA	-
GO:0005925	focal adhesion	-	HDA	21423176
GO:0030018	Z disc	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	19056867 19199708 23533145
GO:1904115	axon cytoplasm	-	IEA	-

KEGG ID	KEGG Term
hsa04010	MAPK signaling pathway
hsa04370	VEGF signaling pathway
hsa05146	Amoebiasis

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-194138	Signaling by VEGF	TAS
R-HSA-4420097	VEGFA-VEGFR2 Pathway	TAS
R-HSA-450408	AUF1 (hnRNP D0) binds and destabilizes mRNA	TAS
R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5687128	MAPK6/MAPK4 signaling	TAS
R-HSA-8953854	Metabolism of RNA	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29017331	Distinct prognostic roles of HSPB1 expression in non-small cell lung cancer. (2018)	Huang ZC	Neoplasma