Gene info: ID 3320

Gene: HSP90AA1

GENE ID: 3320

Description: heat shock protein 90 alpha family class A member 1

Gene type: protein-coding

Location: 14q32.31

dbXrefs: Ensembl:ENSG00000080824 MIM:140571 Vega:OTTHUMG00000171752 UniprotKB:P07900

RefSeq: NC_000014.9

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: CD|ND|AD

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.515e-1 (AD) 1.103e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs1190596	chr14:102129288 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PTGES3	0.944
DNAJA1	0.929
TCP1	0.92
DNAJB6	0.904
HSP90AB1	0.904
HSP90B1	0.895
CACYBP	0.889
FKBP4	0.889
STIP1	0.889
HSPH1	0.888

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.748
OR4F5	-0.741
CEACAM4	-0.266
KLRF1	-0.264
IL2RB	-0.254
KLRB1	-0.246
CC2D2B	-0.245
CLEC12A	-0.241
IL18RAP	-0.237
CEACAM8	-0.235

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00615	Rifabutin	Small Molecule	72559-06-9	Approved\|Investigational	Target
DB00716	Nedocromil	Small Molecule	69049-73-6	Approved\|Investigational	Target
DB02359	9-Butyl-8-(2,5-Dimethoxy-Benzyl)-9h-Purin-6-Ylamine	Small Molecule		Experimental	Target
DB02424	Geldanamycin	Small Molecule	30562-34-6	Experimental\|Investigational	Target
DB02550	8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-2-Fluoro-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine	Small Molecule		Experimental	Target
DB02754	9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine	Small Molecule		Experimental	Target
DB02840	4-(1,3-Benzodioxol-5-Yl)-5-(5-Ethyl-2,4-Dihydroxyphenyl)-2h-Pyrazole-3-Carboxylic Acid	Small Molecule		Experimental	Target
DB03093	8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-Ylamine	Small Molecule		Experimental	Target
DB03137	8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9-Pent-9h-Purin-6-Ylamine	Small Molecule		Experimental	Target
DB03504	9-Butyl-8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9h-Purin-6-Ylamine	Small Molecule		Experimental	Target
DB03749	4-(1h-Imidazol-4-Yl)-3-(5-Ethyl-2,4-Dihydroxy-Phenyl)-1h-Pyrazole	Small Molecule		Experimental	Target
DB03809	9-Butyl-8-(3-Methoxybenzyl)-9h-Purin-6-Amine	Small Molecule		Experimental	Target
DB03899	9-Butyl-8-(4-Methoxybenzyl)-9h-Purin-6-Amine	Small Molecule		Experimental	Target
DB04054	9-Butyl-8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-Ylamine	Small Molecule		Experimental	Target
DB04216	Quercetin	Small Molecule	117-39-5	Experimental\|Investigational	Target
DB04254	8-Benzo[1,3]Dioxol-,5-Ylmethyl-9-Butyl-2-Fluoro-9h-Purin-6-Ylamine	Small Molecule		Experimental	Target
DB04505	8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine	Small Molecule		Experimental	Target
DB04588	N-[4-(AMINOSULFONYL)BENZYL]-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE	Small Molecule		Experimental	Target
DB05134	Tanespimycin	Small Molecule	75747-14-7	Investigational	Target
DB06070	SNX-5422	Small Molecule		Investigational	Target
DB06956	N-(4-ACETYLPHENYL)-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE	Small Molecule		Experimental	Target
DB06957	4-CHLORO-6-(4-{4-[4-(METHYLSULFONYL)BENZYL]PIPERAZIN-1-YL}-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL	Small Molecule		Experimental	Target
DB06958	5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-PIPERAZIN-1-YL-1H-PYRAZOLE-3-CARBOXAMIDE	Small Molecule		Experimental	Target
DB06961	5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]isoxazole-3-carboxamide	Small Molecule		Experimental	Target
DB06964	5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)ISOXAZOLE-3-CARBOXAMIDE	Small Molecule		Experimental	Target
DB06969	2-amino-4-[2,4-dichloro-5-(2-pyrrolidin-1-ylethoxy)phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide	Small Molecule		Experimental	Target
DB07100	4-CHLORO-6-(4-PIPERAZIN-1-YL-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL	Small Molecule		Experimental	Target
DB07317	(3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one	Small Molecule		Experimental	Target
DB07319	6-(3-BROMO-2-NAPHTHYL)-1,3,5-TRIAZINE-2,4-DIAMINE	Small Molecule		Experimental	Target
DB07324	3-({2-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)ETHYNYL]BENZYL}AMINO)-1,3-OXAZOL-2(3H)-ONE	Small Molecule		Experimental	Target
DB07325	N-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)METHYL]-3-{[(E)-(2-OXODIHYDROFURAN-3(2H)-YLIDENE)METHYL]AMINO}BENZENESULFONAMIDE	Small Molecule		Experimental	Target
DB07495	5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDE	Small Molecule		Experimental	Target
DB07502	4-bromo-6-(6-hydroxy-1,2-benzisoxazol-3-yl)benzene-1,3-diol	Small Molecule		Experimental	Target
DB07594	4-[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-METHYL-1H-PYRAZOL-5-YL]-6-ETHYLBENZENE-1,3-DIOL	Small Molecule		Experimental	Target
DB07601	4-chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diol	Small Molecule		Experimental	Target
DB07877	8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE	Small Molecule		Experimental	Target
DB08194	4-methyl-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-amine	Small Molecule		Experimental	Target
DB08197	(5E,7S)-2-amino-7-(4-fluoro-2-pyridin-3-ylphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one oxime	Small Molecule		Experimental	Target
DB08436	8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL-9H-	Small Molecule		Experimental	Target
DB08442	4-{[(2R)-2-(2-methylphenyl)pyrrolidin-1-yl]carbonyl}benzene-1,3-diol	Small Molecule		Experimental	Target
DB08443	2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol	Small Molecule		Experimental	Target
DB08557	2-[(2-methoxyethyl)amino]-4-(4-oxo-1,2,3,4-tetrahydro-9H-carbazol-9-yl)benzamide	Small Molecule		Experimental	Target
DB08786	4-(2-methoxyethoxy)-6-methylpyrimidin-2-amine	Small Molecule		Experimental	Target
DB08787	4-(2,4-dichlorophenyl)-5-phenyldiazenyl-pyrimidin-2-amine	Small Molecule		Experimental	Target
DB08788	3,6-DIAMINO-5-CYANO-4-(4-ETHOXYPHENYL)THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE	Small Molecule		Experimental	Target
DB08789	2-AMINO-4-(2,4-DICHLOROPHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE	Small Molecule		Experimental	Target
DB09130	Copper	Small Molecule	7440-50-8	Approved\|Investigational	Target
DB09221	Polaprezinc	Small Molecule	107667-60-7	Approved\|Investigational	Target
DB12442	Alvespimycin	Small Molecule	467214-20-6	Investigational	Target

ID	Drug Name	Action	PubMed
C025603	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Humic Substances results in increased expression of HSP90AA1 protein]"	23836447
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of HSP90AA1 mRNA"	15375163
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of HSP90AA1 mRNA"	28903501
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of HSP90AA1 protein"	21673325
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of HSP90AA1 mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene results in increased expression of HSP90AA1 mRNA"	19417177
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of HSP90AA1 mRNA"	21346803
C024709	2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone	"2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone binds to HSP90AA1 protein"	16533022
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HSP90AA1 mRNA"	15215175
C035208	2-amino-4,6-dinitrotoluene	"2-amino-4,6-dinitrotoluene affects the expression of HSP90AA1 mRNA"	21346803
C030370	2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone	"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of HSP90AA1 mRNA"	20206263
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Smoke results in increased expression of HSP90AA1 mRNA]	23069111
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Smoke results in increased expression of HSP90AA1 protein]	23069111
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of HSP90AA1 mRNA	12958071
C517041	(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of HSP90AA1 mRNA"	19561079
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of HSP90AA1 mRNA"	21346803
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal analog binds to HSP90AA1	18232660
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal binds to HSP90AA1 protein	21749116
C011421	5-chloro-2-methyl-4-isothiazolin-3-one	5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of HSP90AA1 protein	29267982
C041715	6-anilino-5,8-quinolinedione	"6-anilino-5,8-quinolinedione results in increased expression of and results in increased secretion of HSP90AA1 protein"	10617604
C526550	9H-purine-9-propanamine, 6-amino-8-((6-iodo-1,3-benzodioxol-5-yl)thio)-N-(1-methylethyl)-	"9H-purine-9-propanamine, 6-amino-8-((6-iodo-1,3-benzodioxol-5-yl)thio)-N-(1-methylethyl)- inhibits the reaction [HSP90AA1 protein binds to PTGES3 protein]"	22895790
D000082	Acetaminophen	Acetaminophen results in increased expression of HSP90AA1 mRNA	21420995
D000082	Acetaminophen	Acetaminophen affects the expression of HSP90AA1 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of HSP90AA1 mRNA	11743745\|1295819
D000082	Acetaminophen	PPARA protein affects the reaction [Acetaminophen results in increased expression of HSP90AA1 mRNA]	12958197
D000082	Acetaminophen	PTGS2 protein affects the reaction [Acetaminophen results in increased expression of HSP90AA1 mRNA]	11743745
D000082	Acetaminophen	Acetaminophen results in increased expression of HSP90AA1 mRNA	17202762
C109238	acyline	acyline results in increased expression of HSP90AA1 mRNA	17510436
D000244	Adenosine Diphosphate	Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]	23184943
D000244	Adenosine Diphosphate	Calcium promotes the reaction [Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]]	23184943
D000255	Adenosine Triphosphate	Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to HSP90AA1 protein]	23184943
D000255	Adenosine Triphosphate	Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]	23184943
D000255	Adenosine Triphosphate	Calcium promotes the reaction [Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]]	23184943
C000188	alachlor	alachlor results in increased expression of HSP90AA1 mRNA alternative form	8792849
D015766	Albendazole	[Ivermectin co-treated with Albendazole] results in increased expression of HSP90AA1 mRNA	16861626
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin analog results in decreased expression of HSP90AA1 protein	26072098
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin analog results in increased expression of HSP90AA1 protein	26597043
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of HSP90AA1 protein	26072098
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of HSP90AA1 mRNA	16483693
D003913	Dextroamphetamine	Dextroamphetamine affects the expression of HSP90AA1 mRNA	12558987
C000228	aristolochic acid I	[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of HSP90AA1 mRNA	23912714
C042310	aristolochic acid II	[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of HSP90AA1 mRNA	23912714
D001151	Arsenic	Arsenic affects the methylation of HSP90AA1 gene	25304211
C006632	arsenic trioxide	arsenic trioxide results in increased expression of HSP90AA1 mRNA	28755286
C006632	arsenic trioxide	arsenic trioxide results in increased expression of HSP90AA1 protein	28755286
C006632	arsenic trioxide	arsenic trioxide results in increased expression of HSP90AA1 mRNA	11940349\|1808189
C006632	arsenic trioxide	arsenic trioxide results in increased expression of HSP90AA1 protein	18081892\|1936412
C006632	arsenic trioxide	HSP90AA1 protein affects the susceptibility to arsenic trioxide	19371599
C006632	arsenic trioxide	sulforafan promotes the reaction [arsenic trioxide results in increased expression of HSP90AA1 protein]	22922937
C006632	arsenic trioxide	arsenic trioxide results in increased expression of HSP90AA1 protein	27592447
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of HSP90AA1 mRNA"	25351596
C019264	avermectin	avermectin results in increased expression of HSP90AA1 mRNA	25446859
C019264	avermectin	avermectin results in increased expression of HSP90AA1 protein	25446859
D001372	Aza Compounds	Aza Compounds results in decreased expression of HSP90AA1 mRNA	20521778
D001372	Aza Compounds	Aza Compounds results in increased expression of HSP90AA1 mRNA	20521778
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of HSP90AA1 mRNA	17690111
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of HSP90AA1 mRNA	17690111
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of HSP90AA1 mRNA	18061397
D001564	Benzo(a)pyrene	AHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of HSP90AA1 mRNA]	15034205
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of HSP90AA1 mRNA	15034205
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of HSP90AA1 mRNA	19770486\|2156981
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of HSP90AA1 mRNA	26466350
D001564	Benzo(a)pyrene	Sulpiride inhibits the reaction [Benzo(a)pyrene results in increased expression of HSP90AA1 mRNA]	26466350
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HSP90AA1 mRNA"	26238291
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HSP90AA1 mRNA	25566086
D004958	Estradiol	Estradiol results in increased expression of HSP90AA1 mRNA	20106945
D004958	Estradiol	Estradiol results in increased expression of and affects the localization of HSP90AA1 protein	11568360
D004958	Estradiol	Estradiol results in increased expression of HSP90AA1 mRNA	12927369
D004958	Estradiol	fulvestrant inhibits the reaction [Estradiol results in increased expression of HSP90AA1 protein]	11568360
C044887	beta-methylcholine	beta-methylcholine affects the expression of HSP90AA1 mRNA	21179406
C110172	BHTOH-QM	BHTOH-QM binds to HSP90AA1 protein	16533022
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HSP90AA1 mRNA	28628672
C070515	bisindolylmaleimide I	bisindolylmaleimide I inhibits the reaction [bisphenol A results in increased expression of HSP90AA1 mRNA]	12927369
C070515	bisindolylmaleimide I	bisindolylmaleimide I results in increased expression of HSP90AA1 mRNA	12927369
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HSP90AA1 mRNA	28628672
C006780	bisphenol A	bisindolylmaleimide I inhibits the reaction [bisphenol A results in increased expression of HSP90AA1 mRNA]	12927369
C006780	bisphenol A	bisphenol A results in increased expression of and affects the localization of HSP90AA1 protein	11568360
C006780	bisphenol A	bisphenol A results in increased expression of HSP90AA1 mRNA	12927369
C006780	bisphenol A	bisphenol A results in increased expression of HSP90AA1 protein	28641223
C006780	bisphenol A	fulvestrant inhibits the reaction [bisphenol A results in increased expression of HSP90AA1 protein]	11568360
C006780	bisphenol A	bisphenol A results in increased expression of HSP90AA1 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of HSP90AA1 protein	15229138
D001761	Bleomycin	[Bleomycin co-treated with Cisplatin co-treated with Etoposide] results in increased expression of HSP90AA1 protein	24478030
D000069286	Bortezomib	Bortezomib results in decreased expression of HSP90AA1 mRNA	20471514
D000069286	Bortezomib	Bortezomib results in increased expression of HSP90AA1 mRNA	17895889
D000069286	Bortezomib	Bortezomib results in increased expression of HSP90AA1 mRNA	20830808
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of HSP90AA1 mRNA	22079614
C515564	bromovanin	bromovanin results in increased expression of HSP90AA1 protein	21419150
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in increased expression of HSP90AA1 protein	23736079
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of HSP90AA1 mRNA	15336504
D002104	Cadmium	Cadmium results in increased expression of HSP90AA1 mRNA	28115653
D002104	Cadmium	Cadmium results in increased expression of HSP90AA1 protein	28115653
D002104	Cadmium	Cadmium results in increased expression of HSP90AA1 mRNA	11985888
D002104	Cadmium	Cadmium results in increased expression of HSP90AA1 mRNA	16020198\|2428428
C028031	cadmium acetate	cadmium acetate affects the expression of HSP90AA1 mRNA	16249259
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of HSP90AA1 mRNA	11985888
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of HSP90AA1 mRNA	23828170
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of HSP90AA1 mRNA	12760830
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of HSP90AA1 mRNA	25882684
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of HSP90AA1 mRNA	15501611
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of HSP90AA1 mRNA	11171528
D019256	Cadmium Chloride	[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of HSP90AA1 mRNA	19840844
D002110	Caffeine	"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HSP90AA1 mRNA"	20230807
D002110	Caffeine	"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSP90AA1 mRNA]"	20230807
D002118	Calcium	Calcium promotes the reaction [Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]]	23184943
D002118	Calcium	Calcium promotes the reaction [Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]]	23184943
D002220	Carbamazepine	Carbamazepine results in decreased expression of HSP90AA1 mRNA	17381134
D002220	Carbamazepine	Carbamazepine results in increased expression of HSP90AA1 mRNA	17381134
D002259	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of HSP90AA1 mRNA	16039398
C099555	CD 437	CD 437 results in decreased expression of HSP90AA1 mRNA	12958071
D002509	Cephaloridine	Cephaloridine results in increased expression of HSP90AA1 mRNA	18500788
D002706	Chlordan	Chlordan results in increased expression of HSP90AA1 mRNA alternative form	8792849
C100187	chloropicrin	chloropicrin results in increased expression of HSP90AA1 mRNA	26352163
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of HSP90AA1 mRNA	26494550
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of HSP90AA1 mRNA	18668222
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of HSP90AA1 mRNA alternative form	8792849
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of HSP90AA1 mRNA	28472532
C012843	cinnamic aldehyde	cinnamic aldehyde results in increased metabolism of HSP90AA1 protein	29267982
D002994	Clofibrate	Clofibrate results in increased expression of HSP90AA1 mRNA	23811191
D002994	Clofibrate	Clofibrate affects the expression of HSP90AA1 mRNA	21318169
D003000	Clonidine	Clonidine results in increased expression of HSP90AA1 mRNA	10684495
D003042	Cocaine	Cocaine deficiency results in increased expression of HSP90AA1 mRNA	22860061
D003300	Copper	[Disulfiram binds to Copper] which results in decreased expression of HSP90AA1 mRNA	24690739
D003300	Copper	HSP90AA1 protein binds to Copper	15359738
D003300	Copper	[Organoselenium Compounds binds to Copper] which results in decreased expression of HSP90AA1 protein	25167922
D003300	Copper	[Organoselenium Compounds binds to Copper] which results in increased expression of HSP90AA1 mRNA	25167922
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of HSP90AA1 mRNA	19549813\|2059984
D019327	Copper Sulfate	Copper Sulfate results in increased expression of HSP90AA1 mRNA	20599845
D003375	Coumestrol	Coumestrol results in increased expression of HSP90AA1 protein	15229138
C402665	CP 31398	CP 31398 results in increased expression of HSP90AA1 mRNA	15155752
C516694	cruentaren A	cruentaren A affects the localization of HSP90AA1 protein	24450340
C029892	cupric chloride	cupric chloride results in increased expression of HSP90AA1 mRNA	17211630
C030973	cupric oxide	cupric oxide results in increased expression of HSP90AA1 mRNA	22077320
D003471	Cuprizone	Cuprizone results in decreased expression of HSP90AA1 mRNA	26577399
D003474	Curcumin	Curcumin analog results in decreased expression of HSP90AA1 mRNA	26409325
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of HSP90AA1 mRNA	11906922
D016572	Cyclosporine	Cyclosporine results in increased expression of HSP90AA1 mRNA	20106945
C014347	decitabine	decitabine results in decreased expression of HSP90AA1 protein	19294695
C014347	decitabine	[trichostatin A co-treated with decitabine] results in decreased expression of HSP90AA1 protein	19294695
D013759	Dronabinol	Dronabinol results in decreased expression of HSP90AA1 mRNA	16039398
D003847	Deoxyglucose	Deoxyglucose inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]	18655187
D003907	Dexamethasone	Dexamethasone results in increased expression of HSP90AA1 mRNA	19064852
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HSP90AA1 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HSP90AA1 mRNA	28628672
C041517	dibenzo(a,l)pyrene	"dibenzo(a,l)pyrene results in decreased expression of HSP90AA1 mRNA"	25908611
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of HSP90AA1 mRNA	17379624
D002945	Cisplatin	Cisplatin results in decreased expression of HSP90AA1 mRNA	27594783
D002945	Cisplatin	Cisplatin results in increased expression of HSP90AA1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of HSP90AA1 mRNA	21151649
D002945	Cisplatin	[Bleomycin co-treated with Cisplatin co-treated with Etoposide] results in increased expression of HSP90AA1 protein	24478030
D004008	Diclofenac	"Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HSP90AA1 mRNA]"	23939143
C000944	dicrotophos	dicrotophos results in decreased expression of HSP90AA1 mRNA	28302478
D004041	Dietary Fats	Dietary Fats results in increased expression of HSP90AA1 mRNA	19030233
D004041	Dietary Fats	rimonabant inhibits the reaction [Dietary Fats results in increased expression of HSP90AA1 mRNA]	19030233
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of HSP90AA1 mRNA	21318169
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of HSP90AA1 protein	21318169
D004051	Diethylhexyl Phthalate	PPARA protein affects the reaction [Diethylhexyl Phthalate results in increased expression of HSP90AA1 protein]	21318169
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of HSP90AA1 mRNA	21318169
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HSP90AA1 mRNA	18544905
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of HSP90AA1 mRNA	28943392
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of HSP90AA1 mRNA	19638242
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of HSP90AA1 protein	15229138
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in decreased expression of HSP90AA1 mRNA	27638505
D004221	Disulfiram	[Disulfiram binds to Copper] which results in decreased expression of HSP90AA1 mRNA	24690739
D004237	Diuron	Diuron results in decreased expression of HSP90AA1 mRNA	21551480
D004317	Doxorubicin	Doxorubicin affects the expression of HSP90AA1 protein	29385562
D004317	Doxorubicin	Doxorubicin results in increased expression of HSP90AA1 mRNA	17680992
D004317	Doxorubicin	Doxorubicin results in increased expression of HSP90AA1 mRNA	25896364
D004317	Doxorubicin	Doxorubicin promotes the reaction [HSP90AA1 protein binds to ERBB2 protein]	17308081
D004317	Doxorubicin	Doxorubicin results in increased expression of HSP90AA1 protein	17308081
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of HSP90AA1 mRNA"	23811387
D004732	Endrin	Endrin results in increased expression of HSP90AA1 mRNA alternative form	8792849
D004785	Environmental Pollutants	Environmental Pollutants affects the expression of HSP90AA1 mRNA	19118595
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of HSP90AA1 protein	23301498
D000431	Ethanol	Ethanol results in decreased expression of HSP90AA1 mRNA	22535522
D000431	Ethanol	Ethanol results in increased expression of HSP90AA1 mRNA	17189318
D000431	Ethanol	HSF1 protein affects the reaction [Ethanol results in increased expression of HSP90AA1 mRNA]	17189318
D000431	Ethanol	Ethanol results in decreased expression of HSP90AA1 mRNA	16098508
D000431	Ethanol	Ethanol results in increased expression of HSP90AA1 mRNA	23273579
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of HSP90AA1 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of HSP90AA1 mRNA	16174780\|1794274
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HSP90AA1 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of HSP90AA1 mRNA	16174780\|1710823
C002994	ethylene dimethanesulfonate	ethylene dimethanesulfonate results in increased expression of HSP90AA1 mRNA	22711419
D005047	Etoposide	[Bleomycin co-treated with Cisplatin co-treated with Etoposide] results in increased expression of HSP90AA1 protein	24478030
C047360	felbamate	felbamate results in decreased expression of HSP90AA1 mRNA	17381134
C047360	felbamate	felbamate results in increased expression of HSP90AA1 mRNA	17381134
D011345	Fenofibrate	Fenofibrate results in increased expression of HSP90AA1 mRNA	21318169
D011345	Fenofibrate	PPARA protein affects the reaction [Fenofibrate results in increased expression of HSP90AA1 mRNA]	21318169
D005284	Fenthion	Fenthion results in increased expression of HSP90AA1 mRNA alternative form	8792849
C020326	ferric nitrilotriacetate	ferric nitrilotriacetate results in increased expression of HSP90AA1 mRNA	10854235
C020748	ferrous sulfate	ferrous sulfate inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]	18655187
D018120	Finasteride	Finasteride results in increased expression of HSP90AA1 mRNA	24136188
D005485	Flutamide	Flutamide results in increased expression of HSP90AA1 mRNA	20566332\|2413618
C070081	fulvestrant	fulvestrant inhibits the reaction [bisphenol A results in increased expression of HSP90AA1 protein]	11568360
C070081	fulvestrant	fulvestrant inhibits the reaction [Estradiol results in increased expression of HSP90AA1 protein]	11568360
C039281	furan	furan results in increased expression of HSP90AA1 mRNA	24183702
C040029	gabapentin	gabapentin results in decreased expression of HSP90AA1 mRNA	17381134
C106014	gedunin	gedunin results in decreased activity of HSP90AA1 protein	17010675
C001277	geldanamycin	geldanamycin inhibits the reaction [HSP90AA1 protein binds to SRC protein binds to CDC37 protein]	17223712
C001277	geldanamycin	geldanamycin inhibits the reaction [KCNH2 protein binds to HSP90AA1 protein]	12775586
C001277	geldanamycin	geldanamycin inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]	18655187
C001277	geldanamycin	geldanamycin binds to HSP90AA1 protein	21749116
C001277	geldanamycin	geldanamycin results in decreased activity of HSP90AA1 protein	12115584
D019833	Genistein	Genistein results in increased expression of HSP90AA1 protein	15229138
C063170	Ginkgo biloba extract	Ginkgo biloba extract results in increased expression of HSP90AA1 mRNA	19064852
D005947	Glucose	Glucose deficiency inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]	18655187
D005947	Glucose	[INS protein co-treated with Glucose] results in decreased expression of HSP90AA1 mRNA	22634610
D005947	Glucose	[INS protein co-treated with Glucose] results in increased expression of HSP90AA1 mRNA	22634610
D006812	Humic Substances	"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Humic Substances results in increased expression of HSP90AA1 protein]"	23836447
D006812	Humic Substances	Humic Substances results in increased expression of HSP90AA1 protein	23836447
D006820	Hyaluronic Acid	Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of HSP90AA1 protein]	23178681
D006861	Hydrogen Peroxide	Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of HSP90AA1 protein]	23178681
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of HSP90AA1 protein	23178681
C013038	hydroxyhydroquinone	hydroxyhydroquinone results in increased expression of HSP90AA1 mRNA	17572062
D006997	Hypochlorous Acid	Hypochlorous Acid results in increased expression of HSP90AA1 mRNA	19376150
C041508	indeno(1,2,3-cd)pyrene	"indeno(1,2,3-cd)pyrene results in decreased expression of HSP90AA1 mRNA"	26377693
C020758	indium trichloride	indium trichloride results in decreased expression of HSP90AA1 protein	19539025
D007211	Indoles	Indoles results in decreased expression of HSP90AA1 mRNA	20521778
D007211	Indoles	Indoles results in increased expression of HSP90AA1 mRNA	20521778
C075954	indolo(3,2-b)carbazole	"indolo(3,2-b)carbazole results in increased expression of HSP90AA1 mRNA"	18061397
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HSP90AA1 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HSP90AA1 mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HSP90AA1 mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HSP90AA1 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HSP90AA1 mRNA	28628672
D007545	Isoproterenol	Isoproterenol results in increased expression of HSP90AA1 mRNA	21335049
D007559	Ivermectin	[Ivermectin co-treated with Albendazole] results in increased expression of HSP90AA1 mRNA	16861626
C410337	K 7174	K 7174 results in decreased expression of HSP90AA1 mRNA	24086573
C011890	kojic acid	[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HSP90AA1 mRNA	18544905
C008261	lead acetate	lead acetate affects the expression of HSP90AA1 mRNA	21829687
C045463	leflunomide	leflunomide results in increased expression of HSP90AA1 mRNA	24136188
C052901	lemongrass oil	lemongrass oil affects the expression of HSP90AA1 mRNA	25976427
C018584	linalool	linalool results in increased expression of HSP90AA1 mRNA	19922762
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in decreased expression of HSP90AA1 mRNA"	24972896
C482199	lipopolysaccharide, E coli O55-B5	"Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HSP90AA1 mRNA]"	23939143
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of HSP90AA1 mRNA"	23939143
D008294	Malathion	Malathion results in increased expression of HSP90AA1 mRNA	26494550
D008344	Maneb	[Maneb co-treated with Paraquat] results in decreased expression of HSP90AA1 mRNA	23963992
D008344	Maneb	Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSP90AA1 mRNA]	23963992
D008344	Maneb	[Paraquat co-treated with Maneb] results in increased expression of HSP90AA1 mRNA	18386188
D008550	Melatonin	Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSP90AA1 mRNA]	23963992
D008628	Mercury	Mercury results in increased expression of HSP90AA1 mRNA	16823088
D008694	Methamphetamine	Methamphetamine results in increased expression of HSP90AA1 mRNA	19564919
D008731	Methoxychlor	Methoxychlor results in increased methylation of HSP90AA1 gene	23303685
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of HSP90AA1 mRNA	23273579
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of HSP90AA1 mRNA	16966085
D008769	Methylnitronitrosoguanidine	[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of HSP90AA1 mRNA	19840844
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSP90AA1 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HSP90AA1 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSP90AA1 mRNA]"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HSP90AA1 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSP90AA1 mRNA]"	20230807
D015741	Metribolone	Metribolone promotes the reaction [NDRG1 protein binds to HSP90AA1 protein]	17220478
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased expression of HSP90AA1 mRNA	22087261
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of HSP90AA1 mRNA	20024957
D009151	Mustard Gas	Mustard Gas results in increased expression of HSP90AA1 mRNA	15674843
C576667	N-(5-methylisoxazol-3-yl)-2-(4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ylthio)acetamide	N-(5-methylisoxazol-3-yl)-2-(4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ylthio)acetamide analog inhibits the reaction [HSP90AA1 protein binds to PTGES3 protein]	22895790
C576667	N-(5-methylisoxazol-3-yl)-2-(4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ylthio)acetamide	N-(5-methylisoxazol-3-yl)-2-(4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ylthio)acetamide binds to and results in decreased activity of HSP90AA1 protein	22895790
C576667	N-(5-methylisoxazol-3-yl)-2-(4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ylthio)acetamide	N-(5-methylisoxazol-3-yl)-2-(4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ylthio)acetamide inhibits the reaction [HSP90AA1 protein binds to PTGES3 protein]	22895790
C576667	N-(5-methylisoxazol-3-yl)-2-(4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ylthio)acetamide	N-(5-methylisoxazol-3-yl)-2-(4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ylthio)acetamide inhibits the reaction [tanespimycin binds to HSP90AA1 protein]	22895790
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of HSP90AA1 mRNA"	25554681
D009285	Naphthoquinones	Naphthoquinones results in increased expression of HSP90AA1 mRNA	23811387
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of HSP90AA1 mRNA	20551477
C051752	nefazodone	nefazodone results in increased expression of HSP90AA1 mRNA	24136188
D009532	Nickel	Nickel results in decreased expression of HSP90AA1 mRNA	18922574
C119536	nickel acetate	nickel acetate affects the expression of HSP90AA1 mRNA	23828170
C017557	nickel subsulfide	nickel subsulfide results in decreased expression of HSP90AA1 mRNA	12760830
D009538	Nicotine	Nicotine results in increased expression of HSP90AA1 mRNA	12115584
D009538	Nicotine	Nicotine results in increased expression of HSP90AA1 protein	12115584
D009538	Nicotine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HSP90AA1 mRNA"	20230807
D009538	Nicotine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSP90AA1 mRNA]"	20230807
C012655	nimesulide	nimesulide results in increased expression of HSP90AA1 mRNA	24136188
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of HSP90AA1 mRNA	17616710
C010615	Nonidet P-40	Nonidet P-40 results in increased expression of HSP90AA1 mRNA	26552463
C025589	ochratoxin A	ochratoxin A results in increased expression of HSP90AA1 protein	26861962
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of HSP90AA1 mRNA"	24096037
C016340	o,p'-DDT	"o,p'-DDT affects the expression of HSP90AA1 mRNA"	17984292
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of HSP90AA1 mRNA"	24096037
D016566	Organoselenium Compounds	[Organoselenium Compounds binds to Copper] which results in decreased expression of HSP90AA1 protein	25167922
D016566	Organoselenium Compounds	[Organoselenium Compounds binds to Copper] which results in increased expression of HSP90AA1 mRNA	25167922
D008939	Mitotane	Mitotane analog results in increased expression of HSP90AA1 mRNA	23485034
D008939	Mitotane	Mitotane results in increased expression of HSP90AA1 mRNA	23485034
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of HSP90AA1 mRNA	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of HSP90AA1 mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of HSP90AA1 mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	Particulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of HSP90AA1 mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	Vehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of HSP90AA1 mRNA]	17655762
D010100	Oxygen	Oxygen results in decreased expression of HSP90AA1 mRNA	27103661
D010126	Ozone	Ozone results in increased expression of HSP90AA1 mRNA	21543283
D010261	Paraoxon	Paraoxon results in decreased expression of HSP90AA1 protein	20931991
D010269	Paraquat	[Maneb co-treated with Paraquat] results in decreased expression of HSP90AA1 mRNA	23963992
D010269	Paraquat	Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSP90AA1 mRNA]	23963992
D010269	Paraquat	[Paraquat co-treated with Maneb] results in increased expression of HSP90AA1 mRNA	18386188
D052638	Particulate Matter	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of HSP90AA1 mRNA]	17655762
D052638	Particulate Matter	Particulate Matter affects the expression of HSP90AA1 mRNA	17655762
D052638	Particulate Matter	Particulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of HSP90AA1 mRNA]	17655762
D052638	Particulate Matter	Particulate Matter results in decreased expression of HSP90AA1 mRNA	24769257
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of HSP90AA1 mRNA	18593933
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of HSP90AA1 mRNA	18486366
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of HSP90AA1 mRNA	19162173
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of HSP90AA1 mRNA	21318169
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of HSP90AA1 mRNA	19162173
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of HSP90AA1 mRNA	21318169
C023036	perfluorooctanoic acid	PPARA protein affects the reaction [perfluorooctanoic acid results in increased expression of HSP90AA1 mRNA]	21318169
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of HSP90AA1 mRNA	19162173\|2131816
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in decreased expression of HSP90AA1 mRNA	17616710
D010634	Phenobarbital	Phenobarbital affects the expression of HSP90AA1 mRNA	23091169
D010634	Phenobarbital	Phenobarbital affects the expression of HSP90AA1 mRNA	19162173\|2327357
D010634	Phenobarbital	Phenobarbital results in increased expression of HSP90AA1 mRNA	17381134\|2131816
D010695	Phlorhizin	Phlorhizin results in decreased expression of HSP90AA1 mRNA	22538082
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of HSP90AA1 mRNA	22484513
C006253	pirinixic acid	pirinixic acid results in increased expression of HSP90AA1 mRNA	15375163\|1830175
C006253	pirinixic acid	pirinixic acid results in increased expression of HSP90AA1 protein	20059764\|2131816
C006253	pirinixic acid	PPARA protein affects the reaction [pirinixic acid results in increased expression of HSP90AA1 mRNA]	20059764\|2131816
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in increased expression of HSP90AA1 protein]	20059764
C006253	pirinixic acid	pirinixic acid results in increased expression of HSP90AA1 mRNA	19162173\|2131816
D010936	Plant Extracts	Plant Extracts affects the expression of HSP90AA1 mRNA	12878215
D010936	Plant Extracts	Plant Extracts results in increased expression of HSP90AA1 mRNA	18061397
D011070	Poly I-C	Poly I-C results in increased expression of HSP90AA1 mRNA	23939143
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of HSP90AA1 mRNA	19162173\|2131816
D011374	Progesterone	Progesterone affects the expression of HSP90AA1 mRNA	17251523
D011372	Progestins	Progestins results in increased expression of HSP90AA1 mRNA	19609016
C045950	propiconazole	propiconazole results in increased expression of HSP90AA1 mRNA	21278054
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of HSP90AA1 mRNA	24780913
C100573	prostaglandin A1	prostaglandin A1 analog results in increased metabolism of HSP90AA1 protein	19800325
C028025	protoporphyrin IX	HSP90AA1 protein results in decreased susceptibility to protoporphyrin IX	23624237
C031280	pyrazole	pyrazole results in increased expression of HSP90AA1 mRNA	17945193
C009131	pyrimidin-2-one beta-ribofuranoside	pyrimidin-2-one beta-ribofuranoside results in decreased expression of HSP90AA1 protein	18830594
C010423	pyrithione zinc	pyrithione zinc results in increased expression of HSP90AA1 mRNA	21424779
D011748	Pyrogallol	Pyrogallol results in increased expression of HSP90AA1 mRNA	20362636
D011794	Quercetin	Deoxyglucose inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]	18655187
D011794	Quercetin	ferrous sulfate inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]	18655187
D011794	Quercetin	geldanamycin inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]	18655187
D011794	Quercetin	Glucose deficiency inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]	18655187
D011794	Quercetin	Quercetin analog binds to HSP90AA1 protein	21798748
D011794	Quercetin	Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]	18655187
D011794	Quercetin	Quercetin results in decreased expression of HSP90AA1 protein	19207037
C012526	quercitrin	quercitrin affects the expression of HSP90AA1 mRNA	25193878
C059514	resveratrol	resveratrol results in decreased expression of HSP90AA1 mRNA	24570423
C059514	resveratrol	resveratrol results in increased expression of HSP90AA1 mRNA	24570423
C089032	rimonabant	rimonabant inhibits the reaction [Dietary Fats results in increased expression of HSP90AA1 mRNA]	19030233
D019438	Ritonavir	HSP90AA1 protein affects the susceptibility to Ritonavir	16551874
C064116	S-(1,1,2,2-tetrafluoroethyl)cysteine	"S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of HSP90AA1 mRNA"	16678137
D012643	Selenium	[Selenium co-treated with Vitamin E] results in decreased expression of HSP90AA1 mRNA	19244175
D012643	Selenium	Selenium results in decreased expression of HSP90AA1 mRNA	19244175
D012822	Silicon Dioxide	Silicon Dioxide analog affects the secretion of HSP90AA1 protein	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of HSP90AA1 mRNA	25351596
D012834	Silver	Silver results in increased expression of HSP90AA1 mRNA	26014281\|2895954
D012835	Silver Nitrate	Silver Nitrate analog results in increased expression of HSP90AA1 mRNA	22831968
D019821	Simvastatin	Simvastatin results in increased expression of HSP90AA1 protein	16375908
D012906	Smoke	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Smoke results in increased expression of HSP90AA1 mRNA]	23069111
D012906	Smoke	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Smoke results in increased expression of HSP90AA1 protein]	23069111
D012906	Smoke	Smoke results in increased expression of HSP90AA1 mRNA	23069111
D012906	Smoke	Smoke results in increased expression of HSP90AA1 protein	23069111
C017947	sodium arsenite	CARM1 mutant form promotes the reaction [sodium arsenite results in increased expression of HSP90AA1 mRNA]	23699174
C017947	sodium arsenite	PRMT1 mutant form promotes the reaction [sodium arsenite results in increased expression of HSP90AA1 mRNA]	23699174
C017947	sodium arsenite	sodium arsenite results in decreased expression of HSP90AA1 mRNA	27068294
C017947	sodium arsenite	sodium arsenite results in increased expression of HSP90AA1 mRNA	12119132\|1276083
C017947	sodium arsenite	sodium arsenite results in increased expression of HSP90AA1 mRNA	16014739
C017947	sodium arsenite	sodium arsenite results in increased expression of HSP90AA1 mRNA	16815819
C016104	sodium bichromate	sodium bichromate results in decreased expression of HSP90AA1 mRNA	12760830
C016104	sodium bichromate	sodium bichromate results in increased expression of HSP90AA1 mRNA	25993096
D017673	Sodium Chloride, Dietary	"Sodium Chloride, Dietary deficiency results in increased expression of and affects the localization of HSP90AA1 protein"	15497505
D017673	Sodium Chloride, Dietary	"Sodium Chloride, Dietary deficiency results in increased expression of HSP90AA1 mRNA"	15497505
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of HSP90AA1 mRNA	27862939
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of HSP90AA1 protein	27548804
C016766	sulforafan	sulforafan inhibits the reaction [HSP90AA1 protein binds to AR protein]	19805354
C016766	sulforafan	sulforafan promotes the reaction [arsenic trioxide results in increased expression of HSP90AA1 protein]	22922937
C016766	sulforafan	sulforafan results in increased acetylation of HSP90AA1 protein	19805354
D013469	Sulpiride	Sulpiride inhibits the reaction [Benzo(a)pyrene results in increased expression of HSP90AA1 mRNA]	26466350
D013469	Sulpiride	Sulpiride results in increased expression of HSP90AA1 mRNA	26466350
D013605	T-2 Toxin	T-2 Toxin affects the expression of HSP90AA1 protein	26141394
D013629	Tamoxifen	Tamoxifen affects the expression of HSP90AA1 mRNA	17555576\|2093736
D013629	Tamoxifen	Tamoxifen results in increased expression of HSP90AA1 mRNA	19400957
D013629	Tamoxifen	Tamoxifen results in increased expression of HSP90AA1 mRNA	19400957
C112765	tanespimycin	N-(5-methylisoxazol-3-yl)-2-(4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ylthio)acetamide inhibits the reaction [tanespimycin binds to HSP90AA1 protein]	22895790
C112765	tanespimycin	tanespimycin binds to HSP90AA1 protein	22895790
C112765	tanespimycin	tanespimycin results in decreased expression of HSP90AA1 protein	18830594
C112765	tanespimycin	tanespimycin results in decreased activity of HSP90AA1 protein	17157164\|1730808
C045037	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of HSP90AA1 mRNA	20189893
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HSP90AA1 mRNA	16039398
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of HSP90AA1 mRNA	18061397
D013749	Tetrachlorodibenzodioxin	AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of HSP90AA1 mRNA]	15034205
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of HSP90AA1 mRNA	21570461\|2468072
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HSP90AA1 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of HSP90AA1 mRNA	15034205\|1794274
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HSP90AA1 mRNA	25613284
D019284	Thapsigargin	Thapsigargin results in decreased expression of HSP90AA1 mRNA	22378314
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of HSP90AA1 mRNA	28943392
D013853	Thioacetamide	Thioacetamide results in increased expression of HSP90AA1 mRNA	16297948\|2341159
D013874	Thiopental	Thiopental results in increased expression of HSP90AA1 mRNA	18218830
C009495	titanium dioxide	titanium dioxide results in decreased expression of HSP90AA1 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of HSP90AA1 mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of HSP90AA1 mRNA	27589885
D014241	Trichloroethylene	PPARA protein inhibits the reaction [Trichloroethylene results in decreased expression of HSP90AA1 mRNA]	15363585
D014241	Trichloroethylene	Trichloroethylene results in increased expression of HSP90AA1 mRNA	11171528\|1944899
C012589	trichostatin A	trichostatin A affects the expression of HSP90AA1 protein	19294695
C012589	trichostatin A	[trichostatin A co-treated with decitabine] results in decreased expression of HSP90AA1 protein	19294695
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of HSP90AA1 mRNA	19042947
C050414	tripterine	tripterine results in decreased activity of HSP90AA1 protein	17010675
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of HSP90AA1 mRNA"	26179874
D014415	Tunicamycin	Tunicamycin results in decreased expression of HSP90AA1 mRNA	22378314
C406224	valdecoxib	valdecoxib results in increased expression of HSP90AA1 mRNA	24136188
D014635	Valproic Acid	Valproic Acid results in decreased expression of HSP90AA1 mRNA	23179753
D014635	Valproic Acid	Valproic Acid results in increased methylation of HSP90AA1 gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of HSP90AA1 mRNA	17292431
D014635	Valproic Acid	Valproic Acid results in decreased expression of HSP90AA1 mRNA	17381134
D014635	Valproic Acid	Valproic Acid results in increased expression of HSP90AA1 mRNA	21318169
D001335	Vehicle Emissions	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of HSP90AA1 mRNA]	17655762
D001335	Vehicle Emissions	Vehicle Emissions affects the expression of HSP90AA1 mRNA	17655762
D001335	Vehicle Emissions	Vehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of HSP90AA1 mRNA]	17655762
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of HSP90AA1 gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of HSP90AA1 mRNA	19015723
C025643	vinclozolin	vinclozolin results in increased expression of HSP90AA1 mRNA	23555832
D014800	Vitallium	Vitallium analog results in increased expression of HSP90AA1 mRNA	23825117
D014810	Vitamin E	[Selenium co-treated with Vitamin E] results in decreased expression of HSP90AA1 mRNA	19244175
D014810	Vitamin E	Vitamin E results in decreased expression of HSP90AA1 mRNA	19244175
C111237	vorinostat	vorinostat results in decreased expression of HSP90AA1 protein	20543569
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of HSP90AA1 mRNA	18593933
D015032	Zinc	Zinc results in decreased expression of HSP90AA1 mRNA	17074742
D019287	Zinc Sulfate	Zinc Sulfate affects the expression of HSP90AA1 protein	25162517
D019287	Zinc Sulfate	Zinc Sulfate results in decreased expression of HSP90AA1 mRNA	17074742
D015054	Zymosan	Zymosan results in increased expression of HSP90AA1 mRNA	19061961

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000166	nucleotide binding	-	TAS	11470816
GO:0003723	RNA binding	-	HDA	22658674 22681889
GO:0004713	protein tyrosine kinase activity	-	EXP	17349580
GO:0005515	protein binding	-	IPI	9660753 9817749 10913161 12176997 12526792 12604615 12853476 12855682 14638689 14676191 14743216 15708368 16083881 16169070 16275660 16307917 17024179 18195352 19026643 19740745 19875381 20029029 20133715 20188096 20195357 20353823 20374249 20558745 20864032 20936779 21360678 21871133 21988832 22022502 22843495 23349634 23414517 23431407 23455922 23995768 24189400 24658140 24794838 24949977 25036637 25416956 25486457 25609649 25738358 26496610 26517842 26754925 27086506 27353360 28330616 29127155
GO:0005524	ATP binding	-	IDA	27353360
GO:0005524	ATP binding	-	TAS	11470816
GO:0016887	ATPase activity	-	IDA	15937123 27353360 29127155
GO:0023026	MHC class II protein complex binding	-	HDA	20458337
GO:0030235	nitric-oxide synthase regulator activity	-	IDA	15937123
GO:0030911	TPR domain binding	-	IDA	9660753
GO:0030911	TPR domain binding	-	TAS	12526792
GO:0031625	ubiquitin protein ligase binding	-	IPI	16207813
GO:0042623	ATPase activity, coupled	-	TAS	-
GO:0042802	identical protein binding	-	IDA	29127155
GO:0042802	identical protein binding	-	IPI	8289821 16169070 21360678 21460846 25036637
GO:0042803	protein homodimerization activity	-	IDA	29127155
GO:0042803	protein homodimerization activity	-	TAS	11470816
GO:0042826	histone deacetylase binding	-	IPI	16809764
GO:0048156	tau protein binding	-	IPI	19363271
GO:0051020	GTPase binding	-	IPI	24337748
GO:0051082	unfolded protein binding	-	IEA	-
GO:0070182	DNA polymerase binding	-	IPI	10197982 19751963
GO:0097110	scaffold protein binding	-	IPI	10409742
GO:0097718	disordered domain specific binding	-	IPI	15713458
GO:1990782	protein tyrosine kinase binding	-	IPI	20353823

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000086	G2/M transition of mitotic cell cycle	-	TAS	-
GO:0001934	positive regulation of protein phosphorylation	-	IDA	19363271
GO:0006839	mitochondrial transport	-	TAS	12526792
GO:0006898	receptor-mediated endocytosis	-	TAS	-
GO:0006986	response to unfolded protein	-	NAS	2527334
GO:0007004	telomere maintenance via telomerase	-	IDA	10197982
GO:0007165	signal transduction	-	NAS	11470816
GO:0009408	response to heat	-	ISS	-
GO:0009409	response to cold	-	ISS	-
GO:0010389	regulation of G2/M transition of mitotic cell cycle	-	TAS	-
GO:0018108	peptidyl-tyrosine phosphorylation	-	IEA	-
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0021955	central nervous system neuron axonogenesis	-	ISS	-
GO:0030010	establishment of cell polarity	-	ISS	-
GO:0031396	regulation of protein ubiquitination	-	IDA	16809764
GO:0032273	positive regulation of protein polymerization	-	IDA	19363271
GO:0033138	positive regulation of peptidyl-serine phosphorylation	-	ISS	-
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	-	TAS	-
GO:0038128	ERBB2 signaling pathway	-	TAS	-
GO:0042026	protein refolding	-	TAS	9660753
GO:0043254	regulation of protein complex assembly	-	NAS	20176123
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0043335	protein unfolding	-	NAS	20176123
GO:0045040	protein import into mitochondrial outer membrane	-	IDA	15644312
GO:0045429	positive regulation of nitric oxide biosynthetic process	-	ISS	-
GO:0046677	response to antibiotic	-	ISS	-
GO:0048010	vascular endothelial growth factor receptor signaling pathway	-	TAS	-
GO:0048675	axon extension	-	ISS	-
GO:0050821	protein stabilization	-	IMP	27353360
GO:0050821	protein stabilization	-	TAS	-
GO:0050999	regulation of nitric-oxide synthase activity	-	TAS	-
GO:0051131	chaperone-mediated protein complex assembly	-	IDA	15644312
GO:0051186	cofactor metabolic process	-	TAS	-
GO:0051897	positive regulation of protein kinase B signaling	-	ISS	-
GO:0051973	positive regulation of telomerase activity	-	IDA	10197982
GO:0061684	chaperone-mediated autophagy	-	TAS	25719862
GO:0097711	ciliary basal body-plasma membrane docking	-	TAS	-
GO:1900034	regulation of cellular response to heat	-	TAS	-
GO:1902949	positive regulation of tau-protein kinase activity	-	IDA	19363271
GO:1903364	positive regulation of cellular protein catabolic process	-	IGI	18292230
GO:1903827	regulation of cellular protein localization	-	ISS	-
GO:1905323	telomerase holoenzyme complex assembly	-	IDA	10197982

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005634	nucleus	-	HDA	21630459
GO:0005634	nucleus	-	ISS	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	IDA	10791971
GO:0005737	cytoplasm	-	ISS	-
GO:0005829	cytosol	-	NAS	12526792
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	TAS	-
GO:0016020	membrane	-	HDA	19946888
GO:0032587	ruffle membrane	-	IEA	-
GO:0032991	protein-containing complex	-	IDA	23349634
GO:0034774	secretory granule lumen	-	TAS	-
GO:0042470	melanosome	-	IEA	-
GO:0043025	neuronal cell body	-	ISS	-
GO:0043202	lysosomal lumen	-	TAS	25719862
GO:0043209	myelin sheath	-	IEA	-
GO:0044294	dendritic growth cone	-	ISS	-
GO:0044295	axonal growth cone	-	ISS	-
GO:0048471	perinuclear region of cytoplasm	-	ISS	-
GO:0070062	extracellular exosome	-	HDA	11487543 12519789 19199708 20458337 23533145
GO:0071682	endocytic vesicle lumen	-	TAS	-
GO:1904813	ficolin-1-rich granule lumen	-	TAS	-

KEGG ID	KEGG Term
hsa04141	Protein processing in endoplasmic reticulum
hsa04612	Antigen processing and presentation
hsa04621	NOD-like receptor signaling pathway
hsa04914	Progesterone-mediated oocyte maturation
hsa05200	Pathways in cancer
hsa05215	Prostate cancer

Reactome ID	Reactome Term	Evidence
R-HSA-1227986	Signaling by ERBB2	TAS
R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	TAS
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1430728	Metabolism	TAS
R-HSA-1474151	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-1640170	Cell Cycle	TAS
R-HSA-1643685	Disease	TAS
R-HSA-1643713	Signaling by EGFR in Cancer	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168254	Influenza Infection	TAS
R-HSA-168255	Influenza Life Cycle	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168273	Influenza Viral RNA Transcription and Replication	TAS
R-HSA-1852241	Organelle biogenesis and maintenance	TAS
R-HSA-192905	vRNP Assembly	TAS
R-HSA-194138	Signaling by VEGF	TAS
R-HSA-194138	Signaling by VEGF	IEA
R-HSA-196854	Metabolism of vitamins and cofactors	TAS
R-HSA-202131	Metabolism of nitric oxide	TAS
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	TAS
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	TAS
R-HSA-203615	eNOS activation	TAS
R-HSA-203765	eNOS activation and regulation	TAS
R-HSA-211000	Gene Silencing by RNA	IEA
R-HSA-2173782	Binding and Uptake of Ligands by Scavenger Receptors	TAS
R-HSA-2173782	Binding and Uptake of Ligands by Scavenger Receptors	IEA
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	TAS
R-HSA-3000484	Scavenging by Class F Receptors	TAS
R-HSA-3000484	Scavenging by Class F Receptors	IEA
R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR)	TAS
R-HSA-3371511	HSF1 activation	TAS
R-HSA-3371556	Cellular response to heat stress	TAS
R-HSA-3371568	Attenuation phase	TAS
R-HSA-3371571	HSF1-dependent transactivation	TAS
R-HSA-373755	Semaphorin interactions	TAS
R-HSA-380259	Loss of Nlp from mitotic centrosomes	TAS
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes	TAS
R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centrosome	TAS
R-HSA-380287	Centrosome maturation	TAS
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	TAS
R-HSA-399954	Sema3A PAK dependent Axon repulsion	TAS
R-HSA-422475	Axon guidance	TAS
R-HSA-4420097	VEGFA-VEGFR2 Pathway	TAS
R-HSA-4420097	VEGFA-VEGFR2 Pathway	IEA
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-453274	Mitotic G2-G2/M phases	TAS
R-HSA-5218920	VEGFR2 mediated vascular permeability	TAS
R-HSA-5336415	Uptake and function of diphtheria toxin	TAS
R-HSA-5339562	Uptake and actions of bacterial toxins	TAS
R-HSA-5601884	PIWI-interacting RNA (piRNA) biogenesis	IEA
R-HSA-5617833	Cilium Assembly	TAS
R-HSA-5620912	Anchoring of the basal body to the plasma membrane	TAS
R-HSA-5637810	Constitutive Signaling by EGFRvIII	TAS
R-HSA-5637812	Signaling by EGFRvIII in Cancer	TAS
R-HSA-5637815	Signaling by Ligand-Responsive EGFR Variants in Cancer	TAS
R-HSA-5653656	Vesicle-mediated transport	TAS
R-HSA-5653656	Vesicle-mediated transport	IEA
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-5663205	Infectious disease	TAS
R-HSA-6785807	Interleukin-4 and 13 signaling	TAS
R-HSA-6798695	Neutrophil degranulation	TAS
R-HSA-68877	Mitotic Prometaphase	TAS
R-HSA-68886	M Phase	TAS
R-HSA-69275	G2/M Transition	TAS
R-HSA-69278	Cell Cycle, Mitotic	TAS
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	TAS
R-HSA-8854518	AURKA Activation by TPX2	TAS
R-HSA-8863795	Downregulation of ERBB2 signaling	TAS
R-HSA-8939211	ESR-mediated signaling	TAS
R-HSA-8953897	Cellular responses to external stimuli	TAS
R-HSA-8978934	Metabolism of cofactors	TAS
R-HSA-9006931	Signaling by Nuclear Receptors	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	IEA
R-HSA-9018519	Estrogen-dependent gene expression	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22860061	Cocaine withdrawal causes delayed dysregulation of stress genes in the hippocampus. (2012)	Garcia-Fuster MJ	PLoS One
23069111	Cigarette smoke condensate induces aryl hydrocarbon receptor-dependent changes in gene expression in spermatocytes. (2012 Dec)	Esakky P	Reprod Toxicol
26124566	An in silico analytical study of lung cancer and smokers datasets from gene expression omnibus (GEO) for prediction of differentially expressed genes. (2015)	Hasan AN	Bioinformation
25803269	Maternal Smoking Dysregulates Protein Expression in Second Trimester Human Fetal Livers in a Sex-Specific Manner. (2015 Jun)	Filis P	J Clin Endocrinol Metab